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P00421

- COX3_EMEND

UniProt

P00421 - COX3_EMEND

Protein

Cytochrome c oxidase subunit 3

Gene

cox3

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:cox3
    Synonyms:oxiC
    Encoded oniMitochondrion
    OrganismiEmericella nidulans (Aspergillus nidulans)
    Taxonomic identifieri162425 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183771Add
    BLAST

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PHVmodel-I12-19[»]
    ProteinModelPortaliP00421.
    SMRiP00421. Positions 10-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 16023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYQSKRNFQ NHPFHLVSPS PWPLFTSISL FILTTATVLF MHGFEGFQYL    50
    VPVAVINVMY VMGLWFRDVI SEGTYLGNHT NAVQKGLNLG VGLFIISEVF 100
    FFLAIFWAFF HSAISPSVEL GAQWPPLGIQ GINPFELPLL NTIILLSSGV 150
    TITYAHHSLI QGNRKGALYG TVVTILLAIV FTFFQGVEYT VSSFTISDSV 200
    YGSCFYFGTG FHGLHVIIGT AFLAVGLWRL AAYHLTDHHH LGYESGILYW 250
    HFVDVVWLFL YISVYYWGY 269
    Length:269
    Mass (Da):30,360
    Last modified:July 21, 1986 - v1
    Checksum:iB68F4F79E8A690D2
    GO

    Sequence cautioni

    The sequence AAA99207.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA30031.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881N → Y in AAA99207. (PubMed:1588598)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06960 Genomic DNA. Translation: CAA30031.1. Different initiation.
    J01390 Genomic DNA. Translation: AAA99207.1. Different initiation.
    PIRiB93436. OTAS3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06960 Genomic DNA. Translation: CAA30031.1 . Different initiation.
    J01390 Genomic DNA. Translation: AAA99207.1 . Different initiation.
    PIRi B93436. OTAS3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PHV model - I 12-19 [» ]
    ProteinModelPortali P00421.
    SMRi P00421. Positions 10-268.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of Aspergillus nidulans mitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA."
      Netzker R., Koechel H.G., Basak N., Kuentzel H.
      Nucleic Acids Res. 10:4783-4794(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: pabaA1 biA1.
    2. Lazarus C.M., Kuentzel H.
      Submitted (MAR-1984) to the PIR data bank
      Cited for: SEQUENCE REVISION TO 11; 19; 123 AND 249.
    3. "Genetic code and phylogenetic origin of oomycetous mitochondria."
      Karlovsky P., Fartmann B.
      J. Mol. Evol. 34:254-258(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_EMEND
    AccessioniPrimary (citable) accession number: P00421
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3