Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 6, mitochondrial

Gene

COX6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:YHR051W-MONOMER.
YEAST:YHR051W-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VI
Gene namesi
Name:COX6
Ordered Locus Names:YHR051W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHR051w.
EuPathDBiFungiDB:YHR051W.
SGDiS000001093. COX6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Mitochondrion1 PublicationAdd
BLAST
Chaini41 – 148108Cytochrome c oxidase subunit 6, mitochondrialPRO_0000006108Add
BLAST

Proteomic databases

MaxQBiP00427.
PaxDbiP00427.
PeptideAtlasiP00427.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi36483. 104 interactions.
DIPiDIP-6606N.
IntActiP00427. 5 interactions.
MINTiMINT-668902.
STRINGi4932.YHR051W.

Structurei

3D structure databases

ProteinModelPortaliP00427.
SMRiP00427. Positions 47-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
InParanoidiP00427.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG7WQ84T.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE
60 70 80 90 100
EFTARYEKEF DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND
110 120 130 140
LPTAIRVFEA LKYKVENEDQ YKAYLDELKD VRQELGVPLK EELFPSSS
Length:148
Mass (Da):17,342
Last modified:August 13, 1987 - v1
Checksum:i91F2AF286BD2FB1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10138 Genomic DNA. Translation: AAA66900.1.
U00062 Genomic DNA. Translation: AAB68899.1.
AY558278 Genomic DNA. Translation: AAS56604.1.
X14452 Genomic DNA. Translation: CAA32622.1.
BK006934 Genomic DNA. Translation: DAA06744.1.
PIRiA22853. OTBY6.
RefSeqiNP_011918.1. NM_001179181.1.

Genome annotation databases

EnsemblFungiiYHR051W; YHR051W; YHR051W.
GeneIDi856448.
KEGGisce:YHR051W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10138 Genomic DNA. Translation: AAA66900.1.
U00062 Genomic DNA. Translation: AAB68899.1.
AY558278 Genomic DNA. Translation: AAS56604.1.
X14452 Genomic DNA. Translation: CAA32622.1.
BK006934 Genomic DNA. Translation: DAA06744.1.
PIRiA22853. OTBY6.
RefSeqiNP_011918.1. NM_001179181.1.

3D structure databases

ProteinModelPortaliP00427.
SMRiP00427. Positions 47-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36483. 104 interactions.
DIPiDIP-6606N.
IntActiP00427. 5 interactions.
MINTiMINT-668902.
STRINGi4932.YHR051W.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP00427.
PaxDbiP00427.
PeptideAtlasiP00427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR051W; YHR051W; YHR051W.
GeneIDi856448.
KEGGisce:YHR051W.

Organism-specific databases

CYGDiYHR051w.
EuPathDBiFungiDB:YHR051W.
SGDiS000001093. COX6.

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
InParanoidiP00427.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG7WQ84T.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciMetaCyc:YHR051W-MONOMER.
YEAST:YHR051W-MONOMER.

Miscellaneous databases

NextBioi982069.
PROiP00427.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
    Wright R.M., Ko C., Cumsky M.G., Poyton R.O.
    J. Biol. Chem. 259:15401-15407(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially."
    Wright R.M., Rosenzweig B., Poyton R.O.
    Nucleic Acids Res. 17:1103-1120(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
  6. "The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
    Gregor I., Tsugita A.
    J. Biol. Chem. 257:13081-13087(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-148.
  7. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX6_YEAST
AccessioniPrimary (citable) accession number: P00427
Secondary accession number(s): D3DL00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: June 24, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.