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P00417 (COX3_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt:CoIII
Synonyms:CoIII
Encoded onMitochondrion
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 3
PRO_0000183767

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane240 – 26021Helical; Potential

Natural variations

Natural variant1701L → M in strain: Zimbabwe 53. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00417 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 68D5AEFC2297C130

FASTA26230,064
        10         20         30         40         50         60 
MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFVLGNII TILTVYQWWR 

        70         80         90        100        110        120 
DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW AFFHSSLSPA IELGASWPPM 

       130        140        150        160        170        180 
GIISFNPFQI PLLNTAILLA SGVTVTWAHH SLMENNHSQT TQGLFFTVLL GIYFTILQAY 

       190        200        210        220        230        240 
EYIEAPFTIA DSIYGSTFFM ATGFHGIHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA 

       250        260 
WYWHFVDVVW LFLYITIYWW GG 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
Ballard J.W.O.
J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-170.
Strain: Oregon-R and Zimbabwe 53.
[2]"I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
Azou Y., Bregliano J.C.
Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Paris.
[3]"Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
O'Grady P.M., DeSalle R.
Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
Lewis D.L., Farr C.L., Kaguni L.S.
Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
de Bruijn M.H.L.
Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179.
Strain: Oregon-R.
[6]"Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes."
Clary D.O., Wahleithner J.A., Wolstenholme D.R.
Nucleic Acids Res. 11:2411-2425(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
[7]"Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations."
Garesse R.
Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
Strain: Bretagne.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF200828 Genomic DNA. Translation: AAF77231.1.
AF200829 Genomic DNA. Translation: AAF77243.1.
AJ400907 Genomic DNA. Translation: CAB91056.1.
EU493887 Genomic DNA. Translation: ACA62455.1.
U37541 Genomic DNA. Translation: AAC47816.1.
J01404 Genomic DNA. Translation: AAB59243.1.
M37275 Genomic DNA. Translation: AAA69708.1.
PIROTFF3. A00485.
RefSeqNP_008282.1. NC_001709.1.

3D structure databases

ProteinModelPortalP00417.
SMRP00417. Positions 4-261.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP00417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0100868; FBpp0100180; FBgn0013676.
GeneID192471.
KEGGdme:COX3.

Organism-specific databases

CTD4514.
FlyBaseFBgn0013676. mt:CoIII.

Phylogenomic databases

eggNOGCOG1845.
GeneTreeENSGT00390000013064.
InParanoidP00417.
KOK02262.
OMAFFWAFYH.
OrthoDBEOG72VH70.
PhylomeDBP00417.
ProtClustDBMTH00155.

Gene expression databases

BgeeP00417.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi192471.
NextBio842186.
PROP00417.

Entry information

Entry nameCOX3_DROME
AccessionPrimary (citable) accession number: P00417
Secondary accession number(s): B1PTQ2, Q7HMA0, Q9MGN4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase