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P00417

- COX3_DROME

UniProt

P00417 - COX3_DROME

Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt:CoIII
    Synonyms:CoIII
    Encoded oniMitochondrion
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Mitochondrion

    Organism-specific databases

    FlyBaseiFBgn0013676. mt:CoIII.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Cytochrome c oxidase subunit 3PRO_0000183767Add
    BLAST

    Proteomic databases

    PRIDEiP00417.

    Expressioni

    Gene expression databases

    BgeeiP00417.

    Structurei

    3D structure databases

    ProteinModelPortaliP00417.
    SMRiP00417. Positions 4-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    GeneTreeiENSGT00390000013064.
    InParanoidiP00417.
    KOiK02262.
    OMAiMEGDRKH.
    OrthoDBiEOG72VH70.
    PhylomeDBiP00417.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00417-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFVLGNII    50
    TILTVYQWWR DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW 100
    AFFHSSLSPA IELGASWPPM GIISFNPFQI PLLNTAILLA SGVTVTWAHH 150
    SLMENNHSQT TQGLFFTVLL GIYFTILQAY EYIEAPFTIA DSIYGSTFFM 200
    ATGFHGIHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA WYWHFVDVVW 250
    LFLYITIYWW GG 262
    Length:262
    Mass (Da):30,064
    Last modified:July 21, 1986 - v1
    Checksum:i68D5AEFC2297C130
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701L → M in strain: Zimbabwe 53. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200828 Genomic DNA. Translation: AAF77231.1.
    AF200829 Genomic DNA. Translation: AAF77243.1.
    AJ400907 Genomic DNA. Translation: CAB91056.1.
    EU493887 Genomic DNA. Translation: ACA62455.1.
    U37541 Genomic DNA. Translation: AAC47816.1.
    J01404 Genomic DNA. Translation: AAB59243.1.
    M37275 Genomic DNA. Translation: AAA69708.1.
    PIRiA00485. OTFF3.
    RefSeqiNP_008282.1. NC_001709.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0100868; FBpp0100180; FBgn0013676.
    GeneIDi192471.
    KEGGidme:COX3.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200828 Genomic DNA. Translation: AAF77231.1 .
    AF200829 Genomic DNA. Translation: AAF77243.1 .
    AJ400907 Genomic DNA. Translation: CAB91056.1 .
    EU493887 Genomic DNA. Translation: ACA62455.1 .
    U37541 Genomic DNA. Translation: AAC47816.1 .
    J01404 Genomic DNA. Translation: AAB59243.1 .
    M37275 Genomic DNA. Translation: AAA69708.1 .
    PIRi A00485. OTFF3.
    RefSeqi NP_008282.1. NC_001709.1.

    3D structure databases

    ProteinModelPortali P00417.
    SMRi P00417. Positions 4-261.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P00417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0100868 ; FBpp0100180 ; FBgn0013676 .
    GeneIDi 192471.
    KEGGi dme:COX3.

    Organism-specific databases

    CTDi 4514.
    FlyBasei FBgn0013676. mt:CoIII.

    Phylogenomic databases

    eggNOGi COG1845.
    GeneTreei ENSGT00390000013064.
    InParanoidi P00417.
    KOi K02262.
    OMAi MEGDRKH.
    OrthoDBi EOG72VH70.
    PhylomeDBi P00417.

    Miscellaneous databases

    GenomeRNAii 192471.
    NextBioi 842186.
    PROi P00417.

    Gene expression databases

    Bgeei P00417.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
      Ballard J.W.O.
      J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-170.
      Strain: Oregon-R and Zimbabwe 53.
    2. "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
      Azou Y., Bregliano J.C.
      Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Paris.
    3. "Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
      O'Grady P.M., DeSalle R.
      Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
      Lewis D.L., Farr C.L., Kaguni L.S.
      Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
      de Bruijn M.H.L.
      Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179.
      Strain: Oregon-R.
    6. "Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes."
      Clary D.O., Wahleithner J.A., Wolstenholme D.R.
      Nucleic Acids Res. 11:2411-2425(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
    7. "Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations."
      Garesse R.
      Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
      Strain: Bretagne.

    Entry informationi

    Entry nameiCOX3_DROME
    AccessioniPrimary (citable) accession number: P00417
    Secondary accession number(s): B1PTQ2, Q7HMA0, Q9MGN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3