P00407 (COX2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	mt-co2
Synonyms:	coii, coxii, mtco2

Encoded on

Mitochondrion

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Cytochrome c oxidase subunit 2		PRO_0000183715
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Potential
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Potential
	Topological domain	83 – 229	147	Mitochondrial intermembrane Potential
Sites
	Metal binding	161	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable
	Metal binding	204	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P00407 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: E671F06B24D834AB	FASTA	229	25,956
	10 20 30 40 50 60 MAHPSQLGFQ DAASPIMEEL LHFHDHTLMA VFLISTLVLY IITIMMTTKL TNTNLMDAQE 70 80 90 100 110 120 IEMVWTIMPA ISLIMIALPS LRILYLMDEV NDPHLTIKAI GHQWYWSYEY TNYEDLSFDS 130 140 150 160 170 180 YMIPTNDLTP GQFRLLEVDN RMVVPMESPT RLLVTAEDVL HSWAVPSLGV KTDAIPGRLH 190 200 210 220 QTSFIATRPG VFYGQCSEIC GANHSFMPIV VEAVPLTDFE NWSSSMLEA

References

[1]	"The complete nucleotide sequence of the Xenopus laevis mitochondrial genome." Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H. J. Biol. Chem. 260:9759-9774(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10217 Genomic DNA. Translation: AAA66461.1.
PIR	OBXL2. A00475.
RefSeq	NP_008137.1. NC_001573.1.
3D structure databases
ProteinModelPortal	P00407.
SMR	P00407. Positions 1-227.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2642081.
KEGG	xla:2642081.
Organism-specific databases
CTD	4513.
Phylogenomic databases
HOVERGEN	HBG012727.
KO	K02261.
ProtClustDB	MTH00076.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_XENLA

Accession

Primary (citable) accession number: P00407

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program