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P00419

- COX3_XENLA

UniProt

P00419 - COX3_XENLA

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Protein
Cytochrome c oxidase subunit 3
Gene
mt-co3, coiii, coxiii, mtco3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded oniMitochondrion
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251961. cox3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 3
PRO_0000183872Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00419.
SMRiP00419. Positions 1-260.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016686.
KOiK02262.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00419-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHAYHM VDPSPWPLTG AVAALLLTSG LAMWFHFGSM ILLTLGLITM    50
VLTMIQWWRD VIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFIGFFWA 100
FYNSSLAPTY ELGECWPPTG ITPLNPFEVP LLNTAVLLAS GVTVTWAHHS 150
IMHGDRKEAI QSLTLTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA 200
TGFHGLHVII GSLFLSVCLL RQIQYHFTSK HHFGFEAAWY WHFVDVVWLF 250
LYVSIYWWGS 260
Length:260
Mass (Da):29,593
Last modified:July 21, 1986 - v1
Checksum:iFA736567CEAB3826
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10217 Genomic DNA. Translation: AAA66464.1.
PIRiA00486. OTXL3.
RefSeqiNP_008140.1. NC_001573.1.

Genome annotation databases

GeneIDi2642084.
KEGGixla:2642084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10217 Genomic DNA. Translation: AAA66464.1 .
PIRi A00486. OTXL3.
RefSeqi NP_008140.1. NC_001573.1.

3D structure databases

ProteinModelPortali P00419.
SMRi P00419. Positions 1-260.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2642084.
KEGGi xla:2642084.

Organism-specific databases

CTDi 4514.
Xenbasei XB-GENE-6251961. cox3.

Phylogenomic databases

HOVERGENi HBG016686.
KOi K02262.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the Xenopus laevis mitochondrial genome."
    Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.
    J. Biol. Chem. 260:9759-9774(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_XENLA
AccessioniPrimary (citable) accession number: P00419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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