Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00415 (COX3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded onMitochondrion
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 261260Cytochrome c oxidase subunit 3
PRO_0000183746

Regions

Topological domain2 – 1514Mitochondrial matrix
Transmembrane16 – 3419Helical; Name=I
Topological domain35 – 406Mitochondrial intermembrane
Transmembrane41 – 6626Helical; Name=II
Topological domain67 – 726Mitochondrial matrix
Transmembrane73 – 10533Helical; Name=III
Topological domain106 – 12823Mitochondrial intermembrane
Transmembrane129 – 15224Helical; Name=IV
Topological domain153 – 1553Mitochondrial matrix
Transmembrane156 – 18328Helical; Name=V
Topological domain184 – 1907Mitochondrial intermembrane
Transmembrane191 – 22333Helical; Name=VI
Topological domain224 – 2329Mitochondrial matrix
Transmembrane233 – 25624Helical; Name=VII
Topological domain257 – 2615Mitochondrial intermembrane

Experimental info

Sequence conflict2381A → G in CAA24003. Ref.1

Secondary structure

........................ 261
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00415 [UniParc].

Last modified February 12, 2003. Version 2.
Checksum: A521E76A9089B3FC

FASTA26129,933
        10         20         30         40         50         60 
MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN MLTMYQWWRD 

        70         80         90        100        110        120 
VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA FYHSSLAPTP ELGGCWPPTG 

       130        140        150        160        170        180 
IHPLNPLEVP LLNTSVLLAS GVSITWAHHS LMEGDRKHML QALFITITLG VYFTLLQASE 

       190        200        210        220        230        240 
YYEAPFTISD GVYGSTFFVA TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S 

« Hide

References

[1]"Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome."
Anderson S., de Bruijn M.H.L., Coulson A.R., Eperon I.C., Sanger F., Young I.G.
J. Mol. Biol. 156:683-717(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Heart.
[2]"Bos taurus mitochondrial protein coding regions."
Wettstein P.J.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 65, 66, D and F.
[3]"Complete sequence of a new Bos taurus mitochondrial genome."
Hiendleder S., Wolf E.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[4]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[5]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[6]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1.
PIROTBO3. A00483.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
ProteinModelPortalP00415.
SMRP00415. Positions 3-261.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1845.
HOVERGENHBG016686.
InParanoidP00415.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00415.

Entry information

Entry nameCOX3_BOVIN
AccessionPrimary (citable) accession number: P00415
Secondary accession number(s): Q576A5, Q8SE13
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 12, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references