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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:Q0250-MONOMER
YEAST:Q0250-MONOMER

Protein family/group databases

TCDBi3.D.4.8.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:OXI1
Ordered Locus Names:Q0250
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:Q0250
SGDiS000007281 COX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 42Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei43 – 64HelicalSequence analysisAdd BLAST22
Topological domaini65 – 82Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Topological domaini108 – 251Mitochondrial intermembraneSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004191801 – 15Removed in mature formAdd BLAST15
ChainiPRO_000000604816 – 251Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The N-terminal sequence of COX2 is processed by IMP1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei15 – 16Cleavage; by IMP12

Proteomic databases

MaxQBiP00410
PaxDbiP00410
PRIDEiP00410

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Binary interactionsi

WithEntry#Exp.IntActNotes
COX20Q049353EBI-5024,EBI-36910

Protein-protein interaction databases

BioGridi34812, 48 interactors
DIPiDIP-7592N
IntActiP00410, 9 interactors
MINTiP00410
STRINGi4932.Q0250

Structurei

3D structure databases

ProteinModelPortaliP00410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017410
HOGENOMiHOG000264988
InParanoidiP00410
KOiK02261
OMAiWSYEYTD
OrthoDBiEOG092C40RV

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLLRLQLT TFIMNDVPTP YACYFQDSAT PNQEGILELH DNIMFYLLVI
60 70 80 90 100
LGLVSWMLYT IVMTYSKNPI AYKYIKHGQT IEVIWTIFPA VILLIIAFPS
110 120 130 140 150
FILLYLCDEV ISPAMTIKAI GYQWYWKYEY SDFINDSGET VEFESYVIPD
160 170 180 190 200
ELLEEGQLRL LDTDTSMVVP VDTHIRFVVT AADVIHDFAI PSLGIKVDAT
210 220 230 240 250
PGRLNQVSAL IQREGVFYGA CSELCGTGHA NMPIKIEAVS LPKFLEWLNE

Q
Length:251
Mass (Da):28,567
Last modified:July 21, 1986 - v1
Checksum:iBA5717C37330DF41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Y → N in AAA32155 (PubMed:2547760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02200 Genomic DNA Translation: AAA32158.2
V00706 Genomic DNA Translation: CAA24078.1
V00685 Genomic DNA Translation: CAA24056.1
KP263414 Genomic DNA Translation: AIZ98897.1
J05007 Genomic DNA Translation: AAA32155.2
L36888 Genomic DNA Translation: AAA67528.1
D55725 Genomic DNA Translation: BAA09539.1
PIRiA00478 OBBY2
RefSeqiNP_009326.1, NC_001224.1

Genome annotation databases

EnsemblFungiiQ0250; Q0250; Q0250
GeneIDi854622
KEGGisce:Q0250

Entry informationi

Entry nameiCOX2_YEAST
AccessioniPrimary (citable) accession number: P00410
Secondary accession number(s): A0A0A7NYF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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