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P00426

- COX5A_BOVIN

UniProt

P00426 - COX5A_BOVIN

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Protein
Cytochrome c oxidase subunit 5A, mitochondrial
Gene
COX5A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: AgBase
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:COX5A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: AgBase
  2. mitochondrion Source: AgBase
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion2 Publications
Add
BLAST
Chaini44 – 152109Cytochrome c oxidase subunit 5A, mitochondrial
PRO_0000006099Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-acetyllysine By similarity
Modified residuei115 – 1151N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00426.
PRIDEiP00426.

2D gel databases

UCD-2DPAGEP00426.

Interactioni

Protein-protein interaction databases

IntActiP00426. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 6212
Helixi69 – 7911
Beta strandi82 – 843
Helixi88 – 10013
Helixi104 – 11714
Turni118 – 1203
Helixi124 – 13916
Turni144 – 1507

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80E/R44-152[»]
1OCOX-ray2.80E/R44-152[»]
1OCRX-ray2.35E/R44-152[»]
1OCZX-ray2.90E/R44-152[»]
1V54X-ray1.80E/R44-152[»]
1V55X-ray1.90E/R44-152[»]
2DYRX-ray1.80E/R44-152[»]
2DYSX-ray2.20E/R44-152[»]
2EIJX-ray1.90E/R44-152[»]
2EIKX-ray2.10E/R44-152[»]
2EILX-ray2.10E/R44-152[»]
2EIMX-ray2.60E/R44-152[»]
2EINX-ray2.70E/R44-152[»]
2OCCX-ray2.30E/R44-152[»]
2Y69X-ray1.95E/R1-152[»]
2YBBelectron microscopy19.00P44-152[»]
2ZXWX-ray2.50E/R44-152[»]
3ABKX-ray2.00E/R44-152[»]
3ABLX-ray2.10E/R44-152[»]
3ABMX-ray1.95E/R44-152[»]
3AG1X-ray2.20E/R44-152[»]
3AG2X-ray1.80E/R44-152[»]
3AG3X-ray1.80E/R44-152[»]
3AG4X-ray2.05E/R44-152[»]
3ASNX-ray3.00E/R44-152[»]
3ASOX-ray2.30E/R44-152[»]
3WG7X-ray1.90E/R44-152[»]
ProteinModelPortaliP00426.
SMRiP00426. Positions 44-152.

Miscellaneous databases

EvolutionaryTraceiP00426.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG284808.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP00426.
KOiK02264.
OMAiSIRCYSH.
OrthoDBiEOG74J99R.
TreeFamiTF105062.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00426-1 [UniParc]FASTAAdd to Basket

« Hide

MLGAAVRRCS VAAAAVARAS PRGLLHPTPA PGQAAAVQSL RCYSHGSHET    50
DEEFDARWVT YFNKPDIDAW ELRKGMNTLV GYDLVPEPKI IDAALRACRR 100
LNDFASAVRI LEVVKDKAGP HKEIYPYVIQ ELRPTLNELG ISTPEELGLD 150
KV 152
Length:152
Mass (Da):16,735
Last modified:October 25, 2004 - v2
Checksum:iCE8FA765A8ABBA02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528254 mRNA. Translation: AAS20602.1.
BC109608 mRNA. Translation: AAI09609.1.
PIRiA00493. CABO.
RefSeqiNP_001002891.1. NM_001002891.1.
XP_005221971.1. XM_005221914.1.
UniGeneiBt.55686.

Genome annotation databases

EnsembliENSBTAT00000022949; ENSBTAP00000022949; ENSBTAG00000017267.
GeneIDi444878.
KEGGibta:444878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY528254 mRNA. Translation: AAS20602.1 .
BC109608 mRNA. Translation: AAI09609.1 .
PIRi A00493. CABO.
RefSeqi NP_001002891.1. NM_001002891.1.
XP_005221971.1. XM_005221914.1.
UniGenei Bt.55686.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 E/R 44-152 [» ]
1OCO X-ray 2.80 E/R 44-152 [» ]
1OCR X-ray 2.35 E/R 44-152 [» ]
1OCZ X-ray 2.90 E/R 44-152 [» ]
1V54 X-ray 1.80 E/R 44-152 [» ]
1V55 X-ray 1.90 E/R 44-152 [» ]
2DYR X-ray 1.80 E/R 44-152 [» ]
2DYS X-ray 2.20 E/R 44-152 [» ]
2EIJ X-ray 1.90 E/R 44-152 [» ]
2EIK X-ray 2.10 E/R 44-152 [» ]
2EIL X-ray 2.10 E/R 44-152 [» ]
2EIM X-ray 2.60 E/R 44-152 [» ]
2EIN X-ray 2.70 E/R 44-152 [» ]
2OCC X-ray 2.30 E/R 44-152 [» ]
2Y69 X-ray 1.95 E/R 1-152 [» ]
2YBB electron microscopy 19.00 P 44-152 [» ]
2ZXW X-ray 2.50 E/R 44-152 [» ]
3ABK X-ray 2.00 E/R 44-152 [» ]
3ABL X-ray 2.10 E/R 44-152 [» ]
3ABM X-ray 1.95 E/R 44-152 [» ]
3AG1 X-ray 2.20 E/R 44-152 [» ]
3AG2 X-ray 1.80 E/R 44-152 [» ]
3AG3 X-ray 1.80 E/R 44-152 [» ]
3AG4 X-ray 2.05 E/R 44-152 [» ]
3ASN X-ray 3.00 E/R 44-152 [» ]
3ASO X-ray 2.30 E/R 44-152 [» ]
3WG7 X-ray 1.90 E/R 44-152 [» ]
ProteinModelPortali P00426.
SMRi P00426. Positions 44-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00426. 2 interactions.

2D gel databases

UCD-2DPAGE P00426.

Proteomic databases

PaxDbi P00426.
PRIDEi P00426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000022949 ; ENSBTAP00000022949 ; ENSBTAG00000017267 .
GeneIDi 444878.
KEGGi bta:444878.

Organism-specific databases

CTDi 9377.

Phylogenomic databases

eggNOGi NOG284808.
GeneTreei ENSGT00390000001424.
HOGENOMi HOG000160656.
HOVERGENi HBG051088.
InParanoidi P00426.
KOi K02264.
OMAi SIRCYSH.
OrthoDBi EOG74J99R.
TreeFami TF105062.

Miscellaneous databases

EvolutionaryTracei P00426.
NextBioi 20831766.

Family and domain databases

Gene3Di 1.25.40.40. 1 hit.
InterProi IPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view ]
PANTHERi PTHR14200. PTHR14200. 1 hit.
Pfami PF02284. COX5A. 1 hit.
[Graphical view ]
SUPFAMi SSF48479. SSF48479. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of gene expression in the bovine blastocyst or hatched blastocyst in vitro using ACP method."
    Shin M.L., Cui X.S., Park S.Y., Kim E.Y., Park S.P., Lee W.J., Hwang K.C., Kim N.H.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  3. "Amino acid sequence of subunit V of bovine heart cytochrome oxidase, the heme alpha-containing subunit."
    Tanaka M., Haniu M., Yasunobu K.T., Yu C.-A., Yu L., Wei Y.-H., King T.E.
    J. Biol. Chem. 254:3879-3885(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 44-152.
    Tissue: Heart.
  4. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 44-77.
    Tissue: Liver.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 44-152.
    Tissue: Heart.

Entry informationi

Entry nameiCOX5A_BOVIN
AccessioniPrimary (citable) accession number: P00426
Secondary accession number(s): Q32LF6, Q6QRN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2004
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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