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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
Synonyms:COX7CP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 10, Chromosome 19, Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixAdd BLAST17
Transmembranei34 – 60HelicalAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembrane3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion2 PublicationsAdd BLAST16
ChainiPRO_000000616217 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00430
PRIDEiP00430

PTM databases

iPTMnetiP00430

Expressioni

Tissue specificityi

Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

Gene expression databases

BgeeiENSBTAG00000039440

Interactioni

Protein-protein interaction databases

CORUMiP00430
DIPiDIP-60940N
IntActiP00430, 1 interactor
STRINGi9913.ENSBTAP00000051619

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 25Combined sources3
Beta strandi26 – 29Combined sources4
Helixi34 – 62Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
3X2QX-ray2.00L/Y17-63[»]
5B1AX-ray1.50L/Y17-63[»]
5B1BX-ray1.60L/Y17-63[»]
5B3SX-ray1.68L/Y17-63[»]
5GPNelectron microscopy5.40917-63[»]
5IY5X-ray2.00L/Y18-63[»]
5LUFelectron microscopy9.10917-63[»]
5W97X-ray2.30L/l17-63[»]
5WAUX-ray1.95L/l17-63[»]
5X19X-ray2.20L/Y17-63[»]
5X1BX-ray2.40L/Y17-63[»]
5X1FX-ray2.20L/Y17-63[»]
5XDQX-ray1.77L/Y17-63[»]
5XDXX-ray1.99L/Y17-63[»]
5XTHelectron microscopy3.90817-63[»]
5XTIelectron microscopy17.408/B817-63[»]
ProteinModelPortaliP00430
SMRiP00430
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00430

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527 Eukaryota
ENOG4112B97 LUCA
GeneTreeiENSGT00390000018086
HOGENOMiHOG000237276
HOVERGENiHBG051093
InParanoidiP00430
KOiK02272
OMAiVRHQILK
OrthoDBiEOG091G16OJ
TreeFamiTF105069

Family and domain databases

CDDicd00929 Cyt_c_Oxidase_VIIc, 1 hit
Gene3Di4.10.49.10, 1 hit
InterProiView protein in InterPro
IPR004202 COX7C/Cox8
IPR036636 COX7C/Cox8_sf
PANTHERiPTHR13313 PTHR13313, 1 hit
PfamiView protein in Pfam
PF02935 COX7C, 1 hit
SUPFAMiSSF81427 SSF81427, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,331
Last modified:August 1, 1992 - v3
Checksum:iC6A2AD5CC4E63C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA Translation: CAB57793.1
X58823 Genomic DNA Translation: CAA41627.1
U58655 Genomic DNA Translation: AAC48719.1
AY911320 mRNA Translation: AAW82088.1
BC102263 mRNA Translation: AAI02264.1
PIRiJH0473 OSBO8A
RefSeqiXP_005209785.1, XM_005209728.3
XP_010797710.1, XM_010799408.2
XP_010805898.1, XM_010807596.2
XP_010807835.1, XM_010809533.1
XP_010814166.1, XM_010815864.2
XP_010821463.1, XM_010823161.2
XP_010822314.2, XM_010824012.2
XP_015319858.1, XM_015464372.1
UniGeneiBt.62366
Bt.77

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440
GeneIDi101902937
101903567
327718
KEGGibta:101902937
bta:101903567
bta:327718

Similar proteinsi

Entry informationi

Entry nameiCOX7C_BOVIN
AccessioniPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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