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Protein

Cytochrome c oxidase polypeptide 5A, mitochondrial

Gene

COX5A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3670 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:YNL052W-MONOMER
YEAST:YNL052W-MONOMER

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 5A, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:COX5A
Ordered Locus Names:YNL052W
ORF Names:N2474, YNL2474W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL052W
SGDiS000004997 COX5A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20Mitochondrion2 PublicationsAdd BLAST20
ChainiPRO_000000609721 – 153Cytochrome c oxidase polypeptide 5A, mitochondrialAdd BLAST133

Proteomic databases

MaxQBiP00424
PaxDbiP00424
PRIDEiP00424

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi35772, 208 interactors
DIPiDIP-6820N
IntActiP00424, 8 interactors
MINTiP00424
STRINGi4932.YNL052W

Structurei

3D structure databases

ProteinModelPortaliP00424
SMRiP00424
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000015571
HOGENOMiHOG000175160
InParanoidiP00424
KOiK02263
OMAiKRWEGMP
OrthoDBiEOG092C58YO

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNTFTRAG GLSRITSVRF AQTHALSNAA VMDLQSRWEN MPSTEQQDIV
60 70 80 90 100
SKLSERQKLP WAQLTEPEKQ AVWYISYGEW GPRRPVLNKG DSSFIAKGVA
110 120 130 140 150
AGLLFSVGLF AVVRMAGGQD AKTMNKEWQL KSDEYLKSKN ANPWGGYSQV

QSK
Length:153
Mass (Da):17,140
Last modified:August 13, 1987 - v1
Checksum:i1B1F8A3FE12CF783
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51Missing AA sequence (PubMed:6327686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02561 Genomic DNA Translation: CAA26403.1
M11770 Genomic DNA Translation: AAA34518.1
M17800 Genomic DNA Translation: AAA34520.1
U12141 Genomic DNA Translation: AAA99660.1
Z71328 Genomic DNA Translation: CAA95921.1
AY558131 Genomic DNA Translation: AAS56457.1
M11141 Genomic DNA Translation: AAA34519.1
BK006947 Genomic DNA Translation: DAA10493.1
PIRiS05833 OTBY5A
RefSeqiNP_014346.1, NM_001182891.1

Genome annotation databases

EnsemblFungiiYNL052W; YNL052W; YNL052W
GeneIDi855675
KEGGisce:YNL052W

Similar proteinsi

Entry informationi

Entry nameiCOX5A_YEAST
AccessioniPrimary (citable) accession number: P00424
Secondary accession number(s): D6W1C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: March 28, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health