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P00430

- COX7C_BOVIN

UniProt

P00430 - COX7C_BOVIN

Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7C, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIIIA
    Cytochrome c oxidase polypeptide VIIc
    Gene namesi
    Name:COX7C
    Synonyms:COX7CP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10, UP000009136: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1616Mitochondrion2 PublicationsAdd
    BLAST
    Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000006162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251N6-acetyllysine; alternateBy similarity
    Modified residuei25 – 251N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP00430.

    Expressioni

    Tissue specificityi

    Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60940N.
    STRINGi9913.ENSBTAP00000048302.

    Structurei

    Secondary structure

    1
    63
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni23 – 253
    Beta strandi26 – 294
    Helixi34 – 6027

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80L/Y17-63[»]
    1OCOX-ray2.80L/Y17-63[»]
    1OCRX-ray2.35L/Y17-63[»]
    1OCZX-ray2.90L/Y17-63[»]
    1V54X-ray1.80L/Y17-63[»]
    1V55X-ray1.90L/Y17-63[»]
    2DYRX-ray1.80L/Y17-63[»]
    2DYSX-ray2.20L/Y17-63[»]
    2EIJX-ray1.90L/Y17-63[»]
    2EIKX-ray2.10L/Y17-63[»]
    2EILX-ray2.10L/Y17-63[»]
    2EIMX-ray2.60L/Y17-63[»]
    2EINX-ray2.70L/Y17-63[»]
    2OCCX-ray2.30L/Y17-63[»]
    2Y69X-ray1.95L/Y1-63[»]
    2YBBelectron microscopy19.00W17-63[»]
    2ZXWX-ray2.50L/Y17-63[»]
    3ABKX-ray2.00L/Y17-63[»]
    3ABLX-ray2.10L/Y17-63[»]
    3ABMX-ray1.95L/Y17-63[»]
    3AG1X-ray2.20L/Y17-63[»]
    3AG2X-ray1.80L/Y17-63[»]
    3AG3X-ray1.80L/Y17-63[»]
    3AG4X-ray2.05L/Y17-63[»]
    3ASNX-ray3.00L/Y17-63[»]
    3ASOX-ray2.30L/Y17-63[»]
    3WG7X-ray1.90L/Y17-63[»]
    ProteinModelPortaliP00430.
    SMRiP00430. Positions 17-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00430.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 3317Mitochondrial matrixAdd
    BLAST
    Topological domaini61 – 633Mitochondrial intermembrane

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 6027HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIc family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241420.
    GeneTreeiENSGT00390000018086.
    HOGENOMiHOG000237276.
    HOVERGENiHBG051093.
    InParanoidiP00430.
    KOiK02272.
    OMAiFIVVRHQ.
    OrthoDBiEOG73JKZF.
    TreeFamiTF105069.

    Family and domain databases

    Gene3Di4.10.49.10. 1 hit.
    InterProiIPR004202. COX7C/Cox8.
    [Graphical view]
    PANTHERiPTHR13313. PTHR13313. 1 hit.
    PfamiPF02935. COX7C. 1 hit.
    [Graphical view]
    SUPFAMiSSF81427. SSF81427. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA   50
    APFFIVRHQL LKK 63
    Length:63
    Mass (Da):7,331
    Last modified:August 1, 1992 - v3
    Checksum:iC6A2AD5CC4E63C0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15725 mRNA. Translation: CAB57793.1.
    X58823 Genomic DNA. Translation: CAA41627.1.
    U58655 Genomic DNA. Translation: AAC48719.1.
    AY911320 mRNA. Translation: AAW82088.1.
    BC102263 mRNA. Translation: AAI02264.1.
    PIRiJH0473. OSBO8A.
    RefSeqiXP_002705952.1. XM_002705906.3.
    XP_005209785.1. XM_005209728.1.
    UniGeneiBt.62366.
    Bt.77.

    Genome annotation databases

    EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
    ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
    ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
    GeneIDi100335836.
    KEGGibta:100335836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15725 mRNA. Translation: CAB57793.1 .
    X58823 Genomic DNA. Translation: CAA41627.1 .
    U58655 Genomic DNA. Translation: AAC48719.1 .
    AY911320 mRNA. Translation: AAW82088.1 .
    BC102263 mRNA. Translation: AAI02264.1 .
    PIRi JH0473. OSBO8A.
    RefSeqi XP_002705952.1. XM_002705906.3.
    XP_005209785.1. XM_005209728.1.
    UniGenei Bt.62366.
    Bt.77.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 L/Y 17-63 [» ]
    1OCO X-ray 2.80 L/Y 17-63 [» ]
    1OCR X-ray 2.35 L/Y 17-63 [» ]
    1OCZ X-ray 2.90 L/Y 17-63 [» ]
    1V54 X-ray 1.80 L/Y 17-63 [» ]
    1V55 X-ray 1.90 L/Y 17-63 [» ]
    2DYR X-ray 1.80 L/Y 17-63 [» ]
    2DYS X-ray 2.20 L/Y 17-63 [» ]
    2EIJ X-ray 1.90 L/Y 17-63 [» ]
    2EIK X-ray 2.10 L/Y 17-63 [» ]
    2EIL X-ray 2.10 L/Y 17-63 [» ]
    2EIM X-ray 2.60 L/Y 17-63 [» ]
    2EIN X-ray 2.70 L/Y 17-63 [» ]
    2OCC X-ray 2.30 L/Y 17-63 [» ]
    2Y69 X-ray 1.95 L/Y 1-63 [» ]
    2YBB electron microscopy 19.00 W 17-63 [» ]
    2ZXW X-ray 2.50 L/Y 17-63 [» ]
    3ABK X-ray 2.00 L/Y 17-63 [» ]
    3ABL X-ray 2.10 L/Y 17-63 [» ]
    3ABM X-ray 1.95 L/Y 17-63 [» ]
    3AG1 X-ray 2.20 L/Y 17-63 [» ]
    3AG2 X-ray 1.80 L/Y 17-63 [» ]
    3AG3 X-ray 1.80 L/Y 17-63 [» ]
    3AG4 X-ray 2.05 L/Y 17-63 [» ]
    3ASN X-ray 3.00 L/Y 17-63 [» ]
    3ASO X-ray 2.30 L/Y 17-63 [» ]
    3WG7 X-ray 1.90 L/Y 17-63 [» ]
    ProteinModelPortali P00430.
    SMRi P00430. Positions 17-63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60940N.
    STRINGi 9913.ENSBTAP00000048302.

    Proteomic databases

    PRIDEi P00430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000052050 ; ENSBTAP00000048302 ; ENSBTAG00000039555 .
    ENSBTAT00000053207 ; ENSBTAP00000051619 ; ENSBTAG00000040564 .
    ENSBTAT00000056065 ; ENSBTAP00000050340 ; ENSBTAG00000039440 .
    GeneIDi 100335836.
    KEGGi bta:100335836.

    Phylogenomic databases

    eggNOGi NOG241420.
    GeneTreei ENSGT00390000018086.
    HOGENOMi HOG000237276.
    HOVERGENi HBG051093.
    InParanoidi P00430.
    KOi K02272.
    OMAi FIVVRHQ.
    OrthoDBi EOG73JKZF.
    TreeFami TF105069.

    Miscellaneous databases

    EvolutionaryTracei P00430.
    NextBioi 20810182.

    Family and domain databases

    Gene3Di 4.10.49.10. 1 hit.
    InterProi IPR004202. COX7C/Cox8.
    [Graphical view ]
    PANTHERi PTHR13313. PTHR13313. 1 hit.
    Pfami PF02935. COX7C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81427. SSF81427. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc."
      Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I.
      Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase."
      Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I.
      Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1."
      Seelan R.S., Grossman L.I.
      J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
      Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymphoid epithelium.
    5. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    6. "Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme."
      Buse G., Steffens G.J.
      Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-63.
      Tissue: Heart.
    7. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-42.
      Tissue: Liver.
    8. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    10. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX7C_BOVIN
    AccessioniPrimary (citable) accession number: P00430
    Secondary accession number(s): Q3T0U0, Q56K07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3