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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
Synonyms:COX7CP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 10, Chromosome 19, Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixAdd BLAST17
Transmembranei34 – 60HelicalAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembrane3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion2 PublicationsAdd BLAST16
ChainiPRO_000000616217 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00430.
PRIDEiP00430.

PTM databases

iPTMnetiP00430.

Expressioni

Tissue specificityi

Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

Gene expression databases

BgeeiENSBTAG00000039440.

Interactioni

Protein-protein interaction databases

DIPiDIP-60940N.
STRINGi9913.ENSBTAP00000051619.

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 25Combined sources3
Beta strandi26 – 29Combined sources4
Helixi34 – 62Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
3X2QX-ray2.00L/Y17-63[»]
5B1AX-ray1.50L/Y17-63[»]
5B1BX-ray1.60L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00430.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
TreeFamiTF105069.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,331
Last modified:August 1, 1992 - v3
Checksum:iC6A2AD5CC4E63C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_005209785.1. XM_005209728.3.
XP_010797710.1. XM_010799408.2.
XP_010805898.1. XM_010807596.2.
XP_010807835.1. XM_010809533.1.
XP_010814166.1. XM_010815864.2.
XP_010821463.1. XM_010823161.2.
XP_010822314.2. XM_010824012.2.
XP_015319858.1. XM_015464372.1.
UniGeneiBt.62366.
Bt.77.

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi101902937.
101903567.
327718.
KEGGibta:101902937.
bta:101903567.
bta:327718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_005209785.1. XM_005209728.3.
XP_010797710.1. XM_010799408.2.
XP_010805898.1. XM_010807596.2.
XP_010807835.1. XM_010809533.1.
XP_010814166.1. XM_010815864.2.
XP_010821463.1. XM_010823161.2.
XP_010822314.2. XM_010824012.2.
XP_015319858.1. XM_015464372.1.
UniGeneiBt.62366.
Bt.77.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
3X2QX-ray2.00L/Y17-63[»]
5B1AX-ray1.50L/Y17-63[»]
5B1BX-ray1.60L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60940N.
STRINGi9913.ENSBTAP00000051619.

PTM databases

iPTMnetiP00430.

Proteomic databases

PaxDbiP00430.
PRIDEiP00430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi101902937.
101903567.
327718.
KEGGibta:101902937.
bta:101903567.
bta:327718.

Organism-specific databases

CTDi1350.

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
TreeFamiTF105069.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00430.

Gene expression databases

BgeeiENSBTAG00000039440.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7C_BOVIN
AccessioniPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.