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P00426

- COX5A_BOVIN

UniProt

P00426 - COX5A_BOVIN

Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

COX5A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: AgBase
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 5A, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide Va
    Gene namesi
    Name:COX5A
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: AgBase
    2. mitochondrion Source: AgBase
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343Mitochondrion2 PublicationsAdd
    BLAST
    Chaini44 – 152109Cytochrome c oxidase subunit 5A, mitochondrialPRO_0000006099Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 891N6-acetyllysineBy similarity
    Modified residuei115 – 1151N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP00426.
    PRIDEiP00426.

    2D gel databases

    UCD-2DPAGEP00426.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38982N.
    IntActiP00426. 2 interactions.

    Structurei

    Secondary structure

    1
    152
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi51 – 6212
    Helixi69 – 7911
    Beta strandi82 – 843
    Helixi88 – 10013
    Helixi104 – 11714
    Turni118 – 1203
    Helixi124 – 13916
    Turni144 – 1507

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80E/R44-152[»]
    1OCOX-ray2.80E/R44-152[»]
    1OCRX-ray2.35E/R44-152[»]
    1OCZX-ray2.90E/R44-152[»]
    1V54X-ray1.80E/R44-152[»]
    1V55X-ray1.90E/R44-152[»]
    2DYRX-ray1.80E/R44-152[»]
    2DYSX-ray2.20E/R44-152[»]
    2EIJX-ray1.90E/R44-152[»]
    2EIKX-ray2.10E/R44-152[»]
    2EILX-ray2.10E/R44-152[»]
    2EIMX-ray2.60E/R44-152[»]
    2EINX-ray2.70E/R44-152[»]
    2OCCX-ray2.30E/R44-152[»]
    2Y69X-ray1.95E/R1-152[»]
    2YBBelectron microscopy19.00P44-152[»]
    2ZXWX-ray2.50E/R44-152[»]
    3ABKX-ray2.00E/R44-152[»]
    3ABLX-ray2.10E/R44-152[»]
    3ABMX-ray1.95E/R44-152[»]
    3AG1X-ray2.20E/R44-152[»]
    3AG2X-ray1.80E/R44-152[»]
    3AG3X-ray1.80E/R44-152[»]
    3AG4X-ray2.05E/R44-152[»]
    3ASNX-ray3.00E/R44-152[»]
    3ASOX-ray2.30E/R44-152[»]
    3WG7X-ray1.90E/R44-152[»]
    ProteinModelPortaliP00426.
    SMRiP00426. Positions 44-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00426.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG284808.
    GeneTreeiENSGT00390000001424.
    HOGENOMiHOG000160656.
    HOVERGENiHBG051088.
    InParanoidiP00426.
    KOiK02264.
    OMAiSIRCYSH.
    OrthoDBiEOG74J99R.
    TreeFamiTF105062.

    Family and domain databases

    Gene3Di1.25.40.40. 1 hit.
    InterProiIPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view]
    PANTHERiPTHR14200. PTHR14200. 1 hit.
    PfamiPF02284. COX5A. 1 hit.
    [Graphical view]
    SUPFAMiSSF48479. SSF48479. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00426-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGAAVRRCS VAAAAVARAS PRGLLHPTPA PGQAAAVQSL RCYSHGSHET    50
    DEEFDARWVT YFNKPDIDAW ELRKGMNTLV GYDLVPEPKI IDAALRACRR 100
    LNDFASAVRI LEVVKDKAGP HKEIYPYVIQ ELRPTLNELG ISTPEELGLD 150
    KV 152
    Length:152
    Mass (Da):16,735
    Last modified:October 25, 2004 - v2
    Checksum:iCE8FA765A8ABBA02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY528254 mRNA. Translation: AAS20602.1.
    BC109608 mRNA. Translation: AAI09609.1.
    PIRiA00493. CABO.
    RefSeqiNP_001002891.1. NM_001002891.1.
    XP_005221971.1. XM_005221914.1.
    UniGeneiBt.55686.

    Genome annotation databases

    EnsembliENSBTAT00000022949; ENSBTAP00000022949; ENSBTAG00000017267.
    GeneIDi444878.
    KEGGibta:444878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY528254 mRNA. Translation: AAS20602.1 .
    BC109608 mRNA. Translation: AAI09609.1 .
    PIRi A00493. CABO.
    RefSeqi NP_001002891.1. NM_001002891.1.
    XP_005221971.1. XM_005221914.1.
    UniGenei Bt.55686.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 E/R 44-152 [» ]
    1OCO X-ray 2.80 E/R 44-152 [» ]
    1OCR X-ray 2.35 E/R 44-152 [» ]
    1OCZ X-ray 2.90 E/R 44-152 [» ]
    1V54 X-ray 1.80 E/R 44-152 [» ]
    1V55 X-ray 1.90 E/R 44-152 [» ]
    2DYR X-ray 1.80 E/R 44-152 [» ]
    2DYS X-ray 2.20 E/R 44-152 [» ]
    2EIJ X-ray 1.90 E/R 44-152 [» ]
    2EIK X-ray 2.10 E/R 44-152 [» ]
    2EIL X-ray 2.10 E/R 44-152 [» ]
    2EIM X-ray 2.60 E/R 44-152 [» ]
    2EIN X-ray 2.70 E/R 44-152 [» ]
    2OCC X-ray 2.30 E/R 44-152 [» ]
    2Y69 X-ray 1.95 E/R 1-152 [» ]
    2YBB electron microscopy 19.00 P 44-152 [» ]
    2ZXW X-ray 2.50 E/R 44-152 [» ]
    3ABK X-ray 2.00 E/R 44-152 [» ]
    3ABL X-ray 2.10 E/R 44-152 [» ]
    3ABM X-ray 1.95 E/R 44-152 [» ]
    3AG1 X-ray 2.20 E/R 44-152 [» ]
    3AG2 X-ray 1.80 E/R 44-152 [» ]
    3AG3 X-ray 1.80 E/R 44-152 [» ]
    3AG4 X-ray 2.05 E/R 44-152 [» ]
    3ASN X-ray 3.00 E/R 44-152 [» ]
    3ASO X-ray 2.30 E/R 44-152 [» ]
    3WG7 X-ray 1.90 E/R 44-152 [» ]
    ProteinModelPortali P00426.
    SMRi P00426. Positions 44-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38982N.
    IntActi P00426. 2 interactions.

    2D gel databases

    UCD-2DPAGE P00426.

    Proteomic databases

    PaxDbi P00426.
    PRIDEi P00426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000022949 ; ENSBTAP00000022949 ; ENSBTAG00000017267 .
    GeneIDi 444878.
    KEGGi bta:444878.

    Organism-specific databases

    CTDi 9377.

    Phylogenomic databases

    eggNOGi NOG284808.
    GeneTreei ENSGT00390000001424.
    HOGENOMi HOG000160656.
    HOVERGENi HBG051088.
    InParanoidi P00426.
    KOi K02264.
    OMAi SIRCYSH.
    OrthoDBi EOG74J99R.
    TreeFami TF105062.

    Miscellaneous databases

    EvolutionaryTracei P00426.
    NextBioi 20831766.

    Family and domain databases

    Gene3Di 1.25.40.40. 1 hit.
    InterProi IPR003204. Cyt_c_oxidase_su5A/6.
    [Graphical view ]
    PANTHERi PTHR14200. PTHR14200. 1 hit.
    Pfami PF02284. COX5A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48479. SSF48479. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of gene expression in the bovine blastocyst or hatched blastocyst in vitro using ACP method."
      Shin M.L., Cui X.S., Park S.Y., Kim E.Y., Park S.P., Lee W.J., Hwang K.C., Kim N.H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    3. "Amino acid sequence of subunit V of bovine heart cytochrome oxidase, the heme alpha-containing subunit."
      Tanaka M., Haniu M., Yasunobu K.T., Yu C.-A., Yu L., Wei Y.-H., King T.E.
      J. Biol. Chem. 254:3879-3885(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 44-152.
      Tissue: Heart.
    4. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 44-77.
      Tissue: Liver.
    5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 44-152.
      Tissue: Heart.
    7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 44-152.
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX5A_BOVIN
    AccessioniPrimary (citable) accession number: P00426
    Secondary accession number(s): Q32LF6, Q6QRN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3