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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:Q0250-MONOMER.
YEAST:Q0250-MONOMER.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:OXI1
Ordered Locus Names:Q0250
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:Q0250.
SGDiS000007281. COX2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 42Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei43 – 64HelicalSequence analysisAdd BLAST22
Topological domaini65 – 82Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Topological domaini108 – 251Mitochondrial intermembraneSequence analysisAdd BLAST144

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004191801 – 15Removed in mature formAdd BLAST15
ChainiPRO_000000604816 – 251Cytochrome c oxidase subunit 2Add BLAST236

Post-translational modificationi

The N-terminal sequence of COX2 is processed by IMP1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei15 – 16Cleavage; by IMP12

Proteomic databases

MaxQBiP00410.
PRIDEiP00410.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Binary interactionsi

WithEntry#Exp.IntActNotes
COX20Q049353EBI-5024,EBI-36910

Protein-protein interaction databases

BioGridi34812. 40 interactors.
DIPiDIP-7592N.
IntActiP00410. 9 interactors.
MINTiMINT-434441.

Structurei

3D structure databases

ProteinModelPortaliP00410.
SMRiP00410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOGENOMiHOG000264988.
InParanoidiP00410.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG092C40RV.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLLRLQLT TFIMNDVPTP YACYFQDSAT PNQEGILELH DNIMFYLLVI
60 70 80 90 100
LGLVSWMLYT IVMTYSKNPI AYKYIKHGQT IEVIWTIFPA VILLIIAFPS
110 120 130 140 150
FILLYLCDEV ISPAMTIKAI GYQWYWKYEY SDFINDSGET VEFESYVIPD
160 170 180 190 200
ELLEEGQLRL LDTDTSMVVP VDTHIRFVVT AADVIHDFAI PSLGIKVDAT
210 220 230 240 250
PGRLNQVSAL IQREGVFYGA CSELCGTGHA NMPIKIEAVS LPKFLEWLNE

Q
Length:251
Mass (Da):28,567
Last modified:July 21, 1986 - v1
Checksum:iBA5717C37330DF41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Y → N in AAA32155 (PubMed:2547760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02200 Genomic DNA. Translation: AAA32158.2.
V00706 Genomic DNA. Translation: CAA24078.1.
V00685 Genomic DNA. Translation: CAA24056.1.
KP263414 Genomic DNA. Translation: AIZ98897.1.
J05007 Genomic DNA. Translation: AAA32155.2.
L36888 Genomic DNA. Translation: AAA67528.1.
D55725 Genomic DNA. Translation: BAA09539.1.
PIRiA00478. OBBY2.
RefSeqiNP_009326.1. NC_001224.1.

Genome annotation databases

EnsemblFungiiQ0250; Q0250; Q0250.
GeneIDi854622.
KEGGisce:Q0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02200 Genomic DNA. Translation: AAA32158.2.
V00706 Genomic DNA. Translation: CAA24078.1.
V00685 Genomic DNA. Translation: CAA24056.1.
KP263414 Genomic DNA. Translation: AIZ98897.1.
J05007 Genomic DNA. Translation: AAA32155.2.
L36888 Genomic DNA. Translation: AAA67528.1.
D55725 Genomic DNA. Translation: BAA09539.1.
PIRiA00478. OBBY2.
RefSeqiNP_009326.1. NC_001224.1.

3D structure databases

ProteinModelPortaliP00410.
SMRiP00410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34812. 40 interactors.
DIPiDIP-7592N.
IntActiP00410. 9 interactors.
MINTiMINT-434441.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP00410.
PRIDEiP00410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiQ0250; Q0250; Q0250.
GeneIDi854622.
KEGGisce:Q0250.

Organism-specific databases

EuPathDBiFungiDB:Q0250.
SGDiS000007281. COX2.

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOGENOMiHOG000264988.
InParanoidiP00410.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG092C40RV.

Enzyme and pathway databases

BioCyciMetaCyc:Q0250-MONOMER.
YEAST:Q0250-MONOMER.

Miscellaneous databases

PROiP00410.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_YEAST
AccessioniPrimary (citable) accession number: P00410
Secondary accession number(s): A0A0A7NYF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.