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P00417

- COX3_DROME

UniProt

P00417 - COX3_DROME

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Protein

Cytochrome c oxidase subunit 3

Gene
mt:CoIII, CoIII
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt:CoIII
Synonyms:CoIII
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013676. mt:CoIII.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei83 – 10321Helical; Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Reviewed predictionAdd
BLAST
Transmembranei240 – 26021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Cytochrome c oxidase subunit 3PRO_0000183767Add
BLAST

Proteomic databases

PRIDEiP00417.

Expressioni

Gene expression databases

BgeeiP00417.

Structurei

3D structure databases

ProteinModelPortaliP00417.
SMRiP00417. Positions 4-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
InParanoidiP00417.
KOiK02262.
OMAiMEGDRKH.
OrthoDBiEOG72VH70.
PhylomeDBiP00417.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00417-1 [UniParc]FASTAAdd to Basket

« Hide

MSTHSNHPFH LVDYSPWPLT GAIGAMTTVS GMVKWFHQYD ISLFVLGNII    50
TILTVYQWWR DVSREGTYQG LHTYAVTIGL RWGMILFILS EVLFFVSFFW 100
AFFHSSLSPA IELGASWPPM GIISFNPFQI PLLNTAILLA SGVTVTWAHH 150
SLMENNHSQT TQGLFFTVLL GIYFTILQAY EYIEAPFTIA DSIYGSTFFM 200
ATGFHGIHVL IGTTFLLVCL LRHLNNHFSK NHHFGFEAAA WYWHFVDVVW 250
LFLYITIYWW GG 262
Length:262
Mass (Da):30,064
Last modified:July 21, 1986 - v1
Checksum:i68D5AEFC2297C130
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701L → M in strain: Zimbabwe 53. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200828 Genomic DNA. Translation: AAF77231.1.
AF200829 Genomic DNA. Translation: AAF77243.1.
AJ400907 Genomic DNA. Translation: CAB91056.1.
EU493887 Genomic DNA. Translation: ACA62455.1.
U37541 Genomic DNA. Translation: AAC47816.1.
J01404 Genomic DNA. Translation: AAB59243.1.
M37275 Genomic DNA. Translation: AAA69708.1.
PIRiA00485. OTFF3.
RefSeqiNP_008282.1. NC_001709.1.

Genome annotation databases

EnsemblMetazoaiFBtr0100868; FBpp0100180; FBgn0013676.
GeneIDi192471.
KEGGidme:COX3.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200828 Genomic DNA. Translation: AAF77231.1 .
AF200829 Genomic DNA. Translation: AAF77243.1 .
AJ400907 Genomic DNA. Translation: CAB91056.1 .
EU493887 Genomic DNA. Translation: ACA62455.1 .
U37541 Genomic DNA. Translation: AAC47816.1 .
J01404 Genomic DNA. Translation: AAB59243.1 .
M37275 Genomic DNA. Translation: AAA69708.1 .
PIRi A00485. OTFF3.
RefSeqi NP_008282.1. NC_001709.1.

3D structure databases

ProteinModelPortali P00417.
SMRi P00417. Positions 4-261.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P00417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0100868 ; FBpp0100180 ; FBgn0013676 .
GeneIDi 192471.
KEGGi dme:COX3.

Organism-specific databases

CTDi 4514.
FlyBasei FBgn0013676. mt:CoIII.

Phylogenomic databases

eggNOGi COG1845.
GeneTreei ENSGT00390000013064.
InParanoidi P00417.
KOi K02262.
OMAi MEGDRKH.
OrthoDBi EOG72VH70.
PhylomeDBi P00417.

Miscellaneous databases

GenomeRNAii 192471.
NextBioi 842186.
PROi P00417.

Gene expression databases

Bgeei P00417.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
    Ballard J.W.O.
    J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-170.
    Strain: Oregon-R and Zimbabwe 53.
  2. "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
    Azou Y., Bregliano J.C.
    Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Paris.
  3. "Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
    O'Grady P.M., DeSalle R.
    Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
    Lewis D.L., Farr C.L., Kaguni L.S.
    Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
    de Bruijn M.H.L.
    Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179.
    Strain: Oregon-R.
  6. "Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking sequences and comparisons to mammalian mitochondrial tRNA genes."
    Clary D.O., Wahleithner J.A., Wolstenholme D.R.
    Nucleic Acids Res. 11:2411-2425(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
  7. "Drosophila melanogaster mitochondrial DNA: gene organization and evolutionary considerations."
    Garesse R.
    Genetics 118:649-663(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-262.
    Strain: Bretagne.

Entry informationi

Entry nameiCOX3_DROME
AccessioniPrimary (citable) accession number: P00417
Secondary accession number(s): B1PTQ2, Q7HMA0, Q9MGN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi