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P00420 (COX3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COX3
Synonyms:OXI2
Ordered Locus Names:Q0275
Encoded onMitochondrion
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subunit structure

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cytochrome c oxidase subunit 3
PRO_0000183874

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane247 – 26721Helical; Potential

Experimental info

Sequence conflict2631V → T in AAA32153. Ref.1
Sequence conflict2631V → T in AAA67530. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P00420 [UniParc].

Last modified April 23, 2003. Version 3.
Checksum: 81B24A54F63BD8B1

FASTA26930,360
        10         20         30         40         50         60 
MTHLERSRHQ QHPFHMVMPS PWPIVVSFAL LSLALSTALT MHGYIGNMNM VYLALFVLLT 

        70         80         90        100        110        120 
SSILWFRDIV AEATYLGDHT MAVRKGINLG FLMFVLSEVL IFAGLFWAYF HSAMSPDVTL 

       130        140        150        160        170        180 
GACWPPVGIE AVQPTELPLL NTIILLSSGA TVTYSHHALI AGNRNKALSG LLITFWLIVI 

       190        200        210        220        230        240 
FVTCQYIEYT NAAFTISDGV YGSVFYAGTG LHFLHMVMLA AMLGVNYWRM RNYHLTAGHH 

       250        260 
VGYETTIIYT HVLDVIWLFL YVVFYWWGV 

« Hide

References

« Hide 'large scale' references
[1]"Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA."
Thalenfeld B.E., Tzagoloff A.
J. Biol. Chem. 255:6173-6180(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: D273-10B/A48.
[2]"The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review."
de Zamaroczy M., Bernardi G.
Gene 47:155-177(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae."
Foury F., Roganti T., Lecrenier N., Purnelle B.
FEBS Lett. 440:325-331(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]"Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01478 Genomic DNA. Translation: AAA32153.2.
L36890 Genomic DNA. Translation: AAA67530.1.
AJ011856 Genomic DNA. Translation: CAA09846.1.
PIROTBY3. A00487.
S78686.
RefSeqNP_009328.1. NM_001184375.1.

3D structure databases

ProteinModelPortalP00420.
SMRP00420. Positions 9-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34817. 25 interactions.
DIPDIP-8133N.
IntActP00420. 2 interactions.
MINTMINT-4981611.
STRING4932.Q0275.

Protein family/group databases

TCDB3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiQ0275; Q0275; Q0275.
GeneID854627.
KEGGsce:Q0275.

Organism-specific databases

CYGDQ0275.
SGDS000007283. COX3.

Phylogenomic databases

eggNOGCOG1845.
GeneTreeENSGT00390000013064.
HOGENOMHOG000264954.
KOK02262.
OMARESIADK.
OrthoDBEOG7V76HP.

Enzyme and pathway databases

BioCycMetaCyc:Q0275-MONOMER.
YEAST:Q0275-MONOMER.

Gene expression databases

GenevestigatorP00420.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977142.
PROP00420.

Entry information

Entry nameCOX3_YEAST
AccessionPrimary (citable) accession number: P00420
Secondary accession number(s): Q9ZZV9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 23, 2003
Last modified: May 14, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families