P00418 (COX3_DROYA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	mt:CoIII
Synonyms:	CoIII

Encoded on

Mitochondrion

Organism

Drosophila yakuba (Fruit fly) [Complete proteome]

Taxonomic identifier

7245 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 3		PRO_0000183769
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	201 – 221	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P00418 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: ED0C07F573666730	FASTA	262	30,039
	10 20 30 40 50 60 MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFLLGNII TILTVYQWWR 70 80 90 100 110 120 DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW AFFHSSLSPA IELGASWPPM 130 140 150 160 170 180 GIISFNPFQI PLLNTAILLA SGVTVTWAHH SLMESNHSQT TQGLFFTVLL GIYFTILQAY 190 200 210 220 230 240 EYIEAPFTIA DSVYGSTFYM ATGFHGVHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA 250 260 WYWHFVDVVW LFLYITIYWW GG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a segment of Drosophila mitochondrial DNA that contains the genes for cytochrome c oxidase subunits II and III and ATPase subunit 6." Clary D.O., Wolstenholme D.R. Nucleic Acids Res. 11:4211-4227(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code." Clary D.O., Wolstenholme D.R. J. Mol. Evol. 22:252-271(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2317.6 Ivory Coast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00924 Genomic DNA. Translation: CAA25443.1. X03240 Genomic DNA. Translation: CAA26990.1.
PIR	OTFF3Y. B93477.
RefSeq	NP_006907.1. NC_001322.1.
3D structure databases
ProteinModelPortal	P00418.
SMR	P00418. Positions 3-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807631.
KEGG	dya:COX3.
Organism-specific databases
CTD	4514.
FlyBase	FBgn0013181. Dyak\mt:CoIII.
Phylogenomic databases
KO	K02262.
ProtClustDB	MTH00155.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_DROYA

Accession

Primary (citable) accession number: P00418

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project