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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron (heme A axial ligand)Curated1
Metal bindingi241Copper BCurated1
Metal bindingi245Copper BCurated1
Metal bindingi290Copper BCurated1
Metal bindingi291Copper BCurated1
Metal bindingi376Iron (heme A3 axial ligand)Curated1
Metal bindingi378Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • mitochondrial electron transport, cytochrome c to oxygen Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:Q0045-MONOMER.
YEAST:Q0045-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:OXI3
Ordered Locus Names:Q0045
Encoded oniMitochondrion
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Mitochondrion

Organism-specific databases

EuPathDBiFungiDB:Q0045.
SGDiS000007260. COX1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 38HelicalSequence analysisAdd BLAST23
Transmembranei58 – 80HelicalSequence analysisAdd BLAST23
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Transmembranei148 – 170HelicalSequence analysisAdd BLAST23
Transmembranei183 – 205HelicalSequence analysisAdd BLAST23
Transmembranei237 – 259HelicalSequence analysisAdd BLAST23
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
Transmembranei374 – 396HelicalSequence analysisAdd BLAST23
Transmembranei409 – 431HelicalSequence analysisAdd BLAST23
Transmembranei451 – 473HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex IV Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834321 – 534Cytochrome c oxidase subunit 1Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

MaxQBiP00401.
PRIDEiP00401.

Interactioni

Subunit structurei

Cytochrome c oxidase is composed of 11 subunits: one copy each of COX1, COX2, COX3, COX4, COX5A or COX5B, COX6, COX7, COX9, COX12, COX13 and two copies of COX8.

Protein-protein interaction databases

BioGridi34790. 45 interactors.
IntActiP00401. 6 interactors.
MINTiMINT-4981480.

Structurei

3D structure databases

ProteinModelPortaliP00401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000001518.
HOGENOMiHOG000085274.
InParanoidiP00401.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG
60 70 80 90 100
NSQLFNVLVV GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN
110 120 130 140 150
IAFWVLPMGL VCLVTSTLVE SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA
160 170 180 190 200
LHLTSISSLL GAINFIVTTL NMRTNGMTMH KLPLFVWSIF ITAFLLLLSL
210 220 230 240 250
PVLSAGITML LLDRNFNTSF FEVSGGGDPI LYEHLFWFFG HPEVYILIIP
260 270 280 290 300
GFGIISHVVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD
310 320 330 340 350
TRAYFTSATM IIAIPTGIKI FSWLATIHGG SIRLATPMLY AIAFLFLFTM
360 370 380 390 400
GGLTGVALAN ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI
410 420 430 440 450
LGLNYNEKLA QIQFWLIFIG ANVIFFPMHF LGINGMPRRI PDYPDAFAGW
460 470 480 490 500
NYVASIGSFI ATLSLFLFIY ILYDQLVNGL NNKVNNKSVI YNKAPDFVES
510 520 530
NTIFNLNTVK SSSIEFLLTS PPAVHSFNTP AVQS
Length:534
Mass (Da):58,798
Last modified:April 23, 2003 - v2
Checksum:i5D555084C127E8B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57Missing in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti69F → CT in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti224S → A in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti328H → Y in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti378H → Y in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti479 – 485Missing in CAA24070 (PubMed:6254986).Curated7
Sequence conflicti492N → A in CAA24070 (PubMed:6254986).Curated1
Sequence conflicti496 – 510Missing in CAA24070 (PubMed:6254986).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00694 Genomic DNA. Translation: CAA24070.1.
KP263414 Genomic DNA. Translation: AIZ98881.1.
X14910 Genomic DNA. Translation: CAA33036.1.
PIRiA00468. ODBY1.
S78640.
RefSeqiNP_009305.1. NC_001224.1.

Genome annotation databases

EnsemblFungiiQ0045; Q0045; Q0045.
GeneIDi854598.
KEGGisce:Q0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00694 Genomic DNA. Translation: CAA24070.1.
KP263414 Genomic DNA. Translation: AIZ98881.1.
X14910 Genomic DNA. Translation: CAA33036.1.
PIRiA00468. ODBY1.
S78640.
RefSeqiNP_009305.1. NC_001224.1.

3D structure databases

ProteinModelPortaliP00401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34790. 45 interactors.
IntActiP00401. 6 interactors.
MINTiMINT-4981480.

Protein family/group databases

TCDBi3.D.4.8.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

MaxQBiP00401.
PRIDEiP00401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiQ0045; Q0045; Q0045.
GeneIDi854598.
KEGGisce:Q0045.

Organism-specific databases

EuPathDBiFungiDB:Q0045.
SGDiS000007260. COX1.

Phylogenomic databases

GeneTreeiENSGT00390000001518.
HOGENOMiHOG000085274.
InParanoidiP00401.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciMetaCyc:Q0045-MONOMER.
YEAST:Q0045-MONOMER.

Miscellaneous databases

PROiP00401.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_YEAST
AccessioniPrimary (citable) accession number: P00401
Secondary accession number(s): A0A0A7NYF6, Q9ZZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 23, 2003
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.