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P00428

- COX5B_BOVIN

UniProt

P00428 - COX5B_BOVIN

Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Zinc
    Metal bindingi93 – 931Zinc
    Metal bindingi113 – 1131Zinc
    Metal bindingi116 – 1161Zinc

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIa
    Cytochrome c oxidase polypeptide Vb
    Gene namesi
    Name:COX5B
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131Mitochondrion2 PublicationsAdd
    BLAST
    Chaini32 – 12998Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000197028Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei86 – 861N6-acetyllysineBy similarity
    Modified residuei121 – 1211N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP00428.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38985N.
    IntActiP00428. 2 interactions.

    Structurei

    Secondary structure

    1
    129
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi40 – 434
    Helixi46 – 5611
    Beta strandi74 – 763
    Beta strandi78 – 814
    Beta strandi83 – 919
    Beta strandi94 – 963
    Beta strandi101 – 1099
    Beta strandi111 – 1133
    Turni114 – 1163
    Beta strandi119 – 1235

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80F/S32-129[»]
    1OCOX-ray2.80F/S32-129[»]
    1OCRX-ray2.35F/S32-129[»]
    1OCZX-ray2.90F/S32-129[»]
    1V54X-ray1.80F/S32-129[»]
    1V55X-ray1.90F/S32-129[»]
    2DYRX-ray1.80F/S32-129[»]
    2DYSX-ray2.20F/S32-129[»]
    2EIJX-ray1.90F/S32-129[»]
    2EIKX-ray2.10F/S32-129[»]
    2EILX-ray2.10F/S32-129[»]
    2EIMX-ray2.60F/S32-129[»]
    2EINX-ray2.70F/S32-129[»]
    2OCCX-ray2.30F/S32-129[»]
    2Y69X-ray1.95F/S1-129[»]
    2YBBelectron microscopy19.00Q32-129[»]
    2ZXWX-ray2.50F/S32-129[»]
    3ABKX-ray2.00F/S32-129[»]
    3ABLX-ray2.10F/S32-129[»]
    3ABMX-ray1.95F/S32-129[»]
    3AG1X-ray2.20F/S32-129[»]
    3AG2X-ray1.80F/S32-129[»]
    3AG3X-ray1.80F/S32-129[»]
    3AG4X-ray2.05F/S32-129[»]
    3ASNX-ray3.00F/S32-129[»]
    3ASOX-ray2.30F/S32-129[»]
    3WG7X-ray1.90F/S32-129[»]
    ProteinModelPortaliP00428.
    SMRiP00428. Positions 32-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00428.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG316751.
    GeneTreeiENSGT00390000011010.
    HOGENOMiHOG000184129.
    HOVERGENiHBG051089.
    InParanoidiP00428.
    KOiK02265.
    OMAiYYKLVPH.
    OrthoDBiEOG7D85ZC.
    TreeFamiTF105063.

    Family and domain databases

    Gene3Di2.60.11.10. 1 hit.
    InterProiIPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view]
    PANTHERiPTHR10122. PTHR10122. 1 hit.
    PfamiPF01215. COX5B. 1 hit.
    [Graphical view]
    ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00428-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRLLRGVG ALASQALRAR GPNGVSVVRS MASGGGVPTD EEQATGLERE    50
    VMLAARKGQD PYNILAPKAT SGTKEDPNLV PSITNKRIVG CICEEDNSTV 100
    IWFWLHKGEA QRCPSCGTHY KLVPHQLAH 129
    Length:129
    Mass (Da):13,834
    Last modified:June 27, 2006 - v2
    Checksum:iC78CE7552CE6C313
    GO

    Sequence cautioni

    The sequence AAA30465.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102579 mRNA. Translation: AAI02580.1.
    BC147855 mRNA. Translation: AAI47856.1.
    M19962 mRNA. Translation: AAA30465.1. Different initiation.
    PIRiA00495. OGBO6A.
    RefSeqiNP_001029218.1. NM_001034046.2.
    UniGeneiBt.87845.

    Genome annotation databases

    EnsembliENSBTAT00000024678; ENSBTAP00000024678; ENSBTAG00000018542.
    GeneIDi287012.
    KEGGibta:287012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102579 mRNA. Translation: AAI02580.1 .
    BC147855 mRNA. Translation: AAI47856.1 .
    M19962 mRNA. Translation: AAA30465.1 . Different initiation.
    PIRi A00495. OGBO6A.
    RefSeqi NP_001029218.1. NM_001034046.2.
    UniGenei Bt.87845.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 F/S 32-129 [» ]
    1OCO X-ray 2.80 F/S 32-129 [» ]
    1OCR X-ray 2.35 F/S 32-129 [» ]
    1OCZ X-ray 2.90 F/S 32-129 [» ]
    1V54 X-ray 1.80 F/S 32-129 [» ]
    1V55 X-ray 1.90 F/S 32-129 [» ]
    2DYR X-ray 1.80 F/S 32-129 [» ]
    2DYS X-ray 2.20 F/S 32-129 [» ]
    2EIJ X-ray 1.90 F/S 32-129 [» ]
    2EIK X-ray 2.10 F/S 32-129 [» ]
    2EIL X-ray 2.10 F/S 32-129 [» ]
    2EIM X-ray 2.60 F/S 32-129 [» ]
    2EIN X-ray 2.70 F/S 32-129 [» ]
    2OCC X-ray 2.30 F/S 32-129 [» ]
    2Y69 X-ray 1.95 F/S 1-129 [» ]
    2YBB electron microscopy 19.00 Q 32-129 [» ]
    2ZXW X-ray 2.50 F/S 32-129 [» ]
    3ABK X-ray 2.00 F/S 32-129 [» ]
    3ABL X-ray 2.10 F/S 32-129 [» ]
    3ABM X-ray 1.95 F/S 32-129 [» ]
    3AG1 X-ray 2.20 F/S 32-129 [» ]
    3AG2 X-ray 1.80 F/S 32-129 [» ]
    3AG3 X-ray 1.80 F/S 32-129 [» ]
    3AG4 X-ray 2.05 F/S 32-129 [» ]
    3ASN X-ray 3.00 F/S 32-129 [» ]
    3ASO X-ray 2.30 F/S 32-129 [» ]
    3WG7 X-ray 1.90 F/S 32-129 [» ]
    ProteinModelPortali P00428.
    SMRi P00428. Positions 32-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38985N.
    IntActi P00428. 2 interactions.

    Proteomic databases

    PRIDEi P00428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000024678 ; ENSBTAP00000024678 ; ENSBTAG00000018542 .
    GeneIDi 287012.
    KEGGi bta:287012.

    Organism-specific databases

    CTDi 1329.

    Phylogenomic databases

    eggNOGi NOG316751.
    GeneTreei ENSGT00390000011010.
    HOGENOMi HOG000184129.
    HOVERGENi HBG051089.
    InParanoidi P00428.
    KOi K02265.
    OMAi YYKLVPH.
    OrthoDBi EOG7D85ZC.
    TreeFami TF105063.

    Miscellaneous databases

    EvolutionaryTracei P00428.
    NextBioi 20806536.

    Family and domain databases

    Gene3Di 2.60.11.10. 1 hit.
    InterProi IPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view ]
    PANTHERi PTHR10122. PTHR10122. 1 hit.
    Pfami PF01215. COX5B. 1 hit.
    [Graphical view ]
    ProDomi PD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus and Hereford.
      Tissue: Heart ventricle and Ileum.
    2. "Studies on cytochrome c oxidase, IX. The primary structure of polypeptide VIa."
      Biewald R., Buse G.
      Hoppe-Seyler's Z. Physiol. Chem. 363:1141-1153(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-129.
    3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-57.
      Tissue: Liver.
    4. "Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
      Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
      Gene 65:1-11(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-129.
    5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
      Tissue: Heart.
    7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-129.
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX5B_BOVIN
    AccessioniPrimary (citable) accession number: P00428
    Secondary accession number(s): A6QL66, P11949, Q3T041
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3