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P00428

- COX5B_BOVIN

UniProt

P00428 - COX5B_BOVIN

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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Zinc
Metal bindingi93 – 931Zinc
Metal bindingi113 – 1131Zinc
Metal bindingi116 – 1161Zinc

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion2 PublicationsAdd
BLAST
Chaini32 – 12998Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000197028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-acetyllysineBy similarity
Modified residuei86 – 861N6-acetyllysineBy similarity
Modified residuei121 – 1211N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00428.

Interactioni

Protein-protein interaction databases

DIPiDIP-38985N.
IntActiP00428. 2 interactions.

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi40 – 434Combined sources
Helixi46 – 5611Combined sources
Beta strandi74 – 763Combined sources
Beta strandi78 – 814Combined sources
Beta strandi83 – 919Combined sources
Beta strandi94 – 963Combined sources
Beta strandi101 – 1099Combined sources
Beta strandi111 – 1133Combined sources
Turni114 – 1163Combined sources
Beta strandi119 – 1235Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80F/S32-129[»]
1OCOX-ray2.80F/S32-129[»]
1OCRX-ray2.35F/S32-129[»]
1OCZX-ray2.90F/S32-129[»]
1V54X-ray1.80F/S32-129[»]
1V55X-ray1.90F/S32-129[»]
2DYRX-ray1.80F/S32-129[»]
2DYSX-ray2.20F/S32-129[»]
2EIJX-ray1.90F/S32-129[»]
2EIKX-ray2.10F/S32-129[»]
2EILX-ray2.10F/S32-129[»]
2EIMX-ray2.60F/S32-129[»]
2EINX-ray2.70F/S32-129[»]
2OCCX-ray2.30F/S32-129[»]
2Y69X-ray1.95F/S1-129[»]
2YBBelectron microscopy19.00Q32-129[»]
2ZXWX-ray2.50F/S32-129[»]
3ABKX-ray2.00F/S32-129[»]
3ABLX-ray2.10F/S32-129[»]
3ABMX-ray1.95F/S32-129[»]
3AG1X-ray2.20F/S32-129[»]
3AG2X-ray1.80F/S32-129[»]
3AG3X-ray1.80F/S32-129[»]
3AG4X-ray2.05F/S32-129[»]
3ASNX-ray3.00F/S32-129[»]
3ASOX-ray2.30F/S32-129[»]
3WG7X-ray1.90F/S32-129[»]
ProteinModelPortaliP00428.
SMRiP00428. Positions 32-129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00428.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG316751.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP00428.
KOiK02265.
OMAiYYKLVPH.
OrthoDBiEOG7D85ZC.
TreeFamiTF105063.

Family and domain databases

Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00428-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRLLRGVG ALASQALRAR GPNGVSVVRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
VMLAARKGQD PYNILAPKAT SGTKEDPNLV PSITNKRIVG CICEEDNSTV
110 120
IWFWLHKGEA QRCPSCGTHY KLVPHQLAH
Length:129
Mass (Da):13,834
Last modified:June 27, 2006 - v2
Checksum:iC78CE7552CE6C313
GO

Sequence cautioni

The sequence AAA30465.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102579 mRNA. Translation: AAI02580.1.
BC147855 mRNA. Translation: AAI47856.1.
M19962 mRNA. Translation: AAA30465.1. Different initiation.
PIRiA00495. OGBO6A.
RefSeqiNP_001029218.1. NM_001034046.2.
UniGeneiBt.87845.

Genome annotation databases

EnsembliENSBTAT00000024678; ENSBTAP00000024678; ENSBTAG00000018542.
GeneIDi287012.
KEGGibta:287012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102579 mRNA. Translation: AAI02580.1 .
BC147855 mRNA. Translation: AAI47856.1 .
M19962 mRNA. Translation: AAA30465.1 . Different initiation.
PIRi A00495. OGBO6A.
RefSeqi NP_001029218.1. NM_001034046.2.
UniGenei Bt.87845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 F/S 32-129 [» ]
1OCO X-ray 2.80 F/S 32-129 [» ]
1OCR X-ray 2.35 F/S 32-129 [» ]
1OCZ X-ray 2.90 F/S 32-129 [» ]
1V54 X-ray 1.80 F/S 32-129 [» ]
1V55 X-ray 1.90 F/S 32-129 [» ]
2DYR X-ray 1.80 F/S 32-129 [» ]
2DYS X-ray 2.20 F/S 32-129 [» ]
2EIJ X-ray 1.90 F/S 32-129 [» ]
2EIK X-ray 2.10 F/S 32-129 [» ]
2EIL X-ray 2.10 F/S 32-129 [» ]
2EIM X-ray 2.60 F/S 32-129 [» ]
2EIN X-ray 2.70 F/S 32-129 [» ]
2OCC X-ray 2.30 F/S 32-129 [» ]
2Y69 X-ray 1.95 F/S 1-129 [» ]
2YBB electron microscopy 19.00 Q 32-129 [» ]
2ZXW X-ray 2.50 F/S 32-129 [» ]
3ABK X-ray 2.00 F/S 32-129 [» ]
3ABL X-ray 2.10 F/S 32-129 [» ]
3ABM X-ray 1.95 F/S 32-129 [» ]
3AG1 X-ray 2.20 F/S 32-129 [» ]
3AG2 X-ray 1.80 F/S 32-129 [» ]
3AG3 X-ray 1.80 F/S 32-129 [» ]
3AG4 X-ray 2.05 F/S 32-129 [» ]
3ASN X-ray 3.00 F/S 32-129 [» ]
3ASO X-ray 2.30 F/S 32-129 [» ]
3WG7 X-ray 1.90 F/S 32-129 [» ]
ProteinModelPortali P00428.
SMRi P00428. Positions 32-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38985N.
IntActi P00428. 2 interactions.

Proteomic databases

PRIDEi P00428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000024678 ; ENSBTAP00000024678 ; ENSBTAG00000018542 .
GeneIDi 287012.
KEGGi bta:287012.

Organism-specific databases

CTDi 1329.

Phylogenomic databases

eggNOGi NOG316751.
GeneTreei ENSGT00390000011010.
HOGENOMi HOG000184129.
HOVERGENi HBG051089.
InParanoidi P00428.
KOi K02265.
OMAi YYKLVPH.
OrthoDBi EOG7D85ZC.
TreeFami TF105063.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Miscellaneous databases

EvolutionaryTracei P00428.
NextBioi 20806536.

Family and domain databases

Gene3Di 2.60.11.10. 1 hit.
InterProi IPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view ]
PANTHERi PTHR10122. PTHR10122. 1 hit.
Pfami PF01215. COX5B. 1 hit.
[Graphical view ]
ProDomi PD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus and Hereford.
    Tissue: Heart ventricle and Ileum.
  2. "Studies on cytochrome c oxidase, IX. The primary structure of polypeptide VIa."
    Biewald R., Buse G.
    Hoppe-Seyler's Z. Physiol. Chem. 363:1141-1153(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-129.
  3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-57.
    Tissue: Liver.
  4. "Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
    Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
    Gene 65:1-11(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-129.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-129.
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-129.
    Tissue: Heart.

Entry informationi

Entry nameiCOX5B_BOVIN
AccessioniPrimary (citable) accession number: P00428
Secondary accession number(s): A6QL66, P11949, Q3T041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3