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Protein

Cytochrome c oxidase polypeptide 5B, mitochondrial

Gene

COX5B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciYEAST:YIL111W-MONOMER

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 5B, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
Ordered Locus Names:YIL111W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL111W
SGDiS000001373 COX5B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000000609818 – 151Cytochrome c oxidase polypeptide 5B, mitochondrialAdd BLAST134

Proteomic databases

MaxQBiP00425
PaxDbiP00425
PRIDEiP00425

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34880, 57 interactors
DIPiDIP-4709N
IntActiP00425, 2 interactors
MINTiP00425
STRINGi4932.YIL111W

Structurei

3D structure databases

ProteinModelPortaliP00425
SMRiP00425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000015571
HOGENOMiHOG000175160
InParanoidiP00425
KOiK02263
OMAiWQEKSNE
OrthoDBiEOG092C58YO

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL
60 70 80 90 100
TERQKLPWKT LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL
110 120 130 140 150
GISFGLFGLV RLLANPETPK TMNREWQLKS DEYLKSKNAN PWGGYSQVQS

K
Length:151
Mass (Da):17,197
Last modified:March 1, 1992 - v3
Checksum:i566B4E69631CBDE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA Translation: CAA86269.1
M17799 Genomic DNA Translation: AAA96310.1
M11140 Genomic DNA Translation: AAA34521.1
BK006942 Genomic DNA Translation: DAA08442.1
PIRiS05755 OTBY5B
RefSeqiNP_012155.1, NM_001179459.1

Genome annotation databases

EnsemblFungiiYIL111W; YIL111W; YIL111W
GeneIDi854695
KEGGisce:YIL111W

Similar proteinsi

Entry informationi

Entry nameiCOX5B_YEAST
AccessioniPrimary (citable) accession number: P00425
Secondary accession number(s): D6VVH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

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