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Protein

Cytochrome c oxidase subunit 3

Gene

mt-Co3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102502. mt-Co3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838091 – 261Cytochrome c oxidase subunit 3Add BLAST261

Proteomic databases

PaxDbiP00416.
PRIDEiP00416.

PTM databases

PhosphoSitePlusiP00416.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064358.
ExpressionAtlasiP00416. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi201543. 1 interactor.
CORUMiP00416.
STRINGi10090.ENSMUSP00000080997.

Structurei

3D structure databases

ProteinModelPortaliP00416.
SMRiP00416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP00416.
KOiK02262.
OMAiPWPLTGA.
OrthoDBiEOG091G0GH8.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR035973. Cyt_c_oxidase_su3-like_sf.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

P00416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN
60 70 80 90 100
ILTMYQWWRD VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ISPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGKRNHMN QALLITIMLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,923
Last modified:September 18, 2013 - v2
Checksum:iDAF2EA44599B704E
GO

Sequence cautioni

P00416: The sequence CAA24090 differs from that shown. Reason: Erroneous termination at position 262. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248V → I in AAB48650 (PubMed:7332926).Curated1
Sequence conflicti248V → I in CAA24090 (PubMed:7332926).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1. Sequence problems.
AY172335 Genomic DNA. Translation: AAN85128.1.
PIRiA00484. OTMS3.
RefSeqiNP_904334.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneIDi17710.
KEGGimmu:17710.

Similar proteinsi

Entry informationi

Entry nameiCOX3_MOUSE
AccessioniPrimary (citable) accession number: P00416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: October 25, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families