Reviewed,
UniProtKB/Swiss-Prot P00400 (COX1_DROYA)
Last modified
November 24, 2009.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c oxidase subunit 1 EC=1.9.3.1 Alternative name(s): Cytochrome c oxidase polypeptide I | ||||
| Gene names |
| ||||
| Encoded on | Mitochondrion | ||||
| Organism | Drosophila yakuba (Fruit fly) | ||||
| Taxonomic identifier | 7245 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 512 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. |
| Catalytic activity | 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the heme-copper respiratory oxidase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 512 | 512 | Cytochrome c oxidase subunit 1 | PRO_0000183329 | |||||||
Regions | |||||||||||
| Transmembrane | 16 – 36 | 21 | Potential | ||||||||
| Transmembrane | 55 – 75 | 21 | Potential | ||||||||
| Transmembrane | 101 – 121 | 21 | Potential | ||||||||
| Transmembrane | 144 – 164 | 21 | Potential | ||||||||
| Transmembrane | 182 – 202 | 21 | Potential | ||||||||
| Transmembrane | 233 – 253 | 21 | Potential | ||||||||
| Transmembrane | 267 – 287 | 21 | Potential | ||||||||
| Transmembrane | 304 – 324 | 21 | Potential | ||||||||
| Transmembrane | 337 – 357 | 21 | Potential | ||||||||
| Transmembrane | 379 – 399 | 21 | Potential | ||||||||
| Transmembrane | 413 – 433 | 21 | Potential | ||||||||
| Transmembrane | 451 – 471 | 21 | Potential | ||||||||
Sites | |||||||||||
| Metal binding | 60 | 1 | Iron (heme A axial ligand) Probable | ||||||||
| Metal binding | 239 | 1 | Copper B Probable | ||||||||
| Metal binding | 243 | 1 | Copper B Probable | ||||||||
| Metal binding | 289 | 1 | Copper B Probable | ||||||||
| Metal binding | 290 | 1 | Copper B Probable | ||||||||
| Metal binding | 375 | 1 | Iron (heme A3 axial ligand) Probable | ||||||||
| Metal binding | 377 | 1 | Iron (heme A axial ligand) Probable | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 239 ↔ 243 | 1'-histidyl-3'-tyrosine (His-Tyr) By similarity | |||||||||
Sequences
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References
| [1] | "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code." Clary D.O., Wolstenholme D.R. J. Mol. Evol. 22:252-271(1985) [PubMed: 3001325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2317.6 Ivory Coast. |
| [2] | "Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in Drosophila mitochondrial DNA." Clary D.O., Wolstenholme D.R. Nucleic Acids Res. 11:6859-6872(1983) [PubMed: 6314262] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X03240 Genomic DNA. Translation: CAC14066.1. |
| PIR | ODFF1Y. A93488. |
3D structure databases | |
| SMR | P00400. Positions 4-506. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0013179. Dyak\mt:CoI. |
Enzyme and pathway databases | |
| BRENDA | 1.9.3.1. 278535. |
Family and domain databases | |
| InterPro | IPR000883. Cyt_c_oxidase_su1. [Graphical view] |
| Gene3D | G3DSA:1.20.210.10. COX1. 1 hit. |
| PANTHER | PTHR10422. COX1. 1 hit. |
| Pfam | PF00115. COX1. 1 hit. [Graphical view] |
| PRINTS | PR01165. CYCOXIDASEI. |
| PROSITE | PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COX1_DROYA | ||||||||
| Accession | Primary (citable) accession number: P00400 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


