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P00418

- COX3_DROYA

UniProt

P00418 - COX3_DROYA

Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt:CoIII
    Synonyms:CoIII
    Encoded oniMitochondrion
    OrganismiDrosophila yakuba (Fruit fly)
    Taxonomic identifieri7245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002856: Mitochondrion

    Organism-specific databases

    FlyBaseiFBgn0013181. Dyak\mt:CoIII.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Cytochrome c oxidase subunit 3PRO_0000183769Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP00418.
    SMRiP00418. Positions 3-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02262.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00418-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFLLGNII    50
    TILTVYQWWR DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW 100
    AFFHSSLSPA IELGASWPPM GIISFNPFQI PLLNTAILLA SGVTVTWAHH 150
    SLMESNHSQT TQGLFFTVLL GIYFTILQAY EYIEAPFTIA DSVYGSTFYM 200
    ATGFHGVHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA WYWHFVDVVW 250
    LFLYITIYWW GG 262
    Length:262
    Mass (Da):30,039
    Last modified:July 21, 1986 - v1
    Checksum:iED0C07F573666730
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00924 Genomic DNA. Translation: CAA25443.1.
    X03240 Genomic DNA. Translation: CAA26990.1.
    PIRiB93477. OTFF3Y.
    RefSeqiNP_006907.1. NC_001322.1.

    Genome annotation databases

    GeneIDi807631.
    KEGGidya:COX3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00924 Genomic DNA. Translation: CAA25443.1 .
    X03240 Genomic DNA. Translation: CAA26990.1 .
    PIRi B93477. OTFF3Y.
    RefSeqi NP_006907.1. NC_001322.1.

    3D structure databases

    ProteinModelPortali P00418.
    SMRi P00418. Positions 3-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807631.
    KEGGi dya:COX3.

    Organism-specific databases

    CTDi 4514.
    FlyBasei FBgn0013181. Dyak\mt:CoIII.

    Phylogenomic databases

    KOi K02262.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a segment of Drosophila mitochondrial DNA that contains the genes for cytochrome c oxidase subunits II and III and ATPase subunit 6."
      Clary D.O., Wolstenholme D.R.
      Nucleic Acids Res. 11:4211-4227(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code."
      Clary D.O., Wolstenholme D.R.
      J. Mol. Evol. 22:252-271(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2317.6 Ivory Coast.

    Entry informationi

    Entry nameiCOX3_DROYA
    AccessioniPrimary (citable) accession number: P00418
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3