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Protein

Cytochrome c oxidase subunit 6B1

Gene

COX6B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase polypeptide VII
Cytochrome c oxidase subunit AED
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:COX6B1
Synonyms:COX6B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001949112 – 86Cytochrome c oxidase subunit 6B1Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Disulfide bondi30 ↔ 65PROSITE-ProRule annotation
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation1 Publication
Modified residuei62N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP00429.
PeptideAtlasiP00429.
PRIDEiP00429.

Interactioni

Protein-protein interaction databases

DIPiDIP-38988N.
IntActiP00429. 2 interactors.
STRINGi9913.ENSBTAP00000007369.

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Helixi27 – 46Combined sources20
Helixi51 – 54Combined sources4
Helixi55 – 64Combined sources10
Helixi67 – 79Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80H/U2-86[»]
1OCOX-ray2.80H/U2-86[»]
1OCRX-ray2.35H/U2-86[»]
1OCZX-ray2.90H/U2-86[»]
1V54X-ray1.80H/U2-86[»]
1V55X-ray1.90H/U2-86[»]
2DYRX-ray1.80H/U2-86[»]
2DYSX-ray2.20H/U2-86[»]
2EIJX-ray1.90H/U2-86[»]
2EIKX-ray2.10H/U2-86[»]
2EILX-ray2.10H/U2-86[»]
2EIMX-ray2.60H/U2-86[»]
2EINX-ray2.70H/U2-86[»]
2OCCX-ray2.30H/U2-86[»]
2Y69X-ray1.95H/U1-86[»]
2YBBelectron microscopy19.00S2-86[»]
2ZXWX-ray2.50H/U2-86[»]
3ABKX-ray2.00H/U2-86[»]
3ABLX-ray2.10H/U2-86[»]
3ABMX-ray1.95H/U2-86[»]
3AG1X-ray2.20H/U2-86[»]
3AG2X-ray1.80H/U2-86[»]
3AG3X-ray1.80H/U2-86[»]
3AG4X-ray2.05H/U2-86[»]
3ASNX-ray3.00H/U2-86[»]
3ASOX-ray2.30H/U2-86[»]
3WG7X-ray1.90H/U2-86[»]
3X2QX-ray2.00H/U2-86[»]
5B1AX-ray1.50H/U2-86[»]
5B1BX-ray1.60H/U2-86[»]
ProteinModelPortaliP00429.
SMRiP00429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 73CHCHPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 40Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi54 – 65Cx10C motifPROSITE-ProRule annotationAdd BLAST12

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP00429.
KOiK02267.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPISWV STWDDRRAEG TFPGKI
Length:86
Mass (Da):10,156
Last modified:January 23, 2007 - v2
Checksum:iA8933C01C71ACB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.
PIRiS05432. OGBO7.
RefSeqiNP_788848.1. NM_176675.3.
UniGeneiBt.111605.
Bt.67150.
Bt.75.

Genome annotation databases

GeneIDi100270792.
KEGGibta:100270792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.
PIRiS05432. OGBO7.
RefSeqiNP_788848.1. NM_176675.3.
UniGeneiBt.111605.
Bt.67150.
Bt.75.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80H/U2-86[»]
1OCOX-ray2.80H/U2-86[»]
1OCRX-ray2.35H/U2-86[»]
1OCZX-ray2.90H/U2-86[»]
1V54X-ray1.80H/U2-86[»]
1V55X-ray1.90H/U2-86[»]
2DYRX-ray1.80H/U2-86[»]
2DYSX-ray2.20H/U2-86[»]
2EIJX-ray1.90H/U2-86[»]
2EIKX-ray2.10H/U2-86[»]
2EILX-ray2.10H/U2-86[»]
2EIMX-ray2.60H/U2-86[»]
2EINX-ray2.70H/U2-86[»]
2OCCX-ray2.30H/U2-86[»]
2Y69X-ray1.95H/U1-86[»]
2YBBelectron microscopy19.00S2-86[»]
2ZXWX-ray2.50H/U2-86[»]
3ABKX-ray2.00H/U2-86[»]
3ABLX-ray2.10H/U2-86[»]
3ABMX-ray1.95H/U2-86[»]
3AG1X-ray2.20H/U2-86[»]
3AG2X-ray1.80H/U2-86[»]
3AG3X-ray1.80H/U2-86[»]
3AG4X-ray2.05H/U2-86[»]
3ASNX-ray3.00H/U2-86[»]
3ASOX-ray2.30H/U2-86[»]
3WG7X-ray1.90H/U2-86[»]
3X2QX-ray2.00H/U2-86[»]
5B1AX-ray1.50H/U2-86[»]
5B1BX-ray1.60H/U2-86[»]
ProteinModelPortaliP00429.
SMRiP00429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38988N.
IntActiP00429. 2 interactors.
STRINGi9913.ENSBTAP00000007369.

Proteomic databases

PaxDbiP00429.
PeptideAtlasiP00429.
PRIDEiP00429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100270792.
KEGGibta:100270792.

Organism-specific databases

CTDi1340.

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP00429.
KOiK02267.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00429.

Family and domain databases

CDDicd00926. Cyt_c_Oxidase_VIb. 1 hit.
Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6B1_BOVIN
AccessioniPrimary (citable) accession number: P00429
Secondary accession number(s): Q54A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.