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P00413 (COX2_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COII, COXII
Encoded onMitochondrion
OrganismTriticum aestivum (Wheat) [Complete proteome]
Taxonomic identifier4565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

RNA editing

Edited at positions 26, 56, 57, 87, 129, 130, 188, 196, 207, 213, 228 and 235. Ref.2 Ref.3

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183714

Regions

Topological domain1 – 4343Mitochondrial intermembrane Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 8420Mitochondrial matrix Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 260155Mitochondrial intermembrane Potential

Sites

Metal binding1891Copper A Probable
Metal binding2241Copper A Probable
Metal binding2281Copper A Probable
Metal binding2321Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P00413 [UniParc].

Last modified January 1, 1990. Version 2.
Checksum: 272F3C4573DA066D

FASTA26029,515
        10         20         30         40         50         60 
MILRSLSCRF LTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL ILVFVLWMLV 

        70         80         90        100        110        120 
RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI PSFALLYSMD GVLVDPAITI 

       130        140        150        160        170        180 
KAIGHQWYWT YEYSDYNSSD EQSLTFDSYT IPEDDPELGQ SRLLEVDNRV VVPAKTHLRM 

       190        200        210        220        230        240 
IVTPADVLHS WAVPSLGVKC DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE 

       250        260 
AVTLKDYADW VSNQLILQTN 

« Hide

References

[1]"The wheat cytochrome oxidase subunit II gene has an intron insert and three radical amino acid changes relative to maize."
Bonen L., Boer P.H., Gray M.W.
EMBO J. 3:2531-2536(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"RNA editing in wheat mitochondria results in the conservation of protein sequences."
Gualberto J.M., Lamattina L., Bonnard G., Weil J.-H., Grienenberger J.-M.
Nature 341:660-662(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.
[3]"RNA editing in plant mitochondria."
Covello P.S., Gray M.W.
Nature 341:662-666(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01108 Genomic DNA. Translation: CAA25581.1. Sequence problems.
PIROBWT2. A00481.
RefSeqYP_398417.1. NC_007579.1.

3D structure databases

ProteinModelPortalP00413.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3800085.

Organism-specific databases

GrameneP00413.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_WHEAT
AccessionPrimary (citable) accession number: P00413
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families