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P00415

- COX3_BOVIN

UniProt

P00415 - COX3_BOVIN

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Protein
Cytochrome c oxidase subunit 3
Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
  2. respiratory chain complex IV assembly Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514Mitochondrial matrix
Add
BLAST
Transmembranei16 – 3419Helical; Name=I
Add
BLAST
Topological domaini35 – 406Mitochondrial intermembrane
Transmembranei41 – 6626Helical; Name=II
Add
BLAST
Topological domaini67 – 726Mitochondrial matrix
Transmembranei73 – 10533Helical; Name=III
Add
BLAST
Topological domaini106 – 12823Mitochondrial intermembrane
Add
BLAST
Transmembranei129 – 15224Helical; Name=IV
Add
BLAST
Topological domaini153 – 1553Mitochondrial matrix
Transmembranei156 – 18328Helical; Name=V
Add
BLAST
Topological domaini184 – 1907Mitochondrial intermembrane
Transmembranei191 – 22333Helical; Name=VI
Add
BLAST
Topological domaini224 – 2329Mitochondrial matrix
Transmembranei233 – 25624Helical; Name=VII
Add
BLAST
Topological domaini257 – 2615Mitochondrial intermembrane

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 261260Cytochrome c oxidase subunit 3
PRO_0000183746Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83
Helixi16 – 3722
Helixi41 – 6525
Turni66 – 683
Helixi73 – 10634
Helixi110 – 1123
Beta strandi114 – 1174
Turni126 – 1283
Helixi129 – 15224
Helixi156 – 18328
Helixi191 – 22333
Helixi233 – 25523
Turni256 – 2605

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80C/P1-261[»]
1OCOX-ray2.80C/P1-261[»]
1OCRX-ray2.35C/P1-261[»]
1OCZX-ray2.90C/P1-261[»]
1V54X-ray1.80C/P1-261[»]
1V55X-ray1.90C/P1-261[»]
2DYRX-ray1.80C/P1-261[»]
2DYSX-ray2.20C/P1-261[»]
2EIJX-ray1.90C/P1-261[»]
2EIKX-ray2.10C/P1-261[»]
2EILX-ray2.10C/P1-261[»]
2EIMX-ray2.60C/P1-261[»]
2EINX-ray2.70C/P1-261[»]
2OCCX-ray2.30C/P1-261[»]
2Y69X-ray1.95C/P1-261[»]
2YBBelectron microscopy19.00N1-261[»]
2ZXWX-ray2.50C/P1-261[»]
3ABKX-ray2.00C/P1-261[»]
3ABLX-ray2.10C/P1-261[»]
3ABMX-ray1.95C/P1-261[»]
3AG1X-ray2.20C/P1-261[»]
3AG2X-ray1.80C/P1-261[»]
3AG3X-ray1.80C/P1-261[»]
3AG4X-ray2.05C/P1-261[»]
3ASNX-ray3.00C/P1-261[»]
3ASOX-ray2.30C/P1-261[»]
3WG7X-ray1.90C/P1-261[»]
ProteinModelPortaliP00415.
SMRiP00415. Positions 3-261.

Miscellaneous databases

EvolutionaryTraceiP00415.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOVERGENiHBG016686.
InParanoidiP00415.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00415-1 [UniParc]FASTAAdd to Basket

« Hide

MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN    50
MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA 100
FYHSSLAPTP ELGGCWPPTG IHPLNPLEVP LLNTSVLLAS GVSITWAHHS 150
LMEGDRKHML QALFITITLG VYFTLLQASE YYEAPFTISD GVYGSTFFVA 200
TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,933
Last modified:February 12, 2003 - v2
Checksum:iA521E76A9089B3FC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381A → G in CAA24003. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1.
PIRiA00483. OTBO3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00654 Genomic DNA. Translation: CAA24003.1 . Sequence problems.
AF490528 Genomic DNA. Translation: AAM08332.1 . Sequence problems.
AF490529 Genomic DNA. Translation: AAM08345.1 . Sequence problems.
AF493541 Genomic DNA. Translation: AAM12795.1 . Sequence problems.
AF493542 Genomic DNA. Translation: AAM12808.1 . Sequence problems.
AF492351 Genomic DNA. Translation: AAQ06599.1 .
PIRi A00483. OTBO3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 C/P 1-261 [» ]
1OCO X-ray 2.80 C/P 1-261 [» ]
1OCR X-ray 2.35 C/P 1-261 [» ]
1OCZ X-ray 2.90 C/P 1-261 [» ]
1V54 X-ray 1.80 C/P 1-261 [» ]
1V55 X-ray 1.90 C/P 1-261 [» ]
2DYR X-ray 1.80 C/P 1-261 [» ]
2DYS X-ray 2.20 C/P 1-261 [» ]
2EIJ X-ray 1.90 C/P 1-261 [» ]
2EIK X-ray 2.10 C/P 1-261 [» ]
2EIL X-ray 2.10 C/P 1-261 [» ]
2EIM X-ray 2.60 C/P 1-261 [» ]
2EIN X-ray 2.70 C/P 1-261 [» ]
2OCC X-ray 2.30 C/P 1-261 [» ]
2Y69 X-ray 1.95 C/P 1-261 [» ]
2YBB electron microscopy 19.00 N 1-261 [» ]
2ZXW X-ray 2.50 C/P 1-261 [» ]
3ABK X-ray 2.00 C/P 1-261 [» ]
3ABL X-ray 2.10 C/P 1-261 [» ]
3ABM X-ray 1.95 C/P 1-261 [» ]
3AG1 X-ray 2.20 C/P 1-261 [» ]
3AG2 X-ray 1.80 C/P 1-261 [» ]
3AG3 X-ray 1.80 C/P 1-261 [» ]
3AG4 X-ray 2.05 C/P 1-261 [» ]
3ASN X-ray 3.00 C/P 1-261 [» ]
3ASO X-ray 2.30 C/P 1-261 [» ]
3WG7 X-ray 1.90 C/P 1-261 [» ]
ProteinModelPortali P00415.
SMRi P00415. Positions 3-261.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1845.
HOVERGENi HBG016686.
InParanoidi P00415.

Miscellaneous databases

EvolutionaryTracei P00415.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome."
    Anderson S., de Bruijn M.H.L., Coulson A.R., Eperon I.C., Sanger F., Young I.G.
    J. Mol. Biol. 156:683-717(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  2. "Bos taurus mitochondrial protein coding regions."
    Wettstein P.J.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 65, 66, D and F.
  3. "Complete sequence of a new Bos taurus mitochondrial genome."
    Hiendleder S., Wolf E.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX3_BOVIN
AccessioniPrimary (citable) accession number: P00415
Secondary accession number(s): Q576A5, Q8SE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 12, 2003
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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