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P00429 (CX6B1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase polypeptide VII
Cytochrome c oxidase subunit AED
Cytochrome c oxidase subunit VIb isoform 1
Short name=COX VIb-1
Gene names
Name:COX6B1
Synonyms:COX6B
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length86 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Connects the two COX monomers into the physiological dimeric form.

Subcellular location

Mitochondrion intermembrane space.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 6B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3 Ref.4
Chain2 – 8685Cytochrome c oxidase subunit 6B1
PRO_0000194911

Amino acid modifications

Modified residue21N-acetylalanine Ref.4
Modified residue621N6-acetyllysine By similarity
Disulfide bond30 ↔ 65
Disulfide bond40 ↔ 54 Ref.6

Secondary structure

.......... 86
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00429 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A8933C01C71ACB8B

FASTA8610,156
        10         20         30         40         50         60 
MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD VSVCEWYRRV 

        70         80 
YKSLCPISWV STWDDRRAEG TFPGKI 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the cDNA encoding subunit AED (VIB) of beef heart cytochrome c oxidase."
Lightowlers R.N., Capaldi R.A.
Nucleic Acids Res. 17:5845-5845(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[3]"Studies on cytochrome c oxidase, VIII. The amino acid sequence of polypeptide VII."
Steffens G.C.M., Steffens G.J., Buse G.
Hoppe-Seyler's Z. Physiol. Chem. 360:1641-1650(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-86.
[4]"The complete amino acid sequence of bovine heart cytochrome oxidase subunit VI."
Tanaka M., Yasunobu K.T., Wei Y.-H., King T.E.
J. Biol. Chem. 256:4832-4837(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-86, ACETYLATION AT ALA-2.
[5]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 45-67.
Tissue: Liver.
[6]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[7]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[8]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.
PIROGBO7. S05432.
RefSeqNP_788848.1. NM_176675.3.
UniGeneBt.111605.
Bt.67150.
Bt.75.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80H/U2-86[»]
1OCOX-ray2.80H/U2-85[»]
1OCRX-ray2.35H/U2-85[»]
1OCZX-ray2.90H/U2-85[»]
1V54X-ray1.80H/U2-86[»]
1V55X-ray1.90H/U2-86[»]
2DYRX-ray1.80H/U2-86[»]
2DYSX-ray2.20H/U2-86[»]
2EIJX-ray1.90H/U2-86[»]
2EIKX-ray2.10H/U2-86[»]
2EILX-ray2.10H/U2-86[»]
2EIMX-ray2.60H/U2-86[»]
2EINX-ray2.70H/U2-86[»]
2OCCX-ray2.30H/U2-85[»]
2Y69X-ray1.95H/U1-86[»]
2YBBelectron microscopy19.00S2-86[»]
2ZXWX-ray2.50H/U2-86[»]
3ABKX-ray2.00H/U2-86[»]
3ABLX-ray2.10H/U2-86[»]
3ABMX-ray1.95H/U2-86[»]
3AG1X-ray2.20H/U2-86[»]
3AG2X-ray1.80H/U2-86[»]
3AG3X-ray1.80H/U2-86[»]
3AG4X-ray2.05H/U2-86[»]
3ASNX-ray3.00H/U2-86[»]
3ASOX-ray2.30H/U2-86[»]
ProteinModelPortalP00429.
SMRP00429. Positions 8-86.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00429. 2 interactions.
STRING9913.ENSBTAP00000007369.

Proteomic databases

PRIDEP00429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100270792.
KEGGbta:100270792.

Organism-specific databases

CTD1340.

Phylogenomic databases

eggNOGNOG279294.
HOGENOMHOG000165128.
HOVERGENHBG051090.
InParanoidP00429.
KOK02267.

Family and domain databases

Gene3D1.10.10.140. 1 hit.
InterProIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMSSF47694. SSF47694. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00429.
NextBio20795883.

Entry information

Entry nameCX6B1_BOVIN
AccessionPrimary (citable) accession number: P00429
Secondary accession number(s): Q54A32
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references