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P00421

- COX3_EMEND

UniProt

P00421 - COX3_EMEND

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Protein

Cytochrome c oxidase subunit 3

Gene
cox3, oxiC
Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox3
Synonyms:oxiC
Encoded oniMitochondrion
OrganismiEmericella nidulans (Aspergillus nidulans)
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 16023Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei207 – 22721Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183771Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PHVmodel-I12-19[»]
ProteinModelPortaliP00421.
SMRiP00421. Positions 10-268.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00421-1 [UniParc]FASTAAdd to Basket

« Hide

MIYQSKRNFQ NHPFHLVSPS PWPLFTSISL FILTTATVLF MHGFEGFQYL    50
VPVAVINVMY VMGLWFRDVI SEGTYLGNHT NAVQKGLNLG VGLFIISEVF 100
FFLAIFWAFF HSAISPSVEL GAQWPPLGIQ GINPFELPLL NTIILLSSGV 150
TITYAHHSLI QGNRKGALYG TVVTILLAIV FTFFQGVEYT VSSFTISDSV 200
YGSCFYFGTG FHGLHVIIGT AFLAVGLWRL AAYHLTDHHH LGYESGILYW 250
HFVDVVWLFL YISVYYWGY 269
Length:269
Mass (Da):30,360
Last modified:July 21, 1986 - v1
Checksum:iB68F4F79E8A690D2
GO

Sequence cautioni

The sequence AAA99207.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA30031.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881N → Y in AAA99207. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06960 Genomic DNA. Translation: CAA30031.1. Different initiation.
J01390 Genomic DNA. Translation: AAA99207.1. Different initiation.
PIRiB93436. OTAS3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06960 Genomic DNA. Translation: CAA30031.1 . Different initiation.
J01390 Genomic DNA. Translation: AAA99207.1 . Different initiation.
PIRi B93436. OTAS3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PHV model - I 12-19 [» ]
ProteinModelPortali P00421.
SMRi P00421. Positions 10-268.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Aspergillus nidulans mitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA."
    Netzker R., Koechel H.G., Basak N., Kuentzel H.
    Nucleic Acids Res. 10:4783-4794(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: pabaA1 biA1.
  2. Lazarus C.M., Kuentzel H.
    Submitted (MAR-1984) to the PIR data bank
    Cited for: SEQUENCE REVISION TO 11; 19; 123 AND 249.
  3. "Genetic code and phylogenetic origin of oomycetous mitochondria."
    Karlovsky P., Fartmann B.
    J. Mol. Evol. 34:254-258(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_EMEND
AccessioniPrimary (citable) accession number: P00421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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