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Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme A axial ligand)Curated1
Metal bindingi238Copper BCurated1
Metal bindingi242Copper BCurated1
Metal bindingi288Copper BCurated1
Metal bindingi289Copper BCurated1
Metal bindingi374Iron (heme A3 axial ligand)Curated1
Metal bindingi376Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: InterPro
  • mitochondrial DNA replication Source: FlyBase
  • oxidative phosphorylation Source: UniProtKB-UniPathway
  • regulation of neuron death Source: FlyBase
  • sleep Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoI
Synonyms:CoI
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013674. mt:CoI.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833251 – 511Cytochrome c oxidase subunit 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP00399.
PRIDEiP00399.

Expressioni

Gene expression databases

BgeeiFBgn0013674.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0100176.

Structurei

3D structure databases

ProteinModelPortaliP00399.
SMRiP00399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
GeneTreeiENSGT00390000001518.
InParanoidiP00399.
KOiK02256.
OMAiGYKMIAF.
OrthoDBiEOG091G035B.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ
60 70 80 90 100
IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF
110 120 130 140 150
WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL
160 170 180 190 200
AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL
210 220 230 240 250
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR
310 320 330 340 350
AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG
360 370 380 390 400
LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG
410 420 430 440 450
LTLNNKWLKS HFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNI
460 470 480 490 500
VSTIGSTISL LGILFFFFII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE
510
HSYSELPLLT N
Length:511
Mass (Da):56,372
Last modified:January 9, 2013 - v2
Checksum:i332DAFF298EBBA13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti127Y → F in strain: Zimbabwe. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59239.1.
U37541 Genomic DNA. Translation: AAC47812.2.
AF200828 Genomic DNA. Translation: AAF77227.1.
AF200829 Genomic DNA. Translation: AAF77245.1.
AJ400907 Genomic DNA. Translation: CAB91052.2.
FJ190105 Genomic DNA. Translation: ACI28543.1.
FJ190106 Genomic DNA. Translation: ACI28556.1.
FJ190107 Genomic DNA. Translation: ACI28569.1.
FJ190108 Genomic DNA. Translation: ACI28582.1.
FJ190109 Genomic DNA. Translation: ACI28595.1.
FJ190110 Genomic DNA. Translation: ACI28608.1.
GQ229519 mRNA. Translation: ACT21544.1.
JX266575 Genomic DNA. Translation: AFR59645.1.
JX266576 Genomic DNA. Translation: AFR59658.1.
JX266577 Genomic DNA. Translation: AFR59671.1.
JX266578 Genomic DNA. Translation: AFR59684.1.
JX266579 Genomic DNA. Translation: AFR59697.1.
JX266580 Genomic DNA. Translation: AFR59710.1.
JQ686694 Genomic DNA. Translation: AFP47060.1.
JQ686695 Genomic DNA. Translation: AFP47073.1.
JQ686696 Genomic DNA. Translation: AFP47086.1.
JQ686698 Genomic DNA. Translation: AFP47112.1.
JQ686699 Genomic DNA. Translation: AFP47125.1.
M57910 Genomic DNA. Translation: AAB02282.1.
M18022 Genomic DNA. Translation: AAA65480.2.
AY383542 Genomic DNA. Translation: AAQ92343.1.
U51619 Genomic DNA. Translation: AAB68481.2.
PIRiA93307. ODFF1.
RefSeqiYP_009047267.1. NC_024511.2.

Genome annotation databases

EnsemblMetazoaiFBtr0100861; FBpp0100176; FBgn0013674.
GeneIDi19893533.
KEGGidme:COX1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01404 Genomic DNA. Translation: AAB59239.1.
U37541 Genomic DNA. Translation: AAC47812.2.
AF200828 Genomic DNA. Translation: AAF77227.1.
AF200829 Genomic DNA. Translation: AAF77245.1.
AJ400907 Genomic DNA. Translation: CAB91052.2.
FJ190105 Genomic DNA. Translation: ACI28543.1.
FJ190106 Genomic DNA. Translation: ACI28556.1.
FJ190107 Genomic DNA. Translation: ACI28569.1.
FJ190108 Genomic DNA. Translation: ACI28582.1.
FJ190109 Genomic DNA. Translation: ACI28595.1.
FJ190110 Genomic DNA. Translation: ACI28608.1.
GQ229519 mRNA. Translation: ACT21544.1.
JX266575 Genomic DNA. Translation: AFR59645.1.
JX266576 Genomic DNA. Translation: AFR59658.1.
JX266577 Genomic DNA. Translation: AFR59671.1.
JX266578 Genomic DNA. Translation: AFR59684.1.
JX266579 Genomic DNA. Translation: AFR59697.1.
JX266580 Genomic DNA. Translation: AFR59710.1.
JQ686694 Genomic DNA. Translation: AFP47060.1.
JQ686695 Genomic DNA. Translation: AFP47073.1.
JQ686696 Genomic DNA. Translation: AFP47086.1.
JQ686698 Genomic DNA. Translation: AFP47112.1.
JQ686699 Genomic DNA. Translation: AFP47125.1.
M57910 Genomic DNA. Translation: AAB02282.1.
M18022 Genomic DNA. Translation: AAA65480.2.
AY383542 Genomic DNA. Translation: AAQ92343.1.
U51619 Genomic DNA. Translation: AAB68481.2.
PIRiA93307. ODFF1.
RefSeqiYP_009047267.1. NC_024511.2.

3D structure databases

ProteinModelPortaliP00399.
SMRiP00399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0100176.

Proteomic databases

PaxDbiP00399.
PRIDEiP00399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0100861; FBpp0100176; FBgn0013674.
GeneIDi19893533.
KEGGidme:COX1.

Organism-specific databases

CTDi4512.
FlyBaseiFBgn0013674. mt:CoI.

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
GeneTreeiENSGT00390000001518.
InParanoidiP00399.
KOiK02256.
OMAiGYKMIAF.
OrthoDBiEOG091G035B.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

GenomeRNAii19893533.
PROiP00399.

Gene expression databases

BgeeiFBgn0013674.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_DROME
AccessioniPrimary (citable) accession number: P00399
Secondary accession number(s): B6E0P3
, O21461, Q34349, Q6TXT7, Q7GFY7, Q7GHI7, Q9MGN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 9, 2013
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts. In PubMed:19540318, further evidence for the presence of the same start codon coding for Ser in D.melanogaster CoI transcript is presented.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.