ID COX1_HUMAN Reviewed; 513 AA. AC P00395; Q34770; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 24-JAN-2024, entry version 223. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=7.1.1.9; DE AltName: Full=Cytochrome c oxidase polypeptide I; GN Name=MT-CO1; Synonyms=COI, COXI, MTCO1; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=7219534; DOI=10.1038/290457a0; RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., RA Smith A.J.H., Staden R., Young I.G.; RT "Sequence and organization of the human mitochondrial genome."; RL Nature 290:457-465(1981). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-235 AND ALA-415. RC TISSUE=Placenta; RX PubMed=7530363; DOI=10.1073/pnas.92.2.532; RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.; RT "Recent African origin of modern humans revealed by complete sequences of RT hominoid mitochondrial DNAs."; RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12949126; DOI=10.1093/molbev/msg230; RA Moilanen J.S., Finnila S., Majamaa K.; RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a RT segment of MTND5 gene in haplogroup J."; RL Mol. Biol. Evol. 20:2132-2142(2003). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=11130070; DOI=10.1038/35047064; RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12840039; DOI=10.1101/gr.686603; RA Ingman M., Gyllensten U.; RT "Mitochondrial genome variation and evolutionary history of Australian and RT New Guinean aborigines."; RL Genome Res. 13:1600-1606(2003). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6; RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., RA Irwin J.A., Parsons T.J.; RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase RT the power of forensic testing in Caucasians."; RL Int. J. Legal Med. 118:137-146(2004). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187. RX PubMed=6260957; DOI=10.1016/0022-2836(80)90196-5; RA Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.; RT "Cloning in single-stranded bacteriophage as an aid to rapid DNA RT sequencing."; RL J. Mol. Biol. 143:161-178(1980). RN [8] RP INVOLVEMENT IN DFNM. RX PubMed=10577941; DOI=10.1086/302658; RA Pandya A., Xia X.J., Erdenetungalag R., Amendola M., Landa B., RA Radnaabazar J., Dangaasuren B., Van Tuyle G., Nance W.E.; RT "Heterogenous point mutations in the mitochondrial tRNA Ser(UCN) precursor RT coexisting with the A1555G mutation in deaf students from Mongolia."; RL Am. J. Hum. Genet. 65:1803-1806(1999). RN [9] RP INTERACTION WITH COA3 AND SMIM20. RX PubMed=26321642; DOI=10.1016/j.celrep.2015.08.009; RA Dennerlein S., Oeljeklaus S., Jans D., Hellwig C., Bareth B., Jakobs S., RA Deckers M., Warscheid B., Rehling P.; RT "MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint during RT cytochrome c oxidase assembly."; RL Cell Rep. 12:1644-1655(2015). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [11] RP INTERACTION WITH TMEM177. RX PubMed=29154948; DOI=10.1016/j.bbamcr.2017.11.010; RA Lorenzi I., Oeljeklaus S., Aich A., Ronsoer C., Callegari S., Dudek J., RA Warscheid B., Dennerlein S., Rehling P.; RT "The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis."; RL Biochim. Biophys. Acta 1865:323-333(2017). RN [12] RP STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS), AND SUBUNIT. RX PubMed=28844695; DOI=10.1016/j.cell.2017.07.050; RA Guo R., Zong S., Wu M., Gu J., Yang M.; RT "Architecture of human mitochondrial respiratory megacomplex I2III2IV2."; RL Cell 170:1247-1257(2017). RN [13] RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS). RX PubMed=30030519; DOI=10.1038/s41422-018-0071-1; RA Zong S., Wu M., Gu J., Liu T., Guo R., Yang M.; RT "Structure of the intact 14-subunit human cytochrome c oxidase."; RL Cell Res. 28:1026-1034(2018). RN [14] RP VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305. RX PubMed=1757091; DOI=10.1007/bf00206061; RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., RA Utthanaphol P., Byrne E.; RT "Normal variants of human mitochondrial DNA and translation products: the RT building of a reference data base."; RL Hum. Genet. 88:139-145(1991). RN [15] RP VARIANT LHON LYS-GLN-LYS-513 INS. RX PubMed=1322638; RA Brown M.D., Yang C.-C., Trounce I., Torroni A., Lott M.T., Wallace D.C.; RT "A mitochondrial DNA variant, identified in Leber hereditary optic RT neuropathy patients, which extends the amino acid sequence of cytochrome c RT oxidase subunit I."; RL Am. J. Hum. Genet. 51:378-385(1992). RN [16] RP VARIANTS THR-273 AND THR-280, AND POSSIBLE INVOLVEMENT IN ACQUIRED RP IDIOPATHIC SIDEROBLASTIC ANEMIA. RX PubMed=9389715; RA Gattermann N., Retzlaff S., Wang Y.L., Hofhaus G., Heinisch J., Aul C., RA Schneider W.; RT "Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of RT cytochrome c oxidase in two patients with acquired idiopathic sideroblastic RT anemia."; RL Blood 90:4961-4972(1997). RN [17] RP VARIANTS THR-273 AND THR-280, AND POSSIBLE INVOLVEMENT IN ACQUIRED RP IDIOPATHIC SIDEROBLASTIC ANEMIA. RX PubMed=9851701; DOI=10.1046/j.1432-1327.1998.2580132.x; RA Broker S., Meunier B., Rich P., Gattermann N., Hofhaus G.; RT "MtDNA mutations associated with sideroblastic anaemia cause a defect of RT mitochondrial cytochrome c oxidase."; RL Eur. J. Biochem. 258:132-138(1998). RN [18] RP INVOLVEMENT IN RM-MT. RX PubMed=10980727; DOI=10.1212/wnl.55.5.644; RA Karadimas C.L., Greenstein P., Sue C.M., Joseph J.T., Tanji K., RA Haller R.G., Taivassalo T., Davidson M.M., Shanske S., Bonilla E., RA DiMauro S.; RT "Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of RT mitochondrial DNA."; RL Neurology 55:644-649(2000). RN [19] RP VARIANT MT-C4D ILE-196. RX PubMed=12140182; DOI=10.1093/hmg/11.16.1797; RA Varlamov D.A., Kudin A.P., Vielhaber S., Schroeder R., Sassen R., RA Becker A., Kunz D., Haug K., Rebstock J., Heils A., Elger C.E., Kunz W.S.; RT "Metabolic consequences of a novel missense mutation of the mtDNA CO I RT gene."; RL Hum. Mol. Genet. 11:1797-1805(2002). RN [20] RP VARIANT MT-C4D PHE-142, AND CHARACTERIZATION OF VARIANT MT-C4D PHE-142. RX PubMed=16284789; DOI=10.1007/s10048-005-0015-z; RA Lucioli S., Hoffmeier K., Carrozzo R., Tessa A., Ludwig B., RA Santorelli F.M.; RT "Introducing a novel human mtDNA mutation into the Paracoccus denitrificans RT COX I gene explains functional deficits in a patient."; RL Neurogenetics 7:51-57(2006). RN [21] RP VARIANTS CRC ASP-125 AND PRO-458. RX PubMed=16407113; DOI=10.1073/pnas.0505903103; RA Greaves L.C., Preston S.L., Tadrous P.J., Taylor R.W., Barron M.J., RA Oukrif D., Leedham S.J., Deheragoda M., Sasieni P., Novelli M.R., RA Jankowski J.A.Z., Turnbull D.M., Wright N.A., McDonald S.A.C.; RT "Mitochondrial DNA mutations are established in human colonic stem cells, RT and mutated clones expand by crypt fission."; RL Proc. Natl. Acad. Sci. U.S.A. 103:714-719(2006). RN [22] RP CHARACTERIZATION OF VARIANTS CRC ASP-125 AND PRO-458. RX PubMed=19218458; DOI=10.1073/pnas.0811450106; RA Namslauer I., Brzezinski P.; RT "A mitochondrial DNA mutation linked to colon cancer results in proton RT leaks in cytochrome c oxidase."; RL Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009). CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the CC mitochondrial electron transport chain which drives oxidative CC phosphorylation. The respiratory chain contains 3 multisubunit CC complexes succinate dehydrogenase (complex II, CII), ubiquinol- CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to CC transfer electrons derived from NADH and succinate to molecular oxygen, CC creating an electrochemical gradient over the inner membrane that CC drives transmembrane transport and the ATP synthase. Cytochrome c CC oxidase is the component of the respiratory chain that catalyzes the CC reduction of oxygen to water. Electrons originating from reduced CC cytochrome c in the intermembrane space (IMS) are transferred via the CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 CC to the active site in subunit 1, a binuclear center (BNC) formed by CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 CC water molecules using 4 electrons from cytochrome c in the IMS and 4 CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00401}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC Evidence={ECO:0000250|UniProtKB:P00401}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; CC Evidence={ECO:0000250|UniProtKB:P00401}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000269|PubMed:30030519}; CC Note=Binds 2 heme A groups non-covalently per subunit. CC {ECO:0000269|PubMed:30030519}; CC -!- COFACTOR: CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; CC Evidence={ECO:0000269|PubMed:30030519}; CC Note=Binds a copper B center. {ECO:0000269|PubMed:30030519}; CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000250|UniProtKB:P00401}. CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a CC multisubunit enzyme composed of 14 subunits. The complex is composed of CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in CC the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or CC COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, CC COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded CC in the nuclear genome (PubMed:30030519). The complex exists as a CC monomer or a dimer and forms supercomplexes (SCs) in the inner CC mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CC CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, CC complex III, CIII), resulting in different assemblies (supercomplex CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695). CC As a newly synthesized protein, rapidly incorporates into a multi- CC subunit assembly intermediate in the inner membrane, called MITRAC CC (mitochondrial translation regulation assembly intermediate of CC cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 CC and COX14. Within the MITRAC complex, interacts with COA3 and with CC SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly CC synthesized MT-CO1 and prevents its premature turnover CC (PubMed:26321642). Interacts with TMEM177 in a COX20-dependent manner CC (PubMed:29154948). {ECO:0000269|PubMed:26321642, CC ECO:0000269|PubMed:28844695, ECO:0000269|PubMed:29154948, CC ECO:0000269|PubMed:30030519}. CC -!- INTERACTION: CC P00395; Q9Y2R0: COA3; NbExp=11; IntAct=EBI-2117234, EBI-6570446; CC P00395; P13073: COX4I1; NbExp=2; IntAct=EBI-2117234, EBI-1056574; CC P00395; Q9BVV7: TIMM21; NbExp=3; IntAct=EBI-2117234, EBI-6570759; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein CC {ECO:0000269|PubMed:30030519}. CC -!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A CC maternally inherited form of Leber hereditary optic neuropathy, a CC mitochondrial disease resulting in bilateral painless loss of central CC vision due to selective degeneration of the retinal ganglion cells and CC their axons. The disorder shows incomplete penetrance and male CC predominance. Cardiac conduction defects and neurological defects have CC also been described in some LHON patients. LHON results from primary CC mitochondrial DNA mutations affecting the respiratory chain complexes. CC {ECO:0000269|PubMed:1322638}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Note=MT-CO1 may play a role in the pathogenesis of acquired CC idiopathic sideroblastic anemia, a disease characterized by inadequate CC formation of heme and excessive accumulation of iron in mitochondria. CC Mitochondrial iron overload may be attributable to mutations of CC mitochondrial DNA because these can cause respiratory chain CC dysfunction, thereby impairing reduction of ferric iron to ferrous CC iron. The reduced form of iron is essential to the last step of CC mitochondrial heme biosynthesis. {ECO:0000269|PubMed:9389715, CC ECO:0000269|PubMed:9851701}. CC -!- DISEASE: Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A CC disorder of the mitochondrial respiratory chain with heterogeneous CC clinical manifestations, ranging from isolated myopathy to severe CC multisystem disease affecting several tissues and organs. Features CC include hypertrophic cardiomyopathy, hepatomegaly and liver CC dysfunction, hypotonia, muscle weakness, exercise intolerance, CC developmental delay, delayed motor development and intellectual CC disability. Some affected individuals manifest a fatal hypertrophic CC cardiomyopathy resulting in neonatal death. A subset of patients CC manifest Leigh syndrome. {ECO:0000269|PubMed:12140182, CC ECO:0000269|PubMed:16284789}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]: CC Recurrent myoglobinuria is characterized by recurrent attacks of CC rhabdomyolysis (necrosis or disintegration of skeletal muscle) CC associated with muscle pain and weakness, and followed by excretion of CC myoglobin in the urine. {ECO:0000269|PubMed:10980727}. Note=The gene CC represented in this entry may be involved in disease pathogenesis. CC -!- DISEASE: Deafness, sensorineural, mitochondrial (DFNM) [MIM:500008]: A CC form of non-syndromic deafness with maternal inheritance. Affected CC individuals manifest progressive, postlingual, sensorineural hearing CC loss involving high frequencies. {ECO:0000269|PubMed:10577941}. CC Note=The disease is caused by variants affecting the gene represented CC in this entry. CC -!- DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease CC characterized by malignant lesions arising from the inner wall of the CC large intestine (the colon) and the rectum. Genetic alterations are CC often associated with progression from premalignant lesion (adenoma) to CC invasive adenocarcinoma. Risk factors for cancer of the colon and CC rectum include colon polyps, long-standing ulcerative colitis, and CC genetic family history. {ECO:0000269|PubMed:16407113, CC ECO:0000269|PubMed:19218458}. Note=The gene represented in this entry CC may be involved in disease pathogenesis. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V00662; CAA24028.1; -; Genomic_DNA. DR EMBL; J01415; AAB58945.1; -; Genomic_DNA. DR EMBL; D38112; BAA07292.1; -; Genomic_DNA. DR EMBL; AY339402; AAP89038.1; -; Genomic_DNA. DR EMBL; AY339403; AAP89051.1; -; Genomic_DNA. DR EMBL; AY339404; AAP89064.1; -; Genomic_DNA. DR EMBL; AY339405; AAP89077.1; -; Genomic_DNA. DR EMBL; AY339406; AAP89090.1; -; Genomic_DNA. DR EMBL; AY339407; AAP89103.1; -; Genomic_DNA. DR EMBL; AY339408; AAP89116.1; -; Genomic_DNA. DR EMBL; AY339409; AAP89129.1; -; Genomic_DNA. DR EMBL; AY339410; AAP89142.1; -; Genomic_DNA. DR EMBL; AY339411; AAP89155.1; -; Genomic_DNA. DR EMBL; AY339412; AAP89168.1; -; Genomic_DNA. DR EMBL; AY339421; AAP89285.1; -; Genomic_DNA. DR EMBL; AY339422; AAP89298.1; -; Genomic_DNA. DR EMBL; AY339423; AAP89311.1; -; Genomic_DNA. DR EMBL; AY339424; AAP89324.1; -; Genomic_DNA. DR EMBL; AY339425; AAP89337.1; -; Genomic_DNA. DR EMBL; AY339426; AAP89350.1; -; Genomic_DNA. DR EMBL; AY339427; AAP89363.1; -; Genomic_DNA. DR EMBL; AY339428; AAP89376.1; -; Genomic_DNA. DR EMBL; AY339429; AAP89389.1; -; Genomic_DNA. DR EMBL; AY339430; AAP89402.1; -; Genomic_DNA. DR EMBL; AY339431; AAP89415.1; -; Genomic_DNA. DR EMBL; AY339432; AAP89428.1; -; Genomic_DNA. DR EMBL; AY339433; AAP89441.1; -; Genomic_DNA. DR EMBL; AY339434; AAP89454.1; -; Genomic_DNA. DR EMBL; AY339435; AAP89467.1; -; Genomic_DNA. DR EMBL; AY339436; AAP89480.1; -; Genomic_DNA. DR EMBL; AY339437; AAP89493.1; -; Genomic_DNA. DR EMBL; AY339438; AAP89506.1; -; Genomic_DNA. DR EMBL; AY339439; AAP89519.1; -; Genomic_DNA. DR EMBL; AY339440; AAP89532.1; -; Genomic_DNA. DR EMBL; AY339441; AAP89545.1; -; Genomic_DNA. DR EMBL; AY339442; AAP89558.1; -; Genomic_DNA. DR EMBL; AY339443; AAP89571.1; -; Genomic_DNA. DR EMBL; AY339444; AAP89584.1; -; Genomic_DNA. DR EMBL; AY339445; AAP89597.1; -; Genomic_DNA. DR EMBL; AY339451; AAP89675.1; -; Genomic_DNA. DR EMBL; AY339452; AAP89688.1; -; Genomic_DNA. DR EMBL; AY339453; AAP89701.1; -; Genomic_DNA. DR EMBL; AY339454; AAP89714.1; -; Genomic_DNA. DR EMBL; AY339455; AAP89727.1; -; Genomic_DNA. DR EMBL; AY339456; AAP89740.1; -; Genomic_DNA. DR EMBL; AY339457; AAP89753.1; -; Genomic_DNA. DR EMBL; AY339458; AAP89766.1; -; Genomic_DNA. DR EMBL; AY339459; AAP89779.1; -; Genomic_DNA. DR EMBL; AY339460; AAP89792.1; -; Genomic_DNA. DR EMBL; AY339461; AAP89805.1; -; Genomic_DNA. DR EMBL; AY339462; AAP89818.1; -; Genomic_DNA. DR EMBL; AY339463; AAP89831.1; -; Genomic_DNA. DR EMBL; AY339464; AAP89844.1; -; Genomic_DNA. DR EMBL; AY339465; AAP89857.1; -; Genomic_DNA. DR EMBL; AY339466; AAP89870.1; -; Genomic_DNA. DR EMBL; AY339467; AAP89883.1; -; Genomic_DNA. DR EMBL; AY339468; AAP89896.1; -; Genomic_DNA. DR EMBL; AY339469; AAP89909.1; -; Genomic_DNA. DR EMBL; AY339470; AAP89922.1; -; Genomic_DNA. DR EMBL; AY339471; AAP89935.1; -; Genomic_DNA. DR EMBL; AY339472; AAP89948.1; -; Genomic_DNA. DR EMBL; AY339473; AAP89961.1; -; Genomic_DNA. DR EMBL; AY339474; AAP89974.1; -; Genomic_DNA. DR EMBL; AY339475; AAP89987.1; -; Genomic_DNA. DR EMBL; AY339476; AAP90000.1; -; Genomic_DNA. DR EMBL; AY339477; AAP90013.1; -; Genomic_DNA. DR EMBL; AY339478; AAP90026.1; -; Genomic_DNA. DR EMBL; AY339479; AAP90039.1; -; Genomic_DNA. DR EMBL; AY339480; AAP90052.1; -; Genomic_DNA. DR EMBL; AY339481; AAP90065.1; -; Genomic_DNA. DR EMBL; AY339482; AAP90078.1; -; Genomic_DNA. DR EMBL; AY339483; AAP90091.1; -; Genomic_DNA. DR EMBL; AY339484; AAP90104.1; -; Genomic_DNA. DR EMBL; AY339485; AAP90117.1; -; Genomic_DNA. DR EMBL; AY339486; AAP90130.1; -; Genomic_DNA. DR EMBL; AY339487; AAP90143.1; -; Genomic_DNA. DR EMBL; AY339488; AAP90156.1; -; Genomic_DNA. DR EMBL; AY339489; AAP90169.1; -; Genomic_DNA. DR EMBL; AY339490; AAP90182.1; -; Genomic_DNA. DR EMBL; AY339491; AAP90195.1; -; Genomic_DNA. DR EMBL; AY339492; AAP90208.1; -; Genomic_DNA. DR EMBL; AY339493; AAP90221.1; -; Genomic_DNA. DR EMBL; AY339494; AAP90234.1; -; Genomic_DNA. DR EMBL; AY339495; AAP90247.1; -; Genomic_DNA. DR EMBL; AY339496; AAP90260.1; -; Genomic_DNA. DR EMBL; AY339497; AAP90273.1; -; Genomic_DNA. DR EMBL; AY339498; AAP90286.1; -; Genomic_DNA. DR EMBL; AY339499; AAP90299.1; -; Genomic_DNA. DR EMBL; AY339500; AAP90312.1; -; Genomic_DNA. DR EMBL; AY339501; AAP90325.1; -; Genomic_DNA. DR EMBL; AY339502; AAP90338.1; -; Genomic_DNA. DR EMBL; AY339503; AAP90351.1; -; Genomic_DNA. DR EMBL; AY339504; AAP90364.1; -; Genomic_DNA. DR EMBL; AY339505; AAP90377.1; -; Genomic_DNA. DR EMBL; AY339506; AAP90390.1; -; Genomic_DNA. DR EMBL; AY339507; AAP90403.1; -; Genomic_DNA. DR EMBL; AY339508; AAP90416.1; -; Genomic_DNA. DR EMBL; AY339509; AAP90429.1; -; Genomic_DNA. DR EMBL; AY339510; AAP90442.1; -; Genomic_DNA. DR EMBL; AY339511; AAP90455.1; -; Genomic_DNA. DR EMBL; AY339512; AAP90468.1; -; Genomic_DNA. DR EMBL; AY339513; AAP90481.1; -; Genomic_DNA. DR EMBL; AY339514; AAP90494.1; -; Genomic_DNA. DR EMBL; AY339515; AAP90507.1; -; Genomic_DNA. DR EMBL; AY339516; AAP90520.1; -; Genomic_DNA. DR EMBL; AY339517; AAP90533.1; -; Genomic_DNA. DR EMBL; AY339518; AAP90546.1; -; Genomic_DNA. DR EMBL; AY339519; AAP90559.1; -; Genomic_DNA. DR EMBL; AY339520; AAP90572.1; -; Genomic_DNA. DR EMBL; AY339521; AAP90585.1; -; Genomic_DNA. DR EMBL; AY339522; AAP90598.1; -; Genomic_DNA. DR EMBL; AY339523; AAP90611.1; -; Genomic_DNA. DR EMBL; AY339524; AAP90624.1; -; Genomic_DNA. DR EMBL; AY339525; AAP90637.1; -; Genomic_DNA. DR EMBL; AY339526; AAP90650.1; -; Genomic_DNA. DR EMBL; AY339527; AAP90663.1; -; Genomic_DNA. DR EMBL; AY339528; AAP90676.1; -; Genomic_DNA. DR EMBL; AY339529; AAP90689.1; -; Genomic_DNA. DR EMBL; AY339530; AAP90702.1; -; Genomic_DNA. DR EMBL; AY339531; AAP90715.1; -; Genomic_DNA. DR EMBL; AY339532; AAP90728.1; -; Genomic_DNA. DR EMBL; AY339533; AAP90741.1; -; Genomic_DNA. DR EMBL; AY339534; AAP90754.1; -; Genomic_DNA. DR EMBL; AY339535; AAP90767.1; -; Genomic_DNA. DR EMBL; AY339536; AAP90780.1; -; Genomic_DNA. DR EMBL; AY339537; AAP90793.1; -; Genomic_DNA. DR EMBL; AY339538; AAP90806.1; -; Genomic_DNA. DR EMBL; AY339539; AAP90819.1; -; Genomic_DNA. DR EMBL; AY339540; AAP90832.1; -; Genomic_DNA. DR EMBL; AY339541; AAP90845.1; -; Genomic_DNA. DR EMBL; AY339542; AAP90858.1; -; Genomic_DNA. DR EMBL; AY339543; AAP90871.1; -; Genomic_DNA. DR EMBL; AY339544; AAP90884.1; -; Genomic_DNA. DR EMBL; AY339545; AAP90897.1; -; Genomic_DNA. DR EMBL; AY339546; AAP90910.1; -; Genomic_DNA. DR EMBL; AY339547; AAP90923.1; -; Genomic_DNA. DR EMBL; AY339548; AAP90936.1; -; Genomic_DNA. DR EMBL; AY339549; AAP90949.1; -; Genomic_DNA. DR EMBL; AY339550; AAP90962.1; -; Genomic_DNA. DR EMBL; AY339551; AAP90975.1; -; Genomic_DNA. DR EMBL; AY339552; AAP90988.1; -; Genomic_DNA. DR EMBL; AY339553; AAP91001.1; -; Genomic_DNA. DR EMBL; AY339554; AAP91014.1; -; Genomic_DNA. DR EMBL; AY339555; AAP91027.1; -; Genomic_DNA. DR EMBL; AY339556; AAP91040.1; -; Genomic_DNA. DR EMBL; AY339557; AAP91053.1; -; Genomic_DNA. DR EMBL; AY339558; AAP91066.1; -; Genomic_DNA. DR EMBL; AY339559; AAP91079.1; -; Genomic_DNA. DR EMBL; AY339560; AAP91092.1; -; Genomic_DNA. DR EMBL; AY339563; AAP91131.1; -; Genomic_DNA. DR EMBL; AY339564; AAP91144.1; -; Genomic_DNA. DR EMBL; AY339566; AAP91170.1; -; Genomic_DNA. DR EMBL; AY339567; AAP91183.1; -; Genomic_DNA. DR EMBL; AY339568; AAP91196.1; -; Genomic_DNA. DR EMBL; AY339569; AAP91209.1; -; Genomic_DNA. DR EMBL; AY339570; AAP91222.1; -; Genomic_DNA. DR EMBL; AY339571; AAP91235.1; -; Genomic_DNA. DR EMBL; AY339572; AAP91248.1; -; Genomic_DNA. DR EMBL; AY339573; AAP91261.1; -; Genomic_DNA. DR EMBL; AY339574; AAP91274.1; -; Genomic_DNA. DR EMBL; AY339575; AAP91287.1; -; Genomic_DNA. DR EMBL; AY339576; AAP91300.1; -; Genomic_DNA. DR EMBL; AY339577; AAP91313.1; -; Genomic_DNA. DR EMBL; AY339578; AAP91326.1; -; Genomic_DNA. DR EMBL; AY339579; AAP91339.1; -; Genomic_DNA. DR EMBL; AY339580; AAP91352.1; -; Genomic_DNA. DR EMBL; AY339581; AAP91365.1; -; Genomic_DNA. DR EMBL; AY339582; AAP91378.1; -; Genomic_DNA. DR EMBL; AY339583; AAP91391.1; -; Genomic_DNA. DR EMBL; AY339584; AAP91404.1; -; Genomic_DNA. DR EMBL; AY339585; AAP91417.1; -; Genomic_DNA. DR EMBL; AY339586; AAP91430.1; -; Genomic_DNA. DR EMBL; AY339587; AAP91443.1; -; Genomic_DNA. DR EMBL; AY339588; AAP91456.1; -; Genomic_DNA. DR EMBL; AY339589; AAP91469.1; -; Genomic_DNA. DR EMBL; AY339590; AAP91482.1; -; Genomic_DNA. DR EMBL; AY339591; AAP91495.1; -; Genomic_DNA. DR EMBL; AY339592; AAP91508.1; -; Genomic_DNA. DR EMBL; AY339593; AAP91521.1; -; Genomic_DNA. DR EMBL; AF346963; AAK17209.1; -; Genomic_DNA. DR EMBL; AF346964; AAK17222.1; -; Genomic_DNA. DR EMBL; AF346965; AAK17235.1; -; Genomic_DNA. DR EMBL; AF346966; AAK17248.1; -; Genomic_DNA. DR EMBL; AF346967; AAK17261.1; -; Genomic_DNA. DR EMBL; AF346970; AAK17300.1; -; Genomic_DNA. DR EMBL; AF346971; AAK17313.1; -; Genomic_DNA. DR EMBL; AF346972; AAK17326.1; -; Genomic_DNA. DR EMBL; AF346973; AAK17339.1; -; Genomic_DNA. DR EMBL; AF346974; AAK17352.1; -; Genomic_DNA. DR EMBL; AF346975; AAK17365.1; -; Genomic_DNA. DR EMBL; AF346976; AAK17378.1; -; Genomic_DNA. DR EMBL; AF346977; AAK17391.1; -; Genomic_DNA. DR EMBL; AF346978; AAK17404.1; -; Genomic_DNA. DR EMBL; AF346979; AAK17417.1; -; Genomic_DNA. DR EMBL; AF346980; AAK17430.1; -; Genomic_DNA. DR EMBL; AF346981; AAK17443.1; -; Genomic_DNA. DR EMBL; AF346982; AAK17456.1; -; Genomic_DNA. DR EMBL; AF346983; AAK17469.1; -; Genomic_DNA. DR EMBL; AF346984; AAK17482.1; -; Genomic_DNA. DR EMBL; AF346988; AAK17534.1; -; Genomic_DNA. DR EMBL; AF346989; AAK17547.1; -; Genomic_DNA. DR EMBL; AF346990; AAK17560.1; -; Genomic_DNA. DR EMBL; AF346991; AAK17573.1; -; Genomic_DNA. DR EMBL; AF346993; AAK17599.1; -; Genomic_DNA. DR EMBL; AF346994; AAK17612.1; -; Genomic_DNA. DR EMBL; AF346995; AAK17625.1; -; Genomic_DNA. DR EMBL; AF346998; AAK17664.1; -; Genomic_DNA. DR EMBL; AF347000; AAK17690.1; -; Genomic_DNA. DR EMBL; AF347001; AAK17703.1; -; Genomic_DNA. DR EMBL; AF347003; AAK17729.1; -; Genomic_DNA. DR EMBL; AF347004; AAK17742.1; -; Genomic_DNA. DR EMBL; AF347007; AAK17781.1; -; Genomic_DNA. DR EMBL; AF347010; AAK17820.1; -; Genomic_DNA. DR EMBL; AF347011; AAK17833.1; -; Genomic_DNA. DR EMBL; AF347012; AAK17846.1; -; Genomic_DNA. DR EMBL; AF347013; AAK17859.1; -; Genomic_DNA. DR EMBL; AF347014; AAK17872.1; -; Genomic_DNA. DR EMBL; AF347015; AAK17885.1; -; Genomic_DNA. DR EMBL; AY289051; AAP47882.1; -; Genomic_DNA. DR EMBL; AY289052; AAP47895.1; -; Genomic_DNA. DR EMBL; AY289053; AAP47908.1; -; Genomic_DNA. DR EMBL; AY289055; AAP47934.1; -; Genomic_DNA. DR EMBL; AY289056; AAP47947.1; -; Genomic_DNA. DR EMBL; AY289057; AAP47960.1; -; Genomic_DNA. DR EMBL; AY289058; AAP47973.1; -; Genomic_DNA. DR EMBL; AY289059; AAP47986.1; -; Genomic_DNA. DR EMBL; AY289060; AAP47999.1; -; Genomic_DNA. DR EMBL; AY289061; AAP48012.1; -; Genomic_DNA. DR EMBL; AY289062; AAP48025.1; -; Genomic_DNA. DR EMBL; AY289064; AAP48051.1; -; Genomic_DNA. DR EMBL; AY289065; AAP48064.1; -; Genomic_DNA. DR EMBL; AY289066; AAP48077.1; -; Genomic_DNA. DR EMBL; AY289067; AAP48090.1; -; Genomic_DNA. DR EMBL; AY289068; AAP48103.1; -; Genomic_DNA. DR EMBL; AY289069; AAP48116.1; -; Genomic_DNA. DR EMBL; AY289070; AAP48129.1; -; Genomic_DNA. DR EMBL; AY289071; AAP48142.1; -; Genomic_DNA. DR EMBL; AY289073; AAP48168.1; -; Genomic_DNA. DR EMBL; AY289074; AAP48181.1; -; Genomic_DNA. DR EMBL; AY289075; AAP48194.1; -; Genomic_DNA. DR EMBL; AY289076; AAP48207.1; -; Genomic_DNA. DR EMBL; AY289077; AAP48220.1; -; Genomic_DNA. DR EMBL; AY289078; AAP48233.1; -; Genomic_DNA. DR EMBL; AY289079; AAP48246.1; -; Genomic_DNA. DR EMBL; AY289080; AAP48259.1; -; Genomic_DNA. DR EMBL; AY289081; AAP48272.1; -; Genomic_DNA. DR EMBL; AY289082; AAP48285.1; -; Genomic_DNA. DR EMBL; AY289083; AAP48298.1; -; Genomic_DNA. DR EMBL; AY289084; AAP48311.1; -; Genomic_DNA. DR EMBL; AY289085; AAP48324.1; -; Genomic_DNA. DR EMBL; AY289086; AAP48337.1; -; Genomic_DNA. DR EMBL; AY289088; AAP48363.1; -; Genomic_DNA. DR EMBL; AY289089; AAP48376.1; -; Genomic_DNA. DR EMBL; AY289090; AAP48389.1; -; Genomic_DNA. DR EMBL; AY289092; AAP48415.1; -; Genomic_DNA. DR EMBL; AY289093; AAP48427.1; -; Genomic_DNA. DR EMBL; AY289094; AAP48440.1; -; Genomic_DNA. DR EMBL; AY289095; AAP48453.1; -; Genomic_DNA. DR EMBL; AY289096; AAP48466.1; -; Genomic_DNA. DR EMBL; AY289097; AAP48479.1; -; Genomic_DNA. DR EMBL; AY289098; AAP48492.1; -; Genomic_DNA. DR EMBL; AY289099; AAP48505.1; -; Genomic_DNA. DR EMBL; AY289100; AAP48518.1; -; Genomic_DNA. DR EMBL; AY289101; AAP48531.1; -; Genomic_DNA. DR EMBL; AY289102; AAP48544.1; -; Genomic_DNA. DR EMBL; AY495090; AAR92498.1; -; Genomic_DNA. DR EMBL; AY495091; AAR92511.1; -; Genomic_DNA. DR EMBL; AY495092; AAR92524.1; -; Genomic_DNA. DR EMBL; AY495093; AAR92537.1; -; Genomic_DNA. DR EMBL; AY495094; AAR92550.1; -; Genomic_DNA. DR EMBL; AY495095; AAR92563.1; -; Genomic_DNA. DR EMBL; AY495096; AAR92576.1; -; Genomic_DNA. DR EMBL; AY495097; AAR92589.1; -; Genomic_DNA. DR EMBL; AY495098; AAR92602.1; -; Genomic_DNA. DR EMBL; AY495099; AAR92615.1; -; Genomic_DNA. DR EMBL; AY495100; AAR92628.1; -; Genomic_DNA. DR EMBL; AY495101; AAR92641.1; -; Genomic_DNA. DR EMBL; AY495102; AAR92654.1; -; Genomic_DNA. DR EMBL; AY495103; AAR92667.1; -; Genomic_DNA. DR EMBL; AY495104; AAR92680.1; -; Genomic_DNA. DR EMBL; AY495105; AAR92693.1; -; Genomic_DNA. DR EMBL; AY495106; AAR92706.1; -; Genomic_DNA. DR EMBL; AY495107; AAR92719.1; -; Genomic_DNA. DR EMBL; AY495108; AAR92732.1; -; Genomic_DNA. DR EMBL; AY495109; AAR92745.1; -; Genomic_DNA. DR EMBL; AY495110; AAR92758.1; -; Genomic_DNA. DR EMBL; AY495111; AAR92771.1; -; Genomic_DNA. DR EMBL; AY495112; AAR92784.1; -; Genomic_DNA. DR EMBL; AY495113; AAR92797.1; -; Genomic_DNA. DR EMBL; AY495114; AAR92810.1; -; Genomic_DNA. DR EMBL; AY495116; AAR92836.1; -; Genomic_DNA. DR EMBL; AY495117; AAR92849.1; -; Genomic_DNA. DR EMBL; AY495118; AAR92862.1; -; Genomic_DNA. DR EMBL; AY495119; AAR92875.1; -; Genomic_DNA. DR EMBL; AY495120; AAR92888.1; -; Genomic_DNA. DR EMBL; AY495121; AAR92901.1; -; Genomic_DNA. DR EMBL; AY495122; AAR92914.1; -; Genomic_DNA. DR EMBL; AY495123; AAR92927.1; -; Genomic_DNA. DR EMBL; AY495124; AAR92940.1; -; Genomic_DNA. DR EMBL; AY495125; AAR92953.1; -; Genomic_DNA. DR EMBL; AY495126; AAR92966.1; -; Genomic_DNA. DR EMBL; AY495127; AAR92979.1; -; Genomic_DNA. DR EMBL; AY495128; AAR92992.1; -; Genomic_DNA. DR EMBL; AY495129; AAR93005.1; -; Genomic_DNA. DR EMBL; AY495130; AAR93018.1; -; Genomic_DNA. DR EMBL; AY495131; AAR93031.1; -; Genomic_DNA. DR EMBL; AY495132; AAR93044.1; -; Genomic_DNA. DR EMBL; AY495133; AAR93057.1; -; Genomic_DNA. DR EMBL; AY495134; AAR93070.1; -; Genomic_DNA. DR EMBL; AY495135; AAR93083.1; -; Genomic_DNA. DR EMBL; AY495136; AAR93096.1; -; Genomic_DNA. DR EMBL; AY495137; AAR93109.1; -; Genomic_DNA. DR EMBL; AY495138; AAR93122.1; -; Genomic_DNA. DR EMBL; AY495139; AAR93135.1; -; Genomic_DNA. DR EMBL; AY495140; AAR93148.1; -; Genomic_DNA. DR EMBL; AY495141; AAR93161.1; -; Genomic_DNA. DR EMBL; AY495142; AAR93174.1; -; Genomic_DNA. DR EMBL; AY495143; AAR93187.1; -; Genomic_DNA. DR EMBL; AY495144; AAR93200.1; -; Genomic_DNA. DR EMBL; AY495145; AAR93213.1; -; Genomic_DNA. DR EMBL; AY495147; AAR93239.1; -; Genomic_DNA. DR EMBL; AY495148; AAR93252.1; -; Genomic_DNA. DR EMBL; AY495149; AAR93265.1; -; Genomic_DNA. DR EMBL; AY495150; AAR93278.1; -; Genomic_DNA. DR EMBL; AY495151; AAR93291.1; -; Genomic_DNA. DR EMBL; AY495152; AAR93304.1; -; Genomic_DNA. DR EMBL; AY495153; AAR93317.1; -; Genomic_DNA. DR EMBL; AY495154; AAR93330.1; -; Genomic_DNA. DR EMBL; AY495155; AAR93343.1; -; Genomic_DNA. DR EMBL; AY495156; AAR93356.1; -; Genomic_DNA. DR EMBL; AY495157; AAR93369.1; -; Genomic_DNA. DR EMBL; AY495158; AAR93382.1; -; Genomic_DNA. DR EMBL; AY495159; AAR93395.1; -; Genomic_DNA. DR EMBL; AY495160; AAR93408.1; -; Genomic_DNA. DR EMBL; AY495161; AAR93421.1; -; Genomic_DNA. DR EMBL; AY495162; AAR93434.1; -; Genomic_DNA. DR EMBL; AY495163; AAR93447.1; -; Genomic_DNA. DR EMBL; AY495164; AAR93460.1; -; Genomic_DNA. DR EMBL; AY495165; AAR93473.1; -; Genomic_DNA. DR EMBL; AY495166; AAR93486.1; -; Genomic_DNA. DR EMBL; AY495167; AAR93499.1; -; Genomic_DNA. DR EMBL; AY495168; AAR93512.1; -; Genomic_DNA. DR EMBL; AY495169; AAR93525.1; -; Genomic_DNA. DR EMBL; AY495170; AAR93538.1; -; Genomic_DNA. DR EMBL; AY495171; AAR93551.1; -; Genomic_DNA. DR EMBL; AY495172; AAR93564.1; -; Genomic_DNA. DR EMBL; AY495173; AAR93577.1; -; Genomic_DNA. DR EMBL; AY495174; AAR93590.1; -; Genomic_DNA. DR EMBL; AY495175; AAR93603.1; -; Genomic_DNA. DR EMBL; AY495176; AAR93616.1; -; Genomic_DNA. DR EMBL; AY495177; AAR93629.1; -; Genomic_DNA. DR EMBL; AY495178; AAR93642.1; -; Genomic_DNA. DR EMBL; AY495179; AAR93655.1; -; Genomic_DNA. DR EMBL; AY495180; AAR93668.1; -; Genomic_DNA. DR EMBL; AY495181; AAR93681.1; -; Genomic_DNA. DR EMBL; AY495182; AAR93694.1; -; Genomic_DNA. DR EMBL; AY495183; AAR93707.1; -; Genomic_DNA. DR EMBL; AY495184; AAR93720.1; -; Genomic_DNA. DR EMBL; AY495185; AAR93733.1; -; Genomic_DNA. DR EMBL; AY495186; AAR93746.1; -; Genomic_DNA. DR EMBL; AY495187; AAR93759.1; -; Genomic_DNA. DR EMBL; AY495188; AAR93772.1; -; Genomic_DNA. DR EMBL; AY495189; AAR93785.1; -; Genomic_DNA. DR EMBL; AY495190; AAR93798.1; -; Genomic_DNA. DR EMBL; AY495191; AAR93811.1; -; Genomic_DNA. DR EMBL; AY495192; AAR93824.1; -; Genomic_DNA. DR EMBL; AY495193; AAR93837.1; -; Genomic_DNA. DR EMBL; AY495194; AAR93850.1; -; Genomic_DNA. DR EMBL; AY495195; AAR93863.1; -; Genomic_DNA. DR EMBL; AY495196; AAR93876.1; -; Genomic_DNA. DR EMBL; AY495197; AAR93889.1; -; Genomic_DNA. DR EMBL; AY495198; AAR93902.1; -; Genomic_DNA. DR EMBL; AY495199; AAR93915.1; -; Genomic_DNA. DR EMBL; AY495200; AAR93928.1; -; Genomic_DNA. DR EMBL; AY495201; AAR93941.1; -; Genomic_DNA. DR EMBL; AY495202; AAR93954.1; -; Genomic_DNA. DR EMBL; AY495203; AAR93967.1; -; Genomic_DNA. DR EMBL; AY495204; AAR93980.1; -; Genomic_DNA. DR EMBL; AY495205; AAR93993.1; -; Genomic_DNA. DR EMBL; AY495206; AAR94006.1; -; Genomic_DNA. DR EMBL; AY495207; AAR94019.1; -; Genomic_DNA. DR EMBL; AY495208; AAR94032.1; -; Genomic_DNA. DR EMBL; AY495209; AAR94045.1; -; Genomic_DNA. DR EMBL; AY495210; AAR94058.1; -; Genomic_DNA. DR EMBL; AY495211; AAR94071.1; -; Genomic_DNA. DR EMBL; AY495212; AAR94084.1; -; Genomic_DNA. DR EMBL; AY495213; AAR94097.1; -; Genomic_DNA. DR EMBL; AY495214; AAR94110.1; -; Genomic_DNA. DR EMBL; AY495215; AAR94123.1; -; Genomic_DNA. DR EMBL; AY495216; AAR94136.1; -; Genomic_DNA. DR EMBL; AY495217; AAR94149.1; -; Genomic_DNA. DR EMBL; AY495218; AAR94162.1; -; Genomic_DNA. DR EMBL; AY495219; AAR94175.1; -; Genomic_DNA. DR EMBL; AY495220; AAR94188.1; -; Genomic_DNA. DR EMBL; AY495221; AAR94201.1; -; Genomic_DNA. DR EMBL; AY495222; AAR94214.1; -; Genomic_DNA. DR EMBL; AY495223; AAR94227.1; -; Genomic_DNA. DR EMBL; AY495224; AAR94240.1; -; Genomic_DNA. DR EMBL; AY495225; AAR94253.1; -; Genomic_DNA. DR EMBL; AY495226; AAR94266.1; -; Genomic_DNA. DR EMBL; AY495228; AAR94292.1; -; Genomic_DNA. DR EMBL; AY495230; AAR94318.1; -; Genomic_DNA. DR EMBL; AY495231; AAR94331.1; -; Genomic_DNA. DR EMBL; AY495232; AAR94344.1; -; Genomic_DNA. DR EMBL; AY495233; AAR94357.1; -; Genomic_DNA. DR EMBL; AY495234; AAR94370.1; -; Genomic_DNA. DR EMBL; AY495235; AAR94383.1; -; Genomic_DNA. DR EMBL; AY495236; AAR94396.1; -; Genomic_DNA. DR EMBL; AY495237; AAR94409.1; -; Genomic_DNA. DR EMBL; AY495239; AAR94435.1; -; Genomic_DNA. DR EMBL; AY495240; AAR94448.1; -; Genomic_DNA. DR EMBL; AY495241; AAR94461.1; -; Genomic_DNA. DR EMBL; AY495242; AAR94474.1; -; Genomic_DNA. DR EMBL; AY495243; AAR94487.1; -; Genomic_DNA. DR EMBL; AY495244; AAR94500.1; -; Genomic_DNA. DR EMBL; AY495245; AAR94513.1; -; Genomic_DNA. DR EMBL; AY495246; AAR94526.1; -; Genomic_DNA. DR EMBL; AY495247; AAR94539.1; -; Genomic_DNA. DR EMBL; AY495248; AAR94552.1; -; Genomic_DNA. DR EMBL; AY495249; AAR94565.1; -; Genomic_DNA. DR EMBL; AY495250; AAR94578.1; -; Genomic_DNA. DR EMBL; AY495251; AAR94591.1; -; Genomic_DNA. DR EMBL; AY495252; AAR94604.1; -; Genomic_DNA. DR EMBL; AY495253; AAR94617.1; -; Genomic_DNA. DR EMBL; AY495254; AAR94630.1; -; Genomic_DNA. DR EMBL; AY495255; AAR94643.1; -; Genomic_DNA. DR EMBL; AY495256; AAR94656.1; -; Genomic_DNA. DR EMBL; AY495258; AAR94682.1; -; Genomic_DNA. DR EMBL; AY495259; AAR94695.1; -; Genomic_DNA. DR EMBL; AY495261; AAR94721.1; -; Genomic_DNA. DR EMBL; AY495262; AAR94734.1; -; Genomic_DNA. DR EMBL; AY495263; AAR94747.1; -; Genomic_DNA. DR EMBL; AY495264; AAR94760.1; -; Genomic_DNA. DR EMBL; AY495265; AAR94773.1; -; Genomic_DNA. DR EMBL; AY495266; AAR94786.1; -; Genomic_DNA. DR EMBL; AY495267; AAR94799.1; -; Genomic_DNA. DR EMBL; AY495268; AAR94812.1; -; Genomic_DNA. DR EMBL; AY495269; AAR94825.1; -; Genomic_DNA. DR EMBL; AY495270; AAR94838.1; -; Genomic_DNA. DR EMBL; AY495271; AAR94851.1; -; Genomic_DNA. DR EMBL; AY495272; AAR94864.1; -; Genomic_DNA. DR EMBL; AY495273; AAR94877.1; -; Genomic_DNA. DR EMBL; AY495274; AAR94890.1; -; Genomic_DNA. DR EMBL; AY495275; AAR94903.1; -; Genomic_DNA. DR EMBL; AY495276; AAR94916.1; -; Genomic_DNA. DR EMBL; AY495277; AAR94929.1; -; Genomic_DNA. DR EMBL; AY495278; AAR94942.1; -; Genomic_DNA. DR EMBL; AY495279; AAR94955.1; -; Genomic_DNA. DR EMBL; AY495280; AAR94968.1; -; Genomic_DNA. DR EMBL; AY495281; AAR94981.1; -; Genomic_DNA. DR EMBL; AY495282; AAR94994.1; -; Genomic_DNA. DR EMBL; AY495283; AAR95007.1; -; Genomic_DNA. DR EMBL; AY495284; AAR95020.1; -; Genomic_DNA. DR EMBL; AY495285; AAR95033.1; -; Genomic_DNA. DR EMBL; AY495286; AAR95046.1; -; Genomic_DNA. DR EMBL; AY495287; AAR95059.1; -; Genomic_DNA. DR EMBL; AY495288; AAR95072.1; -; Genomic_DNA. DR EMBL; AY495289; AAR95085.1; -; Genomic_DNA. DR EMBL; AY495290; AAR95098.1; -; Genomic_DNA. DR EMBL; AY495291; AAR95111.1; -; Genomic_DNA. DR EMBL; AY495292; AAR95124.1; -; Genomic_DNA. DR EMBL; AY495293; AAR95137.1; -; Genomic_DNA. DR EMBL; AY495294; AAR95150.1; -; Genomic_DNA. DR EMBL; AY495295; AAR95163.1; -; Genomic_DNA. DR EMBL; AY495297; AAR95189.1; -; Genomic_DNA. DR EMBL; AY495298; AAR95202.1; -; Genomic_DNA. DR EMBL; AY495299; AAR95215.1; -; Genomic_DNA. DR EMBL; AY495300; AAR95228.1; -; Genomic_DNA. DR EMBL; AY495301; AAR95241.1; -; Genomic_DNA. DR EMBL; AY495302; AAR95254.1; -; Genomic_DNA. DR EMBL; AY495303; AAR95267.1; -; Genomic_DNA. DR EMBL; AY495304; AAR95280.1; -; Genomic_DNA. DR EMBL; AY495305; AAR95293.1; -; Genomic_DNA. DR EMBL; AY495306; AAR95306.1; -; Genomic_DNA. DR EMBL; AY495307; AAR95319.1; -; Genomic_DNA. DR EMBL; AY495308; AAR95332.1; -; Genomic_DNA. DR EMBL; AY495309; AAR95345.1; -; Genomic_DNA. DR EMBL; AY495310; AAR95358.1; -; Genomic_DNA. DR EMBL; AY495311; AAR95371.1; -; Genomic_DNA. DR EMBL; AY495312; AAR95384.1; -; Genomic_DNA. DR EMBL; AY495313; AAR95397.1; -; Genomic_DNA. DR EMBL; AY495314; AAR95410.1; -; Genomic_DNA. DR EMBL; AY495315; AAR95423.1; -; Genomic_DNA. DR EMBL; AY495316; AAR95436.1; -; Genomic_DNA. DR EMBL; AY495317; AAR95449.1; -; Genomic_DNA. DR EMBL; AY495318; AAR95462.1; -; Genomic_DNA. DR EMBL; AY495319; AAR95475.1; -; Genomic_DNA. DR EMBL; AY495320; AAR95488.1; -; Genomic_DNA. DR EMBL; AY495322; AAR95514.1; -; Genomic_DNA. DR EMBL; AY495323; AAR95527.1; -; Genomic_DNA. DR EMBL; AY495324; AAR95540.1; -; Genomic_DNA. DR EMBL; AY495325; AAR95553.1; -; Genomic_DNA. DR EMBL; AY495326; AAR95566.1; -; Genomic_DNA. DR EMBL; AY495327; AAR95579.1; -; Genomic_DNA. DR EMBL; AY495328; AAR95592.1; -; Genomic_DNA. DR EMBL; AY495329; AAR95605.1; -; Genomic_DNA. DR EMBL; AY495330; AAR95618.1; -; Genomic_DNA. DR EMBL; M10546; AAA65503.1; -; Genomic_DNA. DR PIR; A00463; ODHU1. DR RefSeq; YP_003024028.1; NC_012920.1. DR PDB; 5Z62; EM; 3.60 A; A=1-513. DR PDBsum; 5Z62; -. DR AlphaFoldDB; P00395; -. DR SMR; P00395; -. DR BioGRID; 110615; 64. DR ComplexPortal; CPX-6123; Mitochondrial respiratory chain complex IV. DR CORUM; P00395; -. DR IntAct; P00395; 43. DR MINT; P00395; -. DR STRING; 9606.ENSP00000354499; -. DR BindingDB; P00395; -. DR ChEMBL; CHEMBL6173; -. DR DrugBank; DB02659; Cholic Acid. DR DrugBank; DB09130; Copper. DR DrugBank; DB06778; Cupric sulfate. DR DrugBank; DB04464; N-Formylmethionine. DR DrugBank; DB09140; Oxygen. DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily. DR GlyCosmos; P00395; 1 site, 1 glycan. DR GlyGen; P00395; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; P00395; -. DR PhosphoSitePlus; P00395; -. DR SwissPalm; P00395; -. DR BioMuta; MT-CO1; -. DR DMDM; 116977; -. DR EPD; P00395; -. DR jPOST; P00395; -. DR MassIVE; P00395; -. DR PaxDb; 9606-ENSP00000354499; -. DR PeptideAtlas; P00395; -. DR ProteomicsDB; 51246; -. DR Pumba; P00395; -. DR TopDownProteomics; P00395; -. DR Antibodypedia; 4261; 258 antibodies from 32 providers. DR DNASU; 4512; -. DR Ensembl; ENST00000361624.2; ENSP00000354499.2; ENSG00000198804.2. DR GeneID; 4512; -. DR KEGG; hsa:4512; -. DR AGR; HGNC:7419; -. DR CTD; 4512; -. DR DisGeNET; 4512; -. DR GeneCards; MT-CO1; -. DR GeneReviews; MT-CO1; -. DR HGNC; HGNC:7419; MT-CO1. DR HPA; ENSG00000198804; Tissue enhanced (heart muscle, tongue). DR MalaCards; MT-CO1; -. DR MIM; 114500; phenotype. DR MIM; 220110; phenotype. DR MIM; 500008; phenotype. DR MIM; 516030; gene. DR MIM; 535000; phenotype. DR MIM; 550500; phenotype. DR neXtProt; NX_P00395; -. DR OpenTargets; ENSG00000198804; -. DR Orphanet; 99845; Genetic recurrent myoglobinuria. DR Orphanet; 254905; Isolated cytochrome C oxidase deficiency. DR Orphanet; 104; Leber hereditary optic neuropathy. DR Orphanet; 550; MELAS. DR Orphanet; 90641; Rare mitochondrial non-syndromic sensorineural deafness. DR PharmGKB; PA31225; -. DR VEuPathDB; HostDB:ENSG00000198804; -. DR eggNOG; KOG4769; Eukaryota. DR GeneTree; ENSGT00390000001518; -. DR HOGENOM; CLU_011899_7_3_1; -. DR InParanoid; P00395; -. DR OMA; WAMMSIG; -. DR PhylomeDB; P00395; -. DR TreeFam; TF353096; -. DR BioCyc; MetaCyc:HS00026-MONOMER; -. DR BRENDA; 7.1.1.9; 2681. DR PathwayCommons; P00395; -. DR Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes. DR Reactome; R-HSA-611105; Respiratory electron transport. DR Reactome; R-HSA-9707564; Cytoprotection by HMOX1. DR SignaLink; P00395; -. DR SIGNOR; P00395; -. DR UniPathway; UPA00705; -. DR BioGRID-ORCS; 4512; 0 hits in 3 CRISPR screens. DR ChiTaRS; MT-CO1; human. DR GeneWiki; MT-CO1; -. DR GenomeRNAi; 4512; -. DR Pharos; P00395; Tchem. DR PRO; PR:P00395; -. DR Proteomes; UP000005640; Mitochondrion. DR RNAct; P00395; Protein. DR Bgee; ENSG00000198804; Expressed in right uterine tube and 95 other cell types or tissues. DR ExpressionAtlas; P00395; baseline and differential. DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. DR GO; GO:0031966; C:mitochondrial membrane; IDA:ComplexPortal. DR GO; GO:0005750; C:mitochondrial respiratory chain complex III; IDA:UniProtKB. DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IDA:UniProtKB. DR GO; GO:0045277; C:respiratory chain complex IV; IDA:UniProtKB. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0045333; P:cellular respiration; NAS:ComplexPortal. DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl. DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central. DR GO; GO:0046688; P:response to copper ion; IEA:Ensembl. DR GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl. DR CDD; cd01663; Cyt_c_Oxidase_I; 1. DR Gene3D; 1.20.210.10; Cytochrome c oxidase-like, subunit I domain; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS. DR InterPro; IPR033944; Cyt_c_oxase_su1_dom. DR PANTHER; PTHR10422; CYTOCHROME C OXIDASE SUBUNIT 1; 1. DR PANTHER; PTHR10422:SF18; CYTOCHROME C OXIDASE SUBUNIT 1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; Cytochrome c oxidase subunit I-like; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. DR Genevisible; P00395; HS. PE 1: Evidence at protein level; KW 3D-structure; Calcium; Copper; Deafness; Disease variant; KW Electron transport; Heme; Iron; Leber hereditary optic neuropathy; KW Magnesium; Membrane; Metal-binding; Mitochondrion; KW Mitochondrion inner membrane; Non-syndromic deafness; KW Primary mitochondrial disease; Reference proteome; Respiratory chain; KW Sodium; Translocase; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..513 FT /note="Cytochrome c oxidase subunit 1" FT /id="PRO_0000183345" FT TOPO_DOM 1..11 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 12..40 FT /note="Helical; Name=I" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 41..50 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 51..86 FT /note="Helical; Name=II" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 87..94 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 95..117 FT /note="Helical; Name=III" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 118..140 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 141..170 FT /note="Helical; Name=IV" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 171..182 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 183..212 FT /note="Helical; Name=V" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 213..227 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 228..261 FT /note="Helical; Name=VI" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 262..269 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 270..286 FT /note="Helical; Name=VII" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 287..298 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 299..327 FT /note="Helical; Name=VIII" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 328..335 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 336..357 FT /note="Helical; Name=IX" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 358..370 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 371..400 FT /note="Helical; Name=X" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 401..406 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 407..433 FT /note="Helical; Name=XI" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 434..446 FT /note="Mitochondrial intermembrane" FT /evidence="ECO:0000269|PubMed:30030519" FT TRANSMEM 447..478 FT /note="Helical; Name=XII" FT /evidence="ECO:0000250|UniProtKB:P00396" FT TOPO_DOM 479..513 FT /note="Mitochondrial matrix" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 40 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000250|UniProtKB:P00401" FT BINDING 45 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000250|UniProtKB:P00401" FT BINDING 61 FT /ligand="Fe(II)-heme a" FT /ligand_id="ChEBI:CHEBI:61715" FT /ligand_note="low-spin" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 240 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="B" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 244 FT /ligand="O2" FT /ligand_id="ChEBI:CHEBI:15379" FT /evidence="ECO:0000250|UniProtKB:P00396" FT BINDING 290 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="B" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 291 FT /ligand="Cu cation" FT /ligand_id="ChEBI:CHEBI:23378" FT /ligand_label="B" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 368 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_note="ligand shared with MT-CO2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 369 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_note="ligand shared with MT-CO2" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 376 FT /ligand="heme a3" FT /ligand_id="ChEBI:CHEBI:83282" FT /ligand_note="high-spin" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000269|PubMed:30030519" FT BINDING 378 FT /ligand="Fe(II)-heme a" FT /ligand_id="ChEBI:CHEBI:61715" FT /ligand_note="low-spin" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000269|PubMed:30030519" FT CROSSLNK 240..244 FT /note="1'-histidyl-3'-tyrosine (His-Tyr)" FT /evidence="ECO:0000250|UniProtKB:P00396" FT VARIANT 10 FT /note="T -> A" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008566" FT VARIANT 94 FT /note="F -> C" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008567" FT VARIANT 125 FT /note="G -> D (in CRC; displays steady-state catalytic FT activity linked to proton pumping that is approximately 34% FT of wild-type; an intrinsic proton leak is find in the FT enzyme, which will lead to decreased overall FT energy-conversion efficiency of the respiratory chain, FT perturbing transport processes such as protein, ion and FT metabolite trafficking; dbSNP:rs281865417)" FT /evidence="ECO:0000269|PubMed:16407113, FT ECO:0000269|PubMed:19218458" FT /id="VAR_064154" FT VARIANT 142 FT /note="S -> F (in MT-C4D; significant decrease in enzyme FT activity; dbSNP:rs267606883)" FT /evidence="ECO:0000269|PubMed:16284789" FT /id="VAR_033055" FT VARIANT 155 FT /note="V -> L (in dbSNP:rs370673798)" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008568" FT VARIANT 196 FT /note="L -> I (in MT-C4D; dbSNP:rs28461189)" FT /evidence="ECO:0000269|PubMed:12140182" FT /id="VAR_033056" FT VARIANT 224 FT /note="G -> A" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008569" FT VARIANT 235 FT /note="F -> S (in dbSNP:rs2853818)" FT /evidence="ECO:0000269|PubMed:7530363" FT /id="VAR_011342" FT VARIANT 273 FT /note="M -> T (found in two patients with acquired FT idiopathic sideroblastic anemia; dbSNP:rs199476127)" FT /evidence="ECO:0000269|PubMed:9389715, FT ECO:0000269|PubMed:9851701" FT /id="VAR_008385" FT VARIANT 280 FT /note="I -> T (found in two patients with acquired FT idiopathic sideroblastic anemia; dbSNP:rs199476126)" FT /evidence="ECO:0000269|PubMed:9389715, FT ECO:0000269|PubMed:9851701" FT /id="VAR_008386" FT VARIANT 305 FT /note="F -> L (in dbSNP:rs368552121)" FT /evidence="ECO:0000269|PubMed:1757091" FT /id="VAR_008570" FT VARIANT 415 FT /note="T -> A (in dbSNP:rs372136420)" FT /evidence="ECO:0000269|PubMed:7530363" FT /id="VAR_011343" FT VARIANT 458 FT /note="S -> P (in CRC; the mutant is probably not FT expressed, indicating that the amino acid substitution FT results in a severely altered overall structure of the FT enzyme; dbSNP:rs267606884)" FT /evidence="ECO:0000269|PubMed:16407113, FT ECO:0000269|PubMed:19218458" FT /id="VAR_064155" FT VARIANT 513 FT /note="S -> SKQK (in LHON; secondary mutation; does not FT seem to directly cause the disease)" FT /evidence="ECO:0000269|PubMed:1322638" FT /id="VAR_008387" SQ SEQUENCE 513 AA; 57041 MW; DBCBFE808650AE0D CRC64; MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS //