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P00408

- COX2_DROME

UniProt

P00408 - COX2_DROME

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Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_207898. Respiratory electron transport.
REACT_269710. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt:CoII
Synonyms:COII
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013675. mt:CoII.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 228146Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183579Add
BLAST

Proteomic databases

PaxDbiP00408.
PRIDEiP00408.

Expressioni

Gene expression databases

BgeeiP00408.

Interactioni

Protein-protein interaction databases

BioGridi72956. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliP00408.
SMRiP00408. Positions 7-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
GeneTreeiENSGT00390000017410.
InParanoidiP00408.
OMAiNHEMISS.
OrthoDBiEOG7TJ3JX.
PhylomeDBiP00408.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00408-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY
60 70 80 90 100
VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNIEFDS YMIPTNELMT DGFRLLDVDN RVVLPMNSQI
160 170 180 190 200
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC
210 220
GANHSFMPIV IESVPVNYFI KWISSNNS
Length:228
Mass (Da):26,191
Last modified:July 21, 1986 - v1
Checksum:i65FF4502C543335D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391G → S in strain: Mysore. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59240.1.
AF200828 Genomic DNA. Translation: AAF77228.1.
AF200829 Genomic DNA. Translation: AAF77240.1.
AJ400907 Genomic DNA. Translation: CAB91053.1.
FJ190105 Genomic DNA. Translation: ACI28544.1.
FJ190106 Genomic DNA. Translation: ACI28557.1.
FJ190107 Genomic DNA. Translation: ACI28570.1.
FJ190108 Genomic DNA. Translation: ACI28583.1.
FJ190109 Genomic DNA. Translation: ACI28596.1.
FJ190110 Genomic DNA. Translation: ACI28609.1.
EU493757 Genomic DNA. Translation: ACC94832.1.
U37541 Genomic DNA. Translation: AAC47813.1.
AM403329 Genomic DNA. Translation: CAL48258.1.
PIRiA00476. OBFF2.
RefSeqiYP_009047268.1. NC_024511.2.

Genome annotation databases

EnsemblMetazoaiFBtr0100863; FBpp0100177; FBgn0013675.
GeneIDi19893535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59240.1 .
AF200828 Genomic DNA. Translation: AAF77228.1 .
AF200829 Genomic DNA. Translation: AAF77240.1 .
AJ400907 Genomic DNA. Translation: CAB91053.1 .
FJ190105 Genomic DNA. Translation: ACI28544.1 .
FJ190106 Genomic DNA. Translation: ACI28557.1 .
FJ190107 Genomic DNA. Translation: ACI28570.1 .
FJ190108 Genomic DNA. Translation: ACI28583.1 .
FJ190109 Genomic DNA. Translation: ACI28596.1 .
FJ190110 Genomic DNA. Translation: ACI28609.1 .
EU493757 Genomic DNA. Translation: ACC94832.1 .
U37541 Genomic DNA. Translation: AAC47813.1 .
AM403329 Genomic DNA. Translation: CAL48258.1 .
PIRi A00476. OBFF2.
RefSeqi YP_009047268.1. NC_024511.2.

3D structure databases

ProteinModelPortali P00408.
SMRi P00408. Positions 7-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 72956. 19 interactions.

Proteomic databases

PaxDbi P00408.
PRIDEi P00408.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0100863 ; FBpp0100177 ; FBgn0013675 .
GeneIDi 19893535.

Organism-specific databases

FlyBasei FBgn0013675. mt:CoII.

Phylogenomic databases

eggNOGi COG1622.
GeneTreei ENSGT00390000017410.
InParanoidi P00408.
OMAi NHEMISS.
OrthoDBi EOG7TJ3JX.
PhylomeDBi P00408.

Enzyme and pathway databases

Reactomei REACT_207898. Respiratory electron transport.
REACT_269710. Orphan transporters.

Miscellaneous databases

GenomeRNAii 192470.
NextBioi 842183.
PROi P00408.

Gene expression databases

Bgeei P00408.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila melanogaster mitochondrial DNA, a novel organization and genetic code."
    de Bruijn M.H.L.
    Nature 304:234-241(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
    Ballard J.W.O.
    J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R and Zimbabwe 53.
  3. "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition."
    Azou Y., Bregliano J.C.
    Heredity 86:110-116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Paris.
  4. "Variation in mitochondrial genotype has substantial lifespan effects which may be modulated by nuclear background."
    Clancy D.J.
    Aging Cell 7:795-804(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-39.
    Strain: Alstonvl, Brownsvl, Dahomey, Japan, Mysore and W1118iso.
  5. "Out of Hawaii: the origin and biogeography of the genus Scaptomyza (Diptera: Drosophilidae)."
    O'Grady P.M., DeSalle R.
    Biol. Lett. 4:195-199(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons."
    Lewis D.L., Farr C.L., Kaguni L.S.
    Insect Mol. Biol. 4:263-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Intergenomic epistasis for fitness: within-population interactions between cytoplasmic and nuclear genes in Drosophila melanogaster."
    Dowling D.K., Friberg U., Hailer F., Arnqvist G.
    Genetics 175:235-244(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-225.
    Strain: LHM.

Entry informationi

Entry nameiCOX2_DROME
AccessioniPrimary (citable) accession number: P00408
Secondary accession number(s): B2L9S3, B6E0V9, Q05GI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3