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P00429

- CX6B1_BOVIN

UniProt

P00429 - CX6B1_BOVIN

Protein

Cytochrome c oxidase subunit 6B1

Gene

COX6B1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Connects the two COX monomers into the physiological dimeric form.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6B1
    Alternative name(s):
    Cytochrome c oxidase polypeptide VII
    Cytochrome c oxidase subunit AED
    Cytochrome c oxidase subunit VIb isoform 1
    Short name:
    COX VIb-1
    Gene namesi
    Name:COX6B1
    Synonyms:COX6B
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: AgBase
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. mitochondrion Source: AgBase
    4. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 8685Cytochrome c oxidase subunit 6B1PRO_0000194911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Disulfide bondi30 ↔ 65
    Disulfide bondi40 ↔ 541 Publication
    Modified residuei62 – 621N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    PRIDEiP00429.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38988N.
    IntActiP00429. 2 interactions.
    STRINGi9913.ENSBTAP00000007369.

    Structurei

    Secondary structure

    1
    86
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 253
    Helixi27 – 4721
    Helixi51 – 544
    Helixi55 – 6410
    Helixi67 – 7913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80H/U2-86[»]
    1OCOX-ray2.80H/U2-86[»]
    1OCRX-ray2.35H/U2-86[»]
    1OCZX-ray2.90H/U2-86[»]
    1V54X-ray1.80H/U2-86[»]
    1V55X-ray1.90H/U2-86[»]
    2DYRX-ray1.80H/U2-86[»]
    2DYSX-ray2.20H/U2-86[»]
    2EIJX-ray1.90H/U2-86[»]
    2EIKX-ray2.10H/U2-86[»]
    2EILX-ray2.10H/U2-86[»]
    2EIMX-ray2.60H/U2-86[»]
    2EINX-ray2.70H/U2-86[»]
    2OCCX-ray2.30H/U2-86[»]
    2Y69X-ray1.95H/U1-86[»]
    2YBBelectron microscopy19.00S2-86[»]
    2ZXWX-ray2.50H/U2-86[»]
    3ABKX-ray2.00H/U2-86[»]
    3ABLX-ray2.10H/U2-86[»]
    3ABMX-ray1.95H/U2-86[»]
    3AG1X-ray2.20H/U2-86[»]
    3AG2X-ray1.80H/U2-86[»]
    3AG3X-ray1.80H/U2-86[»]
    3AG4X-ray2.05H/U2-86[»]
    3ASNX-ray3.00H/U2-86[»]
    3ASOX-ray2.30H/U2-86[»]
    3WG7X-ray1.90H/U2-86[»]
    ProteinModelPortaliP00429.
    SMRiP00429. Positions 8-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00429.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG279294.
    HOGENOMiHOG000165128.
    HOVERGENiHBG051090.
    InParanoidiP00429.
    KOiK02267.

    Family and domain databases

    Gene3Di1.10.10.140. 1 hit.
    InterProiIPR003213. Cyt_c_oxidase_su6B.
    [Graphical view]
    PfamiPF02297. COX6B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
    SUPFAMiSSF47694. SSF47694. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00429-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD   50
    VSVCEWYRRV YKSLCPISWV STWDDRRAEG TFPGKI 86
    Length:86
    Mass (Da):10,156
    Last modified:January 23, 2007 - v2
    Checksum:iA8933C01C71ACB8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15112 mRNA. Translation: CAA33211.1.
    BC102366 mRNA. Translation: AAI02367.1.
    PIRiS05432. OGBO7.
    RefSeqiNP_788848.1. NM_176675.3.
    UniGeneiBt.111605.
    Bt.67150.
    Bt.75.

    Genome annotation databases

    GeneIDi100270792.
    KEGGibta:100270792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15112 mRNA. Translation: CAA33211.1 .
    BC102366 mRNA. Translation: AAI02367.1 .
    PIRi S05432. OGBO7.
    RefSeqi NP_788848.1. NM_176675.3.
    UniGenei Bt.111605.
    Bt.67150.
    Bt.75.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 H/U 2-86 [» ]
    1OCO X-ray 2.80 H/U 2-86 [» ]
    1OCR X-ray 2.35 H/U 2-86 [» ]
    1OCZ X-ray 2.90 H/U 2-86 [» ]
    1V54 X-ray 1.80 H/U 2-86 [» ]
    1V55 X-ray 1.90 H/U 2-86 [» ]
    2DYR X-ray 1.80 H/U 2-86 [» ]
    2DYS X-ray 2.20 H/U 2-86 [» ]
    2EIJ X-ray 1.90 H/U 2-86 [» ]
    2EIK X-ray 2.10 H/U 2-86 [» ]
    2EIL X-ray 2.10 H/U 2-86 [» ]
    2EIM X-ray 2.60 H/U 2-86 [» ]
    2EIN X-ray 2.70 H/U 2-86 [» ]
    2OCC X-ray 2.30 H/U 2-86 [» ]
    2Y69 X-ray 1.95 H/U 1-86 [» ]
    2YBB electron microscopy 19.00 S 2-86 [» ]
    2ZXW X-ray 2.50 H/U 2-86 [» ]
    3ABK X-ray 2.00 H/U 2-86 [» ]
    3ABL X-ray 2.10 H/U 2-86 [» ]
    3ABM X-ray 1.95 H/U 2-86 [» ]
    3AG1 X-ray 2.20 H/U 2-86 [» ]
    3AG2 X-ray 1.80 H/U 2-86 [» ]
    3AG3 X-ray 1.80 H/U 2-86 [» ]
    3AG4 X-ray 2.05 H/U 2-86 [» ]
    3ASN X-ray 3.00 H/U 2-86 [» ]
    3ASO X-ray 2.30 H/U 2-86 [» ]
    3WG7 X-ray 1.90 H/U 2-86 [» ]
    ProteinModelPortali P00429.
    SMRi P00429. Positions 8-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38988N.
    IntActi P00429. 2 interactions.
    STRINGi 9913.ENSBTAP00000007369.

    Proteomic databases

    PRIDEi P00429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100270792.
    KEGGi bta:100270792.

    Organism-specific databases

    CTDi 1340.

    Phylogenomic databases

    eggNOGi NOG279294.
    HOGENOMi HOG000165128.
    HOVERGENi HBG051090.
    InParanoidi P00429.
    KOi K02267.

    Miscellaneous databases

    EvolutionaryTracei P00429.
    NextBioi 20795883.

    Family and domain databases

    Gene3Di 1.10.10.140. 1 hit.
    InterProi IPR003213. Cyt_c_oxidase_su6B.
    [Graphical view ]
    Pfami PF02297. COX6B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000278. Cyt_c_oxidase_6B. 1 hit.
    SUPFAMi SSF47694. SSF47694. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the cDNA encoding subunit AED (VIB) of beef heart cytochrome c oxidase."
      Lightowlers R.N., Capaldi R.A.
      Nucleic Acids Res. 17:5845-5845(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    3. "Studies on cytochrome c oxidase, VIII. The amino acid sequence of polypeptide VII."
      Steffens G.C.M., Steffens G.J., Buse G.
      Hoppe-Seyler's Z. Physiol. Chem. 360:1641-1650(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-86.
    4. "The complete amino acid sequence of bovine heart cytochrome oxidase subunit VI."
      Tanaka M., Yasunobu K.T., Wei Y.-H., King T.E.
      J. Biol. Chem. 256:4832-4837(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-86, ACETYLATION AT ALA-2.
    5. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 45-67.
      Tissue: Liver.
    6. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    8. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCX6B1_BOVIN
    AccessioniPrimary (citable) accession number: P00429
    Secondary accession number(s): Q54A32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3