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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

SOD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Miscellaneous

Present with 10900 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52ManganeseBy similarity1
Metal bindingi107ManganeseBy similarity1
Metal bindingi194ManganeseBy similarity1
Metal bindingi198ManganeseBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: SGD

GO - Biological processi

  • age-dependent response to oxidative stress involved in chronological cell aging Source: SGD
  • age-dependent response to reactive oxygen species involved in chronological cell aging Source: SGD
  • reactive oxygen species metabolic process Source: SGD
  • replicative cell aging Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-1642
ReactomeiR-SCE-2151201 Transcriptional activation of mitochondrial biogenesis
R-SCE-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:SOD2
Ordered Locus Names:YHR008C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR008C
SGDiS000001050 SOD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Protein family/group databases

Allergomei867 Sac c MnSOD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26Mitochondrion1 PublicationAdd BLAST26
ChainiPRO_000003288827 – 233Superoxide dismutase [Mn], mitochondrialAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphothreonineCombined sources1
Modified residuei149PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP00447
PaxDbiP00447
PRIDEiP00447
TopDownProteomicsiP00447

2D gel databases

UCD-2DPAGEiP00447

PTM databases

iPTMnetiP00447

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi36435228 interactors.
DIPiDIP-4905N
IntActiP00447 15 interactors.
MINTiP00447
STRINGi4932.YHR008C

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 40Combined sources4
Turni41 – 43Combined sources3
Helixi46 – 54Combined sources9
Helixi57 – 79Combined sources23
Helixi84 – 88Combined sources5
Helixi91 – 97Combined sources7
Helixi100 – 112Combined sources13
Helixi117 – 119Combined sources3
Turni120 – 122Combined sources3
Helixi127 – 130Combined sources4
Helixi133 – 137Combined sources5
Helixi140 – 144Combined sources5
Turni147 – 149Combined sources3
Beta strandi156 – 165Combined sources10
Helixi166 – 168Combined sources3
Beta strandi173 – 178Combined sources6
Beta strandi187 – 194Combined sources8
Helixi197 – 199Combined sources3
Helixi201 – 204Combined sources4
Helixi209 – 212Combined sources4
Helixi215 – 218Combined sources4
Helixi224 – 230Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BFRX-ray2.05A27-233[»]
3LSUX-ray1.90A/B/C/D27-233[»]
3RN4X-ray1.79A19-233[»]
4E4EX-ray1.88A/B/C/D27-233[»]
4F6EX-ray1.60A/B/C/D28-233[»]
ProteinModelPortaliP00447
SMRiP00447
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00447

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
InParanoidiP00447
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG092C4NQ6

Family and domain databases

Gene3Di1.10.287.9901 hit
2.40.500.201 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE
60 70 80 90 100
LHYTKHHQTY VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH
110 120 130 140 150
GGGFTNHCLF WENLAPESQG GGEPPTGALA KAIDEQFGSL DELIKLTNTK
160 170 180 190 200
LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ DTVTGPLVPL VAIDAWEHAY
210 220 230
YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI
Length:233
Mass (Da):25,774
Last modified:October 23, 1986 - v1
Checksum:i88A9391FBB31D06E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02156 Genomic DNA Translation: CAA26092.1
U10400 Genomic DNA Translation: AAB68939.1
M24079 Genomic DNA Translation: AAA35065.1
AY557821 Genomic DNA Translation: AAS56147.1
BK006934 Genomic DNA Translation: DAA06697.1
PIRiA00521 DSBYN
RefSeqiNP_011872.1, NM_001179138.1

Genome annotation databases

EnsemblFungiiYHR008C; YHR008C; YHR008C
GeneIDi856399
KEGGisce:YHR008C

Similar proteinsi

Entry informationi

Entry nameiSODM_YEAST
AccessioniPrimary (citable) accession number: P00447
Secondary accession number(s): D3DKV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: March 28, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome