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P00427

- COX6_YEAST

UniProt

P00427 - COX6_YEAST

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Protein

Cytochrome c oxidase subunit 6, mitochondrial

Gene

COX6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:YHR051W-MONOMER.
YEAST:YHR051W-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VI
Gene namesi
Name:COX6
Ordered Locus Names:YHR051W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR051w.
SGDiS000001093. COX6.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Mitochondrion1 PublicationAdd
BLAST
Chaini41 – 148108Cytochrome c oxidase subunit 6, mitochondrialPRO_0000006108Add
BLAST

Proteomic databases

MaxQBiP00427.
PaxDbiP00427.
PeptideAtlasiP00427.

Expressioni

Gene expression databases

GenevestigatoriP00427.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi36483. 101 interactions.
DIPiDIP-6606N.
IntActiP00427. 5 interactions.
MINTiMINT-668902.
STRINGi4932.YHR051W.

Structurei

3D structure databases

ProteinModelPortaliP00427.
SMRiP00427. Positions 47-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
InParanoidiP00427.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG7WQ84T.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00427-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE
60 70 80 90 100
EFTARYEKEF DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND
110 120 130 140
LPTAIRVFEA LKYKVENEDQ YKAYLDELKD VRQELGVPLK EELFPSSS
Length:148
Mass (Da):17,342
Last modified:August 13, 1987 - v1
Checksum:i91F2AF286BD2FB1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10138 Genomic DNA. Translation: AAA66900.1.
U00062 Genomic DNA. Translation: AAB68899.1.
AY558278 Genomic DNA. Translation: AAS56604.1.
X14452 Genomic DNA. Translation: CAA32622.1.
BK006934 Genomic DNA. Translation: DAA06744.1.
PIRiA22853. OTBY6.
RefSeqiNP_011918.1. NM_001179181.1.

Genome annotation databases

EnsemblFungiiYHR051W; YHR051W; YHR051W.
GeneIDi856448.
KEGGisce:YHR051W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10138 Genomic DNA. Translation: AAA66900.1 .
U00062 Genomic DNA. Translation: AAB68899.1 .
AY558278 Genomic DNA. Translation: AAS56604.1 .
X14452 Genomic DNA. Translation: CAA32622.1 .
BK006934 Genomic DNA. Translation: DAA06744.1 .
PIRi A22853. OTBY6.
RefSeqi NP_011918.1. NM_001179181.1.

3D structure databases

ProteinModelPortali P00427.
SMRi P00427. Positions 47-143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36483. 101 interactions.
DIPi DIP-6606N.
IntActi P00427. 5 interactions.
MINTi MINT-668902.
STRINGi 4932.YHR051W.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBi P00427.
PaxDbi P00427.
PeptideAtlasi P00427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR051W ; YHR051W ; YHR051W .
GeneIDi 856448.
KEGGi sce:YHR051W.

Organism-specific databases

CYGDi YHR051w.
SGDi S000001093. COX6.

Phylogenomic databases

eggNOGi NOG284808.
GeneTreei ENSGT00390000001424.
HOGENOMi HOG000160656.
InParanoidi P00427.
KOi K02264.
OMAi SIRCYSH.
OrthoDBi EOG7WQ84T.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci MetaCyc:YHR051W-MONOMER.
YEAST:YHR051W-MONOMER.

Miscellaneous databases

NextBioi 982069.
PROi P00427.

Gene expression databases

Genevestigatori P00427.

Family and domain databases

Gene3Di 1.25.40.40. 1 hit.
InterProi IPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view ]
PANTHERi PTHR14200. PTHR14200. 1 hit.
Pfami PF02284. COX5A. 1 hit.
[Graphical view ]
SUPFAMi SSF48479. SSF48479. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
    Wright R.M., Ko C., Cumsky M.G., Poyton R.O.
    J. Biol. Chem. 259:15401-15407(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Organization and expression of the COX6 genetic locus in Saccharomyces cerevisiae: multiple mRNAs with different 3' termini are transcribed from COX6 and regulated differentially."
    Wright R.M., Rosenzweig B., Poyton R.O.
    Nucleic Acids Res. 17:1103-1120(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
  6. "The amino acid sequence of cytochrome c oxidase subunit VI from Saccharomyces cerevisiae."
    Gregor I., Tsugita A.
    J. Biol. Chem. 257:13081-13087(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 41-148.
  7. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX6_YEAST
AccessioniPrimary (citable) accession number: P00427
Secondary accession number(s): D3DL00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3