Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00425 (COX5B_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase polypeptide 5B, mitochondrial

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene names
Name:COX5B
Ordered Locus Names:YIL111W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subunit structure

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Subcellular location

Mitochondrion inner membrane.

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1717Mitochondrion Potential
Chain18 – 151134Cytochrome c oxidase polypeptide 5B, mitochondrial
PRO_0000006098

Sequences

Sequence LengthMass (Da)Tools
P00425 [UniParc].

Last modified March 1, 1992. Version 3.
Checksum: 566B4E69631CBDE0

FASTA15117,197
        10         20         30         40         50         60 
MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL TERQKLPWKT 

        70         80         90        100        110        120 
LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL GISFGLFGLV RLLANPETPK 

       130        140        150 
TMNREWQLKS DEYLKSKNAN PWGGYSQVQS K 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V."
Cumsky M.G., Trueblood C.E., Ko C., Poyton R.O.
Mol. Cell. Biol. 7:3511-3519(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Splicing of a yeast intron containing an unusual 5' junction sequence."
Hodge M.R., Cumsky M.G.
Mol. Cell. Biol. 9:2765-2770(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
[5]"Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase."
Cumsky M.G., Ko C., Trueblood C.E., Poyton R.O.
Proc. Natl. Acad. Sci. U.S.A. 82:2235-2239(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-85.
[6]"Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38125 Genomic DNA. Translation: CAA86269.1.
M17799 Genomic DNA. Translation: AAA96310.1.
M11140 Genomic DNA. Translation: AAA34521.1.
BK006942 Genomic DNA. Translation: DAA08442.1.
PIROTBY5B. S05755.
RefSeqNP_012155.1. NM_001179459.1.

3D structure databases

ProteinModelPortalP00425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34880. 25 interactions.
DIPDIP-4709N.
IntActP00425. 1 interaction.
MINTMINT-513424.
STRING4932.YIL111W.

Protein family/group databases

TCDB3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbP00425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL111W; YIL111W; YIL111W.
GeneID854695.
KEGGsce:YIL111W.

Organism-specific databases

CYGDYIL111w.
SGDS000001373. COX5B.

Phylogenomic databases

eggNOGNOG263759.
GeneTreeENSGT00390000015571.
HOGENOMHOG000175160.
KOK02263.
OMAKRWEGMP.
OrthoDBEOG7JHMJ1.

Enzyme and pathway databases

BioCycYEAST:YIL111W-MONOMER.

Gene expression databases

GenevestigatorP00425.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Other

NextBio977331.

Entry information

Entry nameCOX5B_YEAST
AccessionPrimary (citable) accession number: P00425
Secondary accession number(s): D6VVH6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: March 19, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families