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P00419

- COX3_XENLA

UniProt

P00419 - COX3_XENLA

Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt-co3
    Synonyms:coiii, coxiii, mtco3
    Encoded oniMitochondrion
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6251961. cox3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Cytochrome c oxidase subunit 3PRO_0000183872Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP00419.
    SMRiP00419. Positions 1-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016686.
    KOiK02262.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQAHAYHM VDPSPWPLTG AVAALLLTSG LAMWFHFGSM ILLTLGLITM    50
    VLTMIQWWRD VIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFIGFFWA 100
    FYNSSLAPTY ELGECWPPTG ITPLNPFEVP LLNTAVLLAS GVTVTWAHHS 150
    IMHGDRKEAI QSLTLTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA 200
    TGFHGLHVII GSLFLSVCLL RQIQYHFTSK HHFGFEAAWY WHFVDVVWLF 250
    LYVSIYWWGS 260
    Length:260
    Mass (Da):29,593
    Last modified:July 21, 1986 - v1
    Checksum:iFA736567CEAB3826
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10217 Genomic DNA. Translation: AAA66464.1.
    PIRiA00486. OTXL3.
    RefSeqiNP_008140.1. NC_001573.1.

    Genome annotation databases

    GeneIDi2642084.
    KEGGixla:2642084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10217 Genomic DNA. Translation: AAA66464.1 .
    PIRi A00486. OTXL3.
    RefSeqi NP_008140.1. NC_001573.1.

    3D structure databases

    ProteinModelPortali P00419.
    SMRi P00419. Positions 1-260.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2642084.
    KEGGi xla:2642084.

    Organism-specific databases

    CTDi 4514.
    Xenbasei XB-GENE-6251961. cox3.

    Phylogenomic databases

    HOVERGENi HBG016686.
    KOi K02262.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of the Xenopus laevis mitochondrial genome."
      Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.
      J. Biol. Chem. 260:9759-9774(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_XENLA
    AccessioniPrimary (citable) accession number: P00419
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3