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P00423 (COX41_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1
Gene names
Name:COX4I1
Synonyms:COX4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion Ref.5 Ref.6
Chain23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
PRO_0000006083

Regions

Topological domain23 – 9876Mitochondrial matrix
Transmembrane99 – 12426Helical
Topological domain125 – 16945Mitochondrial intermembrane

Amino acid modifications

Modified residue291N6-acetyllysine; alternate By similarity
Modified residue291N6-succinyllysine; alternate By similarity
Modified residue531N6-acetyllysine By similarity
Modified residue601N6-acetyllysine; alternate By similarity
Modified residue601N6-succinyllysine; alternate By similarity
Modified residue671N6-acetyllysine By similarity

Secondary structure

......................... 169
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00423 [UniParc].

Last modified October 23, 1986. Version 1.
Checksum: 76D2B2D15F8D02A1

FASTA16919,572
        10         20         30         40         50         60 
MLATRVFSLI GRRAISTSVC VRAHGSVVKS EDYALPSYVD RRDYPLPDVA HVKNLSASQK 

        70         80         90        100        110        120 
ALKEKEKASW SSLSIDEKVE LYRLKFKESF AEMNRSTNEW KTVVGAAMFF IGFTALLLIW 

       130        140        150        160 
EKHYVYGPIP HTFEEEWVAK QTKRMLDMKV APIQGFSAKW DYDKNEWKK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the functional gene encoding bovine cytochrome c oxidase subunit IV."
Bachman N.J.
Gene 162:313-318(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[4]"Isolation and characterization of a cDNA clone for bovine cytochrome c oxidase subunit IV."
Lomax M.I., Bachman N.J., Nasoff M.S., Caruthers M.H., Grossman L.I.
Proc. Natl. Acad. Sci. U.S.A. 81:6295-6299(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-104.
[5]"Studies on cytochrome c oxidase, VI. Polypeptide IV: the complete primary structure."
Sacher R., Steffens G.J., Buse G.
Hoppe-Seyler's Z. Physiol. Chem. 360:1385-1392(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-109.
Tissue: Heart.
[6]"Studies on cytochrome c oxidase, V. Polypeptide IV: alignment and amino acid sequences on cyanogen bromide fragments."
Sacher R., Buse G., Steffens G.J.
Hoppe-Seyler's Z. Physiol. Chem. 360:1377-1383(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-109.
Tissue: Heart.
[7]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[8]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[9]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34015 expand/collapse EMBL AC list , L34012, L34013, L34014 Genomic DNA. Translation: AAA30461.1.
U11070 expand/collapse EMBL AC list , U11067, U11068, U11069 Genomic DNA. Translation: AAA93149.1.
BT021029 mRNA. Translation: AAX09046.1.
BC102733 mRNA. Translation: AAI02734.1.
K02064 mRNA. Translation: AAA30463.1.
PIROLBO4. A30618.
RefSeqNP_001001439.1. NM_001001439.3.
XP_005218495.1. XM_005218438.1.
UniGeneBt.107085.
Bt.16025.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80D/Q23-169[»]
1OCOX-ray2.80D/Q23-169[»]
1OCRX-ray2.35D/Q23-169[»]
1OCZX-ray2.90D/Q23-169[»]
1V54X-ray1.80D/Q23-169[»]
1V55X-ray1.90D/Q23-169[»]
2DYRX-ray1.80D/Q23-169[»]
2DYSX-ray2.20D/Q23-169[»]
2EIJX-ray1.90D/Q23-169[»]
2EIKX-ray2.10D/Q23-169[»]
2EILX-ray2.10D/Q23-169[»]
2EIMX-ray2.60D/Q23-169[»]
2EINX-ray2.70D/Q23-169[»]
2OCCX-ray2.30D/Q23-169[»]
2Y69X-ray1.95D/Q1-169[»]
2YBBelectron microscopy19.00O23-169[»]
2ZXWX-ray2.50D/Q23-169[»]
3ABKX-ray2.00D/Q23-169[»]
3ABLX-ray2.10D/Q23-169[»]
3ABMX-ray1.95D/Q23-169[»]
3AG1X-ray2.20D/Q23-169[»]
3AG2X-ray1.80D/Q23-169[»]
3AG3X-ray1.80D/Q23-169[»]
3AG4X-ray2.05D/Q23-169[»]
3ASNX-ray3.00D/Q23-169[»]
3ASOX-ray2.30D/Q23-169[»]
ProteinModelPortalP00423.
SMRP00423. Positions 26-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00423. 2 interactions.

Proteomic databases

PRIDEP00423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021397; ENSBTAP00000021397; ENSBTAG00000016079.
ENSBTAT00000053881; ENSBTAP00000049613; ENSBTAG00000016079.
GeneID281090.
KEGGbta:281090.

Organism-specific databases

CTD1327.

Phylogenomic databases

GeneTreeENSGT00390000002407.
HOVERGENHBG051087.
KOK02263.
OMAVAMQTKR.
OrthoDBEOG7BKCWF.
TreeFamTF105061.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
PRINTSPR01873. CYTCOXIDASE4.
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00423.
NextBio20805164.

Entry information

Entry nameCOX41_BOVIN
AccessionPrimary (citable) accession number: P00423
Secondary accession number(s): Q3SZS0, Q5E991
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references