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P00405 (COX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:Mtco2
Synonyms:COII, mt-Co2
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Cytochrome c oxidase subunit 2
PRO_0000183635

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 227145Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P00405 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 306C6EAD54802D11

FASTA22725,976
        10         20         30         40         50         60 
MAYPFQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY IISLMLTTKL THTSTMDAQE 

        70         80         90        100        110        120 
VETIWTILPA VILIMIALPS LRILYMMDEI NNPVLTVKTM GHQWYWSYEY TDYEDLCFDS 

       130        140        150        160        170        180 
YMIPTNDLKP GELRLLEVDN RVVLPMELPI RMLISSEDVL HSWAVPSLGL KTDAIPGRLN 

       190        200        210        220 
QATVTSNRPG LFYGQCSEIC GSNHSFMPIV LEMVPLKYFE NWSASMI 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a deleted mitochondrial DNA molecule in heteroplasmic mice."
Nelson I., Gerasimov S., Marsac C., Lestienne P., Boursot P.
Mamm. Genome 4:680-683(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-63.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 83-98; 135-171 AND 218-227, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48647.1.
V00711 Genomic DNA. Translation: CAA24083.1.
S68119 Genomic DNA. Translation: AAP15814.1.
PIROBMS2. A00474.
RefSeqNP_904331.1. NC_005089.1.

3D structure databases

ProteinModelPortalP00405.
SMRP00405. Positions 2-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201542. 1 interaction.
IntActP00405. 5 interactions.
MINTMINT-1858197.
STRING10090.ENSMUSP00000080994.

PTM databases

PhosphoSiteP00405.

2D gel databases

SWISS-2DPAGEP00405.

Proteomic databases

PaxDbP00405.
PRIDEP00405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082405; ENSMUSP00000080994; ENSMUSG00000064354.
GeneID17709.
KEGGmmu:17709.

Organism-specific databases

CTD4513.
MGIMGI:102503. mt-Co2.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
HOVERGENHBG012727.
InParanoidP00405.
KOK02261.
OMAEDVLHSW.
OrthoDBEOG7TJ3JX.
PhylomeDBP00405.
ProtClustDBMTH00098.
TreeFamTF344269.

Gene expression databases

BgeeP00405.
GenevestigatorP00405.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292315.
PROP00405.
SOURCESearch...

Entry information

Entry nameCOX2_MOUSE
AccessionPrimary (citable) accession number: P00405
Secondary accession number(s): Q85K21
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot