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P00418

- COX3_DROYA

UniProt

P00418 - COX3_DROYA

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Protein
Cytochrome c oxidase subunit 3
Gene
mt:CoIII, CoIII
Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIII
Synonyms:CoIII
Encoded oniMitochondrion
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002856: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013181. Dyak\mt:CoIII.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Transmembranei240 – 26021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Cytochrome c oxidase subunit 3
PRO_0000183769Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00418.
SMRiP00418. Positions 3-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02262.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00418-1 [UniParc]FASTAAdd to Basket

« Hide

MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFLLGNII    50
TILTVYQWWR DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW 100
AFFHSSLSPA IELGASWPPM GIISFNPFQI PLLNTAILLA SGVTVTWAHH 150
SLMESNHSQT TQGLFFTVLL GIYFTILQAY EYIEAPFTIA DSVYGSTFYM 200
ATGFHGVHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA WYWHFVDVVW 250
LFLYITIYWW GG 262
Length:262
Mass (Da):30,039
Last modified:July 21, 1986 - v1
Checksum:iED0C07F573666730
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00924 Genomic DNA. Translation: CAA25443.1.
X03240 Genomic DNA. Translation: CAA26990.1.
PIRiB93477. OTFF3Y.
RefSeqiNP_006907.1. NC_001322.1.

Genome annotation databases

GeneIDi807631.
KEGGidya:COX3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00924 Genomic DNA. Translation: CAA25443.1 .
X03240 Genomic DNA. Translation: CAA26990.1 .
PIRi B93477. OTFF3Y.
RefSeqi NP_006907.1. NC_001322.1.

3D structure databases

ProteinModelPortali P00418.
SMRi P00418. Positions 3-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807631.
KEGGi dya:COX3.

Organism-specific databases

CTDi 4514.
FlyBasei FBgn0013181. Dyak\mt:CoIII.

Phylogenomic databases

KOi K02262.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a segment of Drosophila mitochondrial DNA that contains the genes for cytochrome c oxidase subunits II and III and ATPase subunit 6."
    Clary D.O., Wolstenholme D.R.
    Nucleic Acids Res. 11:4211-4227(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code."
    Clary D.O., Wolstenholme D.R.
    J. Mol. Evol. 22:252-271(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2317.6 Ivory Coast.

Entry informationi

Entry nameiCOX3_DROYA
AccessioniPrimary (citable) accession number: P00418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi