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P00405

- COX2_MOUSE

UniProt

P00405 - COX2_MOUSE

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Protein

Cytochrome c oxidase subunit 2

Gene

Mtco2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:Mtco2
Synonyms:COII, mt-Co2
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102503. mt-Co2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 227145Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
  5. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Cytochrome c oxidase subunit 2PRO_0000183635Add
BLAST

Proteomic databases

MaxQBiP00405.
PaxDbiP00405.
PRIDEiP00405.

2D gel databases

SWISS-2DPAGEP00405.

PTM databases

PhosphoSiteiP00405.

Expressioni

Gene expression databases

BgeeiP00405.
ExpressionAtlasiP00405. baseline and differential.
GenevestigatoriP00405.

Interactioni

Protein-protein interaction databases

BioGridi201542. 2 interactions.
IntActiP00405. 5 interactions.
MINTiMINT-1858197.
STRINGi10090.ENSMUSP00000080994.

Structurei

3D structure databases

ProteinModelPortaliP00405.
SMRiP00405. Positions 2-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
HOVERGENiHBG012727.
InParanoidiP00405.
KOiK02261.
OMAiDHALMIV.
OrthoDBiEOG7TJ3JX.
PhylomeDBiP00405.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00405-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYPFQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY IISLMLTTKL
60 70 80 90 100
THTSTMDAQE VETIWTILPA VILIMIALPS LRILYMMDEI NNPVLTVKTM
110 120 130 140 150
GHQWYWSYEY TDYEDLCFDS YMIPTNDLKP GELRLLEVDN RVVLPMELPI
160 170 180 190 200
RMLISSEDVL HSWAVPSLGL KTDAIPGRLN QATVTSNRPG LFYGQCSEIC
210 220
GSNHSFMPIV LEMVPLKYFE NWSASMI
Length:227
Mass (Da):25,976
Last modified:July 21, 1986 - v1
Checksum:i306C6EAD54802D11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48647.1.
V00711 Genomic DNA. Translation: CAA24083.1.
S68119 Genomic DNA. Translation: AAP15814.1.
PIRiA00474. OBMS2.
RefSeqiNP_904331.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082405; ENSMUSP00000080994; ENSMUSG00000064354.
GeneIDi17709.
KEGGimmu:17709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48647.1 .
V00711 Genomic DNA. Translation: CAA24083.1 .
S68119 Genomic DNA. Translation: AAP15814.1 .
PIRi A00474. OBMS2.
RefSeqi NP_904331.1. NC_005089.1.

3D structure databases

ProteinModelPortali P00405.
SMRi P00405. Positions 2-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201542. 2 interactions.
IntActi P00405. 5 interactions.
MINTi MINT-1858197.
STRINGi 10090.ENSMUSP00000080994.

PTM databases

PhosphoSitei P00405.

2D gel databases

SWISS-2DPAGE P00405.

Proteomic databases

MaxQBi P00405.
PaxDbi P00405.
PRIDEi P00405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082405 ; ENSMUSP00000080994 ; ENSMUSG00000064354 .
GeneIDi 17709.
KEGGi mmu:17709.

Organism-specific databases

CTDi 4513.
MGIi MGI:102503. mt-Co2.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
HOVERGENi HBG012727.
InParanoidi P00405.
KOi K02261.
OMAi DHALMIV.
OrthoDBi EOG7TJ3JX.
PhylomeDBi P00405.
TreeFami TF344269.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.
REACT_268398. Orphan transporters.

Miscellaneous databases

NextBioi 292315.
PROi P00405.
SOURCEi Search...

Gene expression databases

Bgeei P00405.
ExpressionAtlasi P00405. baseline and differential.
Genevestigatori P00405.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a deleted mitochondrial DNA molecule in heteroplasmic mice."
    Nelson I., Gerasimov S., Marsac C., Lestienne P., Boursot P.
    Mamm. Genome 4:680-683(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-63.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 83-98; 135-171 AND 218-227, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCOX2_MOUSE
AccessioniPrimary (citable) accession number: P00405
Secondary accession number(s): Q85K21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3