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P00427 (COX6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 6, mitochondrial

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide VI
Gene names
Name:COX6
Ordered Locus Names:YHR051W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subunit structure

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Subcellular location

Mitochondrion inner membrane.

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Mitochondrion Ref.6
Chain41 – 148108Cytochrome c oxidase subunit 6, mitochondrial
PRO_0000006108

Sequences

Sequence LengthMass (Da)Tools
P00427 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 91F2AF286BD2FB1A

FASTA14817,342
        10         20         30         40         50         60 
MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE EFTARYEKEF 

        70         80         90        100        110        120 
DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND LPTAIRVFEA LKYKVENEDQ 

       130        140 
YKAYLDELKD VRQELGVPLK EELFPSSS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
Wright R.M., Ko C., Cumsky M.G., Poyton R.O.
J. Biol. Chem. 259:15401-15407(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially."
Wright R.M., Rosenzweig B., Poyton R.O.
Nucleic Acids Res. 17:1103-1120(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
[6]"The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
Gregor I., Tsugita A.
J. Biol. Chem. 257:13081-13087(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 41-148.
[7]"Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10138 Genomic DNA. Translation: AAA66900.1.
U00062 Genomic DNA. Translation: AAB68899.1.
AY558278 Genomic DNA. Translation: AAS56604.1.
X14452 Genomic DNA. Translation: CAA32622.1.
BK006934 Genomic DNA. Translation: DAA06744.1.
PIROTBY6. A22853.
RefSeqNP_011918.1. NM_001179181.1.

3D structure databases

ProteinModelPortalP00427.
SMRP00427. Positions 47-143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36483. 101 interactions.
DIPDIP-6606N.
IntActP00427. 5 interactions.
MINTMINT-668902.
STRING4932.YHR051W.

Protein family/group databases

TCDB3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBP00427.
PaxDbP00427.
PeptideAtlasP00427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR051W; YHR051W; YHR051W.
GeneID856448.
KEGGsce:YHR051W.

Organism-specific databases

CYGDYHR051w.
SGDS000001093. COX6.

Phylogenomic databases

eggNOGNOG284808.
GeneTreeENSGT00390000001424.
HOGENOMHOG000160656.
KOK02264.
OMASIRCYSH.
OrthoDBEOG7WQ84T.

Enzyme and pathway databases

BioCycMetaCyc:YHR051W-MONOMER.
YEAST:YHR051W-MONOMER.
UniPathwayUPA00705.

Gene expression databases

GenevestigatorP00427.

Family and domain databases

Gene3D1.25.40.40. 1 hit.
InterProIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERPTHR14200. PTHR14200. 1 hit.
PfamPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMSSF48479. SSF48479. 1 hit.
ProtoNetSearch...

Other

NextBio982069.
PROP00427.

Entry information

Entry nameCOX6_YEAST
AccessionPrimary (citable) accession number: P00427
Secondary accession number(s): D3DL00
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: May 14, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways