Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P00425

- COX5B_YEAST

UniProt

P00425 - COX5B_YEAST

Protein

Cytochrome c oxidase polypeptide 5B, mitochondrial

Gene

COX5B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (01 Mar 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. mitochondrial electron transport, cytochrome c to oxygen Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciYEAST:YIL111W-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide 5B, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide Vb
    Gene namesi
    Name:COX5B
    Ordered Locus Names:YIL111W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL111w.
    SGDiS000001373. COX5B.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex IV Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1717MitochondrionSequence AnalysisAdd
    BLAST
    Chaini18 – 151134Cytochrome c oxidase polypeptide 5B, mitochondrialPRO_0000006098Add
    BLAST

    Proteomic databases

    MaxQBiP00425.
    PaxDbiP00425.

    Expressioni

    Gene expression databases

    GenevestigatoriP00425.

    Interactioni

    Subunit structurei

    Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

    Protein-protein interaction databases

    BioGridi34880. 25 interactions.
    DIPiDIP-4709N.
    IntActiP00425. 1 interaction.
    MINTiMINT-513424.
    STRINGi4932.YIL111W.

    Structurei

    3D structure databases

    ProteinModelPortaliP00425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG263759.
    GeneTreeiENSGT00390000015571.
    HOGENOMiHOG000175160.
    KOiK02263.
    OMAiKRWEGMP.
    OrthoDBiEOG7JHMJ1.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRTSLTKGA RLTGTRFVQT KALSKATLTD LPERWENMPN LEQKEIADNL    50
    TERQKLPWKT LNNEEIKAAW YISYGEWGPR RPVHGKGDVA FITKGVFLGL 100
    GISFGLFGLV RLLANPETPK TMNREWQLKS DEYLKSKNAN PWGGYSQVQS 150
    K 151
    Length:151
    Mass (Da):17,197
    Last modified:March 1, 1992 - v3
    Checksum:i566B4E69631CBDE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38125 Genomic DNA. Translation: CAA86269.1.
    M17799 Genomic DNA. Translation: AAA96310.1.
    M11140 Genomic DNA. Translation: AAA34521.1.
    BK006942 Genomic DNA. Translation: DAA08442.1.
    PIRiS05755. OTBY5B.
    RefSeqiNP_012155.1. NM_001179459.1.

    Genome annotation databases

    EnsemblFungiiYIL111W; YIL111W; YIL111W.
    GeneIDi854695.
    KEGGisce:YIL111W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38125 Genomic DNA. Translation: CAA86269.1 .
    M17799 Genomic DNA. Translation: AAA96310.1 .
    M11140 Genomic DNA. Translation: AAA34521.1 .
    BK006942 Genomic DNA. Translation: DAA08442.1 .
    PIRi S05755. OTBY5B.
    RefSeqi NP_012155.1. NM_001179459.1.

    3D structure databases

    ProteinModelPortali P00425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34880. 25 interactions.
    DIPi DIP-4709N.
    IntActi P00425. 1 interaction.
    MINTi MINT-513424.
    STRINGi 4932.YIL111W.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    MaxQBi P00425.
    PaxDbi P00425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL111W ; YIL111W ; YIL111W .
    GeneIDi 854695.
    KEGGi sce:YIL111W.

    Organism-specific databases

    CYGDi YIL111w.
    SGDi S000001373. COX5B.

    Phylogenomic databases

    eggNOGi NOG263759.
    GeneTreei ENSGT00390000015571.
    HOGENOMi HOG000175160.
    KOi K02263.
    OMAi KRWEGMP.
    OrthoDBi EOG7JHMJ1.

    Enzyme and pathway databases

    BioCyci YEAST:YIL111W-MONOMER.

    Miscellaneous databases

    NextBioi 977331.

    Gene expression databases

    Genevestigatori P00425.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of two genes encoding divergent forms of yeast cytochrome c oxidase subunit V."
      Cumsky M.G., Trueblood C.E., Ko C., Poyton R.O.
      Mol. Cell. Biol. 7:3511-3519(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Splicing of a yeast intron containing an unusual 5' junction sequence."
      Hodge M.R., Cumsky M.G.
      Mol. Cell. Biol. 9:2765-2770(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-79.
    5. "Two nonidentical forms of subunit V are functional in yeast cytochrome c oxidase."
      Cumsky M.G., Ko C., Trueblood C.E., Poyton R.O.
      Proc. Natl. Acad. Sci. U.S.A. 82:2235-2239(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-85.
    6. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
      Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
      Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX5B_YEAST
    AccessioniPrimary (citable) accession number: P00425
    Secondary accession number(s): D6VVH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2250 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3