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Protein

Cytochrome c oxidase subunit 3

Gene

mt-Co3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_278797. Respiratory electron transport.
REACT_297274. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-Co3
Synonyms:COIII, Mtco3
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Mitochondrion

Organism-specific databases

MGIiMGI:102502. mt-Co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183809Add
BLAST

Proteomic databases

PaxDbiP00416.
PRIDEiP00416.

Expressioni

Gene expression databases

ExpressionAtlasiP00416. baseline.
GenevestigatoriP00416.

Structurei

3D structure databases

ProteinModelPortaliP00416.
SMRiP00416. Positions 3-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP00416.
KOiK02262.
OMAiGFFWAFY.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG AFSALLLTSG LVMWFHYNSI TLLTLGLLTN
60 70 80 90 100
ILTMYQWWRD VIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ISPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGKRNHMN QALLITIMLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,923
Last modified:September 18, 2013 - v2
Checksum:iDAF2EA44599B704E
GO

Sequence cautioni

The sequence CAA24090.1 differs from that shown. Reason: Erroneous termination at position 262. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481V → I in AAB48650 (PubMed:7332926).Curated
Sequence conflicti248 – 2481V → I in CAA24090 (PubMed:7332926).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1. Sequence problems.
AY172335 Genomic DNA. Translation: AAN85128.1.
PIRiA00484. OTMS3.
RefSeqiNP_904334.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneIDi17710.
KEGGimmu:17710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48650.1.
V00711 Genomic DNA. Translation: CAA24090.1. Sequence problems.
AY172335 Genomic DNA. Translation: AAN85128.1.
PIRiA00484. OTMS3.
RefSeqiNP_904334.1. NC_005089.1.

3D structure databases

ProteinModelPortaliP00416.
SMRiP00416. Positions 3-261.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP00416.
PRIDEiP00416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082409; ENSMUSP00000080997; ENSMUSG00000064358.
GeneIDi17710.
KEGGimmu:17710.

Organism-specific databases

CTDi4514.
MGIiMGI:102502. mt-Co3.

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP00416.
KOiK02262.
OMAiGFFWAFY.

Enzyme and pathway databases

ReactomeiREACT_278797. Respiratory electron transport.
REACT_297274. Orphan transporters.

Miscellaneous databases

NextBioi35563455.
PROiP00416.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP00416. baseline.
GenevestigatoriP00416.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCOX3_MOUSE
AccessioniPrimary (citable) accession number: P00416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 18, 2013
Last modified: April 1, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.