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P00419 (COX3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded onMitochondrion
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 3
PRO_0000183872

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane31 – 5121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane238 – 25821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P00419 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: FA736567CEAB3826

FASTA26029,593
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPLTG AVAALLLTSG LAMWFHFGSM ILLTLGLITM VLTMIQWWRD 

        70         80         90        100        110        120 
VIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFIGFFWA FYNSSLAPTY ELGECWPPTG 

       130        140        150        160        170        180 
ITPLNPFEVP LLNTAVLLAS GVTVTWAHHS IMHGDRKEAI QSLTLTILLG LYFTALQAME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSLFLSVCLL RQIQYHFTSK HHFGFEAAWY 

       250        260 
WHFVDVVWLF LYVSIYWWGS 

« Hide

References

[1]"The complete nucleotide sequence of the Xenopus laevis mitochondrial genome."
Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.
J. Biol. Chem. 260:9759-9774(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10217 Genomic DNA. Translation: AAA66464.1.
PIROTXL3. A00486.
RefSeqNP_008140.1. NC_001573.1.

3D structure databases

ProteinModelPortalP00419.
SMRP00419. Positions 1-260.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2642084.
KEGGxla:2642084.

Organism-specific databases

CTD4514.
XenbaseXB-GENE-6251961. cox3.

Phylogenomic databases

HOVERGENHBG016686.
KOK02262.
ProtClustDBMTH00075.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_XENLA
AccessionPrimary (citable) accession number: P00419
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families