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P00402

- COX1_EMEND

UniProt

P00402 - COX1_EMEND

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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron (heme A axial ligand)Curated
Metal bindingi280 – 2801Copper BCurated
Metal bindingi284 – 2841Copper BCurated
Metal bindingi329 – 3291Copper BCurated
Metal bindingi330 – 3301Copper BCurated
Metal bindingi415 – 4151Iron (heme A3 axial ligand)Curated
Metal bindingi417 – 4171Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox1
Synonyms:oxiA
Encoded oniMitochondrion
OrganismiEmericella nidulans (Aspergillus nidulans)
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Cytochrome c oxidase subunit 1PRO_0000183331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP00402.
SMRiP00402. Positions 44-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00402-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIDLNTNNV LGKKFSTSTK KENIKQIESS SFLTFKQPTE WQERWYLSSN
60 70 80 90 100
AKDIGTLYLM FALFSGLLGT AFSVLIRLEL SGPGVQYIAD NQLYNSIITA
110 120 130 140 150
HAIMMIFFMV MPALIGGFGN FLLPLLVGGP DMAFPRLNNI SFWLLVPSLL
160 170 180 190 200
LFVFSATIEN GAGTGWTLYP PLSGIQSHSG PSVDLAIFGL HLSGISSMLG
210 220 230 240 250
AMNFITTILN MRSPGIRLHK LALFGWAVII TAVLLLLSLP VLAGGITMVL
260 270 280 290 300
TDRNFNTSFF EVAGGGDPIL FQHLFWFFGH PEVYILIIPG FGIISTVIAA
310 320 330 340 350
GSGKNVFGYL GMVYAMMSIG VLGFLVWSHH MYTVGLDVDT RAYFTAATLI
360 370 380 390 400
IAVPTGIKIF SWLATCYGGS LHLTPPMLFA LGFVVLFTIG GLSGVVLANA
410 420 430 440 450
SLDVAFHDTY YVVAHFHYVL SMGAVFALFS GWYLWIPKLL GLSYDQFAAK
460 470 480 490 500
VHFWILFIGV NLTFFPQHFL GLQLMPRRIS DYPDAFYGWN LLSSIGSIIS
510 520 530 540 550
VVATWYFLTI IYKQLTEGKA VSRYPWLTPQ LFSDTFQVLF TRNNSSLEWC
560
LTSPPKPHAF ASLPLQS
Length:567
Mass (Da):62,621
Last modified:September 26, 2001 - v2
Checksum:i9163AAEA8C02F6A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00790 Genomic DNA. Translation: CAB38220.1.
PIRiA22735. ODAS1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00790 Genomic DNA. Translation: CAB38220.1 .
PIRi A22735. ODAS1.

3D structure databases

ProteinModelPortali P00402.
SMRi P00402. Positions 44-560.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Three variant introns of the same general class in the mitochondrial gene for cytochrome oxidase subunit 1 in Aspergillus nidulans."
    Waring R.B., Brown T.A., Ray J.A., Scazzocchio C., Davies R.W.
    EMBO J. 3:2121-2128(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: yA2 pyroA4 cnxC3.
  2. "Nucleotide sequence of Aspergillus nidulans mitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA."
    Netzker R., Koechel H.G., Basak N., Kuentzel H.
    Nucleic Acids Res. 10:4783-4794(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-133.
    Strain: pabaA1 biA1.

Entry informationi

Entry nameiCOX1_EMEND
AccessioniPrimary (citable) accession number: P00402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3