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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIIA
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
Synonyms:COX7CP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 10, Chromosome 19, Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrixAdd
BLAST
Transmembranei34 – 6027HelicalAdd
BLAST
Topological domaini61 – 633Mitochondrial intermembrane

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion2 PublicationsAdd
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000006162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternateBy similarity
Modified residuei25 – 251N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00430.
PRIDEiP00430.

PTM databases

iPTMnetiP00430.

Expressioni

Tissue specificityi

Liver, heart, muscle and brain, contain the same isoform of COX VIIc, but at different concentrations.

Interactioni

Protein-protein interaction databases

DIPiDIP-60940N.
STRINGi9913.ENSBTAP00000051619.

Structurei

Secondary structure

1
63
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni23 – 253Combined sources
Beta strandi26 – 294Combined sources
Helixi34 – 6027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
3X2QX-ray2.00L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430. Positions 17-63.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00430.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNIPFS VENKWRLLAM MTLFFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,331
Last modified:August 1, 1992 - v3
Checksum:iC6A2AD5CC4E63C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_005209785.1. XM_005209728.3.
XP_010797710.1. XM_010799408.2.
XP_010805898.1. XM_010807596.2.
XP_010807835.1. XM_010809533.1.
XP_010814166.1. XM_010815864.2.
XP_010821463.1. XM_010823161.2.
XP_010822314.2. XM_010824012.2.
XP_015319858.1. XM_015464372.1.
UniGeneiBt.62366.
Bt.77.

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi101902937.
101903567.
327718.
KEGGibta:101902937.
bta:101903567.
bta:327718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15725 mRNA. Translation: CAB57793.1.
X58823 Genomic DNA. Translation: CAA41627.1.
U58655 Genomic DNA. Translation: AAC48719.1.
AY911320 mRNA. Translation: AAW82088.1.
BC102263 mRNA. Translation: AAI02264.1.
PIRiJH0473. OSBO8A.
RefSeqiXP_005209785.1. XM_005209728.3.
XP_010797710.1. XM_010799408.2.
XP_010805898.1. XM_010807596.2.
XP_010807835.1. XM_010809533.1.
XP_010814166.1. XM_010815864.2.
XP_010821463.1. XM_010823161.2.
XP_010822314.2. XM_010824012.2.
XP_015319858.1. XM_015464372.1.
UniGeneiBt.62366.
Bt.77.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80L/Y17-63[»]
1OCOX-ray2.80L/Y17-63[»]
1OCRX-ray2.35L/Y17-63[»]
1OCZX-ray2.90L/Y17-63[»]
1V54X-ray1.80L/Y17-63[»]
1V55X-ray1.90L/Y17-63[»]
2DYRX-ray1.80L/Y17-63[»]
2DYSX-ray2.20L/Y17-63[»]
2EIJX-ray1.90L/Y17-63[»]
2EIKX-ray2.10L/Y17-63[»]
2EILX-ray2.10L/Y17-63[»]
2EIMX-ray2.60L/Y17-63[»]
2EINX-ray2.70L/Y17-63[»]
2OCCX-ray2.30L/Y17-63[»]
2Y69X-ray1.95L/Y1-63[»]
2YBBelectron microscopy19.00W17-63[»]
2ZXWX-ray2.50L/Y17-63[»]
3ABKX-ray2.00L/Y17-63[»]
3ABLX-ray2.10L/Y17-63[»]
3ABMX-ray1.95L/Y17-63[»]
3AG1X-ray2.20L/Y17-63[»]
3AG2X-ray1.80L/Y17-63[»]
3AG3X-ray1.80L/Y17-63[»]
3AG4X-ray2.05L/Y17-63[»]
3ASNX-ray3.00L/Y17-63[»]
3ASOX-ray2.30L/Y17-63[»]
3WG7X-ray1.90L/Y17-63[»]
3X2QX-ray2.00L/Y17-63[»]
ProteinModelPortaliP00430.
SMRiP00430. Positions 17-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60940N.
STRINGi9913.ENSBTAP00000051619.

PTM databases

iPTMnetiP00430.

Proteomic databases

PaxDbiP00430.
PRIDEiP00430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000052050; ENSBTAP00000048302; ENSBTAG00000039555.
ENSBTAT00000053207; ENSBTAP00000051619; ENSBTAG00000040564.
ENSBTAT00000056065; ENSBTAP00000050340; ENSBTAG00000039440.
GeneIDi101902937.
101903567.
327718.
KEGGibta:101902937.
bta:101903567.
bta:327718.

Organism-specific databases

CTDi1350.

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP00430.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
TreeFamiTF105069.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00430.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIc."
    Aqua M.S., Lomax M.I., Schon E.A., Grossman L.I.
    Nucleic Acids Res. 17:8376-8376(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and expression of a cDNA specifying subunit VIIc of bovine cytochrome c oxidase."
    Aqua M.S., Bachman N.J., Lomax M.I., Grossman L.I.
    Gene 104:211-217(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1."
    Seelan R.S., Grossman L.I.
    J. Biol. Chem. 272:10175-10181(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  6. "Studies on cytochrome c oxidase, II. The chemical constitution of a short polypeptide from the beef heart enzyme."
    Buse G., Steffens G.J.
    Hoppe-Seyler's Z. Physiol. Chem. 359:1005-1009(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-63.
    Tissue: Heart.
  7. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-42.
    Tissue: Liver.
  8. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  10. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX7C_BOVIN
AccessioniPrimary (citable) accession number: P00430
Secondary accession number(s): Q3T0U0, Q56K07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: June 8, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.