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P00412 (COX2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COXII, MOX1
Encoded onMitochondrion
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

RNA editing

Edited at positions 5, 11, 26, 56, 57, 87, 95, 129, 130, 150, 156, 161, 184, 188, 196, 207, 213 and 235. Ref.2 Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183629

Regions

Topological domain1 – 4343Mitochondrial intermembrane Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 8420Mitochondrial matrix Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 260155Mitochondrial intermembrane Potential

Sites

Metal binding1891Copper A Probable
Metal binding2241Copper A Probable
Metal binding2281Copper A Probable
Metal binding2321Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P00412 [UniParc].

Last modified October 1, 1996. Version 4.
Checksum: 2F90F35CFB1A702F

FASTA26029,680
        10         20         30         40         50         60 
MILRLLECRF FTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL ILVFVLWMLV 

        70         80         90        100        110        120 
RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI PSFALLYSMD GVLVDPAITI 

       130        140        150        160        170        180 
KAIGHQWYWT YEYSDYNSSD EQSLTFDSYM IPEDDLELGQ LRLLEVDNRV VVPAKTHLRM 

       190        200        210        220        230        240 
IVTSADVLHS WAVPSLGVKC DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE 

       250        260 
AVTLKDYADW VSNQLILQTN 

« Hide

References

[1]"The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons."
Fox T.D., Leaver C.J.
Cell 26:315-323(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"RNA editing intermediates of cox2 transcripts in maize mitochondria."
Yang A.J., Mulligan R.M.
Mol. Cell. Biol. 11:4278-4281(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, RNA EDITING.
[3]"Differences in editing at homologous sites in messenger RNAs from angiosperm mitochondria."
Covello P.S., Gray M.W.
Nucleic Acids Res. 18:5189-5195(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-248, RNA EDITING.
Strain: cv. Golden Bantam early.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00712 Genomic DNA. Translation: CAA24094.1. Sequence problems.
X52865 mRNA. Translation: CAA37046.1. Sequence problems.
PIROBZM2. B41260.

3D structure databases

ProteinModelPortalP00412.
SMRP00412. Positions 19-255.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP00412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP00412.
MaizeGDB69218.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MAIZE
AccessionPrimary (citable) accession number: P00412
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families