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P00420

- COX3_YEAST

UniProt

P00420 - COX3_YEAST

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Protein

Cytochrome c oxidase subunit 3

Gene
COX3, OXI2, Q0275
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. aerobic respiration Source: SGD
  3. hydrogen ion transmembrane transport Source: GOC
  4. mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciMetaCyc:Q0275-MONOMER.
YEAST:Q0275-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Synonyms:OXI2
Ordered Locus Names:Q0275
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Mitochondrion

Organism-specific databases

CYGDiQ0275.
SGDiS000007283. COX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183874Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP00420.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34817. 25 interactions.
DIPiDIP-8133N.
IntActiP00420. 2 interactions.
MINTiMINT-4981611.
STRINGi4932.Q0275.

Structurei

3D structure databases

ProteinModelPortaliP00420.
SMRiP00420. Positions 9-268.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
KOiK02262.
OMAiRESIADK.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00420-1 [UniParc]FASTAAdd to Basket

« Hide

MTHLERSRHQ QHPFHMVMPS PWPIVVSFAL LSLALSTALT MHGYIGNMNM    50
VYLALFVLLT SSILWFRDIV AEATYLGDHT MAVRKGINLG FLMFVLSEVL 100
IFAGLFWAYF HSAMSPDVTL GACWPPVGIE AVQPTELPLL NTIILLSSGA 150
TVTYSHHALI AGNRNKALSG LLITFWLIVI FVTCQYIEYT NAAFTISDGV 200
YGSVFYAGTG LHFLHMVMLA AMLGVNYWRM RNYHLTAGHH VGYETTIIYT 250
HVLDVIWLFL YVVFYWWGV 269
Length:269
Mass (Da):30,360
Last modified:April 23, 2003 - v3
Checksum:i81B24A54F63BD8B1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631V → T in AAA32153. 1 Publication
Sequence conflicti263 – 2631V → T in AAA67530. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01478 Genomic DNA. Translation: AAA32153.2.
L36890 Genomic DNA. Translation: AAA67530.1.
AJ011856 Genomic DNA. Translation: CAA09846.1.
PIRiA00487. OTBY3.
S78686.
RefSeqiNP_009328.1. NM_001184375.1.

Genome annotation databases

EnsemblFungiiQ0275; Q0275; Q0275.
GeneIDi854627.
KEGGisce:Q0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01478 Genomic DNA. Translation: AAA32153.2 .
L36890 Genomic DNA. Translation: AAA67530.1 .
AJ011856 Genomic DNA. Translation: CAA09846.1 .
PIRi A00487. OTBY3.
S78686.
RefSeqi NP_009328.1. NM_001184375.1.

3D structure databases

ProteinModelPortali P00420.
SMRi P00420. Positions 9-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34817. 25 interactions.
DIPi DIP-8133N.
IntActi P00420. 2 interactions.
MINTi MINT-4981611.
STRINGi 4932.Q0275.

Protein family/group databases

TCDBi 3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii Q0275 ; Q0275 ; Q0275 .
GeneIDi 854627.
KEGGi sce:Q0275.

Organism-specific databases

CYGDi Q0275.
SGDi S000007283. COX3.

Phylogenomic databases

eggNOGi COG1845.
GeneTreei ENSGT00390000013064.
HOGENOMi HOG000264954.
KOi K02262.
OMAi RESIADK.
OrthoDBi EOG7V76HP.

Enzyme and pathway databases

BioCyci MetaCyc:Q0275-MONOMER.
YEAST:Q0275-MONOMER.

Miscellaneous databases

NextBioi 977142.
PROi P00420.

Gene expression databases

Genevestigatori P00420.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA."
    Thalenfeld B.E., Tzagoloff A.
    J. Biol. Chem. 255:6173-6180(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D273-10B/A48.
  2. "The primary structure of the mitochondrial genome of Saccharomyces cerevisiae -- a review."
    de Zamaroczy M., Bernardi G.
    Gene 47:155-177(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae."
    Foury F., Roganti T., Lecrenier N., Purnelle B.
    FEBS Lett. 440:325-331(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. "Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method."
    Geier B.M., Schagger H., Ortwein C., Link T.A., Hagen W.R., Brandt U., Von Jagow G.
    Eur. J. Biochem. 227:296-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE CYTOCHROME C OXIDASE COMPLEX.

Entry informationi

Entry nameiCOX3_YEAST
AccessioniPrimary (citable) accession number: P00420
Secondary accession number(s): Q9ZZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 23, 2003
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

External Data

Dasty 3

Similar proteinsi