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P00423

- COX41_BOVIN

UniProt

P00423 - COX41_BOVIN

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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene
COX4I1, COX4
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: MGI

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 9876Mitochondrial matrixAdd
BLAST
Transmembranei99 – 12426HelicalAdd
BLAST
Topological domaini125 – 16945Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: MGI
  3. nucleus Source: Ensembl
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion2 PublicationsAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; alternate By similarity
Modified residuei29 – 291N6-succinyllysine; alternate By similarity
Modified residuei53 – 531N6-acetyllysine By similarity
Modified residuei60 – 601N6-acetyllysine; alternate By similarity
Modified residuei60 – 601N6-succinyllysine; alternate By similarity
Modified residuei67 – 671N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP00423.

Interactioni

Protein-protein interaction databases

IntActiP00423. 2 interactions.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323
Beta strandi44 – 463
Helixi57 – 659
Helixi70 – 723
Helixi75 – 8511
Helixi90 – 934
Helixi99 – 12426
Helixi131 – 1333
Helixi135 – 14713
Turni152 – 1554
Helixi157 – 1593
Turni162 – 1654

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80D/Q23-169[»]
1OCOX-ray2.80D/Q23-169[»]
1OCRX-ray2.35D/Q23-169[»]
1OCZX-ray2.90D/Q23-169[»]
1V54X-ray1.80D/Q23-169[»]
1V55X-ray1.90D/Q23-169[»]
2DYRX-ray1.80D/Q23-169[»]
2DYSX-ray2.20D/Q23-169[»]
2EIJX-ray1.90D/Q23-169[»]
2EIKX-ray2.10D/Q23-169[»]
2EILX-ray2.10D/Q23-169[»]
2EIMX-ray2.60D/Q23-169[»]
2EINX-ray2.70D/Q23-169[»]
2OCCX-ray2.30D/Q23-169[»]
2Y69X-ray1.95D/Q1-169[»]
2YBBelectron microscopy19.00O23-169[»]
2ZXWX-ray2.50D/Q23-169[»]
3ABKX-ray2.00D/Q23-169[»]
3ABLX-ray2.10D/Q23-169[»]
3ABMX-ray1.95D/Q23-169[»]
3AG1X-ray2.20D/Q23-169[»]
3AG2X-ray1.80D/Q23-169[»]
3AG3X-ray1.80D/Q23-169[»]
3AG4X-ray2.05D/Q23-169[»]
3ASNX-ray3.00D/Q23-169[»]
3ASOX-ray2.30D/Q23-169[»]
3WG7X-ray1.90D/Q23-169[»]
ProteinModelPortaliP00423.
SMRiP00423. Positions 26-169.

Miscellaneous databases

EvolutionaryTraceiP00423.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002407.
HOVERGENiHBG051087.
KOiK02263.
OMAiVAMQTKR.
OrthoDBiEOG7BKCWF.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00423-1 [UniParc]FASTAAdd to Basket

« Hide

MLATRVFSLI GRRAISTSVC VRAHGSVVKS EDYALPSYVD RRDYPLPDVA    50
HVKNLSASQK ALKEKEKASW SSLSIDEKVE LYRLKFKESF AEMNRSTNEW 100
KTVVGAAMFF IGFTALLLIW EKHYVYGPIP HTFEEEWVAK QTKRMLDMKV 150
APIQGFSAKW DYDKNEWKK 169
Length:169
Mass (Da):19,572
Last modified:October 23, 1986 - v1
Checksum:i76D2B2D15F8D02A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34015
, L34012, L34013, L34014 Genomic DNA. Translation: AAA30461.1.
U11070
, U11067, U11068, U11069 Genomic DNA. Translation: AAA93149.1.
BT021029 mRNA. Translation: AAX09046.1.
BC102733 mRNA. Translation: AAI02734.1.
K02064 mRNA. Translation: AAA30463.1.
PIRiA30618. OLBO4.
RefSeqiNP_001001439.1. NM_001001439.3.
XP_005218495.1. XM_005218438.1.
UniGeneiBt.107085.
Bt.16025.

Genome annotation databases

EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079.
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079.
GeneIDi281090.
KEGGibta:281090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34015
, L34012 , L34013 , L34014 Genomic DNA. Translation: AAA30461.1 .
U11070
, U11067 , U11068 , U11069 Genomic DNA. Translation: AAA93149.1 .
BT021029 mRNA. Translation: AAX09046.1 .
BC102733 mRNA. Translation: AAI02734.1 .
K02064 mRNA. Translation: AAA30463.1 .
PIRi A30618. OLBO4.
RefSeqi NP_001001439.1. NM_001001439.3.
XP_005218495.1. XM_005218438.1.
UniGenei Bt.107085.
Bt.16025.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 D/Q 23-169 [» ]
1OCO X-ray 2.80 D/Q 23-169 [» ]
1OCR X-ray 2.35 D/Q 23-169 [» ]
1OCZ X-ray 2.90 D/Q 23-169 [» ]
1V54 X-ray 1.80 D/Q 23-169 [» ]
1V55 X-ray 1.90 D/Q 23-169 [» ]
2DYR X-ray 1.80 D/Q 23-169 [» ]
2DYS X-ray 2.20 D/Q 23-169 [» ]
2EIJ X-ray 1.90 D/Q 23-169 [» ]
2EIK X-ray 2.10 D/Q 23-169 [» ]
2EIL X-ray 2.10 D/Q 23-169 [» ]
2EIM X-ray 2.60 D/Q 23-169 [» ]
2EIN X-ray 2.70 D/Q 23-169 [» ]
2OCC X-ray 2.30 D/Q 23-169 [» ]
2Y69 X-ray 1.95 D/Q 1-169 [» ]
2YBB electron microscopy 19.00 O 23-169 [» ]
2ZXW X-ray 2.50 D/Q 23-169 [» ]
3ABK X-ray 2.00 D/Q 23-169 [» ]
3ABL X-ray 2.10 D/Q 23-169 [» ]
3ABM X-ray 1.95 D/Q 23-169 [» ]
3AG1 X-ray 2.20 D/Q 23-169 [» ]
3AG2 X-ray 1.80 D/Q 23-169 [» ]
3AG3 X-ray 1.80 D/Q 23-169 [» ]
3AG4 X-ray 2.05 D/Q 23-169 [» ]
3ASN X-ray 3.00 D/Q 23-169 [» ]
3ASO X-ray 2.30 D/Q 23-169 [» ]
3WG7 X-ray 1.90 D/Q 23-169 [» ]
ProteinModelPortali P00423.
SMRi P00423. Positions 26-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00423. 2 interactions.

Proteomic databases

PRIDEi P00423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021397 ; ENSBTAP00000021397 ; ENSBTAG00000016079 .
ENSBTAT00000053881 ; ENSBTAP00000049613 ; ENSBTAG00000016079 .
GeneIDi 281090.
KEGGi bta:281090.

Organism-specific databases

CTDi 1327.

Phylogenomic databases

GeneTreei ENSGT00390000002407.
HOVERGENi HBG051087.
KOi K02263.
OMAi VAMQTKR.
OrthoDBi EOG7BKCWF.
TreeFami TF105061.

Miscellaneous databases

EvolutionaryTracei P00423.
NextBioi 20805164.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the functional gene encoding bovine cytochrome c oxidase subunit IV."
    Bachman N.J.
    Gene 162:313-318(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  4. "Isolation and characterization of a cDNA clone for bovine cytochrome c oxidase subunit IV."
    Lomax M.I., Bachman N.J., Nasoff M.S., Caruthers M.H., Grossman L.I.
    Proc. Natl. Acad. Sci. U.S.A. 81:6295-6299(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-104.
  5. "Studies on cytochrome c oxidase, VI. Polypeptide IV: the complete primary structure."
    Sacher R., Steffens G.J., Buse G.
    Hoppe-Seyler's Z. Physiol. Chem. 360:1385-1392(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-109.
    Tissue: Heart.
  6. "Studies on cytochrome c oxidase, V. Polypeptide IV: alignment and amino acid sequences on cyanogen bromide fragments."
    Sacher R., Buse G., Steffens G.J.
    Hoppe-Seyler's Z. Physiol. Chem. 360:1377-1383(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-109.
    Tissue: Heart.
  7. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  9. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX41_BOVIN
AccessioniPrimary (citable) accession number: P00423
Secondary accession number(s): Q3SZS0, Q5E991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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