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P00430

- COX7C_BOVIN

UniProt

P00430 - COX7C_BOVIN

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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
Synonyms:COX7CP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10, UP000009136: Chromosome 19, UP000009136: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrixAdd
BLAST
Transmembranei34 – 6027HelicalAdd
BLAST
Topological domaini61 – 633Mitochondrial intermembrane

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion2 PublicationsAdd
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000006162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternateBy similarity
Modified residuei25 – 251N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00430.

Expressioni

Tissue specificityi

Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

Interactioni

Protein-protein interaction databases

DIPiDIP-60940N.
STRINGi9913.ENSBTAP00000048302.

Structurei

Secondary structure

1
63
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni23 – 253Combined sources
Beta strandi26 – 294Combined sources
Helixi34 – 6027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430. Positions 17-63.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00430.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241420.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiFIVVRHQ.
OrthoDBiEOG73JKZF.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,331
Last modified:August 1, 1992 - v3
Checksum:iC6A2AD5CC4E63C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_002705952.1. XM_002705906.3.
XP_005209785.1. XM_005209728.1.
UniGeneiBt.62366.
Bt.77.

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi100335836.
KEGGibta:100335836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1 .
X58823 Genomic DNA. Translation: CAA41627.1 .
U58655 Genomic DNA. Translation: AAC48719.1 .
AY911320 mRNA. Translation: AAW82088.1 .
BC102263 mRNA. Translation: AAI02264.1 .
PIRi JH0473. OSBO8A.
RefSeqi XP_002705952.1. XM_002705906.3.
XP_005209785.1. XM_005209728.1.
UniGenei Bt.62366.
Bt.77.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 L/Y 17-63 [» ]
1OCO X-ray 2.80 L/Y 17-63 [» ]
1OCR X-ray 2.35 L/Y 17-63 [» ]
1OCZ X-ray 2.90 L/Y 17-63 [» ]
1V54 X-ray 1.80 L/Y 17-63 [» ]
1V55 X-ray 1.90 L/Y 17-63 [» ]
2DYR X-ray 1.80 L/Y 17-63 [» ]
2DYS X-ray 2.20 L/Y 17-63 [» ]
2EIJ X-ray 1.90 L/Y 17-63 [» ]
2EIK X-ray 2.10 L/Y 17-63 [» ]
2EIL X-ray 2.10 L/Y 17-63 [» ]
2EIM X-ray 2.60 L/Y 17-63 [» ]
2EIN X-ray 2.70 L/Y 17-63 [» ]
2OCC X-ray 2.30 L/Y 17-63 [» ]
2Y69 X-ray 1.95 L/Y 1-63 [» ]
2YBB electron microscopy 19.00 W 17-63 [» ]
2ZXW X-ray 2.50 L/Y 17-63 [» ]
3ABK X-ray 2.00 L/Y 17-63 [» ]
3ABL X-ray 2.10 L/Y 17-63 [» ]
3ABM X-ray 1.95 L/Y 17-63 [» ]
3AG1 X-ray 2.20 L/Y 17-63 [» ]
3AG2 X-ray 1.80 L/Y 17-63 [» ]
3AG3 X-ray 1.80 L/Y 17-63 [» ]
3AG4 X-ray 2.05 L/Y 17-63 [» ]
3ASN X-ray 3.00 L/Y 17-63 [» ]
3ASO X-ray 2.30 L/Y 17-63 [» ]
3WG7 X-ray 1.90 L/Y 17-63 [» ]
ProteinModelPortali P00430.
SMRi P00430. Positions 17-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60940N.
STRINGi 9913.ENSBTAP00000048302.

Proteomic databases

PRIDEi P00430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000052050 ; ENSBTAP00000048302 ; ENSBTAG00000039555 .
ENSBTAT00000053207 ; ENSBTAP00000051619 ; ENSBTAG00000040564 .
ENSBTAT00000056065 ; ENSBTAP00000050340 ; ENSBTAG00000039440 .
GeneIDi 100335836.
KEGGi bta:100335836.

Phylogenomic databases

eggNOGi NOG241420.
GeneTreei ENSGT00390000018086.
HOGENOMi HOG000237276.
HOVERGENi HBG051093.
InParanoidi P00430.
KOi K02272.
OMAi FIVVRHQ.
OrthoDBi EOG73JKZF.
TreeFami TF105069.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Miscellaneous databases

EvolutionaryTracei P00430.
NextBioi 20810182.

Family and domain databases

Gene3Di 4.10.49.10. 1 hit.
InterProi IPR004202. COX7C/Cox8.
[Graphical view ]
PANTHERi PTHR13313. PTHR13313. 1 hit.
Pfami PF02935. COX7C. 1 hit.
[Graphical view ]
SUPFAMi SSF81427. SSF81427. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc."
    Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I.
    Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase."
    Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I.
    Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1."
    Seelan R.S., Grossman L.I.
    J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  6. "Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme."
    Buse G., Steffens G.J.
    Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-63.
    Tissue: Heart.
  7. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-42.
    Tissue: Liver.
  8. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  10. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX7C_BOVIN
AccessioniPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: November 26, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3