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P00408 (COX2_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt:CoII
Synonyms:COII
Encoded onMitochondrion
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183579

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 228146Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Natural variations

Natural variant391G → S in strain: Mysore. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P00408 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 65FF4502C543335D

FASTA22826,191
        10         20         30         40         50         60 
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY VNRFLLHGQL 

        70         80         90        100        110        120 
IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI GHQWYWSYEY SDFNNIEFDS 

       130        140        150        160        170        180 
YMIPTNELMT DGFRLLDVDN RVVLPMNSQI RILVTAADVI HSWTVPALGV KVDGTPGRLN 

       190        200        210        220 
QTNFFINRPG LFYGQCSEIC GANHSFMPIV IESVPVNYFI KWISSNNS 

« Hide

References

« Hide 'large scale' references
[1]"Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
de Bruijn M.H.L.
Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R.
Tissue: Embryo.
[2]"Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
Ballard J.W.O.
J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R and Zimbabwe 53.
[3]"I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
Azou Y., Bregliano J.C.
Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Paris.
[4]"Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background."
Clancy D.J.
Aging Cell 7:795-804(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-39.
Strain: Alstonvl, Brownsvl, Dahomey, Japan, Mysore and W1118iso.
[5]"Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
O'Grady P.M., DeSalle R.
Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
Lewis D.L., Farr C.L., Kaguni L.S.
Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Intergenomic epistasis for fitness: within-population interactions between cytoplasmic and nuclear genes in Drosophila melanogaster."
Dowling D.K., Friberg U., Hailer F., Arnqvist G.
Genetics 175:235-244(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-225.
Strain: LHM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01404 Genomic DNA. Translation: AAB59240.1.
AF200828 Genomic DNA. Translation: AAF77228.1.
AF200829 Genomic DNA. Translation: AAF77240.1.
AJ400907 Genomic DNA. Translation: CAB91053.1.
FJ190105 Genomic DNA. Translation: ACI28544.1.
FJ190106 Genomic DNA. Translation: ACI28557.1.
FJ190107 Genomic DNA. Translation: ACI28570.1.
FJ190108 Genomic DNA. Translation: ACI28583.1.
FJ190109 Genomic DNA. Translation: ACI28596.1.
FJ190110 Genomic DNA. Translation: ACI28609.1.
EU493757 Genomic DNA. Translation: ACC94832.1.
U37541 Genomic DNA. Translation: AAC47813.1.
AM403329 Genomic DNA. Translation: CAL48258.1.
PIROBFF2. A00476.
RefSeqNP_008279.1. NC_001709.1.

3D structure databases

ProteinModelPortalP00408.
SMRP00408. Positions 7-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid72956. 19 interactions.

Proteomic databases

PaxDbP00408.
PRIDEP00408.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0100863; FBpp0100177; FBgn0013675.
GeneID192470.
KEGGdme:COX2.

Organism-specific databases

CTD4513.
FlyBaseFBgn0013675. mt:CoII.

Phylogenomic databases

eggNOGCOG1622.
GeneTreeENSGT00390000017410.
InParanoidP00408.
KOK02261.
OMAEDVLHSW.
OrthoDBEOG7TJ3JX.
PhylomeDBP00408.
ProtClustDBMTH00154.

Gene expression databases

BgeeP00408.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi192470.
NextBio842183.
PROP00408.

Entry information

Entry nameCOX2_DROME
AccessionPrimary (citable) accession number: P00408
Secondary accession number(s): B2L9S3, B6E0V9, Q05GI7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase