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P00425

- COX5B_YEAST

UniProt

P00425 - COX5B_YEAST

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Protein

Cytochrome c oxidase polypeptide 5B, mitochondrial

Gene

COX5B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:YIL111W-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 5B, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
Ordered Locus Names:YIL111W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL111w.
SGDiS000001373. COX5B.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionSequence AnalysisAdd
BLAST
Chaini18 – 151134Cytochrome c oxidase polypeptide 5B, mitochondrialPRO_0000006098Add
BLAST

Proteomic databases

MaxQBiP00425.
PaxDbiP00425.

Expressioni

Gene expression databases

GenevestigatoriP00425.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34880. 25 interactions.
DIPiDIP-4709N.
IntActiP00425. 1 interaction.
MINTiMINT-513424.
STRINGi4932.YIL111W.

Structurei

3D structure databases

ProteinModelPortaliP00425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG263759.
GeneTreeiENSGT00390000015571.
HOGENOMiHOG000175160.
InParanoidiP00425.
KOiK02263.
OMAiKRWEGMP.
OrthoDBiEOG7JHMJ1.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL
60 70 80 90 100
TERQKLPWKT LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL
110 120 130 140 150
GISFGLFGLV RLLANPETPK TMNREWQLKS DEYLKSKNAN PWGGYSQVQS

K
Length:151
Mass (Da):17,197
Last modified:March 1, 1992 - v3
Checksum:i566B4E69631CBDE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86269.1.
M17799 Genomic DNA. Translation: AAA96310.1.
M11140 Genomic DNA. Translation: AAA34521.1.
BK006942 Genomic DNA. Translation: DAA08442.1.
PIRiS05755. OTBY5B.
RefSeqiNP_012155.1. NM_001179459.1.

Genome annotation databases

EnsemblFungiiYIL111W; YIL111W; YIL111W.
GeneIDi854695.
KEGGisce:YIL111W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38125 Genomic DNA. Translation: CAA86269.1 .
M17799 Genomic DNA. Translation: AAA96310.1 .
M11140 Genomic DNA. Translation: AAA34521.1 .
BK006942 Genomic DNA. Translation: DAA08442.1 .
PIRi S05755. OTBY5B.
RefSeqi NP_012155.1. NM_001179459.1.

3D structure databases

ProteinModelPortali P00425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34880. 25 interactions.
DIPi DIP-4709N.
IntActi P00425. 1 interaction.
MINTi MINT-513424.
STRINGi 4932.YIL111W.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBi P00425.
PaxDbi P00425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL111W ; YIL111W ; YIL111W .
GeneIDi 854695.
KEGGi sce:YIL111W.

Organism-specific databases

CYGDi YIL111w.
SGDi S000001373. COX5B.

Phylogenomic databases

eggNOGi NOG263759.
GeneTreei ENSGT00390000015571.
HOGENOMi HOG000175160.
InParanoidi P00425.
KOi K02263.
OMAi KRWEGMP.
OrthoDBi EOG7JHMJ1.

Enzyme and pathway databases

BioCyci YEAST:YIL111W-MONOMER.

Miscellaneous databases

NextBioi 977331.

Gene expression databases

Genevestigatori P00425.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V."
    Cumsky M.G., Trueblood C.E., Ko C., Poyton R.O.
    Mol. Cell. Biol. 7:3511-3519(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Splicing of a yeast intron containing an unusual 5' junction sequence."
    Hodge M.R., Cumsky M.G.
    Mol. Cell. Biol. 9:2765-2770(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
  5. "Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase."
    Cumsky M.G., Ko C., Trueblood C.E., Poyton R.O.
    Proc. Natl. Acad. Sci. U.S.A. 82:2235-2239(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-85.
  6. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX5B_YEAST
AccessioniPrimary (citable) accession number: P00425
Secondary accession number(s): D6VVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3