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P00421 (COX3_EMEND) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:cox3
Synonyms:oxiC
Encoded onMitochondrion
OrganismEmericella nidulans (Aspergillus nidulans)
Taxonomic identifier162425 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence caution

The sequence AAA99207.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA30031.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cytochrome c oxidase subunit 3
PRO_0000183771

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane138 – 16023Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane247 – 26721Helical; Potential

Experimental info

Sequence conflict881N → Y in AAA99207. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P00421 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: B68F4F79E8A690D2

FASTA26930,360
        10         20         30         40         50         60 
MIYQSKRNFQ NHPFHLVSPS PWPLFTSISL FILTTATVLF MHGFEGFQYL VPVAVINVMY 

        70         80         90        100        110        120 
VMGLWFRDVI SEGTYLGNHT NAVQKGLNLG VGLFIISEVF FFLAIFWAFF HSAISPSVEL 

       130        140        150        160        170        180 
GAQWPPLGIQ GINPFELPLL NTIILLSSGV TITYAHHSLI QGNRKGALYG TVVTILLAIV 

       190        200        210        220        230        240 
FTFFQGVEYT VSSFTISDSV YGSCFYFGTG FHGLHVIIGT AFLAVGLWRL AAYHLTDHHH 

       250        260 
LGYESGILYW HFVDVVWLFL YISVYYWGY 

« Hide

References

[1]"Nucleotide sequence of Aspergillus nidulans mitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA."
Netzker R., Koechel H.G., Basak N., Kuentzel H.
Nucleic Acids Res. 10:4783-4794(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: pabaA1 biA1.
[2]Lazarus C.M., Kuentzel H.
Submitted (MAR-1984) to the PIR data bank
Cited for: SEQUENCE REVISION TO 11; 19; 123 AND 249.
[3]"Genetic code and phylogenetic origin of oomycetous mitochondria."
Karlovsky P., Fartmann B.
J. Mol. Evol. 34:254-258(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06960 Genomic DNA. Translation: CAA30031.1. Different initiation.
J01390 Genomic DNA. Translation: AAA99207.1. Different initiation.
PIROTAS3. B93436.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PHVmodel-I12-19[»]
ProteinModelPortalP00421.
SMRP00421. Positions 10-268.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_EMEND
AccessionPrimary (citable) accession number: P00421
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references