Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 98Mitochondrial matrixAdd BLAST76
Transmembranei99 – 124HelicalAdd BLAST26
Topological domaini125 – 169Mitochondrial intermembraneAdd BLAST45

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: MGI
  • nucleus Source: Ensembl
  • respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion2 PublicationsAdd BLAST22
ChainiPRO_000000608323 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP00423.
PeptideAtlasiP00423.
PRIDEiP00423.

PTM databases

iPTMnetiP00423.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016079.

Interactioni

Protein-protein interaction databases

DIPiDIP-38979N.
IntActiP00423. 2 interactors.
STRINGi9913.ENSBTAP00000049613.

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 32Combined sources3
Beta strandi44 – 46Combined sources3
Helixi57 – 65Combined sources9
Helixi70 – 72Combined sources3
Helixi75 – 85Combined sources11
Helixi90 – 93Combined sources4
Helixi99 – 124Combined sources26
Helixi131 – 133Combined sources3
Helixi135 – 147Combined sources13
Turni152 – 155Combined sources4
Helixi157 – 159Combined sources3
Turni162 – 165Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80D/Q23-169[»]
1OCOX-ray2.80D/Q23-169[»]
1OCRX-ray2.35D/Q23-169[»]
1OCZX-ray2.90D/Q23-169[»]
1V54X-ray1.80D/Q23-169[»]
1V55X-ray1.90D/Q23-169[»]
2DYRX-ray1.80D/Q23-169[»]
2DYSX-ray2.20D/Q23-169[»]
2EIJX-ray1.90D/Q23-169[»]
2EIKX-ray2.10D/Q23-169[»]
2EILX-ray2.10D/Q23-169[»]
2EIMX-ray2.60D/Q23-169[»]
2EINX-ray2.70D/Q23-169[»]
2OCCX-ray2.30D/Q23-169[»]
2Y69X-ray1.95D/Q1-169[»]
2YBBelectron microscopy19.00O23-169[»]
2ZXWX-ray2.50D/Q23-169[»]
3ABKX-ray2.00D/Q23-169[»]
3ABLX-ray2.10D/Q23-169[»]
3ABMX-ray1.95D/Q23-169[»]
3AG1X-ray2.20D/Q23-169[»]
3AG2X-ray1.80D/Q23-169[»]
3AG3X-ray1.80D/Q23-169[»]
3AG4X-ray2.05D/Q23-169[»]
3ASNX-ray3.00D/Q23-169[»]
3ASOX-ray2.30D/Q23-169[»]
3WG7X-ray1.90D/Q23-169[»]
3X2QX-ray2.00D/Q23-169[»]
5B1AX-ray1.50D/Q23-169[»]
5B1BX-ray1.60D/Q23-169[»]
ProteinModelPortaliP00423.
SMRiP00423.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00423.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOVERGENiHBG051087.
InParanoidiP00423.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
TreeFamiTF105061.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRVFSLI GRRAISTSVC VRAHGSVVKS EDYALPSYVD RRDYPLPDVA
60 70 80 90 100
HVKNLSASQK ALKEKEKASW SSLSIDEKVE LYRLKFKESF AEMNRSTNEW
110 120 130 140 150
KTVVGAAMFF IGFTALLLIW EKHYVYGPIP HTFEEEWVAK QTKRMLDMKV
160
APIQGFSAKW DYDKNEWKK
Length:169
Mass (Da):19,572
Last modified:October 23, 1986 - v1
Checksum:i76D2B2D15F8D02A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34015
, L34012, L34013, L34014 Genomic DNA. Translation: AAA30461.1.
U11070
, U11067, U11068, U11069 Genomic DNA. Translation: AAA93149.1.
BT021029 mRNA. Translation: AAX09046.1.
BC102733 mRNA. Translation: AAI02734.1.
K02064 mRNA. Translation: AAA30463.1.
PIRiA30618. OLBO4.
RefSeqiNP_001001439.1. NM_001001439.3.
XP_005218495.1. XM_005218438.1.
UniGeneiBt.107085.
Bt.16025.

Genome annotation databases

EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079.
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079.
GeneIDi281090.
KEGGibta:281090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34015
, L34012, L34013, L34014 Genomic DNA. Translation: AAA30461.1.
U11070
, U11067, U11068, U11069 Genomic DNA. Translation: AAA93149.1.
BT021029 mRNA. Translation: AAX09046.1.
BC102733 mRNA. Translation: AAI02734.1.
K02064 mRNA. Translation: AAA30463.1.
PIRiA30618. OLBO4.
RefSeqiNP_001001439.1. NM_001001439.3.
XP_005218495.1. XM_005218438.1.
UniGeneiBt.107085.
Bt.16025.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80D/Q23-169[»]
1OCOX-ray2.80D/Q23-169[»]
1OCRX-ray2.35D/Q23-169[»]
1OCZX-ray2.90D/Q23-169[»]
1V54X-ray1.80D/Q23-169[»]
1V55X-ray1.90D/Q23-169[»]
2DYRX-ray1.80D/Q23-169[»]
2DYSX-ray2.20D/Q23-169[»]
2EIJX-ray1.90D/Q23-169[»]
2EIKX-ray2.10D/Q23-169[»]
2EILX-ray2.10D/Q23-169[»]
2EIMX-ray2.60D/Q23-169[»]
2EINX-ray2.70D/Q23-169[»]
2OCCX-ray2.30D/Q23-169[»]
2Y69X-ray1.95D/Q1-169[»]
2YBBelectron microscopy19.00O23-169[»]
2ZXWX-ray2.50D/Q23-169[»]
3ABKX-ray2.00D/Q23-169[»]
3ABLX-ray2.10D/Q23-169[»]
3ABMX-ray1.95D/Q23-169[»]
3AG1X-ray2.20D/Q23-169[»]
3AG2X-ray1.80D/Q23-169[»]
3AG3X-ray1.80D/Q23-169[»]
3AG4X-ray2.05D/Q23-169[»]
3ASNX-ray3.00D/Q23-169[»]
3ASOX-ray2.30D/Q23-169[»]
3WG7X-ray1.90D/Q23-169[»]
3X2QX-ray2.00D/Q23-169[»]
5B1AX-ray1.50D/Q23-169[»]
5B1BX-ray1.60D/Q23-169[»]
ProteinModelPortaliP00423.
SMRiP00423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38979N.
IntActiP00423. 2 interactors.
STRINGi9913.ENSBTAP00000049613.

PTM databases

iPTMnetiP00423.

Proteomic databases

PaxDbiP00423.
PeptideAtlasiP00423.
PRIDEiP00423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079.
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079.
GeneIDi281090.
KEGGibta:281090.

Organism-specific databases

CTDi1327.

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOVERGENiHBG051087.
InParanoidiP00423.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
TreeFamiTF105061.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00423.

Gene expression databases

BgeeiENSBTAG00000016079.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX41_BOVIN
AccessioniPrimary (citable) accession number: P00423
Secondary accession number(s): Q3SZS0, Q5E991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.