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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

  • aerobic electron transport chain Source: InterPro
  • aerobic respiration Source: SGD
  • hydrogen ion transmembrane transport Source: GOC
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:Q0275-MONOMER.
YEAST:Q0275-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Synonyms:OXI2
Ordered Locus Names:Q0275
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Mitochondrion

Organism-specific databases

CYGDiQ0275.
EuPathDBiFungiDB:Q0275.
SGDiS000007283. COX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183874Add
BLAST

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34817. 27 interactions.
DIPiDIP-8133N.
IntActiP00420. 2 interactions.
MINTiMINT-4981611.

Structurei

3D structure databases

ProteinModelPortaliP00420.
SMRiP00420. Positions 9-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
InParanoidiP00420.
KOiK02262.
OMAiTEANIHG.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLERSRHQ QHPFHMVMPS PWPIVVSFAL LSLALSTALT MHGYIGNMNM
60 70 80 90 100
VYLALFVLLT SSILWFRDIV AEATYLGDHT MAVRKGINLG FLMFVLSEVL
110 120 130 140 150
IFAGLFWAYF HSAMSPDVTL GACWPPVGIE AVQPTELPLL NTIILLSSGA
160 170 180 190 200
TVTYSHHALI AGNRNKALSG LLITFWLIVI FVTCQYIEYT NAAFTISDGV
210 220 230 240 250
YGSVFYAGTG LHFLHMVMLA AMLGVNYWRM RNYHLTAGHH VGYETTIIYT
260
HVLDVIWLFL YVVFYWWGV
Length:269
Mass (Da):30,360
Last modified:April 23, 2003 - v3
Checksum:i81B24A54F63BD8B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631V → T in AAA32153 (PubMed:6248512).Curated
Sequence conflicti263 – 2631V → T in AAA67530 (PubMed:3549452).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01478 Genomic DNA. Translation: AAA32153.2.
L36890 Genomic DNA. Translation: AAA67530.1.
KP263414 Genomic DNA. Translation: AIZ98899.1.
PIRiA00487. OTBY3.
S78686.
RefSeqiNP_009328.1. NC_001224.1.

Genome annotation databases

EnsemblFungiiQ0275; Q0275; Q0275.
GeneIDi854627.
KEGGisce:Q0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01478 Genomic DNA. Translation: AAA32153.2.
L36890 Genomic DNA. Translation: AAA67530.1.
KP263414 Genomic DNA. Translation: AIZ98899.1.
PIRiA00487. OTBY3.
S78686.
RefSeqiNP_009328.1. NC_001224.1.

3D structure databases

ProteinModelPortaliP00420.
SMRiP00420. Positions 9-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34817. 27 interactions.
DIPiDIP-8133N.
IntActiP00420. 2 interactions.
MINTiMINT-4981611.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiQ0275; Q0275; Q0275.
GeneIDi854627.
KEGGisce:Q0275.

Organism-specific databases

CYGDiQ0275.
EuPathDBiFungiDB:Q0275.
SGDiS000007283. COX3.

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
InParanoidiP00420.
KOiK02262.
OMAiTEANIHG.
OrthoDBiEOG7V76HP.

Enzyme and pathway databases

BioCyciMetaCyc:Q0275-MONOMER.
YEAST:Q0275-MONOMER.

Miscellaneous databases

NextBioi977142.
PROiP00420.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA."
    Thalenfeld B.E., Tzagoloff A.
    J. Biol. Chem. 255:6173-6180(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D273-10B/A48.
  2. "The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review."
    de Zamaroczy M., Bernardi G.
    Gene 47:155-177(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae."
    Foury F., Roganti T., Lecrenier N., Purnelle B.
    FEBS Lett. 440:325-331(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 96604 / S288c / FY1679.
  5. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.

Entry informationi

Entry nameiCOX3_YEAST
AccessioniPrimary (citable) accession number: P00420
Secondary accession number(s): A0A0A7P087, Q9ZZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 23, 2003
Last modified: July 22, 2015
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.