Cytochrome c oxidase subunit 6B1 - Bos taurus (Bovine)

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P00429 (CX6B1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 6B1

Alternative name(s):
Cytochrome c oxidase polypeptide VII
Cytochrome c oxidase subunit AED
Cytochrome c oxidase subunit VIb isoform 1
Short name=COX VIb-1

Gene names

Name:	COX6B1
Synonyms:	COX6B

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	86 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Connects the two COX monomers into the physiological dimeric form.
Subcellular location	Mitochondrion intermembrane space.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 6B family.

Ontologies

Keywords
Cellular component	Mitochondrion
PTM	Acetylation Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial inner membrane Inferred from sequence or structural similarity. Source: AgBase mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.3 Ref.4

Chain

2 – 86

Cytochrome c oxidase subunit 6B1

PRO_0000194911

Amino acid modifications

Modified residue

N-acetylalanine Ref.4

Disulfide bond

30 ↔ 65

Disulfide bond

40 ↔ 54

Ref.6

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P00429 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A8933C01C71ACB8B
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FASTA

10,156

        10         20         30         40         50         60 
MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD VSVCEWYRRV 

        70         80 
YKSLCPISWV STWDDRRAEG TFPGKI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the cDNA encoding subunit AED (VIB) of beef heart cytochrome c oxidase." Lightowlers R.N., Capaldi R.A. Nucleic Acids Res. 17:5845-5845(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.
[3]	"Studies on cytochrome c oxidase, VIII. The amino acid sequence of polypeptide VII." Steffens G.C.M., Steffens G.J., Buse G. Hoppe-Seyler's Z. Physiol. Chem. 360:1641-1650(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-86.
[4]	"The complete amino acid sequence of bovine heart cytochrome oxidase subunit VI." Tanaka M., Yasunobu K.T., Wei Y.-H., King T.E. J. Biol. Chem. 256:4832-4837(1981) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-86, ACETYLATION AT ALA-2.
[5]	"Tissue-specific differences between heart and liver cytochrome c oxidase." Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A. Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 45-67. Tissue: Liver.
[6]	"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A." Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[7]	"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S. Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). Tissue: Heart.
[8]	"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution." Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S. Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS). Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.

IPI

IPI00709627.

PIR

OGBO7. S05432.

RefSeq

NP_788848.1. NM_176675.3.

UniGene

Bt.111605.
Bt.67150.
Bt.75.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OCC	X-ray	2.80	H/U	2-86	[»]
1OCO	X-ray	2.80	H/U	2-85	[»]
1OCR	X-ray	2.35	H/U	2-85	[»]
1OCZ	X-ray	2.90	H/U	2-85	[»]
1V54	X-ray	1.80	H/U	2-86	[»]
1V55	X-ray	1.90	H/U	2-86	[»]
2DYR	X-ray	1.80	H/U	2-86	[»]
2DYS	X-ray	2.20	H/U	2-86	[»]
2EIJ	X-ray	1.90	H/U	2-86	[»]
2EIK	X-ray	2.10	H/U	2-86	[»]
2EIL	X-ray	2.10	H/U	2-86	[»]
2EIM	X-ray	2.60	H/U	2-86	[»]
2EIN	X-ray	2.70	H/U	2-86	[»]
2OCC	X-ray	2.30	H/U	2-85	[»]
2Y69	X-ray	1.95	H/U	1-86	[»]
2YBB	electron microscopy	19.00	S	2-86	[»]
2ZXW	X-ray	2.50	H/U	2-86	[»]
3ABK	X-ray	2.00	H/U	2-86	[»]
3ABL	X-ray	2.10	H/U	2-86	[»]
3ABM	X-ray	1.95	H/U	2-86	[»]
3AG1	X-ray	2.20	H/U	2-86	[»]
3AG2	X-ray	1.80	H/U	2-86	[»]
3AG3	X-ray	1.80	H/U	2-86	[»]
3AG4	X-ray	2.05	H/U	2-86	[»]
3ASN	X-ray	3.00	H/U	2-86	[»]
3ASO	X-ray	2.30	H/U	2-86	[»]

ProteinModelPortal

P00429.

SMR

P00429. Positions 8-86.

ModBase

Search...

Protein-protein interaction databases

IntAct

P00429. 2 interactions.

STRING

9913.ENSBTAP00000007369.

Proteomic databases

PRIDE

P00429.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

100270792.

KEGG

bta:100270792.

Organism-specific databases

CTD

1340.

Phylogenomic databases

eggNOG

NOG279294.

HOGENOM

HOG000165128.

HOVERGEN

HBG051090.

InParanoid

P00429.

K02267.

OrthoDB

EOG4QNMXS.

Family and domain databases

Gene3D

1.10.10.140. 1 hit.

InterPro

IPR003213. Cyt_c_oxidase_su6B.
[Graphical view]

Pfam

PF02297. COX6B. 1 hit.
[Graphical view]

PIRSF

PIRSF000278. Cyt_c_oxidase_6B. 1 hit.

SUPFAM

SSF47694. Cyt_c_oxidase_6B. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P00429.

NextBio

20795883.

Entry information

Entry name

CX6B1_BOVIN

Accession

Primary (citable) accession number: P00429
Secondary accession number(s): Q54A32

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents