##gff-version 3
P00414	UniProtKB	Chain	1	261	.	.	.	ID=PRO_0000183793;Note=Cytochrome c oxidase subunit 3	
P00414	UniProtKB	Topological domain	1	15	.	.	.	Note=Mitochondrial matrix;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	16	34	.	.	.	Note=Helical%3B Name%3DI;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	35	40	.	.	.	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	41	66	.	.	.	Note=Helical%3B Name%3DII;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	67	72	.	.	.	Note=Mitochondrial matrix;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	73	105	.	.	.	Note=Helical%3B Name%3DIII;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	106	128	.	.	.	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	129	152	.	.	.	Note=Helical%3B Name%3DIV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	153	155	.	.	.	Note=Mitochondrial matrix;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	156	183	.	.	.	Note=Helical%3B Name%3DV;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	184	190	.	.	.	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	191	223	.	.	.	Note=Helical%3B Name%3DVI;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	224	232	.	.	.	Note=Mitochondrial matrix;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Transmembrane	233	256	.	.	.	Note=Helical%3B Name%3DVII;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00415	
P00414	UniProtKB	Topological domain	257	261	.	.	.	Note=Mitochondrial intermembrane;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30030519;Dbxref=PMID:30030519	
P00414	UniProtKB	Natural variant	3	3	.	.	.	ID=VAR_008573;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9461455;Dbxref=dbSNP:rs1556423637,PMID:9461455	
P00414	UniProtKB	Natural variant	35	35	.	.	.	ID=VAR_008574;Note=F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9461455;Dbxref=PMID:9461455	
P00414	UniProtKB	Natural variant	78	78	.	.	.	ID=VAR_002167;Note=In LHON%3B secondary mutation%3B does not seem to directly cause the disease. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8240356;Dbxref=dbSNP:rs267606611,PMID:8240356	
P00414	UniProtKB	Natural variant	91	91	.	.	.	ID=VAR_008575;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=dbSNP:rs2853825,PMID:1757091	
P00414	UniProtKB	Natural variant	94	98	.	.	.	ID=VAR_033057;Note=In MT-C4D%3B with RM-MT. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8630495;Dbxref=PMID:8630495	
P00414	UniProtKB	Natural variant	177	177	.	.	.	ID=VAR_008576;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=PMID:1757091	
P00414	UniProtKB	Natural variant	200	200	.	.	.	ID=VAR_002168;Note=In LHON%3B possible rare primary mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8240356;Dbxref=dbSNP:rs200613617,PMID:8240356	
P00414	UniProtKB	Natural variant	251	251	.	.	.	ID=VAR_002169;Note=Found in two patients with a diagnosis of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome%3B uncertain significance. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18587274,ECO:0000269|PubMed:7496173;Dbxref=dbSNP:rs1556423753,PMID:18587274,PMID:7496173	
P00414	UniProtKB	Natural variant	254	254	.	.	.	ID=VAR_008577;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1757091;Dbxref=dbSNP:rs200809063,PMID:1757091	
P00414	UniProtKB	Sequence conflict	118	118	.	.	.	Note=P->R;Ontology_term=ECO:0000305;evidence=ECO:0000305