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P00420

- COX3_YEAST

UniProt

P00420 - COX3_YEAST

Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (23 Apr 2003)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro
    2. aerobic respiration Source: SGD
    3. hydrogen ion transmembrane transport Source: GOC
    4. mitochondrial electron transport, cytochrome c to oxygen Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciMetaCyc:Q0275-MONOMER.
    YEAST:Q0275-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:COX3
    Synonyms:OXI2
    Ordered Locus Names:Q0275
    Encoded oniMitochondrion
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Mitochondrion

    Organism-specific databases

    CYGDiQ0275.
    SGDiS000007283. COX3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183874Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP00420.

    Interactioni

    Subunit structurei

    Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

    Protein-protein interaction databases

    BioGridi34817. 25 interactions.
    DIPiDIP-8133N.
    IntActiP00420. 2 interactions.
    MINTiMINT-4981611.
    STRINGi4932.Q0275.

    Structurei

    3D structure databases

    ProteinModelPortaliP00420.
    SMRiP00420. Positions 9-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    GeneTreeiENSGT00390000013064.
    HOGENOMiHOG000264954.
    KOiK02262.
    OMAiRESIADK.
    OrthoDBiEOG7V76HP.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00420-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHLERSRHQ QHPFHMVMPS PWPIVVSFAL LSLALSTALT MHGYIGNMNM    50
    VYLALFVLLT SSILWFRDIV AEATYLGDHT MAVRKGINLG FLMFVLSEVL 100
    IFAGLFWAYF HSAMSPDVTL GACWPPVGIE AVQPTELPLL NTIILLSSGA 150
    TVTYSHHALI AGNRNKALSG LLITFWLIVI FVTCQYIEYT NAAFTISDGV 200
    YGSVFYAGTG LHFLHMVMLA AMLGVNYWRM RNYHLTAGHH VGYETTIIYT 250
    HVLDVIWLFL YVVFYWWGV 269
    Length:269
    Mass (Da):30,360
    Last modified:April 23, 2003 - v3
    Checksum:i81B24A54F63BD8B1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631V → T in AAA32153. (PubMed:6248512)Curated
    Sequence conflicti263 – 2631V → T in AAA67530. (PubMed:3549452)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01478 Genomic DNA. Translation: AAA32153.2.
    L36890 Genomic DNA. Translation: AAA67530.1.
    AJ011856 Genomic DNA. Translation: CAA09846.1.
    PIRiA00487. OTBY3.
    S78686.
    RefSeqiNP_009328.1. NM_001184375.1.

    Genome annotation databases

    EnsemblFungiiQ0275; Q0275; Q0275.
    GeneIDi854627.
    KEGGisce:Q0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01478 Genomic DNA. Translation: AAA32153.2 .
    L36890 Genomic DNA. Translation: AAA67530.1 .
    AJ011856 Genomic DNA. Translation: CAA09846.1 .
    PIRi A00487. OTBY3.
    S78686.
    RefSeqi NP_009328.1. NM_001184375.1.

    3D structure databases

    ProteinModelPortali P00420.
    SMRi P00420. Positions 9-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34817. 25 interactions.
    DIPi DIP-8133N.
    IntActi P00420. 2 interactions.
    MINTi MINT-4981611.
    STRINGi 4932.Q0275.

    Protein family/group databases

    TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii Q0275 ; Q0275 ; Q0275 .
    GeneIDi 854627.
    KEGGi sce:Q0275.

    Organism-specific databases

    CYGDi Q0275.
    SGDi S000007283. COX3.

    Phylogenomic databases

    eggNOGi COG1845.
    GeneTreei ENSGT00390000013064.
    HOGENOMi HOG000264954.
    KOi K02262.
    OMAi RESIADK.
    OrthoDBi EOG7V76HP.

    Enzyme and pathway databases

    BioCyci MetaCyc:Q0275-MONOMER.
    YEAST:Q0275-MONOMER.

    Miscellaneous databases

    NextBioi 977142.
    PROi P00420.

    Gene expression databases

    Genevestigatori P00420.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA."
      Thalenfeld B.E., Tzagoloff A.
      J. Biol. Chem. 255:6173-6180(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: D273-10B/A48.
    2. "The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review."
      de Zamaroczy M., Bernardi G.
      Gene 47:155-177(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae."
      Foury F., Roganti T., Lecrenier N., Purnelle B.
      FEBS Lett. 440:325-331(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    4. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
      Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
      Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.

    Entry informationi

    Entry nameiCOX3_YEAST
    AccessioniPrimary (citable) accession number: P00420
    Secondary accession number(s): Q9ZZV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

    External Data

    Dasty 3