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P00408

- COX2_DROME

UniProt

P00408 - COX2_DROME

Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:mt:CoII
    Synonyms:COII
    Encoded oniMitochondrion
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Mitochondrion

    Organism-specific databases

    FlyBaseiFBgn0013675. mt:CoII.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183579Add
    BLAST

    Proteomic databases

    PaxDbiP00408.
    PRIDEiP00408.

    Expressioni

    Gene expression databases

    BgeeiP00408.

    Interactioni

    Protein-protein interaction databases

    BioGridi72956. 19 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP00408.
    SMRiP00408. Positions 7-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 228146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    GeneTreeiENSGT00390000017410.
    InParanoidiP00408.
    KOiK02261.
    OMAiNHEMISS.
    OrthoDBiEOG7TJ3JX.
    PhylomeDBiP00408.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00408-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY    50
    VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI 100
    GHQWYWSYEY SDFNNIEFDS YMIPTNELMT DGFRLLDVDN RVVLPMNSQI 150
    RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC 200
    GANHSFMPIV IESVPVNYFI KWISSNNS 228
    Length:228
    Mass (Da):26,191
    Last modified:July 21, 1986 - v1
    Checksum:i65FF4502C543335D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391G → S in strain: Mysore. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01404 Genomic DNA. Translation: AAB59240.1.
    AF200828 Genomic DNA. Translation: AAF77228.1.
    AF200829 Genomic DNA. Translation: AAF77240.1.
    AJ400907 Genomic DNA. Translation: CAB91053.1.
    FJ190105 Genomic DNA. Translation: ACI28544.1.
    FJ190106 Genomic DNA. Translation: ACI28557.1.
    FJ190107 Genomic DNA. Translation: ACI28570.1.
    FJ190108 Genomic DNA. Translation: ACI28583.1.
    FJ190109 Genomic DNA. Translation: ACI28596.1.
    FJ190110 Genomic DNA. Translation: ACI28609.1.
    EU493757 Genomic DNA. Translation: ACC94832.1.
    U37541 Genomic DNA. Translation: AAC47813.1.
    AM403329 Genomic DNA. Translation: CAL48258.1.
    PIRiA00476. OBFF2.
    RefSeqiNP_008279.1. NC_001709.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0100863; FBpp0100177; FBgn0013675.
    GeneIDi192470.
    KEGGidme:COX2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01404 Genomic DNA. Translation: AAB59240.1 .
    AF200828 Genomic DNA. Translation: AAF77228.1 .
    AF200829 Genomic DNA. Translation: AAF77240.1 .
    AJ400907 Genomic DNA. Translation: CAB91053.1 .
    FJ190105 Genomic DNA. Translation: ACI28544.1 .
    FJ190106 Genomic DNA. Translation: ACI28557.1 .
    FJ190107 Genomic DNA. Translation: ACI28570.1 .
    FJ190108 Genomic DNA. Translation: ACI28583.1 .
    FJ190109 Genomic DNA. Translation: ACI28596.1 .
    FJ190110 Genomic DNA. Translation: ACI28609.1 .
    EU493757 Genomic DNA. Translation: ACC94832.1 .
    U37541 Genomic DNA. Translation: AAC47813.1 .
    AM403329 Genomic DNA. Translation: CAL48258.1 .
    PIRi A00476. OBFF2.
    RefSeqi NP_008279.1. NC_001709.1.

    3D structure databases

    ProteinModelPortali P00408.
    SMRi P00408. Positions 7-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 72956. 19 interactions.

    Proteomic databases

    PaxDbi P00408.
    PRIDEi P00408.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0100863 ; FBpp0100177 ; FBgn0013675 .
    GeneIDi 192470.
    KEGGi dme:COX2.

    Organism-specific databases

    CTDi 4513.
    FlyBasei FBgn0013675. mt:CoII.

    Phylogenomic databases

    eggNOGi COG1622.
    GeneTreei ENSGT00390000017410.
    InParanoidi P00408.
    KOi K02261.
    OMAi NHEMISS.
    OrthoDBi EOG7TJ3JX.
    PhylomeDBi P00408.

    Miscellaneous databases

    GenomeRNAii 192470.
    NextBioi 842183.
    PROi P00408.

    Gene expression databases

    Bgeei P00408.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
      de Bruijn M.H.L.
      Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Oregon-R.
      Tissue: Embryo.
    2. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
      Ballard J.W.O.
      J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Oregon-R and Zimbabwe 53.
    3. "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
      Azou Y., Bregliano J.C.
      Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Paris.
    4. "Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background."
      Clancy D.J.
      Aging Cell 7:795-804(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-39.
      Strain: Alstonvl, Brownsvl, Dahomey, Japan, Mysore and W1118iso.
    5. "Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
      O'Grady P.M., DeSalle R.
      Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
      Lewis D.L., Farr C.L., Kaguni L.S.
      Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Intergenomic epistasis for fitness: within-population interactions between cytoplasmic and nuclear genes in Drosophila melanogaster."
      Dowling D.K., Friberg U., Hailer F., Arnqvist G.
      Genetics 175:235-244(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-225.
      Strain: LHM.

    Entry informationi

    Entry nameiCOX2_DROME
    AccessioniPrimary (citable) accession number: P00408
    Secondary accession number(s): B2L9S3, B6E0V9, Q05GI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3