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P00413

- COX2_WHEAT

UniProt

P00413 - COX2_WHEAT

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2, COII, COXII
Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi189 – 1891Copper A Inferred
Metal bindingi224 – 2241Copper A Inferred
Metal bindingi228 – 2281Copper A Inferred
Metal bindingi232 – 2321Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII, COXII
Encoded oniMitochondrion
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiP00413.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Topological domaini65 – 8420Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 260155Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183714Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00413.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00413-1 [UniParc]FASTAAdd to Basket

« Hide

MILRSLSCRF LTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL    50
ILVFVLWMLV RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI 100
PSFALLYSMD GVLVDPAITI KAIGHQWYWT YEYSDYNSSD EQSLTFDSYT 150
IPEDDPELGQ SRLLEVDNRV VVPAKTHLRM IVTPADVLHS WAVPSLGVKC 200
DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE AVTLKDYADW 250
VSNQLILQTN 260
Length:260
Mass (Da):29,515
Last modified:January 1, 1990 - v2
Checksum:i272F3C4573DA066D
GO

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01108 Genomic DNA. Translation: CAA25581.1. Sequence problems.
PIRiA00481. OBWT2.
RefSeqiYP_398417.1. NC_007579.1.

Genome annotation databases

GeneIDi3800085.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01108 Genomic DNA. Translation: CAA25581.1 . Sequence problems.
PIRi A00481. OBWT2.
RefSeqi YP_398417.1. NC_007579.1.

3D structure databases

ProteinModelPortali P00413.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3800085.

Organism-specific databases

Gramenei P00413.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The wheat cytochrome oxidase subunit II gene has an intron insert and three radical amino acid changes relative to maize."
    Bonen L., Boer P.H., Gray M.W.
    EMBO J. 3:2531-2536(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "RNA editing in wheat mitochondria results in the conservation of protein sequences."
    Gualberto J.M., Lamattina L., Bonnard G., Weil J.-H., Grienenberger J.-M.
    Nature 341:660-662(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.
  3. "RNA editing in plant mitochondria."
    Covello P.S., Gray M.W.
    Nature 341:662-666(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.

Entry informationi

Entry nameiCOX2_WHEAT
AccessioniPrimary (citable) accession number: P00413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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