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P00427

- COX6_YEAST

UniProt

P00427 - COX6_YEAST

Protein

Cytochrome c oxidase subunit 6, mitochondrial

Gene

COX6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:YHR051W-MONOMER.
    YEAST:YHR051W-MONOMER.
    UniPathwayiUPA00705.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide VI
    Gene namesi
    Name:COX6
    Ordered Locus Names:YHR051W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR051w.
    SGDiS000001093. COX6.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex IV Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040Mitochondrion1 PublicationAdd
    BLAST
    Chaini41 – 148108Cytochrome c oxidase subunit 6, mitochondrialPRO_0000006108Add
    BLAST

    Proteomic databases

    MaxQBiP00427.
    PaxDbiP00427.
    PeptideAtlasiP00427.

    Expressioni

    Gene expression databases

    GenevestigatoriP00427.

    Interactioni

    Subunit structurei

    Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

    Protein-protein interaction databases

    BioGridi36483. 101 interactions.
    DIPiDIP-6606N.
    IntActiP00427. 5 interactions.
    MINTiMINT-668902.
    STRINGi4932.YHR051W.

    Structurei

    3D structure databases

    ProteinModelPortaliP00427.
    SMRiP00427. Positions 47-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG284808.
    GeneTreeiENSGT00390000001424.
    HOGENOMiHOG000160656.
    KOiK02264.
    OMAiSIRCYSH.
    OrthoDBiEOG7WQ84T.

    Family and domain databases

    Gene3Di1.25.40.40. 1 hit.
    InterProiIPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view]
    PANTHERiPTHR14200. PTHR14200. 1 hit.
    PfamiPF02284. COX5A. 1 hit.
    [Graphical view]
    SUPFAMiSSF48479. SSF48479. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00427-1 [UniParc]FASTAAdd to Basket

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    MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE    50
    EFTARYEKEF DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND 100
    LPTAIRVFEA LKYKVENEDQ YKAYLDELKD VRQELGVPLK EELFPSSS 148
    Length:148
    Mass (Da):17,342
    Last modified:August 13, 1987 - v1
    Checksum:i91F2AF286BD2FB1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10138 Genomic DNA. Translation: AAA66900.1.
    U00062 Genomic DNA. Translation: AAB68899.1.
    AY558278 Genomic DNA. Translation: AAS56604.1.
    X14452 Genomic DNA. Translation: CAA32622.1.
    BK006934 Genomic DNA. Translation: DAA06744.1.
    PIRiA22853. OTBY6.
    RefSeqiNP_011918.1. NM_001179181.1.

    Genome annotation databases

    EnsemblFungiiYHR051W; YHR051W; YHR051W.
    GeneIDi856448.
    KEGGisce:YHR051W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10138 Genomic DNA. Translation: AAA66900.1 .
    U00062 Genomic DNA. Translation: AAB68899.1 .
    AY558278 Genomic DNA. Translation: AAS56604.1 .
    X14452 Genomic DNA. Translation: CAA32622.1 .
    BK006934 Genomic DNA. Translation: DAA06744.1 .
    PIRi A22853. OTBY6.
    RefSeqi NP_011918.1. NM_001179181.1.

    3D structure databases

    ProteinModelPortali P00427.
    SMRi P00427. Positions 47-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36483. 101 interactions.
    DIPi DIP-6606N.
    IntActi P00427. 5 interactions.
    MINTi MINT-668902.
    STRINGi 4932.YHR051W.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    MaxQBi P00427.
    PaxDbi P00427.
    PeptideAtlasi P00427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR051W ; YHR051W ; YHR051W .
    GeneIDi 856448.
    KEGGi sce:YHR051W.

    Organism-specific databases

    CYGDi YHR051w.
    SGDi S000001093. COX6.

    Phylogenomic databases

    eggNOGi NOG284808.
    GeneTreei ENSGT00390000001424.
    HOGENOMi HOG000160656.
    KOi K02264.
    OMAi SIRCYSH.
    OrthoDBi EOG7WQ84T.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci MetaCyc:YHR051W-MONOMER.
    YEAST:YHR051W-MONOMER.

    Miscellaneous databases

    NextBioi 982069.
    PROi P00427.

    Gene expression databases

    Genevestigatori P00427.

    Family and domain databases

    Gene3Di 1.25.40.40. 1 hit.
    InterProi IPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view ]
    PANTHERi PTHR14200. PTHR14200. 1 hit.
    Pfami PF02284. COX5A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48479. SSF48479. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
      Wright R.M., Ko C., Cumsky M.G., Poyton R.O.
      J. Biol. Chem. 259:15401-15407(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially."
      Wright R.M., Rosenzweig B., Poyton R.O.
      Nucleic Acids Res. 17:1103-1120(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
    6. "The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
      Gregor I., Tsugita A.
      J. Biol. Chem. 257:13081-13087(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-148.
    7. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
      Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
      Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX6_YEAST
    AccessioniPrimary (citable) accession number: P00427
    Secondary accession number(s): D3DL00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 12500 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3