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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Zinc1
Metal bindingi93Zinc1
Metal bindingi113Zinc1
Metal bindingi116Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: GO_Central
  • respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31Mitochondrion2 PublicationsAdd BLAST31
ChainiPRO_000019702832 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00428.
PRIDEiP00428.

PTM databases

iPTMnetiP00428.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018542.

Interactioni

Protein-protein interaction databases

DIPiDIP-38985N.
IntActiP00428. 2 interactors.
STRINGi9913.ENSBTAP00000024678.

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi40 – 43Combined sources4
Helixi46 – 56Combined sources11
Beta strandi74 – 76Combined sources3
Beta strandi78 – 91Combined sources14
Beta strandi94 – 96Combined sources3
Beta strandi101 – 109Combined sources9
Beta strandi111 – 113Combined sources3
Turni114 – 116Combined sources3
Beta strandi119 – 124Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80F/S32-129[»]
1OCOX-ray2.80F/S32-129[»]
1OCRX-ray2.35F/S32-129[»]
1OCZX-ray2.90F/S32-129[»]
1V54X-ray1.80F/S32-129[»]
1V55X-ray1.90F/S32-129[»]
2DYRX-ray1.80F/S32-129[»]
2DYSX-ray2.20F/S32-129[»]
2EIJX-ray1.90F/S32-129[»]
2EIKX-ray2.10F/S32-129[»]
2EILX-ray2.10F/S32-129[»]
2EIMX-ray2.60F/S32-129[»]
2EINX-ray2.70F/S32-129[»]
2OCCX-ray2.30F/S32-129[»]
2Y69X-ray1.95F/S1-129[»]
2YBBelectron microscopy19.00Q32-129[»]
2ZXWX-ray2.50F/S32-129[»]
3ABKX-ray2.00F/S32-129[»]
3ABLX-ray2.10F/S32-129[»]
3ABMX-ray1.95F/S32-129[»]
3AG1X-ray2.20F/S32-129[»]
3AG2X-ray1.80F/S32-129[»]
3AG3X-ray1.80F/S32-129[»]
3AG4X-ray2.05F/S32-129[»]
3ASNX-ray3.00F/S32-129[»]
3ASOX-ray2.30F/S32-129[»]
3WG7X-ray1.90F/S32-129[»]
3X2QX-ray2.00F/S32-129[»]
5B1AX-ray1.50F/S32-129[»]
5B1BX-ray1.60F/S32-129[»]
ProteinModelPortaliP00428.
SMRiP00428.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00428.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP00428.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
TreeFamiTF105063.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALASQALRAR GPNGVSVVRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
VMLAARKGQD PYNILAPKAT SGTKEDPNLV PSITNKRIVG CICEEDNSTV
110 120
IWFWLHKGEA QRCPSCGTHY KLVPHQLAH
Length:129
Mass (Da):13,834
Last modified:June 27, 2006 - v2
Checksum:iC78CE7552CE6C313
GO

Sequence cautioni

The sequence AAA30465 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102579 mRNA. Translation: AAI02580.1.
BC147855 mRNA. Translation: AAI47856.1.
M19962 mRNA. Translation: AAA30465.1. Different initiation.
PIRiA00495. OGBO6A.
RefSeqiNP_001029218.1. NM_001034046.2.
UniGeneiBt.87845.

Genome annotation databases

EnsembliENSBTAT00000024678; ENSBTAP00000024678; ENSBTAG00000018542.
GeneIDi287012.
KEGGibta:287012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102579 mRNA. Translation: AAI02580.1.
BC147855 mRNA. Translation: AAI47856.1.
M19962 mRNA. Translation: AAA30465.1. Different initiation.
PIRiA00495. OGBO6A.
RefSeqiNP_001029218.1. NM_001034046.2.
UniGeneiBt.87845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80F/S32-129[»]
1OCOX-ray2.80F/S32-129[»]
1OCRX-ray2.35F/S32-129[»]
1OCZX-ray2.90F/S32-129[»]
1V54X-ray1.80F/S32-129[»]
1V55X-ray1.90F/S32-129[»]
2DYRX-ray1.80F/S32-129[»]
2DYSX-ray2.20F/S32-129[»]
2EIJX-ray1.90F/S32-129[»]
2EIKX-ray2.10F/S32-129[»]
2EILX-ray2.10F/S32-129[»]
2EIMX-ray2.60F/S32-129[»]
2EINX-ray2.70F/S32-129[»]
2OCCX-ray2.30F/S32-129[»]
2Y69X-ray1.95F/S1-129[»]
2YBBelectron microscopy19.00Q32-129[»]
2ZXWX-ray2.50F/S32-129[»]
3ABKX-ray2.00F/S32-129[»]
3ABLX-ray2.10F/S32-129[»]
3ABMX-ray1.95F/S32-129[»]
3AG1X-ray2.20F/S32-129[»]
3AG2X-ray1.80F/S32-129[»]
3AG3X-ray1.80F/S32-129[»]
3AG4X-ray2.05F/S32-129[»]
3ASNX-ray3.00F/S32-129[»]
3ASOX-ray2.30F/S32-129[»]
3WG7X-ray1.90F/S32-129[»]
3X2QX-ray2.00F/S32-129[»]
5B1AX-ray1.50F/S32-129[»]
5B1BX-ray1.60F/S32-129[»]
ProteinModelPortaliP00428.
SMRiP00428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38985N.
IntActiP00428. 2 interactors.
STRINGi9913.ENSBTAP00000024678.

PTM databases

iPTMnetiP00428.

Proteomic databases

PaxDbiP00428.
PRIDEiP00428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024678; ENSBTAP00000024678; ENSBTAG00000018542.
GeneIDi287012.
KEGGibta:287012.

Organism-specific databases

CTDi1329.

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP00428.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
TreeFamiTF105063.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00428.

Gene expression databases

BgeeiENSBTAG00000018542.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX5B_BOVIN
AccessioniPrimary (citable) accession number: P00428
Secondary accession number(s): A6QL66, P11949, Q3T041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.