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P00412

- COX2_MAIZE

UniProt

P00412 - COX2_MAIZE

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 4 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi189 – 1891Copper ACurated
    Metal bindingi224 – 2241Copper ACurated
    Metal bindingi228 – 2281Copper ACurated
    Metal bindingi232 – 2321Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Synonyms:COXII, MOX1
    Encoded oniMitochondrion
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP00412.
    MaizeGDBi69218.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183629Add
    BLAST

    Proteomic databases

    PRIDEiP00412.

    Structurei

    3D structure databases

    ProteinModelPortaliP00412.
    SMRiP00412. Positions 19-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini65 – 8420Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini106 – 260155Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILRLLECRF FTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL    50
    ILVFVLWMLV RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI 100
    PSFALLYSMD GVLVDPAITI KAIGHQWYWT YEYSDYNSSD EQSLTFDSYM 150
    IPEDDLELGQ LRLLEVDNRV VVPAKTHLRM IVTSADVLHS WAVPSLGVKC 200
    DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE AVTLKDYADW 250
    VSNQLILQTN 260
    Length:260
    Mass (Da):29,680
    Last modified:October 1, 1996 - v4
    Checksum:i2F90F35CFB1A702F
    GO

    RNA editingi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00712 Genomic DNA. Translation: CAA24094.1. Sequence problems.
    X52865 mRNA. Translation: CAA37046.1. Sequence problems.
    PIRiB41260. OBZM2.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00712 Genomic DNA. Translation: CAA24094.1 . Sequence problems.
    X52865 mRNA. Translation: CAA37046.1 . Sequence problems.
    PIRi B41260. OBZM2.

    3D structure databases

    ProteinModelPortali P00412.
    SMRi P00412. Positions 19-255.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P00412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P00412.
    MaizeGDBi 69218.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons."
      Fox T.D., Leaver C.J.
      Cell 26:315-323(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "RNA editing intermediates of cox2 transcripts in maize mitochondria."
      Yang A.J., Mulligan R.M.
      Mol. Cell. Biol. 11:4278-4281(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, RNA EDITING.
    3. "Differences in editing at homologous sites in messenger RNAs from angiosperm mitochondria."
      Covello P.S., Gray M.W.
      Nucleic Acids Res. 18:5189-5195(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-248, RNA EDITING.
      Strain: cv. Golden Bantam early.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCOX2_MAIZE
    AccessioniPrimary (citable) accession number: P00412
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3