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P00426 (COX5A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene names
Name:COX5A
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Mitochondrion Ref.3 Ref.4
Chain44 – 152109Cytochrome c oxidase subunit 5A, mitochondrial
PRO_0000006099

Secondary structure

1 ................ 152
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00426 [UniParc].

Last modified October 25, 2004. Version 2.
Checksum: CE8FA765A8ABBA02

FASTA15216,735
        10         20         30         40         50         60 
MLGAAVRRCS VAAAAVARAS PRGLLHPTPA PGQAAAVQSL RCYSHGSHET DEEFDARWVT 

        70         80         90        100        110        120 
YFNKPDIDAW ELRKGMNTLV GYDLVPEPKI IDAALRACRR LNDFASAVRI LEVVKDKAGP 

       130        140        150 
HKEIYPYVIQ ELRPTLNELG ISTPEELGLD KV

« Hide

References

« Hide 'large scale' references
[1]"Analysis of gene expression in the bovine blastocyst or hatched blastocyst in vitro using ACP method."
Shin M.L., Cui X.S., Park S.Y., Kim E.Y., Park S.P., Lee W.J., Hwang K.C., Kim N.H.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[3]"Amino acid sequence of subunit V of bovine heart cytochrome oxidase, the heme alpha-containing subunit."
Tanaka M., Haniu M., Yasunobu K.T., Yu C.-A., Yu L., Wei Y.-H., King T.E.
J. Biol. Chem. 254:3879-3885(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 44-152.
Tissue: Heart.
[4]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 44-77.
Tissue: Liver.
[5]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
[6]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
Tissue: Heart.
[7]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 44-152.
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY528254 mRNA. Translation: AAS20602.1.
BC109608 mRNA. Translation: AAI09609.1.
IPIIPI00691338.
PIRCABO. A00493.
RefSeqNP_001002891.1. NM_001002891.1.
UniGeneBt.55686.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80E/R44-152[»]
1OCOX-ray2.80E/R44-152[»]
1OCRX-ray2.35E/R44-152[»]
1OCZX-ray2.90E/R44-152[»]
1V54X-ray1.80E/R44-152[»]
1V55X-ray1.90E/R44-152[»]
2DYRX-ray1.80E/R44-152[»]
2DYSX-ray2.20E/R44-152[»]
2EIJX-ray1.90E/R44-152[»]
2EIKX-ray2.10E/R44-152[»]
2EILX-ray2.10E/R44-152[»]
2EIMX-ray2.60E/R44-152[»]
2EINX-ray2.70E/R44-152[»]
2OCCX-ray2.30E/R44-152[»]
2Y69X-ray1.95E/R1-152[»]
2YBBelectron microscopy19.00P44-152[»]
2ZXWX-ray2.50E/R44-152[»]
3ABKX-ray2.00E/R44-152[»]
3ABLX-ray2.10E/R44-152[»]
3ABMX-ray1.95E/R44-152[»]
3AG1X-ray2.20E/R44-152[»]
3AG2X-ray1.80E/R44-152[»]
3AG3X-ray1.80E/R44-152[»]
3AG4X-ray2.05E/R44-152[»]
3ASNX-ray3.00E/R44-152[»]
3ASOX-ray2.30E/R44-152[»]
ProteinModelPortalP00426.
SMRP00426. Positions 44-152.
ModBaseSearch...

Protein-protein interaction databases

IntActP00426. 2 interactions.

2D gel databases

UCD-2DPAGEP00426.

Proteomic databases

PaxDbP00426.
PRIDEP00426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000022949; ENSBTAP00000022949; ENSBTAG00000017267.
GeneID444878.
KEGGbta:444878.

Organism-specific databases

CTD9377.

Phylogenomic databases

eggNOGNOG284808.
GeneTreeENSGT00390000001424.
HOGENOMHOG000160656.
HOVERGENHBG051088.
InParanoidP00426.
KOK02264.
OMALQEIRPT.
OrthoDBEOG4D7Z71.

Family and domain databases

Gene3D1.25.40.40. 1 hit.
InterProIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERPTHR14200. PTHR14200. 1 hit.
PfamPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMSSF48479. Cyt_c_ox5A. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00426.
NextBio20831766.

Entry information

Entry nameCOX5A_BOVIN
AccessionPrimary (citable) accession number: P00426
Secondary accession number(s): Q32LF6, Q6QRN2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2004
Last modified: April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents