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P00422 (COX3_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:cox-3
Synonyms:cox3, oxi2
ORF Names:NCM012, NCU16003
Encoded onMitochondrion
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cytochrome c oxidase subunit 3
PRO_0000183813

Regions

Transmembrane46 – 6621Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane138 – 16023Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane247 – 26721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P00422 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: DADCF118933781BC

FASTA26930,089
        10         20         30         40         50         60 
MTNLIRSNFQ DHPFHLVSPS PWPLNTSVCL LNLTTTGALS MHNFNNIHYL YYIALIGLVS 

        70         80         90        100        110        120 
AMFLWFRDII SEGTFLGDHT LAVQRGLNLG IILFIVSEAL FFLAIFWAFF HSALTPTVEL 

       130        140        150        160        170        180 
GAQWPPIGIE PVNPFELPLL NTVILLSSGA TITYAHHALI KGEREGALYG SIATILLAII 

       190        200        210        220        230        240 
FTGFQGVEYS VSSFTISDGA FGTCFFFSTG FHGIHVIIGT IFLAVALWRI FAYHLTDNHH 

       250        260 
VGFEGGILYW HFVDVVWLFL YISVYYWGS 

« Hide

References

« Hide 'large scale' references
[1]"Cytochrome oxidase subunit III gene in Neurospora crassa mitochondria. Location and sequence."
Browning K.S., RajBhandary U.L.
J. Biol. Chem. 257:5253-5256(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"Mitochondrial genetics of Neurospora."
Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.
(In) Kueck U. (eds.); The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112, Springer-Verlag, Berlin-Heidelberg (2004)
Cited for: GENOME REANNOTATION.
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"Products of mitochondrial protein synthesis in Neurospora crassa. Determination of equimolar amounts of three products in cytochrome oxidase on the basis of amino-acid analysis."
Sebald W., Machleidt W., Otto J.
Eur. J. Biochem. 38:311-324(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: AMINO-ACID COMPOSITION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00668 Genomic DNA. Translation: CAA24041.1.
KC683708 Genomic DNA. Translation: AGG15992.1.
PIROTNC3. A00489.

3D structure databases

ProteinModelPortalP00422.
SMRP00422. Positions 10-269.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7V76HP.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_NEUCR
AccessionPrimary (citable) accession number: P00422
Secondary accession number(s): M1R9R0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families