Cytochrome c oxidase subunit 2

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P00412 (COX2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
Synonyms:	COXII, MOX1

Encoded on

Mitochondrion

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
RNA editing	Edited at positions 5, 11, 26, 56, 57, 87, 95, 129, 130, 150, 156, 161, 184, 188, 196, 207, 213 and 235. Ref.2 Ref.3

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: EnsemblPlants/Gramene mitochondrial electron transport, cytochrome c to oxygen Inferred from electronic annotation. Source: EnsemblPlants/Gramene secretion by cell Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Cellular_component	chloroplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: EnsemblPlants/Gramene integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex IV Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 260

260

Cytochrome c oxidase subunit 2

PRO_0000183629

Regions

Topological domain

1 – 43

Mitochondrial intermembrane Potential

Transmembrane

44 – 64

Helical; Potential

Topological domain

65 – 84

Mitochondrial matrix Potential

Transmembrane

85 – 105

Helical; Potential

Topological domain

106 – 260

155

Mitochondrial intermembrane Potential

Sites

Metal binding

189

Copper A Probable

Metal binding

224

Copper A Probable

Metal binding

228

Copper A Probable

Metal binding

232

Copper A Probable

Sequences

Sequence

Length

Mass (Da)

Tools

P00412 [UniParc].

Last modified October 1, 1996. Version 4.
Checksum: 2F90F35CFB1A702F
Show »

FASTA

260

29,680

        10         20         30         40         50         60 
MILRLLECRF FTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL ILVFVLWMLV 

        70         80         90        100        110        120 
RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI PSFALLYSMD GVLVDPAITI 

       130        140        150        160        170        180 
KAIGHQWYWT YEYSDYNSSD EQSLTFDSYM IPEDDLELGQ LRLLEVDNRV VVPAKTHLRM 

       190        200        210        220        230        240 
IVTSADVLHS WAVPSLGVKC DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE 

       250        260 
AVTLKDYADW VSNQLILQTN

« Hide

References

[1]	"The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons." Fox T.D., Leaver C.J. Cell 26:315-323(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"RNA editing intermediates of cox2 transcripts in maize mitochondria." Yang A.J., Mulligan R.M. Mol. Cell. Biol. 11:4278-4281(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, RNA EDITING.
[3]	"Differences in editing at homologous sites in messenger RNAs from angiosperm mitochondria." Covello P.S., Gray M.W. Nucleic Acids Res. 18:5189-5195(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-248, RNA EDITING. Strain: cv. Golden Bantam early. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00712 Genomic DNA. Translation: CAA24094.1. Sequence problems. X52865 mRNA. Translation: CAA37046.1. Sequence problems.
PIR	OBZM2. B41260.
3D structure databases
ProteinModelPortal	P00412.
SMR	P00412. Positions 19-255.
ModBase	Search...
Proteomic databases
PRIDE	P00412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P00412.
MaizeGDB	69218.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_MAIZE

Accession

Primary (citable) accession number: P00412

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Family and domain databases

Entry information

Relevant documents