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P00415

- COX3_BOVIN

UniProt

P00415 - COX3_BOVIN

Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (12 Feb 2003)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro
    2. respiratory chain complex IV assembly Source: UniProtKB

    Protein family/group databases

    TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:MT-CO3
    Synonyms:COIII, COXIII, MTCO3
    Encoded oniMitochondrion
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183746Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60938N.

    Structurei

    Secondary structure

    1
    261
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 83
    Helixi16 – 3722
    Helixi41 – 6525
    Turni66 – 683
    Helixi73 – 10634
    Helixi110 – 1123
    Beta strandi114 – 1174
    Turni126 – 1283
    Helixi129 – 15224
    Helixi156 – 18328
    Helixi191 – 22333
    Helixi233 – 25523
    Turni256 – 2605

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80C/P1-261[»]
    1OCOX-ray2.80C/P1-261[»]
    1OCRX-ray2.35C/P1-261[»]
    1OCZX-ray2.90C/P1-261[»]
    1V54X-ray1.80C/P1-261[»]
    1V55X-ray1.90C/P1-261[»]
    2DYRX-ray1.80C/P1-261[»]
    2DYSX-ray2.20C/P1-261[»]
    2EIJX-ray1.90C/P1-261[»]
    2EIKX-ray2.10C/P1-261[»]
    2EILX-ray2.10C/P1-261[»]
    2EIMX-ray2.60C/P1-261[»]
    2EINX-ray2.70C/P1-261[»]
    2OCCX-ray2.30C/P1-261[»]
    2Y69X-ray1.95C/P1-261[»]
    2YBBelectron microscopy19.00N1-261[»]
    2ZXWX-ray2.50C/P1-261[»]
    3ABKX-ray2.00C/P1-261[»]
    3ABLX-ray2.10C/P1-261[»]
    3ABMX-ray1.95C/P1-261[»]
    3AG1X-ray2.20C/P1-261[»]
    3AG2X-ray1.80C/P1-261[»]
    3AG3X-ray1.80C/P1-261[»]
    3AG4X-ray2.05C/P1-261[»]
    3ASNX-ray3.00C/P1-261[»]
    3ASOX-ray2.30C/P1-261[»]
    3WG7X-ray1.90C/P1-261[»]
    ProteinModelPortaliP00415.
    SMRiP00415. Positions 3-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00415.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1514Mitochondrial matrixAdd
    BLAST
    Topological domaini35 – 406Mitochondrial intermembrane
    Topological domaini67 – 726Mitochondrial matrix
    Topological domaini106 – 12823Mitochondrial intermembraneAdd
    BLAST
    Topological domaini153 – 1553Mitochondrial matrix
    Topological domaini184 – 1907Mitochondrial intermembrane
    Topological domaini224 – 2329Mitochondrial matrix
    Topological domaini257 – 2615Mitochondrial intermembrane

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3419Helical; Name=IAdd
    BLAST
    Transmembranei41 – 6626Helical; Name=IIAdd
    BLAST
    Transmembranei73 – 10533Helical; Name=IIIAdd
    BLAST
    Transmembranei129 – 15224Helical; Name=IVAdd
    BLAST
    Transmembranei156 – 18328Helical; Name=VAdd
    BLAST
    Transmembranei191 – 22333Helical; Name=VIAdd
    BLAST
    Transmembranei233 – 25624Helical; Name=VIIAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    HOVERGENiHBG016686.
    InParanoidiP00415.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00415-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHQTHAYHM VNPSPWPLTG ALSALLMTSG LTMWFHFNSM TLLMIGLTTN    50
    MLTMYQWWRD VIRESTFQGH HTPAVQKGLR YGMILFIISE VLFFTGFFWA 100
    FYHSSLAPTP ELGGCWPPTG IHPLNPLEVP LLNTSVLLAS GVSITWAHHS 150
    LMEGDRKHML QALFITITLG VYFTLLQASE YYEAPFTISD GVYGSTFFVA 200
    TGFHGLHVII GSTFLIVCFF RQLKFHFTSN HHFGFEAAAW YWHFVDVVWL 250
    FLYVSIYWWG S 261
    Length:261
    Mass (Da):29,933
    Last modified:February 12, 2003 - v2
    Checksum:iA521E76A9089B3FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti238 – 2381A → G in CAA24003. (PubMed:7120390)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00654 Genomic DNA. Translation: CAA24003.1. Sequence problems.
    AF490528 Genomic DNA. Translation: AAM08332.1. Sequence problems.
    AF490529 Genomic DNA. Translation: AAM08345.1. Sequence problems.
    AF493541 Genomic DNA. Translation: AAM12795.1. Sequence problems.
    AF493542 Genomic DNA. Translation: AAM12808.1. Sequence problems.
    AF492351 Genomic DNA. Translation: AAQ06599.1.
    PIRiA00483. OTBO3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00654 Genomic DNA. Translation: CAA24003.1 . Sequence problems.
    AF490528 Genomic DNA. Translation: AAM08332.1 . Sequence problems.
    AF490529 Genomic DNA. Translation: AAM08345.1 . Sequence problems.
    AF493541 Genomic DNA. Translation: AAM12795.1 . Sequence problems.
    AF493542 Genomic DNA. Translation: AAM12808.1 . Sequence problems.
    AF492351 Genomic DNA. Translation: AAQ06599.1 .
    PIRi A00483. OTBO3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 C/P 1-261 [» ]
    1OCO X-ray 2.80 C/P 1-261 [» ]
    1OCR X-ray 2.35 C/P 1-261 [» ]
    1OCZ X-ray 2.90 C/P 1-261 [» ]
    1V54 X-ray 1.80 C/P 1-261 [» ]
    1V55 X-ray 1.90 C/P 1-261 [» ]
    2DYR X-ray 1.80 C/P 1-261 [» ]
    2DYS X-ray 2.20 C/P 1-261 [» ]
    2EIJ X-ray 1.90 C/P 1-261 [» ]
    2EIK X-ray 2.10 C/P 1-261 [» ]
    2EIL X-ray 2.10 C/P 1-261 [» ]
    2EIM X-ray 2.60 C/P 1-261 [» ]
    2EIN X-ray 2.70 C/P 1-261 [» ]
    2OCC X-ray 2.30 C/P 1-261 [» ]
    2Y69 X-ray 1.95 C/P 1-261 [» ]
    2YBB electron microscopy 19.00 N 1-261 [» ]
    2ZXW X-ray 2.50 C/P 1-261 [» ]
    3ABK X-ray 2.00 C/P 1-261 [» ]
    3ABL X-ray 2.10 C/P 1-261 [» ]
    3ABM X-ray 1.95 C/P 1-261 [» ]
    3AG1 X-ray 2.20 C/P 1-261 [» ]
    3AG2 X-ray 1.80 C/P 1-261 [» ]
    3AG3 X-ray 1.80 C/P 1-261 [» ]
    3AG4 X-ray 2.05 C/P 1-261 [» ]
    3ASN X-ray 3.00 C/P 1-261 [» ]
    3ASO X-ray 2.30 C/P 1-261 [» ]
    3WG7 X-ray 1.90 C/P 1-261 [» ]
    ProteinModelPortali P00415.
    SMRi P00415. Positions 3-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60938N.

    Protein family/group databases

    TCDBi 3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1845.
    HOVERGENi HBG016686.
    InParanoidi P00415.

    Miscellaneous databases

    EvolutionaryTracei P00415.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome."
      Anderson S., de Bruijn M.H.L., Coulson A.R., Eperon I.C., Sanger F., Young I.G.
      J. Mol. Biol. 156:683-717(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Heart.
    2. "Bos taurus mitochondrial protein coding regions."
      Wettstein P.J.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 65, 66, D and F.
    3. "Complete sequence of a new Bos taurus mitochondrial genome."
      Hiendleder S., Wolf E.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX3_BOVIN
    AccessioniPrimary (citable) accession number: P00415
    Secondary accession number(s): Q576A5, Q8SE13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 12, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3