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P00423

- COX41_BOVIN

UniProt

P00423 - COX41_BOVIN

Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (23 Oct 1986)
      Previous versions | rss
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    Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: MGI

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide IV
    Cytochrome c oxidase subunit IV isoform 1
    Short name:
    COX IV-1
    Gene namesi
    Name:COX4I1
    Synonyms:COX4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: MGI
    3. nucleus Source: Ensembl
    4. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222Mitochondrion2 PublicationsAdd
    BLAST
    Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291N6-acetyllysine; alternateBy similarity
    Modified residuei29 – 291N6-succinyllysine; alternateBy similarity
    Modified residuei53 – 531N6-acetyllysineBy similarity
    Modified residuei60 – 601N6-acetyllysine; alternateBy similarity
    Modified residuei60 – 601N6-succinyllysine; alternateBy similarity
    Modified residuei67 – 671N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP00423.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38979N.
    IntActiP00423. 2 interactions.

    Structurei

    Secondary structure

    1
    169
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi30 – 323
    Beta strandi44 – 463
    Helixi57 – 659
    Helixi70 – 723
    Helixi75 – 8511
    Helixi90 – 934
    Helixi99 – 12426
    Helixi131 – 1333
    Helixi135 – 14713
    Turni152 – 1554
    Helixi157 – 1593
    Turni162 – 1654

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80D/Q23-169[»]
    1OCOX-ray2.80D/Q23-169[»]
    1OCRX-ray2.35D/Q23-169[»]
    1OCZX-ray2.90D/Q23-169[»]
    1V54X-ray1.80D/Q23-169[»]
    1V55X-ray1.90D/Q23-169[»]
    2DYRX-ray1.80D/Q23-169[»]
    2DYSX-ray2.20D/Q23-169[»]
    2EIJX-ray1.90D/Q23-169[»]
    2EIKX-ray2.10D/Q23-169[»]
    2EILX-ray2.10D/Q23-169[»]
    2EIMX-ray2.60D/Q23-169[»]
    2EINX-ray2.70D/Q23-169[»]
    2OCCX-ray2.30D/Q23-169[»]
    2Y69X-ray1.95D/Q1-169[»]
    2YBBelectron microscopy19.00O23-169[»]
    2ZXWX-ray2.50D/Q23-169[»]
    3ABKX-ray2.00D/Q23-169[»]
    3ABLX-ray2.10D/Q23-169[»]
    3ABMX-ray1.95D/Q23-169[»]
    3AG1X-ray2.20D/Q23-169[»]
    3AG2X-ray1.80D/Q23-169[»]
    3AG3X-ray1.80D/Q23-169[»]
    3AG4X-ray2.05D/Q23-169[»]
    3ASNX-ray3.00D/Q23-169[»]
    3ASOX-ray2.30D/Q23-169[»]
    3WG7X-ray1.90D/Q23-169[»]
    ProteinModelPortaliP00423.
    SMRiP00423. Positions 26-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00423.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 9876Mitochondrial matrixAdd
    BLAST
    Topological domaini125 – 16945Mitochondrial intermembraneAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei99 – 12426HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000002407.
    HOVERGENiHBG051087.
    KOiK02263.
    OMAiVAMQTKR.
    OrthoDBiEOG7BKCWF.
    TreeFamiTF105061.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    PRINTSiPR01873. CYTCOXIDASE4.
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00423-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLATRVFSLI GRRAISTSVC VRAHGSVVKS EDYALPSYVD RRDYPLPDVA    50
    HVKNLSASQK ALKEKEKASW SSLSIDEKVE LYRLKFKESF AEMNRSTNEW 100
    KTVVGAAMFF IGFTALLLIW EKHYVYGPIP HTFEEEWVAK QTKRMLDMKV 150
    APIQGFSAKW DYDKNEWKK 169
    Length:169
    Mass (Da):19,572
    Last modified:October 23, 1986 - v1
    Checksum:i76D2B2D15F8D02A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34015
    , L34012, L34013, L34014 Genomic DNA. Translation: AAA30461.1.
    U11070
    , U11067, U11068, U11069 Genomic DNA. Translation: AAA93149.1.
    BT021029 mRNA. Translation: AAX09046.1.
    BC102733 mRNA. Translation: AAI02734.1.
    K02064 mRNA. Translation: AAA30463.1.
    PIRiA30618. OLBO4.
    RefSeqiNP_001001439.1. NM_001001439.3.
    XP_005218495.1. XM_005218438.1.
    UniGeneiBt.107085.
    Bt.16025.

    Genome annotation databases

    EnsembliENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079.
    ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079.
    GeneIDi281090.
    KEGGibta:281090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34015
    , L34012 , L34013 , L34014 Genomic DNA. Translation: AAA30461.1 .
    U11070
    , U11067 , U11068 , U11069 Genomic DNA. Translation: AAA93149.1 .
    BT021029 mRNA. Translation: AAX09046.1 .
    BC102733 mRNA. Translation: AAI02734.1 .
    K02064 mRNA. Translation: AAA30463.1 .
    PIRi A30618. OLBO4.
    RefSeqi NP_001001439.1. NM_001001439.3.
    XP_005218495.1. XM_005218438.1.
    UniGenei Bt.107085.
    Bt.16025.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 D/Q 23-169 [» ]
    1OCO X-ray 2.80 D/Q 23-169 [» ]
    1OCR X-ray 2.35 D/Q 23-169 [» ]
    1OCZ X-ray 2.90 D/Q 23-169 [» ]
    1V54 X-ray 1.80 D/Q 23-169 [» ]
    1V55 X-ray 1.90 D/Q 23-169 [» ]
    2DYR X-ray 1.80 D/Q 23-169 [» ]
    2DYS X-ray 2.20 D/Q 23-169 [» ]
    2EIJ X-ray 1.90 D/Q 23-169 [» ]
    2EIK X-ray 2.10 D/Q 23-169 [» ]
    2EIL X-ray 2.10 D/Q 23-169 [» ]
    2EIM X-ray 2.60 D/Q 23-169 [» ]
    2EIN X-ray 2.70 D/Q 23-169 [» ]
    2OCC X-ray 2.30 D/Q 23-169 [» ]
    2Y69 X-ray 1.95 D/Q 1-169 [» ]
    2YBB electron microscopy 19.00 O 23-169 [» ]
    2ZXW X-ray 2.50 D/Q 23-169 [» ]
    3ABK X-ray 2.00 D/Q 23-169 [» ]
    3ABL X-ray 2.10 D/Q 23-169 [» ]
    3ABM X-ray 1.95 D/Q 23-169 [» ]
    3AG1 X-ray 2.20 D/Q 23-169 [» ]
    3AG2 X-ray 1.80 D/Q 23-169 [» ]
    3AG3 X-ray 1.80 D/Q 23-169 [» ]
    3AG4 X-ray 2.05 D/Q 23-169 [» ]
    3ASN X-ray 3.00 D/Q 23-169 [» ]
    3ASO X-ray 2.30 D/Q 23-169 [» ]
    3WG7 X-ray 1.90 D/Q 23-169 [» ]
    ProteinModelPortali P00423.
    SMRi P00423. Positions 26-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38979N.
    IntActi P00423. 2 interactions.

    Proteomic databases

    PRIDEi P00423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021397 ; ENSBTAP00000021397 ; ENSBTAG00000016079 .
    ENSBTAT00000053881 ; ENSBTAP00000049613 ; ENSBTAG00000016079 .
    GeneIDi 281090.
    KEGGi bta:281090.

    Organism-specific databases

    CTDi 1327.

    Phylogenomic databases

    GeneTreei ENSGT00390000002407.
    HOVERGENi HBG051087.
    KOi K02263.
    OMAi VAMQTKR.
    OrthoDBi EOG7BKCWF.
    TreeFami TF105061.

    Miscellaneous databases

    EvolutionaryTracei P00423.
    NextBioi 20805164.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    PRINTSi PR01873. CYTCOXIDASE4.
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the functional gene encoding bovine cytochrome c oxidase subunit IV."
      Bachman N.J.
      Gene 162:313-318(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    4. "Isolation and characterization of a cDNA clone for bovine cytochrome c oxidase subunit IV."
      Lomax M.I., Bachman N.J., Nasoff M.S., Caruthers M.H., Grossman L.I.
      Proc. Natl. Acad. Sci. U.S.A. 81:6295-6299(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-104.
    5. "Studies on cytochrome c oxidase, VI. Polypeptide IV: the complete primary structure."
      Sacher R., Steffens G.J., Buse G.
      Hoppe-Seyler's Z. Physiol. Chem. 360:1385-1392(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-109.
      Tissue: Heart.
    6. "Studies on cytochrome c oxidase, V. Polypeptide IV: alignment and amino acid sequences on cyanogen bromide fragments."
      Sacher R., Buse G., Steffens G.J.
      Hoppe-Seyler's Z. Physiol. Chem. 360:1377-1383(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-109.
      Tissue: Heart.
    7. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    9. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX41_BOVIN
    AccessioniPrimary (citable) accession number: P00423
    Secondary accession number(s): Q3SZS0, Q5E991
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 23, 1986
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3