Cytochrome c oxidase subunit 7C, mitochondrial precursor

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P00430 (COX7C_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc

Gene names

Name:	COX7C
Synonyms:	COX7CP1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.
Sequence similarities	Belongs to the cytochrome c oxidase VIIc family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 16

Mitochondrion Ref.6 Ref.7

Chain

17 – 63

Cytochrome c oxidase subunit 7C, mitochondrial Ref.2

PRO_0000006162

Regions

Topological domain

17 – 33

Mitochondrial matrix

Transmembrane

34 – 60

Helical

Topological domain

61 – 63

Mitochondrial intermembrane

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P00430 [UniParc].

Last modified August 1, 1992. Version 3.
Checksum: C6A2AD5CC4E63C0B
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FASTA

7,331

        10         20         30         40         50         60 
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA APFFIVRHQL 


LKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc." Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I. Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase." Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I. Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1." Seelan R.S., Grossman L.I. J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Analysis of sequences obtained from constructed full-length bovine cDNA libraries." Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymphoid epithelium.
[5]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.
[6]	"Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme." Buse G., Steffens G.J. Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 17-63. Tissue: Heart.
[7]	"Tissue-specific differences between heart and liver cytochrome c oxidase." Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A. Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 17-42. Tissue: Liver.
[8]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[9]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). Tissue: Heart.
[10]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.

IPI

IPI00694475.

PIR

OSBO8A. JH0473.

RefSeq

NP_787025.1. NM_175831.3.
XP_002705952.1. XM_002705906.2.

UniGene

Bt.62366.
Bt.77.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	L/Y	17-63	[»]
1OCO	X-ray	2.80	L/Y	17-63	[»]
1OCR	X-ray	2.35	L/Y	17-63	[»]
1OCZ	X-ray	2.90	L/Y	17-63	[»]
1V54	X-ray	1.80	L/Y	17-63	[»]
1V55	X-ray	1.90	L/Y	17-63	[»]
2DYR	X-ray	1.80	L/Y	17-63	[»]
2DYS	X-ray	2.20	L/Y	17-63	[»]
2EIJ	X-ray	1.90	L/Y	17-63	[»]
2EIK	X-ray	2.10	L/Y	17-63	[»]
2EIL	X-ray	2.10	L/Y	17-63	[»]
2EIM	X-ray	2.60	L/Y	17-63	[»]
2EIN	X-ray	2.70	L/Y	17-63	[»]
2OCC	X-ray	2.30	L/Y	17-63	[»]
2Y69	X-ray	1.95	L/Y	1-63	[»]
2YBB	electron microscopy	19.00	W	17-63	[»]
2ZXW	X-ray	2.50	L/Y	17-63	[»]
3ABK	X-ray	2.00	L/Y	17-63	[»]
3ABL	X-ray	2.10	L/Y	17-63	[»]
3ABM	X-ray	1.95	L/Y	17-63	[»]
3AG1	X-ray	2.20	L/Y	17-63	[»]
3AG2	X-ray	1.80	L/Y	17-63	[»]
3AG3	X-ray	1.80	L/Y	17-63	[»]
3AG4	X-ray	2.05	L/Y	17-63	[»]
3ASN	X-ray	3.00	L/Y	17-63	[»]
3ASO	X-ray	2.30	L/Y	17-63	[»]

ProteinModelPortal

P00430.

SMR

P00430. Positions 17-63.

ModBase

Search...

Protein-protein interaction databases

STRING

9913.ENSBTAP00000048302.

Proteomic databases

PRIDE

P00430.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.

GeneID

100335836.
327718.

KEGG

bta:100335836.
bta:327718.

Organism-specific databases

CTD

1350.

Phylogenomic databases

eggNOG

NOG241420.

GeneTree

ENSGT00390000018086.

HOGENOM

HOG000237276.

HOVERGEN

HBG051093.

InParanoid

P00430.

K02272.

OMA

FIVVRHQ.

OrthoDB

EOG47WNQD.

Family and domain databases

Gene3D

4.10.49.10. 1 hit.

InterPro

IPR023284. Cyt_c_Oxase_suVIIc_dom.
IPR004202. Cyt_c_oxidsae_su7c.
[Graphical view]

PANTHER

PTHR13313. PTHR13313. 1 hit.

Pfam

PF02935. COX7C. 1 hit.
[Graphical view]

SUPFAM

SSF81427. Cyt_c_Oxase_suVIIc_dom. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P00430.

NextBio

20810182.

Entry information

Entry name

COX7C_BOVIN

Accession

Primary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents