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P00425

- COX5B_YEAST

UniProt

P00425 - COX5B_YEAST

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Protein
Cytochrome c oxidase polypeptide 5B, mitochondrial
Gene
COX5B, YIL111W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:YIL111W-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 5B, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
Ordered Locus Names:YIL111W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL111w.
SGDiS000001373. COX5B.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717Mitochondrion Reviewed prediction
Add
BLAST
Chaini18 – 151134Cytochrome c oxidase polypeptide 5B, mitochondrial
PRO_0000006098Add
BLAST

Proteomic databases

MaxQBiP00425.
PaxDbiP00425.

Expressioni

Gene expression databases

GenevestigatoriP00425.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34880. 25 interactions.
DIPiDIP-4709N.
IntActiP00425. 1 interaction.
MINTiMINT-513424.
STRINGi4932.YIL111W.

Structurei

3D structure databases

ProteinModelPortaliP00425.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG263759.
GeneTreeiENSGT00390000015571.
HOGENOMiHOG000175160.
KOiK02263.
OMAiKRWEGMP.
OrthoDBiEOG7JHMJ1.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00425-1 [UniParc]FASTAAdd to Basket

« Hide

MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL    50
TERQKLPWKT LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL 100
GISFGLFGLV RLLANPETPK TMNREWQLKS DEYLKSKNAN PWGGYSQVQS 150
K 151
Length:151
Mass (Da):17,197
Last modified:March 1, 1992 - v3
Checksum:i566B4E69631CBDE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86269.1.
M17799 Genomic DNA. Translation: AAA96310.1.
M11140 Genomic DNA. Translation: AAA34521.1.
BK006942 Genomic DNA. Translation: DAA08442.1.
PIRiS05755. OTBY5B.
RefSeqiNP_012155.1. NM_001179459.1.

Genome annotation databases

EnsemblFungiiYIL111W; YIL111W; YIL111W.
GeneIDi854695.
KEGGisce:YIL111W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38125 Genomic DNA. Translation: CAA86269.1 .
M17799 Genomic DNA. Translation: AAA96310.1 .
M11140 Genomic DNA. Translation: AAA34521.1 .
BK006942 Genomic DNA. Translation: DAA08442.1 .
PIRi S05755. OTBY5B.
RefSeqi NP_012155.1. NM_001179459.1.

3D structure databases

ProteinModelPortali P00425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34880. 25 interactions.
DIPi DIP-4709N.
IntActi P00425. 1 interaction.
MINTi MINT-513424.
STRINGi 4932.YIL111W.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBi P00425.
PaxDbi P00425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL111W ; YIL111W ; YIL111W .
GeneIDi 854695.
KEGGi sce:YIL111W.

Organism-specific databases

CYGDi YIL111w.
SGDi S000001373. COX5B.

Phylogenomic databases

eggNOGi NOG263759.
GeneTreei ENSGT00390000015571.
HOGENOMi HOG000175160.
KOi K02263.
OMAi KRWEGMP.
OrthoDBi EOG7JHMJ1.

Enzyme and pathway databases

BioCyci YEAST:YIL111W-MONOMER.

Miscellaneous databases

NextBioi 977331.

Gene expression databases

Genevestigatori P00425.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V."
    Cumsky M.G., Trueblood C.E., Ko C., Poyton R.O.
    Mol. Cell. Biol. 7:3511-3519(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Splicing of a yeast intron containing an unusual 5' junction sequence."
    Hodge M.R., Cumsky M.G.
    Mol. Cell. Biol. 9:2765-2770(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
  5. "Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase."
    Cumsky M.G., Ko C., Trueblood C.E., Poyton R.O.
    Proc. Natl. Acad. Sci. U.S.A. 82:2235-2239(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-85.
  6. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX5B_YEAST
AccessioniPrimary (citable) accession number: P00425
Secondary accession number(s): D6VVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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