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Protein

Cytochrome c oxidase subunit 3

Gene

cox-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox-3
Synonyms:cox3, oxi2
ORF Names:NCM012, NCU16003
Encoded oniMitochondrion
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:NCU16003

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838131 – 269Cytochrome c oxidase subunit 3Add BLAST269

Structurei

3D structure databases

ProteinModelPortaliP00422
SMRiP00422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP00422
KOiK02262
OrthoDBiEOG092C4IN0

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P00422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLIRSNFQ DHPFHLVSPS PWPLNTSVCL LNLTTTGALS MHNFNNIHYL
60 70 80 90 100
YYIALIGLVS AMFLWFRDII SEGTFLGDHT LAVQRGLNLG IILFIVSEAL
110 120 130 140 150
FFLAIFWAFF HSALTPTVEL GAQWPPIGIE PVNPFELPLL NTVILLSSGA
160 170 180 190 200
TITYAHHALI KGEREGALYG SIATILLAII FTGFQGVEYS VSSFTISDGA
210 220 230 240 250
FGTCFFFSTG FHGIHVIIGT IFLAVALWRI FAYHLTDNHH VGFEGGILYW
260
HFVDVVWLFL YISVYYWGS
Length:269
Mass (Da):30,089
Last modified:July 21, 1986 - v1
Checksum:iDADCF118933781BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00668 Genomic DNA Translation: CAA24041.1
KC683708 Genomic DNA Translation: AGG15992.1
PIRiA00489 OTNC3
RefSeqiYP_009126704.1, NC_026614.1

Genome annotation databases

EnsemblFungiiAGG15992; AGG15992; NCU16003
GeneIDi23681534
KEGGincr:NCU16003

Similar proteinsi

Entry informationi

Entry nameiCOX3_NEUCR
AccessioniPrimary (citable) accession number: P00422
Secondary accession number(s): M1R9R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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