Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00416

- COX3_MOUSE

UniProt

P00416 - COX3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 3

Gene

mt-Co3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102502. mt-Co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183809Add
BLAST

Proteomic databases

PaxDbiP00416.
PRIDEiP00416.

Expressioni

Gene expression databases

GenevestigatoriP00416.

Structurei

3D structure databases

ProteinModelPortaliP00416.
SMRiP00416. Positions 3-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP00416.
KOiK02262.
OMAiYFVPGPS.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00416-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN
60 70 80 90 100
ILTMYQWWRD VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ISPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGKRNHMN QALLITIMLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,923
Last modified:September 18, 2013 - v2
Checksum:iDAF2EA44599B704E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481V → I in AAB48650. (PubMed:7332926)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1.
PIRiA00484. OTMS3.
RefSeqiNP_904334.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneIDi17710.
KEGGimmu:17710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1 .
V00711 Genomic DNA. Translation: CAA24090.1 .
PIRi A00484. OTMS3.
RefSeqi NP_904334.1. NC_005089.1.

3D structure databases

ProteinModelPortali P00416.
SMRi P00416. Positions 3-261.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P00416.
PRIDEi P00416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082409 ; ENSMUSP00000080997 ; ENSMUSG00000064358 .
GeneIDi 17710.
KEGGi mmu:17710.

Organism-specific databases

CTDi 4514.
MGIi MGI:102502. mt-Co3.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
HOVERGENi HBG016686.
InParanoidi P00416.
KOi K02262.
OMAi YFVPGPS.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Miscellaneous databases

NextBioi 35563455.
PROi P00416.
SOURCEi Search...

Gene expression databases

Genevestigatori P00416.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_MOUSE
AccessioniPrimary (citable) accession number: P00416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3