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P00416 (COX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 261260Cytochrome c oxidase subunit 3
PRO_0000183809

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane162 – 18221Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Experimental info

Sequence conflict2481V → I in AAB48650. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00416 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: DAF2EA44599B704E

FASTA26129,923
        10         20         30         40         50         60 
MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN ILTMYQWWRD 

        70         80         90        100        110        120 
VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA FYHSSLVPTH DLGGCWPPTG 

       130        140        150        160        170        180 
ISPLNPLEVP LLNTSVLLAS GVSITWAHHS LMEGKRNHMN QALLITIMLG LYFTILQASE 

       190        200        210        220        230        240 
YFETSFSISD GIYGSTFFMA TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1.
PIROTMS3. A00484.
RefSeqNP_904334.1. NC_005089.1.

3D structure databases

ProteinModelPortalP00416.
SMRP00416. Positions 3-261.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP00416.
PRIDEP00416.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneID17710.
KEGGmmu:17710.

Organism-specific databases

CTD4514.
MGIMGI:102502. mt-Co3.

Phylogenomic databases

eggNOGCOG1845.
HOGENOMHOG000264954.
HOVERGENHBG016686.
InParanoidP00416.
KOK02262.
OMAYFVPGPS.

Gene expression databases

GenevestigatorP00416.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35563455.
PROP00416.
SOURCESearch...

Entry information

Entry nameCOX3_MOUSE
AccessionPrimary (citable) accession number: P00416
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot