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Protein

Cytochrome c oxidase subunit 3

Gene

mt:CoIII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiREACT_342103. Respiratory electron transport.
REACT_358894. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIII
Synonyms:CoIII
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013676. mt:CoIII.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Cytochrome c oxidase subunit 3PRO_0000183767Add
BLAST

Proteomic databases

PRIDEiP00417.

Expressioni

Gene expression databases

BgeeiP00417.

Structurei

3D structure databases

ProteinModelPortaliP00417.
SMRiP00417. Positions 4-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
InParanoidiP00417.
KOiK02262.
OMAiGFFWAFY.
OrthoDBiEOG72VH70.
PhylomeDBiP00417.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFVLGNII
60 70 80 90 100
TILTVYQWWR DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW
110 120 130 140 150
AFFHSSLSPA IELGASWPPM GIISFNPFQI PLLNTAILLA SGVTVTWAHH
160 170 180 190 200
SLMENNHSQT TQGLFFTVLL GIYFTILQAY EYIEAPFTIA DSIYGSTFFM
210 220 230 240 250
ATGFHGIHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA WYWHFVDVVW
260
LFLYITIYWW GG
Length:262
Mass (Da):30,064
Last modified:July 21, 1986 - v1
Checksum:i68D5AEFC2297C130
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701L → M in strain: Zimbabwe 53. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200828 Genomic DNA. Translation: AAF77231.1.
AF200829 Genomic DNA. Translation: AAF77243.1.
AJ400907 Genomic DNA. Translation: CAB91056.1.
EU493887 Genomic DNA. Translation: ACA62455.1.
U37541 Genomic DNA. Translation: AAC47816.1.
J01404 Genomic DNA. Translation: AAB59243.1.
M37275 Genomic DNA. Translation: AAA69708.1.
PIRiA00485. OTFF3.
RefSeqiYP_009047271.1. NC_024511.2.

Genome annotation databases

EnsemblMetazoaiFBtr0100868; FBpp0100180; FBgn0013676.
GeneIDi19893540.
KEGGidme:COX3.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200828 Genomic DNA. Translation: AAF77231.1.
AF200829 Genomic DNA. Translation: AAF77243.1.
AJ400907 Genomic DNA. Translation: CAB91056.1.
EU493887 Genomic DNA. Translation: ACA62455.1.
U37541 Genomic DNA. Translation: AAC47816.1.
J01404 Genomic DNA. Translation: AAB59243.1.
M37275 Genomic DNA. Translation: AAA69708.1.
PIRiA00485. OTFF3.
RefSeqiYP_009047271.1. NC_024511.2.

3D structure databases

ProteinModelPortaliP00417.
SMRiP00417. Positions 4-261.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP00417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0100868; FBpp0100180; FBgn0013676.
GeneIDi19893540.
KEGGidme:COX3.

Organism-specific databases

CTDi4514.
FlyBaseiFBgn0013676. mt:CoIII.

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
InParanoidiP00417.
KOiK02262.
OMAiGFFWAFY.
OrthoDBiEOG72VH70.
PhylomeDBiP00417.

Enzyme and pathway databases

ReactomeiREACT_342103. Respiratory electron transport.
REACT_358894. TP53 Regulates Metabolic Genes.

Miscellaneous databases

GenomeRNAii192471.
NextBioi842186.
PROiP00417.

Gene expression databases

BgeeiP00417.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
    Ballard J.W.O.
    J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-170.
    Strain: Oregon-R and Zimbabwe 53.
  2. "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
    Azou Y., Bregliano J.C.
    Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Paris.
  3. "Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
    O'Grady P.M., DeSalle R.
    Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
    Lewis D.L., Farr C.L., Kaguni L.S.
    Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
    de Bruijn M.H.L.
    Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179.
    Strain: Oregon-R.
  6. "Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes."
    Clary D.O., Wahleithner J.A., Wolstenholme D.R.
    Nucleic Acids Res. 11:2411-2425(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
  7. "Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations."
    Garesse R.
    Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
    Strain: Bretagne.

Entry informationi

Entry nameiCOX3_DROME
AccessioniPrimary (citable) accession number: P00417
Secondary accession number(s): B1PTQ2, Q7HMA0, Q9MGN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 27, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.