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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Copper ACurated1
Metal bindingi224Copper ACurated1
Metal bindingi228Copper ACurated1
Metal bindingi232Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII, MOX1
Encoded oniMitochondrion
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea

Organism-specific databases

MaizeGDBi69218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 84Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 260Mitochondrial intermembraneSequence analysisAdd BLAST155

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836291 – 260Cytochrome c oxidase subunit 2Add BLAST260

Proteomic databases

PRIDEiP00412

Expressioni

Gene expression databases

ExpressionAtlasiP00412 differential

Structurei

3D structure databases

ProteinModelPortaliP00412
SMRiP00412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P00412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILRLLECRF FTIALCDAAE PWQLGFQDAA TPMMQGIIDL HHDIFFFLIL
60 70 80 90 100
ILVFVLWMLV RALWHFNEQT NPIPQRIVHG TTIEIIWTIF PSVILLFIAI
110 120 130 140 150
PSFALLYSMD GVLVDPAITI KAIGHQWYWT YEYSDYNSSD EQSLTFDSYM
160 170 180 190 200
IPEDDLELGQ LRLLEVDNRV VVPAKTHLRM IVTSADVLHS WAVPSLGVKC
210 220 230 240 250
DAVPGRLNLT SILVQREGVY YGQCSEICGT NHAFMPIVVE AVTLKDYADW
260
VSNQLILQTN
Length:260
Mass (Da):29,680
Last modified:October 1, 1996 - v4
Checksum:i2F90F35CFB1A702F
GO

RNA editingi

Edited at positions 5, 11, 26, 56, 57, 87, 95, 129, 130, 150, 156, 161, 184, 188, 196, 207, 213 and 235.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00712 Genomic DNA Translation: CAA24094.1 Sequence problems.
X52865 mRNA Translation: CAA37046.1 Sequence problems.
PIRiB41260 OBZM2

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiCOX2_MAIZE
AccessioniPrimary (citable) accession number: P00412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health