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P00409

- COX2_DROYA

UniProt

P00409 - COX2_DROYA

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Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt:CoII
Synonyms:CoII
Encoded oniMitochondrion
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000002282: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013180. Dyak\mt:CoII.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 228146Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183588Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00409.
SMRiP00409. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00409-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY
60 70 80 90 100
VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNIEFDS YMIPTNELAI DGFRLLDVDN RVILPMNSQI
160 170 180 190 200
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC
210 220
GANHSFMPIV IESVPVNNFI KWISSNNS
Length:228
Mass (Da):26,107
Last modified:July 21, 1986 - v1
Checksum:i2669A593DAF0B3BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00924 Genomic DNA. Translation: CAA25440.1.
X03240 Genomic DNA. Translation: CAA26987.1.
PIRiA93477. OBFF2Y.
RefSeqiNP_006904.1. NC_001322.1.

Genome annotation databases

GeneIDi807630.
KEGGidya:COX2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00924 Genomic DNA. Translation: CAA25440.1 .
X03240 Genomic DNA. Translation: CAA26987.1 .
PIRi A93477. OBFF2Y.
RefSeqi NP_006904.1. NC_001322.1.

3D structure databases

ProteinModelPortali P00409.
SMRi P00409. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807630.
KEGGi dya:COX2.

Organism-specific databases

CTDi 4513.
FlyBasei FBgn0013180. Dyak\mt:CoII.

Phylogenomic databases

KOi K02261.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a segment of Drosophila mitochondrial DNA that contains the genes for cytochrome c oxidase subunits II and III and ATPase subunit 6."
    Clary D.O., Wolstenholme D.R.
    Nucleic Acids Res. 11:4211-4227(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code."
    Clary D.O., Wolstenholme D.R.
    J. Mol. Evol. 22:252-271(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2317.6 Ivory Coast.

Entry informationi

Entry nameiCOX2_DROYA
AccessioniPrimary (citable) accession number: P00409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3