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Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt:CoII
Synonyms:COII
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013675. mt:CoII.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalSequence analysisAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 228Mitochondrial intermembraneSequence analysisAdd BLAST146

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835791 – 228Cytochrome c oxidase subunit 2Add BLAST228

Proteomic databases

PaxDbiP00408.
PRIDEiP00408.

Expressioni

Gene expression databases

BgeeiFBgn0013675.

Interactioni

Protein-protein interaction databases

BioGridi2595064. 19 interactors.
STRINGi7227.FBpp0100177.

Structurei

3D structure databases

ProteinModelPortaliP00408.
SMRiP00408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
GeneTreeiENSGT00390000017410.
InParanoidiP00408.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG091G0IO9.
PhylomeDBiP00408.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY
60 70 80 90 100
VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNIEFDS YMIPTNELMT DGFRLLDVDN RVVLPMNSQI
160 170 180 190 200
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC
210 220
GANHSFMPIV IESVPVNYFI KWISSNNS
Length:228
Mass (Da):26,191
Last modified:July 21, 1986 - v1
Checksum:i65FF4502C543335D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39G → S in strain: Mysore. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59240.1.
AF200828 Genomic DNA. Translation: AAF77228.1.
AF200829 Genomic DNA. Translation: AAF77240.1.
AJ400907 Genomic DNA. Translation: CAB91053.1.
FJ190105 Genomic DNA. Translation: ACI28544.1.
FJ190106 Genomic DNA. Translation: ACI28557.1.
FJ190107 Genomic DNA. Translation: ACI28570.1.
FJ190108 Genomic DNA. Translation: ACI28583.1.
FJ190109 Genomic DNA. Translation: ACI28596.1.
FJ190110 Genomic DNA. Translation: ACI28609.1.
EU493757 Genomic DNA. Translation: ACC94832.1.
U37541 Genomic DNA. Translation: AAC47813.1.
AM403329 Genomic DNA. Translation: CAL48258.1.
PIRiA00476. OBFF2.
RefSeqiYP_009047268.1. NC_024511.2.

Genome annotation databases

EnsemblMetazoaiFBtr0100863; FBpp0100177; FBgn0013675.
GeneIDi19893535.
KEGGidme:COX2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59240.1.
AF200828 Genomic DNA. Translation: AAF77228.1.
AF200829 Genomic DNA. Translation: AAF77240.1.
AJ400907 Genomic DNA. Translation: CAB91053.1.
FJ190105 Genomic DNA. Translation: ACI28544.1.
FJ190106 Genomic DNA. Translation: ACI28557.1.
FJ190107 Genomic DNA. Translation: ACI28570.1.
FJ190108 Genomic DNA. Translation: ACI28583.1.
FJ190109 Genomic DNA. Translation: ACI28596.1.
FJ190110 Genomic DNA. Translation: ACI28609.1.
EU493757 Genomic DNA. Translation: ACC94832.1.
U37541 Genomic DNA. Translation: AAC47813.1.
AM403329 Genomic DNA. Translation: CAL48258.1.
PIRiA00476. OBFF2.
RefSeqiYP_009047268.1. NC_024511.2.

3D structure databases

ProteinModelPortaliP00408.
SMRiP00408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2595064. 19 interactors.
STRINGi7227.FBpp0100177.

Proteomic databases

PaxDbiP00408.
PRIDEiP00408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0100863; FBpp0100177; FBgn0013675.
GeneIDi19893535.
KEGGidme:COX2.

Organism-specific databases

CTDi4513.
FlyBaseiFBgn0013675. mt:CoII.

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
GeneTreeiENSGT00390000017410.
InParanoidiP00408.
KOiK02261.
OMAiPLKIFEM.
OrthoDBiEOG091G0IO9.
PhylomeDBiP00408.

Miscellaneous databases

GenomeRNAii19893535.
PROiP00408.

Gene expression databases

BgeeiFBgn0013675.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_DROME
AccessioniPrimary (citable) accession number: P00408
Secondary accession number(s): B2L9S3, B6E0V9, Q05GI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.