SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00430

- COX7C_BOVIN

UniProt

P00430 - COX7C_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 7C, mitochondrial
Gene
COX7C, COX7CP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
Synonyms:COX7CP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10, UP000009136: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrix
Add
BLAST
Transmembranei34 – 6027Helical
Add
BLAST
Topological domaini61 – 633Mitochondrial intermembrane

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion2 Publications
Add
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrial1 Publication
PRO_0000006162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternate By similarity
Modified residuei25 – 251N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00430.

Expressioni

Tissue specificityi

Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048302.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni23 – 253
Beta strandi26 – 294
Helixi34 – 6027

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430. Positions 17-63.

Miscellaneous databases

EvolutionaryTraceiP00430.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241420.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiFIVVRHQ.
OrthoDBiEOG73JKZF.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00430-1 [UniParc]FASTAAdd to Basket

« Hide

MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA   50
APFFIVRHQL LKK 63
Length:63
Mass (Da):7,331
Last modified:August 1, 1992 - v3
Checksum:iC6A2AD5CC4E63C0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_002705952.1. XM_002705906.3.
XP_005209785.1. XM_005209728.1.
UniGeneiBt.62366.
Bt.77.

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi100335836.
KEGGibta:100335836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15725 mRNA. Translation: CAB57793.1 .
X58823 Genomic DNA. Translation: CAA41627.1 .
U58655 Genomic DNA. Translation: AAC48719.1 .
AY911320 mRNA. Translation: AAW82088.1 .
BC102263 mRNA. Translation: AAI02264.1 .
PIRi JH0473. OSBO8A.
RefSeqi XP_002705952.1. XM_002705906.3.
XP_005209785.1. XM_005209728.1.
UniGenei Bt.62366.
Bt.77.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 L/Y 17-63 [» ]
1OCO X-ray 2.80 L/Y 17-63 [» ]
1OCR X-ray 2.35 L/Y 17-63 [» ]
1OCZ X-ray 2.90 L/Y 17-63 [» ]
1V54 X-ray 1.80 L/Y 17-63 [» ]
1V55 X-ray 1.90 L/Y 17-63 [» ]
2DYR X-ray 1.80 L/Y 17-63 [» ]
2DYS X-ray 2.20 L/Y 17-63 [» ]
2EIJ X-ray 1.90 L/Y 17-63 [» ]
2EIK X-ray 2.10 L/Y 17-63 [» ]
2EIL X-ray 2.10 L/Y 17-63 [» ]
2EIM X-ray 2.60 L/Y 17-63 [» ]
2EIN X-ray 2.70 L/Y 17-63 [» ]
2OCC X-ray 2.30 L/Y 17-63 [» ]
2Y69 X-ray 1.95 L/Y 1-63 [» ]
2YBB electron microscopy 19.00 W 17-63 [» ]
2ZXW X-ray 2.50 L/Y 17-63 [» ]
3ABK X-ray 2.00 L/Y 17-63 [» ]
3ABL X-ray 2.10 L/Y 17-63 [» ]
3ABM X-ray 1.95 L/Y 17-63 [» ]
3AG1 X-ray 2.20 L/Y 17-63 [» ]
3AG2 X-ray 1.80 L/Y 17-63 [» ]
3AG3 X-ray 1.80 L/Y 17-63 [» ]
3AG4 X-ray 2.05 L/Y 17-63 [» ]
3ASN X-ray 3.00 L/Y 17-63 [» ]
3ASO X-ray 2.30 L/Y 17-63 [» ]
3WG7 X-ray 1.90 L/Y 17-63 [» ]
ProteinModelPortali P00430.
SMRi P00430. Positions 17-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000048302.

Proteomic databases

PRIDEi P00430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000052050 ; ENSBTAP00000048302 ; ENSBTAG00000039555 .
ENSBTAT00000053207 ; ENSBTAP00000051619 ; ENSBTAG00000040564 .
ENSBTAT00000056065 ; ENSBTAP00000050340 ; ENSBTAG00000039440 .
GeneIDi 100335836.
KEGGi bta:100335836.

Phylogenomic databases

eggNOGi NOG241420.
GeneTreei ENSGT00390000018086.
HOGENOMi HOG000237276.
HOVERGENi HBG051093.
InParanoidi P00430.
KOi K02272.
OMAi FIVVRHQ.
OrthoDBi EOG73JKZF.
TreeFami TF105069.

Miscellaneous databases

EvolutionaryTracei P00430.
NextBioi 20810182.

Family and domain databases

Gene3Di 4.10.49.10. 1 hit.
InterProi IPR004202. COX7C/Cox8.
[Graphical view ]
PANTHERi PTHR13313. PTHR13313. 1 hit.
Pfami PF02935. COX7C. 1 hit.
[Graphical view ]
SUPFAMi SSF81427. SSF81427. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc."
    Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I.
    Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase."
    Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I.
    Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1."
    Seelan R.S., Grossman L.I.
    J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  6. "Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme."
    Buse G., Steffens G.J.
    Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-63.
    Tissue: Heart.
  7. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-42.
    Tissue: Liver.
  8. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  10. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX7C_BOVIN
AccessioniPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi