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P00428 (COX5B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa
Cytochrome c oxidase polypeptide Vb
Gene names
Name:COX5B
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5B family.

Sequence caution

The sequence AAA30465.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion Ref.2 Ref.3
Chain32 – 12998Cytochrome c oxidase subunit 5B, mitochondrial
PRO_0000197028

Sites

Metal binding911Zinc
Metal binding931Zinc
Metal binding1131Zinc
Metal binding1161Zinc

Secondary structure

1 .................... 129
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00428 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: C78CE7552CE6C313

FASTA12913,834
        10         20         30         40         50         60 
MASRLLRGVG ALASQALRAR GPNGVSVVRS MASGGGVPTD EEQATGLERE VMLAARKGQD 

        70         80         90        100        110        120 
PYNILAPKAT SGTKEDPNLV PSITNKRIVG CICEEDNSTV IWFWLHKGEA QRCPSCGTHY 


KLVPHQLAH

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus and Hereford.
Tissue: Heart ventricle and Ileum.
[2]"Studies on cytochrome c oxidase, IX. The primary structure of polypeptide VIa."
Biewald R., Buse G.
Hoppe-Seyler's Z. Physiol. Chem. 363:1141-1153(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-129.
[3]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-57.
Tissue: Liver.
[4]"Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
Gene 65:1-11(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-129.
[5]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
[6]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
Tissue: Heart.
[7]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-129.
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102579 mRNA. Translation: AAI02580.1.
BC147855 mRNA. Translation: AAI47856.1.
M19962 mRNA. Translation: AAA30465.1. Different initiation.
IPIIPI00694849.
PIROGBO6A. A00495.
RefSeqNP_001029218.1. NM_001034046.2.
UniGeneBt.87845.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80F/S32-129[»]
1OCOX-ray2.80F/S32-129[»]
1OCRX-ray2.35F/S32-129[»]
1OCZX-ray2.90F/S32-129[»]
1V54X-ray1.80F/S32-129[»]
1V55X-ray1.90F/S32-129[»]
2DYRX-ray1.80F/S32-129[»]
2DYSX-ray2.20F/S32-129[»]
2EIJX-ray1.90F/S32-129[»]
2EIKX-ray2.10F/S32-129[»]
2EILX-ray2.10F/S32-129[»]
2EIMX-ray2.60F/S32-129[»]
2EINX-ray2.70F/S32-129[»]
2OCCX-ray2.30F/S32-129[»]
2Y69X-ray1.95F/S1-129[»]
2YBBelectron microscopy19.00Q32-129[»]
2ZXWX-ray2.50F/S32-129[»]
3ABKX-ray2.00F/S32-129[»]
3ABLX-ray2.10F/S32-129[»]
3ABMX-ray1.95F/S32-129[»]
3AG1X-ray2.20F/S32-129[»]
3AG2X-ray1.80F/S32-129[»]
3AG3X-ray1.80F/S32-129[»]
3AG4X-ray2.05F/S32-129[»]
3ASNX-ray3.00F/S32-129[»]
3ASOX-ray2.30F/S32-129[»]
ProteinModelPortalP00428.
SMRP00428. Positions 32-129.
ModBaseSearch...

Protein-protein interaction databases

IntActP00428. 2 interactions.

Proteomic databases

PRIDEP00428.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000024678; ENSBTAP00000024678; ENSBTAG00000018542.
GeneID287012.
KEGGbta:287012.

Organism-specific databases

CTD1329.

Phylogenomic databases

eggNOGNOG316751.
GeneTreeENSGT00390000011010.
HOGENOMHOG000184129.
HOVERGENHBG051089.
InParanoidP00428.
KOK02265.
OMAYYKLVPH.
OrthoDBEOG495ZT9.

Family and domain databases

Gene3D2.60.11.10. 1 hit.
InterProIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERPTHR10122. PTHR10122. 1 hit.
PfamPF01215. COX5B. 1 hit.
[Graphical view]
ProDomPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00428.
NextBio20806536.

Entry information

Entry nameCOX5B_BOVIN
AccessionPrimary (citable) accession number: P00428
Secondary accession number(s): A6QL66, P11949, Q3T041
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: April 3, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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