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Protein

Cytochrome c oxidase subunit 3

Gene

cox-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox-3
Synonyms:cox3, oxi2
ORF Names:NCM012, NCU16003
Encoded oniMitochondrion
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:NCU16003.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838131 – 269Cytochrome c oxidase subunit 3Add BLAST269

Structurei

3D structure databases

ProteinModelPortaliP00422.
SMRiP00422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP00422.
KOiK02262.
OrthoDBiEOG092C4IN0.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR035973. Cyt_c_oxidase_su3-like_sf.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

P00422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLIRSNFQ DHPFHLVSPS PWPLNTSVCL LNLTTTGALS MHNFNNIHYL
60 70 80 90 100
YYIALIGLVS AMFLWFRDII SEGTFLGDHT LAVQRGLNLG IILFIVSEAL
110 120 130 140 150
FFLAIFWAFF HSALTPTVEL GAQWPPIGIE PVNPFELPLL NTVILLSSGA
160 170 180 190 200
TITYAHHALI KGEREGALYG SIATILLAII FTGFQGVEYS VSSFTISDGA
210 220 230 240 250
FGTCFFFSTG FHGIHVIIGT IFLAVALWRI FAYHLTDNHH VGFEGGILYW
260
HFVDVVWLFL YISVYYWGS
Length:269
Mass (Da):30,089
Last modified:July 21, 1986 - v1
Checksum:iDADCF118933781BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00668 Genomic DNA. Translation: CAA24041.1.
KC683708 Genomic DNA. Translation: AGG15992.1.
PIRiA00489. OTNC3.
RefSeqiYP_009126704.1. NC_026614.1.

Genome annotation databases

EnsemblFungiiAGG15992; AGG15992; NCU16003.
GeneIDi23681534.
KEGGincr:NCU16003.

Similar proteinsi

Entry informationi

Entry nameiCOX3_NEUCR
AccessioniPrimary (citable) accession number: P00422
Secondary accession number(s): M1R9R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families