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P00430 (COX7C_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene names
Name:COX7C
Synonyms:COX7CP1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Tissue specificity

Liver, heart, muscle and brain, contain the same isoform ofCOX VIIc, but at different concentrations.

Sequence similarities

Belongs to the cytochrome c oxidase VIIc family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1616Mitochondrion Ref.6 Ref.7
Chain17 – 6347Cytochrome c oxidase subunit 7C, mitochondrial Ref.2
PRO_0000006162

Regions

Topological domain17 – 3317Mitochondrial matrix
Transmembrane34 – 6027Helical
Topological domain61 – 633Mitochondrial intermembrane

Amino acid modifications

Modified residue251N6-acetyllysine; alternate By similarity
Modified residue251N6-succinyllysine; alternate By similarity

Secondary structure

...... 63
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00430 [UniParc].

Last modified August 1, 1992. Version 3.
Checksum: C6A2AD5CC4E63C0B

FASTA637,331
        10         20         30         40         50         60 
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA APFFIVRHQL 


LKK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc."
Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I.
Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase."
Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I.
Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1."
Seelan R.S., Grossman L.I.
J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymphoid epithelium.
[5]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[6]"Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme."
Buse G., Steffens G.J.
Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 17-63.
Tissue: Heart.
[7]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 17-42.
Tissue: Liver.
[8]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[9]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[10]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIROSBO8A. JH0473.
RefSeqNP_787025.1. NM_175831.3.
XP_002705952.1. XM_002705906.3.
XP_005209785.1. XM_005209728.1.
UniGeneBt.62366.
Bt.77.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
ProteinModelPortalP00430.
SMRP00430. Positions 17-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000048302.

Proteomic databases

PRIDEP00430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneID100335836.
327718.
KEGGbta:100335836.
bta:327718.

Organism-specific databases

CTD1350.

Phylogenomic databases

eggNOGNOG241420.
GeneTreeENSGT00390000018086.
HOGENOMHOG000237276.
HOVERGENHBG051093.
InParanoidP00430.
KOK02272.
OMAFIVVRHQ.
OrthoDBEOG73JKZF.
TreeFamTF105069.

Family and domain databases

Gene3D4.10.49.10. 1 hit.
InterProIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERPTHR13313. PTHR13313. 1 hit.
PfamPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMSSF81427. SSF81427. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00430.
NextBio20810182.

Entry information

Entry nameCOX7C_BOVIN
AccessionPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references