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P00411 (COX2_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox-2
Synonyms:cox2, oxi1
ORF Names:NCM018, NCU16028
Encoded onMitochondrion
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Cytochrome c oxidase subunit 2
PRO_0000183638

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 5920Helical; Potential
Topological domain60 – 7617Mitochondrial matrix Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 250153Mitochondrial intermembrane Potential

Sites

Metal binding1851Copper A Probable
Metal binding2201Copper A Probable
Metal binding2241Copper A Probable
Metal binding2281Copper A Probable

Experimental info

Sequence conflict501G → V in AAA31959. Ref.1
Sequence conflict501G → V in CAA32813. Ref.4
Sequence conflict1861S → D in AAA31959. Ref.1
Sequence conflict2011G → R in AAA31959. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00411 [UniParc].

Last modified December 14, 2011. Version 2.
Checksum: 7F8C8642EFAAB013

FASTA25028,555
        10         20         30         40         50         60 
MGLLFNNLIM NFDAPSPWGI YFQDSATPQM EGLVELHDNI MYYLVVILFG VGWILLSIIR 

        70         80         90        100        110        120 
NYISTKSPIS HKYLNHGTLI ELIWTITPAV ILILIAFPSF KLLYLMDEVS DPSMSVLAEG 

       130        140        150        160        170        180 
HQWYWSYQYP DFLDSNDEFI EFDSYIVPES DLEEGALRML EVDNRVILPE LTHVRFIITA 

       190        200        210        220        230        240 
GDVIHSFAVP SLGVKCDAYP GRLNQVSVFI NREGVFYGQC SEICGILHSS MPIVIESVSL 

       250 
EKFLTWLEEQ 

« Hide

References

« Hide 'large scale' references
[1]"Cytochrome oxidase subunit 2 gene in Neurospora crassa mitochondria."
Macino G., Morelli G.
J. Biol. Chem. 258:13230-13235(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"Mitochondrial genetics of Neurospora."
Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.
(In) Kueck U. (eds.); The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112, Springer-Verlag, Berlin-Heidelberg (2004)
Cited for: GENOME REANNOTATION.
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"Molecular characterization of the mitochondrial DNA of a new stopper mutant ER-3 of Neurospora crassa."
Almasan A., Mishra N.C.
Genetics 120:935-945(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65.
Strain: RL3-8A.
[5]"The mitochondrially made subunit 2 of Neurospora crassa cytochrome aa3 is synthesized as a precursor protein."
van den Boogaart P., van Dijk S., Agsteribbe E.
FEBS Lett. 147:97-100(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
Strain: ANT-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K00825 Genomic DNA. Translation: AAA31959.2.
KC683708 Genomic DNA. Translation: AGG16017.1.
X14681 Genomic DNA. Translation: CAA32813.1.
J01429 Genomic DNA. No translation available.
PIROBNC2. A00479.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7WDNDC.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_NEUCR
AccessionPrimary (citable) accession number: P00411
Secondary accession number(s): M1R9T3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 14, 2011
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families