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Protein

Cytochrome c oxidase subunit 6B1

Gene

COX6B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase polypeptide VII
Cytochrome c oxidase subunit AED
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:COX6B1
Synonyms:COX6B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: AgBase
  2. mitochondrial intermembrane space Source: UniProtKB-SubCell
  3. mitochondrion Source: AgBase
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 8685Cytochrome c oxidase subunit 6B1PRO_0000194911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Disulfide bondi30 ↔ 65
Disulfide bondi40 ↔ 541 Publication
Modified residuei62 – 621N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiP00429.

Interactioni

Protein-protein interaction databases

DIPiDIP-38988N.
IntActiP00429. 2 interactions.
STRINGi9913.ENSBTAP00000007369.

Structurei

Secondary structure

1
86
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 253Combined sources
Helixi27 – 4721Combined sources
Helixi51 – 544Combined sources
Helixi55 – 6410Combined sources
Helixi67 – 7913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80H/U2-86[»]
1OCOX-ray2.80H/U2-86[»]
1OCRX-ray2.35H/U2-86[»]
1OCZX-ray2.90H/U2-86[»]
1V54X-ray1.80H/U2-86[»]
1V55X-ray1.90H/U2-86[»]
2DYRX-ray1.80H/U2-86[»]
2DYSX-ray2.20H/U2-86[»]
2EIJX-ray1.90H/U2-86[»]
2EIKX-ray2.10H/U2-86[»]
2EILX-ray2.10H/U2-86[»]
2EIMX-ray2.60H/U2-86[»]
2EINX-ray2.70H/U2-86[»]
2OCCX-ray2.30H/U2-86[»]
2Y69X-ray1.95H/U1-86[»]
2YBBelectron microscopy19.00S2-86[»]
2ZXWX-ray2.50H/U2-86[»]
3ABKX-ray2.00H/U2-86[»]
3ABLX-ray2.10H/U2-86[»]
3ABMX-ray1.95H/U2-86[»]
3AG1X-ray2.20H/U2-86[»]
3AG2X-ray1.80H/U2-86[»]
3AG3X-ray1.80H/U2-86[»]
3AG4X-ray2.05H/U2-86[»]
3ASNX-ray3.00H/U2-86[»]
3ASOX-ray2.30H/U2-86[»]
3WG7X-ray1.90H/U2-86[»]
SMRiP00429. Positions 8-86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00429.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG279294.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP00429.
KOiK02267.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDIQAKIK NYQTAPFDSR FPNQNQTRNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPISWV STWDDRRAEG TFPGKI
Length:86
Mass (Da):10,156
Last modified:January 23, 2007 - v2
Checksum:iA8933C01C71ACB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.
PIRiS05432. OGBO7.
RefSeqiNP_788848.1. NM_176675.3.
UniGeneiBt.111605.
Bt.67150.
Bt.75.

Genome annotation databases

GeneIDi100270792.
KEGGibta:100270792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15112 mRNA. Translation: CAA33211.1.
BC102366 mRNA. Translation: AAI02367.1.
PIRiS05432. OGBO7.
RefSeqiNP_788848.1. NM_176675.3.
UniGeneiBt.111605.
Bt.67150.
Bt.75.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80H/U2-86[»]
1OCOX-ray2.80H/U2-86[»]
1OCRX-ray2.35H/U2-86[»]
1OCZX-ray2.90H/U2-86[»]
1V54X-ray1.80H/U2-86[»]
1V55X-ray1.90H/U2-86[»]
2DYRX-ray1.80H/U2-86[»]
2DYSX-ray2.20H/U2-86[»]
2EIJX-ray1.90H/U2-86[»]
2EIKX-ray2.10H/U2-86[»]
2EILX-ray2.10H/U2-86[»]
2EIMX-ray2.60H/U2-86[»]
2EINX-ray2.70H/U2-86[»]
2OCCX-ray2.30H/U2-86[»]
2Y69X-ray1.95H/U1-86[»]
2YBBelectron microscopy19.00S2-86[»]
2ZXWX-ray2.50H/U2-86[»]
3ABKX-ray2.00H/U2-86[»]
3ABLX-ray2.10H/U2-86[»]
3ABMX-ray1.95H/U2-86[»]
3AG1X-ray2.20H/U2-86[»]
3AG2X-ray1.80H/U2-86[»]
3AG3X-ray1.80H/U2-86[»]
3AG4X-ray2.05H/U2-86[»]
3ASNX-ray3.00H/U2-86[»]
3ASOX-ray2.30H/U2-86[»]
3WG7X-ray1.90H/U2-86[»]
SMRiP00429. Positions 8-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38988N.
IntActiP00429. 2 interactions.
STRINGi9913.ENSBTAP00000007369.

Proteomic databases

PRIDEiP00429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100270792.
KEGGibta:100270792.

Organism-specific databases

CTDi1340.

Phylogenomic databases

eggNOGiNOG279294.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP00429.
KOiK02267.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00429.
NextBioi20795883.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the cDNA encoding subunit AED (VIB) of beef heart cytochrome c oxidase."
    Lightowlers R.N., Capaldi R.A.
    Nucleic Acids Res. 17:5845-5845(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "Studies on cytochrome c oxidase, VIII. The amino acid sequence of polypeptide VII."
    Steffens G.C.M., Steffens G.J., Buse G.
    Hoppe-Seyler's Z. Physiol. Chem. 360:1641-1650(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-86.
  4. "The complete amino acid sequence of bovine heart cytochrome oxidase subunit VI."
    Tanaka M., Yasunobu K.T., Wei Y.-H., King T.E.
    J. Biol. Chem. 256:4832-4837(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-86, ACETYLATION AT ALA-2.
  5. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 45-67.
    Tissue: Liver.
  6. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  8. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCX6B1_BOVIN
AccessioniPrimary (citable) accession number: P00429
Secondary accession number(s): Q54A32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.