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P00415

- COX3_BOVIN

UniProt

P00415 - COX3_BOVIN

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Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Protein family/group databases

TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514Mitochondrial matrixAdd
BLAST
Transmembranei16 – 3419Helical; Name=IAdd
BLAST
Topological domaini35 – 406Mitochondrial intermembrane
Transmembranei41 – 6626Helical; Name=IIAdd
BLAST
Topological domaini67 – 726Mitochondrial matrix
Transmembranei73 – 10533Helical; Name=IIIAdd
BLAST
Topological domaini106 – 12823Mitochondrial intermembraneAdd
BLAST
Transmembranei129 – 15224Helical; Name=IVAdd
BLAST
Topological domaini153 – 1553Mitochondrial matrix
Transmembranei156 – 18328Helical; Name=VAdd
BLAST
Topological domaini184 – 1907Mitochondrial intermembrane
Transmembranei191 – 22333Helical; Name=VIAdd
BLAST
Topological domaini224 – 2329Mitochondrial matrix
Transmembranei233 – 25624Helical; Name=VIIAdd
BLAST
Topological domaini257 – 2615Mitochondrial intermembrane

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183746Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP00415. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-60938N.

Structurei

Secondary structure

1
261
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Helixi16 – 3722Combined sources
Helixi41 – 6525Combined sources
Turni66 – 683Combined sources
Helixi73 – 10634Combined sources
Helixi110 – 1123Combined sources
Beta strandi114 – 1174Combined sources
Turni126 – 1283Combined sources
Helixi129 – 15224Combined sources
Helixi156 – 18328Combined sources
Helixi191 – 22333Combined sources
Helixi233 – 25523Combined sources
Turni256 – 2605Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
ProteinModelPortaliP00415.
SMRiP00415. Positions 3-261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00415.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOVERGENiHBG016686.
InParanoidiP00415.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00415-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN
60 70 80 90 100
MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA
110 120 130 140 150
FYHSSLAPTP ELGGCWPPTG IHPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGDRKHML QALFITITLG VYFTLLQASE YYEAPFTISD GVYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,933
Last modified:February 12, 2003 - v2
Checksum:iA521E76A9089B3FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381A → G in CAA24003. (PubMed:7120390)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1.
PIRiA00483. OTBO3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1 . Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1 . Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1 . Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1 . Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1 . Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1 .
PIRi A00483. OTBO3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 C/P 1-261 [» ]
1OCO X-ray 2.80 C/P 1-261 [» ]
1OCR X-ray 2.35 C/P 1-261 [» ]
1OCZ X-ray 2.90 C/P 1-261 [» ]
1V54 X-ray 1.80 C/P 1-261 [» ]
1V55 X-ray 1.90 C/P 1-261 [» ]
2DYR X-ray 1.80 C/P 1-261 [» ]
2DYS X-ray 2.20 C/P 1-261 [» ]
2EIJ X-ray 1.90 C/P 1-261 [» ]
2EIK X-ray 2.10 C/P 1-261 [» ]
2EIL X-ray 2.10 C/P 1-261 [» ]
2EIM X-ray 2.60 C/P 1-261 [» ]
2EIN X-ray 2.70 C/P 1-261 [» ]
2OCC X-ray 2.30 C/P 1-261 [» ]
2Y69 X-ray 1.95 C/P 1-261 [» ]
2YBB electron microscopy 19.00 N 1-261 [» ]
2ZXW X-ray 2.50 C/P 1-261 [» ]
3ABK X-ray 2.00 C/P 1-261 [» ]
3ABL X-ray 2.10 C/P 1-261 [» ]
3ABM X-ray 1.95 C/P 1-261 [» ]
3AG1 X-ray 2.20 C/P 1-261 [» ]
3AG2 X-ray 1.80 C/P 1-261 [» ]
3AG3 X-ray 1.80 C/P 1-261 [» ]
3AG4 X-ray 2.05 C/P 1-261 [» ]
3ASN X-ray 3.00 C/P 1-261 [» ]
3ASO X-ray 2.30 C/P 1-261 [» ]
3WG7 X-ray 1.90 C/P 1-261 [» ]
ProteinModelPortali P00415.
SMRi P00415. Positions 3-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60938N.

Protein family/group databases

TCDBi 3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1845.
HOVERGENi HBG016686.
InParanoidi P00415.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Miscellaneous databases

EvolutionaryTracei P00415.

Gene expression databases

ExpressionAtlasi P00415. baseline.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome."
    Anderson S., de Bruijn M.H.L., Coulson A.R., Eperon I.C., Sanger F., Young I.G.
    J. Mol. Biol. 156:683-717(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  2. "Bos taurus mitochondrial protein coding regions."
    Wettstein P.J.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 65, 66, D and F.
  3. "Complete sequence of a new Bos taurus mitochondrial genome."
    Hiendleder S., Wolf E.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX3_BOVIN
AccessioniPrimary (citable) accession number: P00415
Secondary accession number(s): Q576A5, Q8SE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 12, 2003
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3