P00417 (COX3_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	mt:CoIII
Synonyms:	CoIII

Encoded on

Mitochondrion

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 3		PRO_0000183767
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential
Natural variations
	Natural variant	170	1	L → M in strain: Zimbabwe 53. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P00417 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 68D5AEFC2297C130	FASTA	262	30,064
	10 20 30 40 50 60 MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFVLGNII TILTVYQWWR 70 80 90 100 110 120 DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW AFFHSSLSPA IELGASWPPM 130 140 150 160 170 180 GIISFNPFQI PLLNTAILLA SGVTVTWAHH SLMENNHSQT TQGLFFTVLL GIYFTILQAY 190 200 210 220 230 240 EYIEAPFTIA DSIYGSTFFM ATGFHGIHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA 250 260 WYWHFVDVVW LFLYITIYWW GG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup." Ballard J.W.O. J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-170. Strain: Oregon-R and Zimbabwe 53.
[2]	"I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition." Azou Y., Bregliano J.C. Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Paris.
[3]	"Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)." O'Grady P.M., DeSalle R. Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons." Lewis D.L., Farr C.L., Kaguni L.S. Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code." de Bruijn M.H.L. Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179. Strain: Oregon-R.
[6]	"Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes." Clary D.O., Wahleithner J.A., Wolstenholme D.R. Nucleic Acids Res. 11:2411-2425(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
[7]	"Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations." Garesse R. Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262. Strain: Bretagne.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF200828 Genomic DNA. Translation: AAF77231.1. AF200829 Genomic DNA. Translation: AAF77243.1. AJ400907 Genomic DNA. Translation: CAB91056.1. EU493887 Genomic DNA. Translation: ACA62455.1. U37541 Genomic DNA. Translation: AAC47816.1. J01404 Genomic DNA. Translation: AAB59243.1. M37275 Genomic DNA. Translation: AAA69708.1.
PIR	OTFF3. A00485.
RefSeq	NP_008282.1. NC_001709.1.
3D structure databases
ProteinModelPortal	P00417.
SMR	P00417. Positions 4-261.
ModBase	Search...
Proteomic databases
PRIDE	P00417.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0100868; FBpp0100180; FBgn0013676.
GeneID	192471.
KEGG	dme:COX3.
Organism-specific databases
CTD	4514.
FlyBase	FBgn0013676. mt:CoIII.
Phylogenomic databases
eggNOG	COG1845.
GeneTree	ENSGT00390000013064.
InParanoid	P00417.
KO	K02262.
OMA	YFVPGPS.
OrthoDB	EOG463XVF.
ProtClustDB	MTH00155.
Gene expression databases
Bgee	P00417.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	192471.
NextBio	842186.

Entry information

Entry name

COX3_DROME

Accession

Primary (citable) accession number: P00417
Secondary accession number(s): B1PTQ2, Q7HMA0, Q9MGN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project