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P00402

- COX1_EMEND

UniProt

P00402 - COX1_EMEND

Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Iron (heme A axial ligand)Curated
    Metal bindingi280 – 2801Copper BCurated
    Metal bindingi284 – 2841Copper BCurated
    Metal bindingi329 – 3291Copper BCurated
    Metal bindingi330 – 3301Copper BCurated
    Metal bindingi415 – 4151Iron (heme A3 axial ligand)Curated
    Metal bindingi417 – 4171Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:cox1
    Synonyms:oxiA
    Encoded oniMitochondrion
    OrganismiEmericella nidulans (Aspergillus nidulans)
    Taxonomic identifieri162425 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Cytochrome c oxidase subunit 1PRO_0000183331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP00402.
    SMRiP00402. Positions 44-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00402-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIDLNTNNV LGKKFSTSTK KENIKQIESS SFLTFKQPTE WQERWYLSSN    50
    AKDIGTLYLM FALFSGLLGT AFSVLIRLEL SGPGVQYIAD NQLYNSIITA 100
    HAIMMIFFMV MPALIGGFGN FLLPLLVGGP DMAFPRLNNI SFWLLVPSLL 150
    LFVFSATIEN GAGTGWTLYP PLSGIQSHSG PSVDLAIFGL HLSGISSMLG 200
    AMNFITTILN MRSPGIRLHK LALFGWAVII TAVLLLLSLP VLAGGITMVL 250
    TDRNFNTSFF EVAGGGDPIL FQHLFWFFGH PEVYILIIPG FGIISTVIAA 300
    GSGKNVFGYL GMVYAMMSIG VLGFLVWSHH MYTVGLDVDT RAYFTAATLI 350
    IAVPTGIKIF SWLATCYGGS LHLTPPMLFA LGFVVLFTIG GLSGVVLANA 400
    SLDVAFHDTY YVVAHFHYVL SMGAVFALFS GWYLWIPKLL GLSYDQFAAK 450
    VHFWILFIGV NLTFFPQHFL GLQLMPRRIS DYPDAFYGWN LLSSIGSIIS 500
    VVATWYFLTI IYKQLTEGKA VSRYPWLTPQ LFSDTFQVLF TRNNSSLEWC 550
    LTSPPKPHAF ASLPLQS 567
    Length:567
    Mass (Da):62,621
    Last modified:September 26, 2001 - v2
    Checksum:i9163AAEA8C02F6A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00790 Genomic DNA. Translation: CAB38220.1.
    PIRiA22735. ODAS1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00790 Genomic DNA. Translation: CAB38220.1 .
    PIRi A22735. ODAS1.

    3D structure databases

    ProteinModelPortali P00402.
    SMRi P00402. Positions 44-560.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three variant introns of the same general class in the mitochondrial gene for cytochrome oxidase subunit 1 in Aspergillus nidulans."
      Waring R.B., Brown T.A., Ray J.A., Scazzocchio C., Davies R.W.
      EMBO J. 3:2121-2128(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: yA2 pyroA4 cnxC3.
    2. "Nucleotide sequence of Aspergillus nidulans mitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA."
      Netzker R., Koechel H.G., Basak N., Kuentzel H.
      Nucleic Acids Res. 10:4783-4794(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-133.
      Strain: pabaA1 biA1.

    Entry informationi

    Entry nameiCOX1_EMEND
    AccessioniPrimary (citable) accession number: P00402
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3