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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi185Copper ACurated1
Metal bindingi220Copper ACurated1
Metal bindingi224Copper ACurated1
Metal bindingi228Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:cox2, oxi1
ORF Names:NCM018, NCU16028
Encoded oniMitochondrion
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:NCU16028

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneSequence analysisAdd BLAST39
Transmembranei40 – 59HelicalSequence analysisAdd BLAST20
Topological domaini60 – 76Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 250Mitochondrial intermembraneSequence analysisAdd BLAST153

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836381 – 250Cytochrome c oxidase subunit 2Add BLAST250

Structurei

3D structure databases

SMRiP00411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP00411
KOiK02261
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P00411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLFNNLIM NFDAPSPWGI YFQDSATPQM EGLVELHDNI MYYLVVILFG
60 70 80 90 100
VGWILLSIIR NYISTKSPIS HKYLNHGTLI ELIWTITPAV ILILIAFPSF
110 120 130 140 150
KLLYLMDEVS DPSMSVLAEG HQWYWSYQYP DFLDSNDEFI EFDSYIVPES
160 170 180 190 200
DLEEGALRML EVDNRVILPE LTHVRFIITA GDVIHSFAVP SLGVKCDAYP
210 220 230 240 250
GRLNQVSVFI NREGVFYGQC SEICGILHSS MPIVIESVSL EKFLTWLEEQ
Length:250
Mass (Da):28,555
Last modified:December 14, 2011 - v2
Checksum:i7F8C8642EFAAB013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50G → V in AAA31959 (PubMed:6313689).Curated1
Sequence conflicti50G → V in CAA32813 (PubMed:2976009).Curated1
Sequence conflicti186S → D in AAA31959 (PubMed:6313689).Curated1
Sequence conflicti201G → R in AAA31959 (PubMed:6313689).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00825 Genomic DNA Translation: AAA31959.2
KC683708 Genomic DNA Translation: AGG16017.1
X14681 Genomic DNA Translation: CAA32813.1
J01429 Genomic DNA No translation available.
PIRiA00479 OBNC2
RefSeqiYP_009126729.1, NC_026614.1

Genome annotation databases

EnsemblFungiiAGG16017; AGG16017; NCU16028
GeneIDi23681583
KEGGincr:NCU16028

Similar proteinsi

Entry informationi

Entry nameiCOX2_NEUCR
AccessioniPrimary (citable) accession number: P00411
Secondary accession number(s): M1R9T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health