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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi185Copper ACurated1
Metal bindingi220Copper ACurated1
Metal bindingi224Copper ACurated1
Metal bindingi228Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:cox2, oxi1
ORF Names:NCM018, NCU16028
Encoded oniMitochondrion
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:NCU16028.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneSequence analysisAdd BLAST39
Transmembranei40 – 59HelicalSequence analysisAdd BLAST20
Topological domaini60 – 76Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 250Mitochondrial intermembraneSequence analysisAdd BLAST153

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836381 – 250Cytochrome c oxidase subunit 2Add BLAST250

Structurei

3D structure databases

SMRiP00411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP00411.
KOiK02261.
OrthoDBiEOG092C40RV.

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

P00411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLFNNLIM NFDAPSPWGI YFQDSATPQM EGLVELHDNI MYYLVVILFG
60 70 80 90 100
VGWILLSIIR NYISTKSPIS HKYLNHGTLI ELIWTITPAV ILILIAFPSF
110 120 130 140 150
KLLYLMDEVS DPSMSVLAEG HQWYWSYQYP DFLDSNDEFI EFDSYIVPES
160 170 180 190 200
DLEEGALRML EVDNRVILPE LTHVRFIITA GDVIHSFAVP SLGVKCDAYP
210 220 230 240 250
GRLNQVSVFI NREGVFYGQC SEICGILHSS MPIVIESVSL EKFLTWLEEQ
Length:250
Mass (Da):28,555
Last modified:December 14, 2011 - v2
Checksum:i7F8C8642EFAAB013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50G → V in AAA31959 (PubMed:6313689).Curated1
Sequence conflicti50G → V in CAA32813 (PubMed:2976009).Curated1
Sequence conflicti186S → D in AAA31959 (PubMed:6313689).Curated1
Sequence conflicti201G → R in AAA31959 (PubMed:6313689).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00825 Genomic DNA. Translation: AAA31959.2.
KC683708 Genomic DNA. Translation: AGG16017.1.
X14681 Genomic DNA. Translation: CAA32813.1.
J01429 Genomic DNA. No translation available.
PIRiA00479. OBNC2.
RefSeqiYP_009126729.1. NC_026614.1.

Genome annotation databases

EnsemblFungiiAGG16017; AGG16017; NCU16028.
GeneIDi23681583.
KEGGincr:NCU16028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00825 Genomic DNA. Translation: AAA31959.2.
KC683708 Genomic DNA. Translation: AGG16017.1.
X14681 Genomic DNA. Translation: CAA32813.1.
J01429 Genomic DNA. No translation available.
PIRiA00479. OBNC2.
RefSeqiYP_009126729.1. NC_026614.1.

3D structure databases

SMRiP00411.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAGG16017; AGG16017; NCU16028.
GeneIDi23681583.
KEGGincr:NCU16028.

Organism-specific databases

EuPathDBiFungiDB:NCU16028.

Phylogenomic databases

InParanoidiP00411.
KOiK02261.
OrthoDBiEOG092C40RV.

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_NEUCR
AccessioniPrimary (citable) accession number: P00411
Secondary accession number(s): M1R9T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 14, 2011
Last modified: March 15, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.