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P00412

- COX2_MAIZE

UniProt

P00412 - COX2_MAIZE

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2, COXII, MOX1
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi189 – 1891Copper A Inferred
Metal bindingi224 – 2241Copper A Inferred
Metal bindingi228 – 2281Copper A Inferred
Metal bindingi232 – 2321Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII, MOX1
Encoded oniMitochondrion
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiP00412.
MaizeGDBi69218.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Topological domaini65 – 8420Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 260155Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183629Add
BLAST

Proteomic databases

PRIDEiP00412.

Structurei

3D structure databases

ProteinModelPortaliP00412.
SMRiP00412. Positions 19-255.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00412-1 [UniParc]FASTAAdd to Basket

« Hide

MILRLLECRF FTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL    50
ILVFVLWMLV RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI 100
PSFALLYSMD GVLVDPAITI KAIGHQWYWT YEYSDYNSSD EQSLTFDSYM 150
IPEDDLELGQ LRLLEVDNRV VVPAKTHLRM IVTSADVLHS WAVPSLGVKC 200
DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE AVTLKDYADW 250
VSNQLILQTN 260
Length:260
Mass (Da):29,680
Last modified:October 1, 1996 - v4
Checksum:i2F90F35CFB1A702F
GO

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00712 Genomic DNA. Translation: CAA24094.1. Sequence problems.
X52865 mRNA. Translation: CAA37046.1. Sequence problems.
PIRiB41260. OBZM2.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00712 Genomic DNA. Translation: CAA24094.1 . Sequence problems.
X52865 mRNA. Translation: CAA37046.1 . Sequence problems.
PIRi B41260. OBZM2.

3D structure databases

ProteinModelPortali P00412.
SMRi P00412. Positions 19-255.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P00412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P00412.
MaizeGDBi 69218.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons."
    Fox T.D., Leaver C.J.
    Cell 26:315-323(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "RNA editing intermediates of cox2 transcripts in maize mitochondria."
    Yang A.J., Mulligan R.M.
    Mol. Cell. Biol. 11:4278-4281(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, RNA EDITING.
  3. "Differences in editing at homologous sites in messenger RNAs from angiosperm mitochondria."
    Covello P.S., Gray M.W.
    Nucleic Acids Res. 18:5189-5195(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-248, RNA EDITING.
    Strain: cv. Golden Bantam early.
    Tissue: Leaf.

Entry informationi

Entry nameiCOX2_MAIZE
AccessioniPrimary (citable) accession number: P00412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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