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P00416

- COX3_MOUSE

UniProt

P00416 - COX3_MOUSE

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Protein

Cytochrome c oxidase subunit 3

Gene
mt-Co3, COIII, Mtco3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced, UP000000589: Mitochondrion

Organism-specific databases

MGIiMGI:102502. mt-Co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei162 – 18221Helical; Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183809Add
BLAST

Proteomic databases

PaxDbiP00416.
PRIDEiP00416.

Expressioni

Gene expression databases

GenevestigatoriP00416.

Structurei

3D structure databases

ProteinModelPortaliP00416.
SMRiP00416. Positions 3-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP00416.
KOiK02262.
OMAiYFVPGPS.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00416-1 [UniParc]FASTAAdd to Basket

« Hide

MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN    50
ILTMYQWWRD VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA 100
FYHSSLVPTH DLGGCWPPTG ISPLNPLEVP LLNTSVLLAS GVSITWAHHS 150
LMEGKRNHMN QALLITIMLG LYFTILQASE YFETSFSISD GIYGSTFFMA 200
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,923
Last modified:September 18, 2013 - v2
Checksum:iDAF2EA44599B704E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481V → I in AAB48650. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1.
PIRiA00484. OTMS3.
RefSeqiNP_904334.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneIDi17710.
KEGGimmu:17710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1 .
V00711 Genomic DNA. Translation: CAA24090.1 .
PIRi A00484. OTMS3.
RefSeqi NP_904334.1. NC_005089.1.

3D structure databases

ProteinModelPortali P00416.
SMRi P00416. Positions 3-261.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P00416.
PRIDEi P00416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082409 ; ENSMUSP00000080997 ; ENSMUSG00000064358 .
GeneIDi 17710.
KEGGi mmu:17710.

Organism-specific databases

CTDi 4514.
MGIi MGI:102502. mt-Co3.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
HOVERGENi HBG016686.
InParanoidi P00416.
KOi K02262.
OMAi YFVPGPS.

Miscellaneous databases

NextBioi 35563455.
PROi P00416.
SOURCEi Search...

Gene expression databases

Genevestigatori P00416.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_MOUSE
AccessioniPrimary (citable) accession number: P00416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi