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Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Protein family/group databases

TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 15Mitochondrial matrixAdd BLAST14
Transmembranei16 – 34Helical; Name=IAdd BLAST19
Topological domaini35 – 40Mitochondrial intermembrane6
Transmembranei41 – 66Helical; Name=IIAdd BLAST26
Topological domaini67 – 72Mitochondrial matrix6
Transmembranei73 – 105Helical; Name=IIIAdd BLAST33
Topological domaini106 – 128Mitochondrial intermembraneAdd BLAST23
Transmembranei129 – 152Helical; Name=IVAdd BLAST24
Topological domaini153 – 155Mitochondrial matrix3
Transmembranei156 – 183Helical; Name=VAdd BLAST28
Topological domaini184 – 190Mitochondrial intermembrane7
Transmembranei191 – 223Helical; Name=VIAdd BLAST33
Topological domaini224 – 232Mitochondrial matrix9
Transmembranei233 – 256Helical; Name=VIIAdd BLAST24
Topological domaini257 – 261Mitochondrial intermembrane5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001837462 – 261Cytochrome c oxidase subunit 3Add BLAST260

Proteomic databases

PaxDbiP00415.

Expressioni

Gene expression databases

BgeeiENSBTAG00000043560.

Interactioni

Protein-protein interaction databases

DIPiDIP-60938N.
STRINGi9913.ENSBTAP00000053157.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Helixi16 – 36Combined sources21
Helixi41 – 65Combined sources25
Turni66 – 68Combined sources3
Helixi73 – 106Combined sources34
Helixi110 – 112Combined sources3
Beta strandi114 – 117Combined sources4
Turni126 – 128Combined sources3
Helixi129 – 152Combined sources24
Helixi156 – 183Combined sources28
Helixi191 – 223Combined sources33
Helixi233 – 255Combined sources23
Turni256 – 260Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
3X2QX-ray2.00C/P1-261[»]
5B1AX-ray1.50C/P1-261[»]
5B1BX-ray1.60C/P1-261[»]
ProteinModelPortaliP00415.
SMRiP00415.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00415.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
HOVERGENiHBG016686.
InParanoidiP00415.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN
60 70 80 90 100
MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA
110 120 130 140 150
FYHSSLAPTP ELGGCWPPTG IHPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGDRKHML QALFITITLG VYFTLLQASE YYEAPFTISD GVYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,933
Last modified:February 12, 2003 - v2
Checksum:iA521E76A9089B3FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238A → G in CAA24003 (PubMed:7120390).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1.
PIRiA00483. OTBO3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1.
PIRiA00483. OTBO3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
3X2QX-ray2.00C/P1-261[»]
5B1AX-ray1.50C/P1-261[»]
5B1BX-ray1.60C/P1-261[»]
ProteinModelPortaliP00415.
SMRiP00415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60938N.
STRINGi9913.ENSBTAP00000053157.

Protein family/group databases

TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP00415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
HOVERGENiHBG016686.
InParanoidiP00415.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP00415.

Gene expression databases

BgeeiENSBTAG00000043560.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_BOVIN
AccessioniPrimary (citable) accession number: P00415
Secondary accession number(s): Q576A5, Q8SE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 12, 2003
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.