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P00405

- COX2_MOUSE

UniProt

P00405 - COX2_MOUSE

Protein

Cytochrome c oxidase subunit 2

Gene

Mtco2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:Mtco2
    Synonyms:COII, mt-Co2
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102503. mt-Co2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI
    4. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Cytochrome c oxidase subunit 2PRO_0000183635Add
    BLAST

    Proteomic databases

    MaxQBiP00405.
    PaxDbiP00405.
    PRIDEiP00405.

    2D gel databases

    SWISS-2DPAGEP00405.

    PTM databases

    PhosphoSiteiP00405.

    Expressioni

    Gene expression databases

    BgeeiP00405.
    GenevestigatoriP00405.

    Interactioni

    Protein-protein interaction databases

    BioGridi201542. 2 interactions.
    IntActiP00405. 5 interactions.
    MINTiMINT-1858197.
    STRINGi10090.ENSMUSP00000080994.

    Structurei

    3D structure databases

    ProteinModelPortaliP00405.
    SMRiP00405. Positions 2-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 227145Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    HOVERGENiHBG012727.
    InParanoidiP00405.
    KOiK02261.
    OMAiDHALMIV.
    OrthoDBiEOG7TJ3JX.
    PhylomeDBiP00405.
    TreeFamiTF344269.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00405-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYPFQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY IISLMLTTKL    50
    THTSTMDAQE VETIWTILPA VILIMIALPS LRILYMMDEI NNPVLTVKTM 100
    GHQWYWSYEY TDYEDLCFDS YMIPTNDLKP GELRLLEVDN RVVLPMELPI 150
    RMLISSEDVL HSWAVPSLGL KTDAIPGRLN QATVTSNRPG LFYGQCSEIC 200
    GSNHSFMPIV LEMVPLKYFE NWSASMI 227
    Length:227
    Mass (Da):25,976
    Last modified:July 21, 1986 - v1
    Checksum:i306C6EAD54802D11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48647.1.
    V00711 Genomic DNA. Translation: CAA24083.1.
    S68119 Genomic DNA. Translation: AAP15814.1.
    PIRiA00474. OBMS2.
    RefSeqiNP_904331.1. NC_005089.1.

    Genome annotation databases

    EnsembliENSMUST00000082405; ENSMUSP00000080994; ENSMUSG00000064354.
    GeneIDi17709.
    KEGGimmu:17709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48647.1 .
    V00711 Genomic DNA. Translation: CAA24083.1 .
    S68119 Genomic DNA. Translation: AAP15814.1 .
    PIRi A00474. OBMS2.
    RefSeqi NP_904331.1. NC_005089.1.

    3D structure databases

    ProteinModelPortali P00405.
    SMRi P00405. Positions 2-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201542. 2 interactions.
    IntActi P00405. 5 interactions.
    MINTi MINT-1858197.
    STRINGi 10090.ENSMUSP00000080994.

    PTM databases

    PhosphoSitei P00405.

    2D gel databases

    SWISS-2DPAGE P00405.

    Proteomic databases

    MaxQBi P00405.
    PaxDbi P00405.
    PRIDEi P00405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082405 ; ENSMUSP00000080994 ; ENSMUSG00000064354 .
    GeneIDi 17709.
    KEGGi mmu:17709.

    Organism-specific databases

    CTDi 4513.
    MGIi MGI:102503. mt-Co2.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    HOVERGENi HBG012727.
    InParanoidi P00405.
    KOi K02261.
    OMAi DHALMIV.
    OrthoDBi EOG7TJ3JX.
    PhylomeDBi P00405.
    TreeFami TF344269.

    Miscellaneous databases

    NextBioi 292315.
    PROi P00405.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00405.
    Genevestigatori P00405.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of a deleted mitochondrial DNA molecule in heteroplasmic mice."
      Nelson I., Gerasimov S., Marsac C., Lestienne P., Boursot P.
      Mamm. Genome 4:680-683(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-63.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 83-98; 135-171 AND 218-227, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCOX2_MOUSE
    AccessioniPrimary (citable) accession number: P00405
    Secondary accession number(s): Q85K21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3