SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00395

- COX1_HUMAN

UniProt

P00395 - COX1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 1
Gene
MT-CO1, COI, COXI, MTCO1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. protein binding Source: IntAct

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. cellular metabolic process Source: Reactome
  3. hydrogen ion transmembrane transport Source: GOC
  4. oxidative phosphorylation Source: UniProtKB-UniPathway
  5. respiratory electron transport chain Source: Reactome
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.9.3.1. 2681.
ReactomeiREACT_22393. Respiratory electron transport.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Mitochondrion

Organism-specific databases

HGNCiHGNC:7419. MT-CO1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei20 – 4223Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini43 – 5614Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei57 – 7923Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 9920Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei100 – 12223Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini123 – 14624Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei147 – 16923Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini170 – 18112Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei182 – 20423Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini205 – 23531Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27012Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei271 – 29323Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini294 – 3029Mitochondrial intermembrane Reviewed prediction
Transmembranei303 – 32523Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini326 – 33611Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei337 – 35923Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini360 – 37314Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei374 – 39623Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini397 – 40812Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei409 – 43123Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini432 – 45019Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei451 – 47323Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini474 – 51340Mitochondrial matrix Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti513 – 5131S → SKQK in LHON; secondary mutation; does not seem to directly cause the disease. 1 Publication
VAR_008387
MT-CO1 may play a role in the pathogenesis of acquired idiopathic sideroblastic anemia, a disease characterized by inadequate formation of heme and excessive accumulation of iron in mitochondria. Mitochondrial iron overload may be attributable to mutations of mitochondrial DNA because these can cause respiratory chain dysfunction, thereby impairing reduction of ferric iron to ferrous iron. The reduced form of iron is essential to the last step of mitochondrial heme biosynthesis.
Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421S → F in MT-C4D; significant decrease in enzyme activity. 1 Publication
VAR_033055
Natural varianti196 – 1961L → I in MT-C4D. 1 Publication
VAR_033056
Recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]: Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine.
Note: The gene represented in this entry may be involved in disease pathogenesis.1 Publication
Deafness, sensorineural, mitochondrial (DFNM) [MIM:500008]: A form of non-syndromic deafness with maternal inheritance. Affected individuals manifest progressive, postlingual, sensorineural hearing loss involving high frequencies.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Note: The gene represented in this entry may be involved in disease pathogenesis.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251G → D in CRC; displays steady-state catalytic activity linked to proton pumping that is approximately 34% of wild-type; an intrinsic proton leak is find in the enzyme, which will lead to decreased overall energy-conversion efficiency of the respiratory chain, perturbing transport processes such as protein, ion and metabolite trafficking. 2 Publications
VAR_064154
Natural varianti458 – 4581S → P in CRC; the mutant is probably not expressed, indicating that the amino acid substitution results in a severely altered overall structure of the enzyme. 2 Publications
VAR_064155

Keywords - Diseasei

Deafness, Disease mutation, Leber hereditary optic neuropathy, Non-syndromic deafness

Organism-specific databases

MIMi114500. phenotype.
220110. phenotype.
500008. phenotype.
535000. phenotype.
550500. phenotype.
Orphaneti99845. Genetic recurrent myoglobinuria.
254905. Isolated cytochrome C oxidase deficiency.
104. Leber hereditary optic neuropathy.
255210. Maternally-inherited Leigh syndrome.
550. MELAS syndrome.
90641. Mitochondrial nonsyndromic sensorineural deafness.
168609. Mitochondrial nonsyndromic sensorineural deafness with susceptibility to aminoglycoside exposure.
PharmGKBiPA31225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Cytochrome c oxidase subunit 1
PRO_0000183345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Proteomic databases

PaxDbiP00395.
PRIDEiP00395.

PTM databases

PhosphoSiteiP00395.

Expressioni

Gene expression databases

BgeeiP00395.
GenevestigatoriP00395.

Organism-specific databases

HPAiCAB016241.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
COA3Q9Y2R011EBI-2117234,EBI-6570446
COX4I1P130732EBI-2117234,EBI-1056574
TIMM21Q9BVV73EBI-2117234,EBI-6570759

Protein-protein interaction databases

BioGridi110615. 12 interactions.
IntActiP00395. 13 interactions.
MINTiMINT-4773455.

Structurei

3D structure databases

ProteinModelPortaliP00395.
SMRiP00395. Positions 2-511.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOVERGENiHBG003841.
InParanoidiP00395.
KOiK02256.
OMAiHTFEKPP.
OrthoDBiEOG7Q8CMW.
PhylomeDBiP00395.
TreeFamiTF353096.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00395-1 [UniParc]FASTAAdd to Basket

« Hide

MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN    50
DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV 350
GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF 400
SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW 450
NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP 500
PYHTFEEPVY MKS 513
Length:513
Mass (Da):57,041
Last modified:July 21, 1986 - v1
Checksum:iDBCBFE808650AE0D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101T → A.1 Publication
VAR_008566
Natural varianti94 – 941F → C.1 Publication
VAR_008567
Natural varianti125 – 1251G → D in CRC; displays steady-state catalytic activity linked to proton pumping that is approximately 34% of wild-type; an intrinsic proton leak is find in the enzyme, which will lead to decreased overall energy-conversion efficiency of the respiratory chain, perturbing transport processes such as protein, ion and metabolite trafficking. 2 Publications
VAR_064154
Natural varianti142 – 1421S → F in MT-C4D; significant decrease in enzyme activity. 1 Publication
VAR_033055
Natural varianti155 – 1551V → L.1 Publication
VAR_008568
Natural varianti196 – 1961L → I in MT-C4D. 1 Publication
VAR_033056
Natural varianti224 – 2241G → A.1 Publication
VAR_008569
Natural varianti235 – 2351F → S.1 Publication
VAR_011342
Natural varianti273 – 2731M → T Found in two patients with acquired idiopathic sideroblastic anemia. 2 Publications
VAR_008385
Natural varianti280 – 2801I → T Found in two patients with acquired idiopathic sideroblastic anemia. 2 Publications
VAR_008386
Natural varianti305 – 3051F → L.1 Publication
VAR_008570
Natural varianti415 – 4151T → A.1 Publication
VAR_011343
Natural varianti458 – 4581S → P in CRC; the mutant is probably not expressed, indicating that the amino acid substitution results in a severely altered overall structure of the enzyme. 2 Publications
VAR_064155
Natural varianti513 – 5131S → SKQK in LHON; secondary mutation; does not seem to directly cause the disease. 1 Publication
VAR_008387

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00662 Genomic DNA. Translation: CAA24028.1.
J01415 Genomic DNA. Translation: AAB58945.1.
D38112 Genomic DNA. Translation: BAA07292.1.
AY339402 Genomic DNA. Translation: AAP89038.1.
AY339403 Genomic DNA. Translation: AAP89051.1.
AY339404 Genomic DNA. Translation: AAP89064.1.
AY339405 Genomic DNA. Translation: AAP89077.1.
AY339406 Genomic DNA. Translation: AAP89090.1.
AY339407 Genomic DNA. Translation: AAP89103.1.
AY339408 Genomic DNA. Translation: AAP89116.1.
AY339409 Genomic DNA. Translation: AAP89129.1.
AY339410 Genomic DNA. Translation: AAP89142.1.
AY339411 Genomic DNA. Translation: AAP89155.1.
AY339412 Genomic DNA. Translation: AAP89168.1.
AY339421 Genomic DNA. Translation: AAP89285.1.
AY339422 Genomic DNA. Translation: AAP89298.1.
AY339423 Genomic DNA. Translation: AAP89311.1.
AY339424 Genomic DNA. Translation: AAP89324.1.
AY339425 Genomic DNA. Translation: AAP89337.1.
AY339426 Genomic DNA. Translation: AAP89350.1.
AY339427 Genomic DNA. Translation: AAP89363.1.
AY339428 Genomic DNA. Translation: AAP89376.1.
AY339429 Genomic DNA. Translation: AAP89389.1.
AY339430 Genomic DNA. Translation: AAP89402.1.
AY339431 Genomic DNA. Translation: AAP89415.1.
AY339432 Genomic DNA. Translation: AAP89428.1.
AY339433 Genomic DNA. Translation: AAP89441.1.
AY339434 Genomic DNA. Translation: AAP89454.1.
AY339435 Genomic DNA. Translation: AAP89467.1.
AY339436 Genomic DNA. Translation: AAP89480.1.
AY339437 Genomic DNA. Translation: AAP89493.1.
AY339438 Genomic DNA. Translation: AAP89506.1.
AY339439 Genomic DNA. Translation: AAP89519.1.
AY339440 Genomic DNA. Translation: AAP89532.1.
AY339441 Genomic DNA. Translation: AAP89545.1.
AY339442 Genomic DNA. Translation: AAP89558.1.
AY339443 Genomic DNA. Translation: AAP89571.1.
AY339444 Genomic DNA. Translation: AAP89584.1.
AY339445 Genomic DNA. Translation: AAP89597.1.
AY339451 Genomic DNA. Translation: AAP89675.1.
AY339452 Genomic DNA. Translation: AAP89688.1.
AY339453 Genomic DNA. Translation: AAP89701.1.
AY339454 Genomic DNA. Translation: AAP89714.1.
AY339455 Genomic DNA. Translation: AAP89727.1.
AY339456 Genomic DNA. Translation: AAP89740.1.
AY339457 Genomic DNA. Translation: AAP89753.1.
AY339458 Genomic DNA. Translation: AAP89766.1.
AY339459 Genomic DNA. Translation: AAP89779.1.
AY339460 Genomic DNA. Translation: AAP89792.1.
AY339461 Genomic DNA. Translation: AAP89805.1.
AY339462 Genomic DNA. Translation: AAP89818.1.
AY339463 Genomic DNA. Translation: AAP89831.1.
AY339464 Genomic DNA. Translation: AAP89844.1.
AY339465 Genomic DNA. Translation: AAP89857.1.
AY339466 Genomic DNA. Translation: AAP89870.1.
AY339467 Genomic DNA. Translation: AAP89883.1.
AY339468 Genomic DNA. Translation: AAP89896.1.
AY339469 Genomic DNA. Translation: AAP89909.1.
AY339470 Genomic DNA. Translation: AAP89922.1.
AY339471 Genomic DNA. Translation: AAP89935.1.
AY339472 Genomic DNA. Translation: AAP89948.1.
AY339473 Genomic DNA. Translation: AAP89961.1.
AY339474 Genomic DNA. Translation: AAP89974.1.
AY339475 Genomic DNA. Translation: AAP89987.1.
AY339476 Genomic DNA. Translation: AAP90000.1.
AY339477 Genomic DNA. Translation: AAP90013.1.
AY339478 Genomic DNA. Translation: AAP90026.1.
AY339479 Genomic DNA. Translation: AAP90039.1.
AY339480 Genomic DNA. Translation: AAP90052.1.
AY339481 Genomic DNA. Translation: AAP90065.1.
AY339482 Genomic DNA. Translation: AAP90078.1.
AY339483 Genomic DNA. Translation: AAP90091.1.
AY339484 Genomic DNA. Translation: AAP90104.1.
AY339485 Genomic DNA. Translation: AAP90117.1.
AY339486 Genomic DNA. Translation: AAP90130.1.
AY339487 Genomic DNA. Translation: AAP90143.1.
AY339488 Genomic DNA. Translation: AAP90156.1.
AY339489 Genomic DNA. Translation: AAP90169.1.
AY339490 Genomic DNA. Translation: AAP90182.1.
AY339491 Genomic DNA. Translation: AAP90195.1.
AY339492 Genomic DNA. Translation: AAP90208.1.
AY339493 Genomic DNA. Translation: AAP90221.1.
AY339494 Genomic DNA. Translation: AAP90234.1.
AY339495 Genomic DNA. Translation: AAP90247.1.
AY339496 Genomic DNA. Translation: AAP90260.1.
AY339497 Genomic DNA. Translation: AAP90273.1.
AY339498 Genomic DNA. Translation: AAP90286.1.
AY339499 Genomic DNA. Translation: AAP90299.1.
AY339500 Genomic DNA. Translation: AAP90312.1.
AY339501 Genomic DNA. Translation: AAP90325.1.
AY339502 Genomic DNA. Translation: AAP90338.1.
AY339503 Genomic DNA. Translation: AAP90351.1.
AY339504 Genomic DNA. Translation: AAP90364.1.
AY339505 Genomic DNA. Translation: AAP90377.1.
AY339506 Genomic DNA. Translation: AAP90390.1.
AY339507 Genomic DNA. Translation: AAP90403.1.
AY339508 Genomic DNA. Translation: AAP90416.1.
AY339509 Genomic DNA. Translation: AAP90429.1.
AY339510 Genomic DNA. Translation: AAP90442.1.
AY339511 Genomic DNA. Translation: AAP90455.1.
AY339512 Genomic DNA. Translation: AAP90468.1.
AY339513 Genomic DNA. Translation: AAP90481.1.
AY339514 Genomic DNA. Translation: AAP90494.1.
AY339515 Genomic DNA. Translation: AAP90507.1.
AY339516 Genomic DNA. Translation: AAP90520.1.
AY339517 Genomic DNA. Translation: AAP90533.1.
AY339518 Genomic DNA. Translation: AAP90546.1.
AY339519 Genomic DNA. Translation: AAP90559.1.
AY339520 Genomic DNA. Translation: AAP90572.1.
AY339521 Genomic DNA. Translation: AAP90585.1.
AY339522 Genomic DNA. Translation: AAP90598.1.
AY339523 Genomic DNA. Translation: AAP90611.1.
AY339524 Genomic DNA. Translation: AAP90624.1.
AY339525 Genomic DNA. Translation: AAP90637.1.
AY339526 Genomic DNA. Translation: AAP90650.1.
AY339527 Genomic DNA. Translation: AAP90663.1.
AY339528 Genomic DNA. Translation: AAP90676.1.
AY339529 Genomic DNA. Translation: AAP90689.1.
AY339530 Genomic DNA. Translation: AAP90702.1.
AY339531 Genomic DNA. Translation: AAP90715.1.
AY339532 Genomic DNA. Translation: AAP90728.1.
AY339533 Genomic DNA. Translation: AAP90741.1.
AY339534 Genomic DNA. Translation: AAP90754.1.
AY339535 Genomic DNA. Translation: AAP90767.1.
AY339536 Genomic DNA. Translation: AAP90780.1.
AY339537 Genomic DNA. Translation: AAP90793.1.
AY339538 Genomic DNA. Translation: AAP90806.1.
AY339539 Genomic DNA. Translation: AAP90819.1.
AY339540 Genomic DNA. Translation: AAP90832.1.
AY339541 Genomic DNA. Translation: AAP90845.1.
AY339542 Genomic DNA. Translation: AAP90858.1.
AY339543 Genomic DNA. Translation: AAP90871.1.
AY339544 Genomic DNA. Translation: AAP90884.1.
AY339545 Genomic DNA. Translation: AAP90897.1.
AY339546 Genomic DNA. Translation: AAP90910.1.
AY339547 Genomic DNA. Translation: AAP90923.1.
AY339548 Genomic DNA. Translation: AAP90936.1.
AY339549 Genomic DNA. Translation: AAP90949.1.
AY339550 Genomic DNA. Translation: AAP90962.1.
AY339551 Genomic DNA. Translation: AAP90975.1.
AY339552 Genomic DNA. Translation: AAP90988.1.
AY339553 Genomic DNA. Translation: AAP91001.1.
AY339554 Genomic DNA. Translation: AAP91014.1.
AY339555 Genomic DNA. Translation: AAP91027.1.
AY339556 Genomic DNA. Translation: AAP91040.1.
AY339557 Genomic DNA. Translation: AAP91053.1.
AY339558 Genomic DNA. Translation: AAP91066.1.
AY339559 Genomic DNA. Translation: AAP91079.1.
AY339560 Genomic DNA. Translation: AAP91092.1.
AY339563 Genomic DNA. Translation: AAP91131.1.
AY339564 Genomic DNA. Translation: AAP91144.1.
AY339566 Genomic DNA. Translation: AAP91170.1.
AY339567 Genomic DNA. Translation: AAP91183.1.
AY339568 Genomic DNA. Translation: AAP91196.1.
AY339569 Genomic DNA. Translation: AAP91209.1.
AY339570 Genomic DNA. Translation: AAP91222.1.
AY339571 Genomic DNA. Translation: AAP91235.1.
AY339572 Genomic DNA. Translation: AAP91248.1.
AY339573 Genomic DNA. Translation: AAP91261.1.
AY339574 Genomic DNA. Translation: AAP91274.1.
AY339575 Genomic DNA. Translation: AAP91287.1.
AY339576 Genomic DNA. Translation: AAP91300.1.
AY339577 Genomic DNA. Translation: AAP91313.1.
AY339578 Genomic DNA. Translation: AAP91326.1.
AY339579 Genomic DNA. Translation: AAP91339.1.
AY339580 Genomic DNA. Translation: AAP91352.1.
AY339581 Genomic DNA. Translation: AAP91365.1.
AY339582 Genomic DNA. Translation: AAP91378.1.
AY339583 Genomic DNA. Translation: AAP91391.1.
AY339584 Genomic DNA. Translation: AAP91404.1.
AY339585 Genomic DNA. Translation: AAP91417.1.
AY339586 Genomic DNA. Translation: AAP91430.1.
AY339587 Genomic DNA. Translation: AAP91443.1.
AY339588 Genomic DNA. Translation: AAP91456.1.
AY339589 Genomic DNA. Translation: AAP91469.1.
AY339590 Genomic DNA. Translation: AAP91482.1.
AY339591 Genomic DNA. Translation: AAP91495.1.
AY339592 Genomic DNA. Translation: AAP91508.1.
AY339593 Genomic DNA. Translation: AAP91521.1.
AF346963 Genomic DNA. Translation: AAK17209.1.
AF346964 Genomic DNA. Translation: AAK17222.1.
AF346965 Genomic DNA. Translation: AAK17235.1.
AF346966 Genomic DNA. Translation: AAK17248.1.
AF346967 Genomic DNA. Translation: AAK17261.1.
AF346970 Genomic DNA. Translation: AAK17300.1.
AF346971 Genomic DNA. Translation: AAK17313.1.
AF346972 Genomic DNA. Translation: AAK17326.1.
AF346973 Genomic DNA. Translation: AAK17339.1.
AF346974 Genomic DNA. Translation: AAK17352.1.
AF346975 Genomic DNA. Translation: AAK17365.1.
AF346976 Genomic DNA. Translation: AAK17378.1.
AF346977 Genomic DNA. Translation: AAK17391.1.
AF346978 Genomic DNA. Translation: AAK17404.1.
AF346979 Genomic DNA. Translation: AAK17417.1.
AF346980 Genomic DNA. Translation: AAK17430.1.
AF346981 Genomic DNA. Translation: AAK17443.1.
AF346982 Genomic DNA. Translation: AAK17456.1.
AF346983 Genomic DNA. Translation: AAK17469.1.
AF346984 Genomic DNA. Translation: AAK17482.1.
AF346988 Genomic DNA. Translation: AAK17534.1.
AF346989 Genomic DNA. Translation: AAK17547.1.
AF346990 Genomic DNA. Translation: AAK17560.1.
AF346991 Genomic DNA. Translation: AAK17573.1.
AF346993 Genomic DNA. Translation: AAK17599.1.
AF346994 Genomic DNA. Translation: AAK17612.1.
AF346995 Genomic DNA. Translation: AAK17625.1.
AF346998 Genomic DNA. Translation: AAK17664.1.
AF347000 Genomic DNA. Translation: AAK17690.1.
AF347001 Genomic DNA. Translation: AAK17703.1.
AF347003 Genomic DNA. Translation: AAK17729.1.
AF347004 Genomic DNA. Translation: AAK17742.1.
AF347007 Genomic DNA. Translation: AAK17781.1.
AF347010 Genomic DNA. Translation: AAK17820.1.
AF347011 Genomic DNA. Translation: AAK17833.1.
AF347012 Genomic DNA. Translation: AAK17846.1.
AF347013 Genomic DNA. Translation: AAK17859.1.
AF347014 Genomic DNA. Translation: AAK17872.1.
AF347015 Genomic DNA. Translation: AAK17885.1.
AY289051 Genomic DNA. Translation: AAP47882.1.
AY289052 Genomic DNA. Translation: AAP47895.1.
AY289053 Genomic DNA. Translation: AAP47908.1.
AY289055 Genomic DNA. Translation: AAP47934.1.
AY289056 Genomic DNA. Translation: AAP47947.1.
AY289057 Genomic DNA. Translation: AAP47960.1.
AY289058 Genomic DNA. Translation: AAP47973.1.
AY289059 Genomic DNA. Translation: AAP47986.1.
AY289060 Genomic DNA. Translation: AAP47999.1.
AY289061 Genomic DNA. Translation: AAP48012.1.
AY289062 Genomic DNA. Translation: AAP48025.1.
AY289064 Genomic DNA. Translation: AAP48051.1.
AY289065 Genomic DNA. Translation: AAP48064.1.
AY289066 Genomic DNA. Translation: AAP48077.1.
AY289067 Genomic DNA. Translation: AAP48090.1.
AY289068 Genomic DNA. Translation: AAP48103.1.
AY289069 Genomic DNA. Translation: AAP48116.1.
AY289070 Genomic DNA. Translation: AAP48129.1.
AY289071 Genomic DNA. Translation: AAP48142.1.
AY289073 Genomic DNA. Translation: AAP48168.1.
AY289074 Genomic DNA. Translation: AAP48181.1.
AY289075 Genomic DNA. Translation: AAP48194.1.
AY289076 Genomic DNA. Translation: AAP48207.1.
AY289077 Genomic DNA. Translation: AAP48220.1.
AY289078 Genomic DNA. Translation: AAP48233.1.
AY289079 Genomic DNA. Translation: AAP48246.1.
AY289080 Genomic DNA. Translation: AAP48259.1.
AY289081 Genomic DNA. Translation: AAP48272.1.
AY289082 Genomic DNA. Translation: AAP48285.1.
AY289083 Genomic DNA. Translation: AAP48298.1.
AY289084 Genomic DNA. Translation: AAP48311.1.
AY289085 Genomic DNA. Translation: AAP48324.1.
AY289086 Genomic DNA. Translation: AAP48337.1.
AY289088 Genomic DNA. Translation: AAP48363.1.
AY289089 Genomic DNA. Translation: AAP48376.1.
AY289090 Genomic DNA. Translation: AAP48389.1.
AY289092 Genomic DNA. Translation: AAP48415.1.
AY289093 Genomic DNA. Translation: AAP48427.1.
AY289094 Genomic DNA. Translation: AAP48440.1.
AY289095 Genomic DNA. Translation: AAP48453.1.
AY289096 Genomic DNA. Translation: AAP48466.1.
AY289097 Genomic DNA. Translation: AAP48479.1.
AY289098 Genomic DNA. Translation: AAP48492.1.
AY289099 Genomic DNA. Translation: AAP48505.1.
AY289100 Genomic DNA. Translation: AAP48518.1.
AY289101 Genomic DNA. Translation: AAP48531.1.
AY289102 Genomic DNA. Translation: AAP48544.1.
AY495090 Genomic DNA. Translation: AAR92498.1.
AY495091 Genomic DNA. Translation: AAR92511.1.
AY495092 Genomic DNA. Translation: AAR92524.1.
AY495093 Genomic DNA. Translation: AAR92537.1.
AY495094 Genomic DNA. Translation: AAR92550.1.
AY495095 Genomic DNA. Translation: AAR92563.1.
AY495096 Genomic DNA. Translation: AAR92576.1.
AY495097 Genomic DNA. Translation: AAR92589.1.
AY495098 Genomic DNA. Translation: AAR92602.1.
AY495099 Genomic DNA. Translation: AAR92615.1.
AY495100 Genomic DNA. Translation: AAR92628.1.
AY495101 Genomic DNA. Translation: AAR92641.1.
AY495102 Genomic DNA. Translation: AAR92654.1.
AY495103 Genomic DNA. Translation: AAR92667.1.
AY495104 Genomic DNA. Translation: AAR92680.1.
AY495105 Genomic DNA. Translation: AAR92693.1.
AY495106 Genomic DNA. Translation: AAR92706.1.
AY495107 Genomic DNA. Translation: AAR92719.1.
AY495108 Genomic DNA. Translation: AAR92732.1.
AY495109 Genomic DNA. Translation: AAR92745.1.
AY495110 Genomic DNA. Translation: AAR92758.1.
AY495111 Genomic DNA. Translation: AAR92771.1.
AY495112 Genomic DNA. Translation: AAR92784.1.
AY495113 Genomic DNA. Translation: AAR92797.1.
AY495114 Genomic DNA. Translation: AAR92810.1.
AY495116 Genomic DNA. Translation: AAR92836.1.
AY495117 Genomic DNA. Translation: AAR92849.1.
AY495118 Genomic DNA. Translation: AAR92862.1.
AY495119 Genomic DNA. Translation: AAR92875.1.
AY495120 Genomic DNA. Translation: AAR92888.1.
AY495121 Genomic DNA. Translation: AAR92901.1.
AY495122 Genomic DNA. Translation: AAR92914.1.
AY495123 Genomic DNA. Translation: AAR92927.1.
AY495124 Genomic DNA. Translation: AAR92940.1.
AY495125 Genomic DNA. Translation: AAR92953.1.
AY495126 Genomic DNA. Translation: AAR92966.1.
AY495127 Genomic DNA. Translation: AAR92979.1.
AY495128 Genomic DNA. Translation: AAR92992.1.
AY495129 Genomic DNA. Translation: AAR93005.1.
AY495130 Genomic DNA. Translation: AAR93018.1.
AY495131 Genomic DNA. Translation: AAR93031.1.
AY495132 Genomic DNA. Translation: AAR93044.1.
AY495133 Genomic DNA. Translation: AAR93057.1.
AY495134 Genomic DNA. Translation: AAR93070.1.
AY495135 Genomic DNA. Translation: AAR93083.1.
AY495136 Genomic DNA. Translation: AAR93096.1.
AY495137 Genomic DNA. Translation: AAR93109.1.
AY495138 Genomic DNA. Translation: AAR93122.1.
AY495139 Genomic DNA. Translation: AAR93135.1.
AY495140 Genomic DNA. Translation: AAR93148.1.
AY495141 Genomic DNA. Translation: AAR93161.1.
AY495142 Genomic DNA. Translation: AAR93174.1.
AY495143 Genomic DNA. Translation: AAR93187.1.
AY495144 Genomic DNA. Translation: AAR93200.1.
AY495145 Genomic DNA. Translation: AAR93213.1.
AY495147 Genomic DNA. Translation: AAR93239.1.
AY495148 Genomic DNA. Translation: AAR93252.1.
AY495149 Genomic DNA. Translation: AAR93265.1.
AY495150 Genomic DNA. Translation: AAR93278.1.
AY495151 Genomic DNA. Translation: AAR93291.1.
AY495152 Genomic DNA. Translation: AAR93304.1.
AY495153 Genomic DNA. Translation: AAR93317.1.
AY495154 Genomic DNA. Translation: AAR93330.1.
AY495155 Genomic DNA. Translation: AAR93343.1.
AY495156 Genomic DNA. Translation: AAR93356.1.
AY495157 Genomic DNA. Translation: AAR93369.1.
AY495158 Genomic DNA. Translation: AAR93382.1.
AY495159 Genomic DNA. Translation: AAR93395.1.
AY495160 Genomic DNA. Translation: AAR93408.1.
AY495161 Genomic DNA. Translation: AAR93421.1.
AY495162 Genomic DNA. Translation: AAR93434.1.
AY495163 Genomic DNA. Translation: AAR93447.1.
AY495164 Genomic DNA. Translation: AAR93460.1.
AY495165 Genomic DNA. Translation: AAR93473.1.
AY495166 Genomic DNA. Translation: AAR93486.1.
AY495167 Genomic DNA. Translation: AAR93499.1.
AY495168 Genomic DNA. Translation: AAR93512.1.
AY495169 Genomic DNA. Translation: AAR93525.1.
AY495170 Genomic DNA. Translation: AAR93538.1.
AY495171 Genomic DNA. Translation: AAR93551.1.
AY495172 Genomic DNA. Translation: AAR93564.1.
AY495173 Genomic DNA. Translation: AAR93577.1.
AY495174 Genomic DNA. Translation: AAR93590.1.
AY495175 Genomic DNA. Translation: AAR93603.1.
AY495176 Genomic DNA. Translation: AAR93616.1.
AY495177 Genomic DNA. Translation: AAR93629.1.
AY495178 Genomic DNA. Translation: AAR93642.1.
AY495179 Genomic DNA. Translation: AAR93655.1.
AY495180 Genomic DNA. Translation: AAR93668.1.
AY495181 Genomic DNA. Translation: AAR93681.1.
AY495182 Genomic DNA. Translation: AAR93694.1.
AY495183 Genomic DNA. Translation: AAR93707.1.
AY495184 Genomic DNA. Translation: AAR93720.1.
AY495185 Genomic DNA. Translation: AAR93733.1.
AY495186 Genomic DNA. Translation: AAR93746.1.
AY495187 Genomic DNA. Translation: AAR93759.1.
AY495188 Genomic DNA. Translation: AAR93772.1.
AY495189 Genomic DNA. Translation: AAR93785.1.
AY495190 Genomic DNA. Translation: AAR93798.1.
AY495191 Genomic DNA. Translation: AAR93811.1.
AY495192 Genomic DNA. Translation: AAR93824.1.
AY495193 Genomic DNA. Translation: AAR93837.1.
AY495194 Genomic DNA. Translation: AAR93850.1.
AY495195 Genomic DNA. Translation: AAR93863.1.
AY495196 Genomic DNA. Translation: AAR93876.1.
AY495197 Genomic DNA. Translation: AAR93889.1.
AY495198 Genomic DNA. Translation: AAR93902.1.
AY495199 Genomic DNA. Translation: AAR93915.1.
AY495200 Genomic DNA. Translation: AAR93928.1.
AY495201 Genomic DNA. Translation: AAR93941.1.
AY495202 Genomic DNA. Translation: AAR93954.1.
AY495203 Genomic DNA. Translation: AAR93967.1.
AY495204 Genomic DNA. Translation: AAR93980.1.
AY495205 Genomic DNA. Translation: AAR93993.1.
AY495206 Genomic DNA. Translation: AAR94006.1.
AY495207 Genomic DNA. Translation: AAR94019.1.
AY495208 Genomic DNA. Translation: AAR94032.1.
AY495209 Genomic DNA. Translation: AAR94045.1.
AY495210 Genomic DNA. Translation: AAR94058.1.
AY495211 Genomic DNA. Translation: AAR94071.1.
AY495212 Genomic DNA. Translation: AAR94084.1.
AY495213 Genomic DNA. Translation: AAR94097.1.
AY495214 Genomic DNA. Translation: AAR94110.1.
AY495215 Genomic DNA. Translation: AAR94123.1.
AY495216 Genomic DNA. Translation: AAR94136.1.
AY495217 Genomic DNA. Translation: AAR94149.1.
AY495218 Genomic DNA. Translation: AAR94162.1.
AY495219 Genomic DNA. Translation: AAR94175.1.
AY495220 Genomic DNA. Translation: AAR94188.1.
AY495221 Genomic DNA. Translation: AAR94201.1.
AY495222 Genomic DNA. Translation: AAR94214.1.
AY495223 Genomic DNA. Translation: AAR94227.1.
AY495224 Genomic DNA. Translation: AAR94240.1.
AY495225 Genomic DNA. Translation: AAR94253.1.
AY495226 Genomic DNA. Translation: AAR94266.1.
AY495228 Genomic DNA. Translation: AAR94292.1.
AY495230 Genomic DNA. Translation: AAR94318.1.
AY495231 Genomic DNA. Translation: AAR94331.1.
AY495232 Genomic DNA. Translation: AAR94344.1.
AY495233 Genomic DNA. Translation: AAR94357.1.
AY495234 Genomic DNA. Translation: AAR94370.1.
AY495235 Genomic DNA. Translation: AAR94383.1.
AY495236 Genomic DNA. Translation: AAR94396.1.
AY495237 Genomic DNA. Translation: AAR94409.1.
AY495239 Genomic DNA. Translation: AAR94435.1.
AY495240 Genomic DNA. Translation: AAR94448.1.
AY495241 Genomic DNA. Translation: AAR94461.1.
AY495242 Genomic DNA. Translation: AAR94474.1.
AY495243 Genomic DNA. Translation: AAR94487.1.
AY495244 Genomic DNA. Translation: AAR94500.1.
AY495245 Genomic DNA. Translation: AAR94513.1.
AY495246 Genomic DNA. Translation: AAR94526.1.
AY495247 Genomic DNA. Translation: AAR94539.1.
AY495248 Genomic DNA. Translation: AAR94552.1.
AY495249 Genomic DNA. Translation: AAR94565.1.
AY495250 Genomic DNA. Translation: AAR94578.1.
AY495251 Genomic DNA. Translation: AAR94591.1.
AY495252 Genomic DNA. Translation: AAR94604.1.
AY495253 Genomic DNA. Translation: AAR94617.1.
AY495254 Genomic DNA. Translation: AAR94630.1.
AY495255 Genomic DNA. Translation: AAR94643.1.
AY495256 Genomic DNA. Translation: AAR94656.1.
AY495258 Genomic DNA. Translation: AAR94682.1.
AY495259 Genomic DNA. Translation: AAR94695.1.
AY495261 Genomic DNA. Translation: AAR94721.1.
AY495262 Genomic DNA. Translation: AAR94734.1.
AY495263 Genomic DNA. Translation: AAR94747.1.
AY495264 Genomic DNA. Translation: AAR94760.1.
AY495265 Genomic DNA. Translation: AAR94773.1.
AY495266 Genomic DNA. Translation: AAR94786.1.
AY495267 Genomic DNA. Translation: AAR94799.1.
AY495268 Genomic DNA. Translation: AAR94812.1.
AY495269 Genomic DNA. Translation: AAR94825.1.
AY495270 Genomic DNA. Translation: AAR94838.1.
AY495271 Genomic DNA. Translation: AAR94851.1.
AY495272 Genomic DNA. Translation: AAR94864.1.
AY495273 Genomic DNA. Translation: AAR94877.1.
AY495274 Genomic DNA. Translation: AAR94890.1.
AY495275 Genomic DNA. Translation: AAR94903.1.
AY495276 Genomic DNA. Translation: AAR94916.1.
AY495277 Genomic DNA. Translation: AAR94929.1.
AY495278 Genomic DNA. Translation: AAR94942.1.
AY495279 Genomic DNA. Translation: AAR94955.1.
AY495280 Genomic DNA. Translation: AAR94968.1.
AY495281 Genomic DNA. Translation: AAR94981.1.
AY495282 Genomic DNA. Translation: AAR94994.1.
AY495283 Genomic DNA. Translation: AAR95007.1.
AY495284 Genomic DNA. Translation: AAR95020.1.
AY495285 Genomic DNA. Translation: AAR95033.1.
AY495286 Genomic DNA. Translation: AAR95046.1.
AY495287 Genomic DNA. Translation: AAR95059.1.
AY495288 Genomic DNA. Translation: AAR95072.1.
AY495289 Genomic DNA. Translation: AAR95085.1.
AY495290 Genomic DNA. Translation: AAR95098.1.
AY495291 Genomic DNA. Translation: AAR95111.1.
AY495292 Genomic DNA. Translation: AAR95124.1.
AY495293 Genomic DNA. Translation: AAR95137.1.
AY495294 Genomic DNA. Translation: AAR95150.1.
AY495295 Genomic DNA. Translation: AAR95163.1.
AY495297 Genomic DNA. Translation: AAR95189.1.
AY495298 Genomic DNA. Translation: AAR95202.1.
AY495299 Genomic DNA. Translation: AAR95215.1.
AY495300 Genomic DNA. Translation: AAR95228.1.
AY495301 Genomic DNA. Translation: AAR95241.1.
AY495302 Genomic DNA. Translation: AAR95254.1.
AY495303 Genomic DNA. Translation: AAR95267.1.
AY495304 Genomic DNA. Translation: AAR95280.1.
AY495305 Genomic DNA. Translation: AAR95293.1.
AY495306 Genomic DNA. Translation: AAR95306.1.
AY495307 Genomic DNA. Translation: AAR95319.1.
AY495308 Genomic DNA. Translation: AAR95332.1.
AY495309 Genomic DNA. Translation: AAR95345.1.
AY495310 Genomic DNA. Translation: AAR95358.1.
AY495311 Genomic DNA. Translation: AAR95371.1.
AY495312 Genomic DNA. Translation: AAR95384.1.
AY495313 Genomic DNA. Translation: AAR95397.1.
AY495314 Genomic DNA. Translation: AAR95410.1.
AY495315 Genomic DNA. Translation: AAR95423.1.
AY495316 Genomic DNA. Translation: AAR95436.1.
AY495317 Genomic DNA. Translation: AAR95449.1.
AY495318 Genomic DNA. Translation: AAR95462.1.
AY495319 Genomic DNA. Translation: AAR95475.1.
AY495320 Genomic DNA. Translation: AAR95488.1.
AY495322 Genomic DNA. Translation: AAR95514.1.
AY495323 Genomic DNA. Translation: AAR95527.1.
AY495324 Genomic DNA. Translation: AAR95540.1.
AY495325 Genomic DNA. Translation: AAR95553.1.
AY495326 Genomic DNA. Translation: AAR95566.1.
AY495327 Genomic DNA. Translation: AAR95579.1.
AY495328 Genomic DNA. Translation: AAR95592.1.
AY495329 Genomic DNA. Translation: AAR95605.1.
AY495330 Genomic DNA. Translation: AAR95618.1.
M10546 Genomic DNA. Translation: AAA65503.1.
PIRiA00463. ODHU1.
RefSeqiYP_003024028.1. NC_012920.1.

Genome annotation databases

EnsembliENST00000361624; ENSP00000354499; ENSG00000198804.
GeneIDi4512.
KEGGihsa:4512.

Polymorphism databases

DMDMi116977.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00662 Genomic DNA. Translation: CAA24028.1 .
J01415 Genomic DNA. Translation: AAB58945.1 .
D38112 Genomic DNA. Translation: BAA07292.1 .
AY339402 Genomic DNA. Translation: AAP89038.1 .
AY339403 Genomic DNA. Translation: AAP89051.1 .
AY339404 Genomic DNA. Translation: AAP89064.1 .
AY339405 Genomic DNA. Translation: AAP89077.1 .
AY339406 Genomic DNA. Translation: AAP89090.1 .
AY339407 Genomic DNA. Translation: AAP89103.1 .
AY339408 Genomic DNA. Translation: AAP89116.1 .
AY339409 Genomic DNA. Translation: AAP89129.1 .
AY339410 Genomic DNA. Translation: AAP89142.1 .
AY339411 Genomic DNA. Translation: AAP89155.1 .
AY339412 Genomic DNA. Translation: AAP89168.1 .
AY339421 Genomic DNA. Translation: AAP89285.1 .
AY339422 Genomic DNA. Translation: AAP89298.1 .
AY339423 Genomic DNA. Translation: AAP89311.1 .
AY339424 Genomic DNA. Translation: AAP89324.1 .
AY339425 Genomic DNA. Translation: AAP89337.1 .
AY339426 Genomic DNA. Translation: AAP89350.1 .
AY339427 Genomic DNA. Translation: AAP89363.1 .
AY339428 Genomic DNA. Translation: AAP89376.1 .
AY339429 Genomic DNA. Translation: AAP89389.1 .
AY339430 Genomic DNA. Translation: AAP89402.1 .
AY339431 Genomic DNA. Translation: AAP89415.1 .
AY339432 Genomic DNA. Translation: AAP89428.1 .
AY339433 Genomic DNA. Translation: AAP89441.1 .
AY339434 Genomic DNA. Translation: AAP89454.1 .
AY339435 Genomic DNA. Translation: AAP89467.1 .
AY339436 Genomic DNA. Translation: AAP89480.1 .
AY339437 Genomic DNA. Translation: AAP89493.1 .
AY339438 Genomic DNA. Translation: AAP89506.1 .
AY339439 Genomic DNA. Translation: AAP89519.1 .
AY339440 Genomic DNA. Translation: AAP89532.1 .
AY339441 Genomic DNA. Translation: AAP89545.1 .
AY339442 Genomic DNA. Translation: AAP89558.1 .
AY339443 Genomic DNA. Translation: AAP89571.1 .
AY339444 Genomic DNA. Translation: AAP89584.1 .
AY339445 Genomic DNA. Translation: AAP89597.1 .
AY339451 Genomic DNA. Translation: AAP89675.1 .
AY339452 Genomic DNA. Translation: AAP89688.1 .
AY339453 Genomic DNA. Translation: AAP89701.1 .
AY339454 Genomic DNA. Translation: AAP89714.1 .
AY339455 Genomic DNA. Translation: AAP89727.1 .
AY339456 Genomic DNA. Translation: AAP89740.1 .
AY339457 Genomic DNA. Translation: AAP89753.1 .
AY339458 Genomic DNA. Translation: AAP89766.1 .
AY339459 Genomic DNA. Translation: AAP89779.1 .
AY339460 Genomic DNA. Translation: AAP89792.1 .
AY339461 Genomic DNA. Translation: AAP89805.1 .
AY339462 Genomic DNA. Translation: AAP89818.1 .
AY339463 Genomic DNA. Translation: AAP89831.1 .
AY339464 Genomic DNA. Translation: AAP89844.1 .
AY339465 Genomic DNA. Translation: AAP89857.1 .
AY339466 Genomic DNA. Translation: AAP89870.1 .
AY339467 Genomic DNA. Translation: AAP89883.1 .
AY339468 Genomic DNA. Translation: AAP89896.1 .
AY339469 Genomic DNA. Translation: AAP89909.1 .
AY339470 Genomic DNA. Translation: AAP89922.1 .
AY339471 Genomic DNA. Translation: AAP89935.1 .
AY339472 Genomic DNA. Translation: AAP89948.1 .
AY339473 Genomic DNA. Translation: AAP89961.1 .
AY339474 Genomic DNA. Translation: AAP89974.1 .
AY339475 Genomic DNA. Translation: AAP89987.1 .
AY339476 Genomic DNA. Translation: AAP90000.1 .
AY339477 Genomic DNA. Translation: AAP90013.1 .
AY339478 Genomic DNA. Translation: AAP90026.1 .
AY339479 Genomic DNA. Translation: AAP90039.1 .
AY339480 Genomic DNA. Translation: AAP90052.1 .
AY339481 Genomic DNA. Translation: AAP90065.1 .
AY339482 Genomic DNA. Translation: AAP90078.1 .
AY339483 Genomic DNA. Translation: AAP90091.1 .
AY339484 Genomic DNA. Translation: AAP90104.1 .
AY339485 Genomic DNA. Translation: AAP90117.1 .
AY339486 Genomic DNA. Translation: AAP90130.1 .
AY339487 Genomic DNA. Translation: AAP90143.1 .
AY339488 Genomic DNA. Translation: AAP90156.1 .
AY339489 Genomic DNA. Translation: AAP90169.1 .
AY339490 Genomic DNA. Translation: AAP90182.1 .
AY339491 Genomic DNA. Translation: AAP90195.1 .
AY339492 Genomic DNA. Translation: AAP90208.1 .
AY339493 Genomic DNA. Translation: AAP90221.1 .
AY339494 Genomic DNA. Translation: AAP90234.1 .
AY339495 Genomic DNA. Translation: AAP90247.1 .
AY339496 Genomic DNA. Translation: AAP90260.1 .
AY339497 Genomic DNA. Translation: AAP90273.1 .
AY339498 Genomic DNA. Translation: AAP90286.1 .
AY339499 Genomic DNA. Translation: AAP90299.1 .
AY339500 Genomic DNA. Translation: AAP90312.1 .
AY339501 Genomic DNA. Translation: AAP90325.1 .
AY339502 Genomic DNA. Translation: AAP90338.1 .
AY339503 Genomic DNA. Translation: AAP90351.1 .
AY339504 Genomic DNA. Translation: AAP90364.1 .
AY339505 Genomic DNA. Translation: AAP90377.1 .
AY339506 Genomic DNA. Translation: AAP90390.1 .
AY339507 Genomic DNA. Translation: AAP90403.1 .
AY339508 Genomic DNA. Translation: AAP90416.1 .
AY339509 Genomic DNA. Translation: AAP90429.1 .
AY339510 Genomic DNA. Translation: AAP90442.1 .
AY339511 Genomic DNA. Translation: AAP90455.1 .
AY339512 Genomic DNA. Translation: AAP90468.1 .
AY339513 Genomic DNA. Translation: AAP90481.1 .
AY339514 Genomic DNA. Translation: AAP90494.1 .
AY339515 Genomic DNA. Translation: AAP90507.1 .
AY339516 Genomic DNA. Translation: AAP90520.1 .
AY339517 Genomic DNA. Translation: AAP90533.1 .
AY339518 Genomic DNA. Translation: AAP90546.1 .
AY339519 Genomic DNA. Translation: AAP90559.1 .
AY339520 Genomic DNA. Translation: AAP90572.1 .
AY339521 Genomic DNA. Translation: AAP90585.1 .
AY339522 Genomic DNA. Translation: AAP90598.1 .
AY339523 Genomic DNA. Translation: AAP90611.1 .
AY339524 Genomic DNA. Translation: AAP90624.1 .
AY339525 Genomic DNA. Translation: AAP90637.1 .
AY339526 Genomic DNA. Translation: AAP90650.1 .
AY339527 Genomic DNA. Translation: AAP90663.1 .
AY339528 Genomic DNA. Translation: AAP90676.1 .
AY339529 Genomic DNA. Translation: AAP90689.1 .
AY339530 Genomic DNA. Translation: AAP90702.1 .
AY339531 Genomic DNA. Translation: AAP90715.1 .
AY339532 Genomic DNA. Translation: AAP90728.1 .
AY339533 Genomic DNA. Translation: AAP90741.1 .
AY339534 Genomic DNA. Translation: AAP90754.1 .
AY339535 Genomic DNA. Translation: AAP90767.1 .
AY339536 Genomic DNA. Translation: AAP90780.1 .
AY339537 Genomic DNA. Translation: AAP90793.1 .
AY339538 Genomic DNA. Translation: AAP90806.1 .
AY339539 Genomic DNA. Translation: AAP90819.1 .
AY339540 Genomic DNA. Translation: AAP90832.1 .
AY339541 Genomic DNA. Translation: AAP90845.1 .
AY339542 Genomic DNA. Translation: AAP90858.1 .
AY339543 Genomic DNA. Translation: AAP90871.1 .
AY339544 Genomic DNA. Translation: AAP90884.1 .
AY339545 Genomic DNA. Translation: AAP90897.1 .
AY339546 Genomic DNA. Translation: AAP90910.1 .
AY339547 Genomic DNA. Translation: AAP90923.1 .
AY339548 Genomic DNA. Translation: AAP90936.1 .
AY339549 Genomic DNA. Translation: AAP90949.1 .
AY339550 Genomic DNA. Translation: AAP90962.1 .
AY339551 Genomic DNA. Translation: AAP90975.1 .
AY339552 Genomic DNA. Translation: AAP90988.1 .
AY339553 Genomic DNA. Translation: AAP91001.1 .
AY339554 Genomic DNA. Translation: AAP91014.1 .
AY339555 Genomic DNA. Translation: AAP91027.1 .
AY339556 Genomic DNA. Translation: AAP91040.1 .
AY339557 Genomic DNA. Translation: AAP91053.1 .
AY339558 Genomic DNA. Translation: AAP91066.1 .
AY339559 Genomic DNA. Translation: AAP91079.1 .
AY339560 Genomic DNA. Translation: AAP91092.1 .
AY339563 Genomic DNA. Translation: AAP91131.1 .
AY339564 Genomic DNA. Translation: AAP91144.1 .
AY339566 Genomic DNA. Translation: AAP91170.1 .
AY339567 Genomic DNA. Translation: AAP91183.1 .
AY339568 Genomic DNA. Translation: AAP91196.1 .
AY339569 Genomic DNA. Translation: AAP91209.1 .
AY339570 Genomic DNA. Translation: AAP91222.1 .
AY339571 Genomic DNA. Translation: AAP91235.1 .
AY339572 Genomic DNA. Translation: AAP91248.1 .
AY339573 Genomic DNA. Translation: AAP91261.1 .
AY339574 Genomic DNA. Translation: AAP91274.1 .
AY339575 Genomic DNA. Translation: AAP91287.1 .
AY339576 Genomic DNA. Translation: AAP91300.1 .
AY339577 Genomic DNA. Translation: AAP91313.1 .
AY339578 Genomic DNA. Translation: AAP91326.1 .
AY339579 Genomic DNA. Translation: AAP91339.1 .
AY339580 Genomic DNA. Translation: AAP91352.1 .
AY339581 Genomic DNA. Translation: AAP91365.1 .
AY339582 Genomic DNA. Translation: AAP91378.1 .
AY339583 Genomic DNA. Translation: AAP91391.1 .
AY339584 Genomic DNA. Translation: AAP91404.1 .
AY339585 Genomic DNA. Translation: AAP91417.1 .
AY339586 Genomic DNA. Translation: AAP91430.1 .
AY339587 Genomic DNA. Translation: AAP91443.1 .
AY339588 Genomic DNA. Translation: AAP91456.1 .
AY339589 Genomic DNA. Translation: AAP91469.1 .
AY339590 Genomic DNA. Translation: AAP91482.1 .
AY339591 Genomic DNA. Translation: AAP91495.1 .
AY339592 Genomic DNA. Translation: AAP91508.1 .
AY339593 Genomic DNA. Translation: AAP91521.1 .
AF346963 Genomic DNA. Translation: AAK17209.1 .
AF346964 Genomic DNA. Translation: AAK17222.1 .
AF346965 Genomic DNA. Translation: AAK17235.1 .
AF346966 Genomic DNA. Translation: AAK17248.1 .
AF346967 Genomic DNA. Translation: AAK17261.1 .
AF346970 Genomic DNA. Translation: AAK17300.1 .
AF346971 Genomic DNA. Translation: AAK17313.1 .
AF346972 Genomic DNA. Translation: AAK17326.1 .
AF346973 Genomic DNA. Translation: AAK17339.1 .
AF346974 Genomic DNA. Translation: AAK17352.1 .
AF346975 Genomic DNA. Translation: AAK17365.1 .
AF346976 Genomic DNA. Translation: AAK17378.1 .
AF346977 Genomic DNA. Translation: AAK17391.1 .
AF346978 Genomic DNA. Translation: AAK17404.1 .
AF346979 Genomic DNA. Translation: AAK17417.1 .
AF346980 Genomic DNA. Translation: AAK17430.1 .
AF346981 Genomic DNA. Translation: AAK17443.1 .
AF346982 Genomic DNA. Translation: AAK17456.1 .
AF346983 Genomic DNA. Translation: AAK17469.1 .
AF346984 Genomic DNA. Translation: AAK17482.1 .
AF346988 Genomic DNA. Translation: AAK17534.1 .
AF346989 Genomic DNA. Translation: AAK17547.1 .
AF346990 Genomic DNA. Translation: AAK17560.1 .
AF346991 Genomic DNA. Translation: AAK17573.1 .
AF346993 Genomic DNA. Translation: AAK17599.1 .
AF346994 Genomic DNA. Translation: AAK17612.1 .
AF346995 Genomic DNA. Translation: AAK17625.1 .
AF346998 Genomic DNA. Translation: AAK17664.1 .
AF347000 Genomic DNA. Translation: AAK17690.1 .
AF347001 Genomic DNA. Translation: AAK17703.1 .
AF347003 Genomic DNA. Translation: AAK17729.1 .
AF347004 Genomic DNA. Translation: AAK17742.1 .
AF347007 Genomic DNA. Translation: AAK17781.1 .
AF347010 Genomic DNA. Translation: AAK17820.1 .
AF347011 Genomic DNA. Translation: AAK17833.1 .
AF347012 Genomic DNA. Translation: AAK17846.1 .
AF347013 Genomic DNA. Translation: AAK17859.1 .
AF347014 Genomic DNA. Translation: AAK17872.1 .
AF347015 Genomic DNA. Translation: AAK17885.1 .
AY289051 Genomic DNA. Translation: AAP47882.1 .
AY289052 Genomic DNA. Translation: AAP47895.1 .
AY289053 Genomic DNA. Translation: AAP47908.1 .
AY289055 Genomic DNA. Translation: AAP47934.1 .
AY289056 Genomic DNA. Translation: AAP47947.1 .
AY289057 Genomic DNA. Translation: AAP47960.1 .
AY289058 Genomic DNA. Translation: AAP47973.1 .
AY289059 Genomic DNA. Translation: AAP47986.1 .
AY289060 Genomic DNA. Translation: AAP47999.1 .
AY289061 Genomic DNA. Translation: AAP48012.1 .
AY289062 Genomic DNA. Translation: AAP48025.1 .
AY289064 Genomic DNA. Translation: AAP48051.1 .
AY289065 Genomic DNA. Translation: AAP48064.1 .
AY289066 Genomic DNA. Translation: AAP48077.1 .
AY289067 Genomic DNA. Translation: AAP48090.1 .
AY289068 Genomic DNA. Translation: AAP48103.1 .
AY289069 Genomic DNA. Translation: AAP48116.1 .
AY289070 Genomic DNA. Translation: AAP48129.1 .
AY289071 Genomic DNA. Translation: AAP48142.1 .
AY289073 Genomic DNA. Translation: AAP48168.1 .
AY289074 Genomic DNA. Translation: AAP48181.1 .
AY289075 Genomic DNA. Translation: AAP48194.1 .
AY289076 Genomic DNA. Translation: AAP48207.1 .
AY289077 Genomic DNA. Translation: AAP48220.1 .
AY289078 Genomic DNA. Translation: AAP48233.1 .
AY289079 Genomic DNA. Translation: AAP48246.1 .
AY289080 Genomic DNA. Translation: AAP48259.1 .
AY289081 Genomic DNA. Translation: AAP48272.1 .
AY289082 Genomic DNA. Translation: AAP48285.1 .
AY289083 Genomic DNA. Translation: AAP48298.1 .
AY289084 Genomic DNA. Translation: AAP48311.1 .
AY289085 Genomic DNA. Translation: AAP48324.1 .
AY289086 Genomic DNA. Translation: AAP48337.1 .
AY289088 Genomic DNA. Translation: AAP48363.1 .
AY289089 Genomic DNA. Translation: AAP48376.1 .
AY289090 Genomic DNA. Translation: AAP48389.1 .
AY289092 Genomic DNA. Translation: AAP48415.1 .
AY289093 Genomic DNA. Translation: AAP48427.1 .
AY289094 Genomic DNA. Translation: AAP48440.1 .
AY289095 Genomic DNA. Translation: AAP48453.1 .
AY289096 Genomic DNA. Translation: AAP48466.1 .
AY289097 Genomic DNA. Translation: AAP48479.1 .
AY289098 Genomic DNA. Translation: AAP48492.1 .
AY289099 Genomic DNA. Translation: AAP48505.1 .
AY289100 Genomic DNA. Translation: AAP48518.1 .
AY289101 Genomic DNA. Translation: AAP48531.1 .
AY289102 Genomic DNA. Translation: AAP48544.1 .
AY495090 Genomic DNA. Translation: AAR92498.1 .
AY495091 Genomic DNA. Translation: AAR92511.1 .
AY495092 Genomic DNA. Translation: AAR92524.1 .
AY495093 Genomic DNA. Translation: AAR92537.1 .
AY495094 Genomic DNA. Translation: AAR92550.1 .
AY495095 Genomic DNA. Translation: AAR92563.1 .
AY495096 Genomic DNA. Translation: AAR92576.1 .
AY495097 Genomic DNA. Translation: AAR92589.1 .
AY495098 Genomic DNA. Translation: AAR92602.1 .
AY495099 Genomic DNA. Translation: AAR92615.1 .
AY495100 Genomic DNA. Translation: AAR92628.1 .
AY495101 Genomic DNA. Translation: AAR92641.1 .
AY495102 Genomic DNA. Translation: AAR92654.1 .
AY495103 Genomic DNA. Translation: AAR92667.1 .
AY495104 Genomic DNA. Translation: AAR92680.1 .
AY495105 Genomic DNA. Translation: AAR92693.1 .
AY495106 Genomic DNA. Translation: AAR92706.1 .
AY495107 Genomic DNA. Translation: AAR92719.1 .
AY495108 Genomic DNA. Translation: AAR92732.1 .
AY495109 Genomic DNA. Translation: AAR92745.1 .
AY495110 Genomic DNA. Translation: AAR92758.1 .
AY495111 Genomic DNA. Translation: AAR92771.1 .
AY495112 Genomic DNA. Translation: AAR92784.1 .
AY495113 Genomic DNA. Translation: AAR92797.1 .
AY495114 Genomic DNA. Translation: AAR92810.1 .
AY495116 Genomic DNA. Translation: AAR92836.1 .
AY495117 Genomic DNA. Translation: AAR92849.1 .
AY495118 Genomic DNA. Translation: AAR92862.1 .
AY495119 Genomic DNA. Translation: AAR92875.1 .
AY495120 Genomic DNA. Translation: AAR92888.1 .
AY495121 Genomic DNA. Translation: AAR92901.1 .
AY495122 Genomic DNA. Translation: AAR92914.1 .
AY495123 Genomic DNA. Translation: AAR92927.1 .
AY495124 Genomic DNA. Translation: AAR92940.1 .
AY495125 Genomic DNA. Translation: AAR92953.1 .
AY495126 Genomic DNA. Translation: AAR92966.1 .
AY495127 Genomic DNA. Translation: AAR92979.1 .
AY495128 Genomic DNA. Translation: AAR92992.1 .
AY495129 Genomic DNA. Translation: AAR93005.1 .
AY495130 Genomic DNA. Translation: AAR93018.1 .
AY495131 Genomic DNA. Translation: AAR93031.1 .
AY495132 Genomic DNA. Translation: AAR93044.1 .
AY495133 Genomic DNA. Translation: AAR93057.1 .
AY495134 Genomic DNA. Translation: AAR93070.1 .
AY495135 Genomic DNA. Translation: AAR93083.1 .
AY495136 Genomic DNA. Translation: AAR93096.1 .
AY495137 Genomic DNA. Translation: AAR93109.1 .
AY495138 Genomic DNA. Translation: AAR93122.1 .
AY495139 Genomic DNA. Translation: AAR93135.1 .
AY495140 Genomic DNA. Translation: AAR93148.1 .
AY495141 Genomic DNA. Translation: AAR93161.1 .
AY495142 Genomic DNA. Translation: AAR93174.1 .
AY495143 Genomic DNA. Translation: AAR93187.1 .
AY495144 Genomic DNA. Translation: AAR93200.1 .
AY495145 Genomic DNA. Translation: AAR93213.1 .
AY495147 Genomic DNA. Translation: AAR93239.1 .
AY495148 Genomic DNA. Translation: AAR93252.1 .
AY495149 Genomic DNA. Translation: AAR93265.1 .
AY495150 Genomic DNA. Translation: AAR93278.1 .
AY495151 Genomic DNA. Translation: AAR93291.1 .
AY495152 Genomic DNA. Translation: AAR93304.1 .
AY495153 Genomic DNA. Translation: AAR93317.1 .
AY495154 Genomic DNA. Translation: AAR93330.1 .
AY495155 Genomic DNA. Translation: AAR93343.1 .
AY495156 Genomic DNA. Translation: AAR93356.1 .
AY495157 Genomic DNA. Translation: AAR93369.1 .
AY495158 Genomic DNA. Translation: AAR93382.1 .
AY495159 Genomic DNA. Translation: AAR93395.1 .
AY495160 Genomic DNA. Translation: AAR93408.1 .
AY495161 Genomic DNA. Translation: AAR93421.1 .
AY495162 Genomic DNA. Translation: AAR93434.1 .
AY495163 Genomic DNA. Translation: AAR93447.1 .
AY495164 Genomic DNA. Translation: AAR93460.1 .
AY495165 Genomic DNA. Translation: AAR93473.1 .
AY495166 Genomic DNA. Translation: AAR93486.1 .
AY495167 Genomic DNA. Translation: AAR93499.1 .
AY495168 Genomic DNA. Translation: AAR93512.1 .
AY495169 Genomic DNA. Translation: AAR93525.1 .
AY495170 Genomic DNA. Translation: AAR93538.1 .
AY495171 Genomic DNA. Translation: AAR93551.1 .
AY495172 Genomic DNA. Translation: AAR93564.1 .
AY495173 Genomic DNA. Translation: AAR93577.1 .
AY495174 Genomic DNA. Translation: AAR93590.1 .
AY495175 Genomic DNA. Translation: AAR93603.1 .
AY495176 Genomic DNA. Translation: AAR93616.1 .
AY495177 Genomic DNA. Translation: AAR93629.1 .
AY495178 Genomic DNA. Translation: AAR93642.1 .
AY495179 Genomic DNA. Translation: AAR93655.1 .
AY495180 Genomic DNA. Translation: AAR93668.1 .
AY495181 Genomic DNA. Translation: AAR93681.1 .
AY495182 Genomic DNA. Translation: AAR93694.1 .
AY495183 Genomic DNA. Translation: AAR93707.1 .
AY495184 Genomic DNA. Translation: AAR93720.1 .
AY495185 Genomic DNA. Translation: AAR93733.1 .
AY495186 Genomic DNA. Translation: AAR93746.1 .
AY495187 Genomic DNA. Translation: AAR93759.1 .
AY495188 Genomic DNA. Translation: AAR93772.1 .
AY495189 Genomic DNA. Translation: AAR93785.1 .
AY495190 Genomic DNA. Translation: AAR93798.1 .
AY495191 Genomic DNA. Translation: AAR93811.1 .
AY495192 Genomic DNA. Translation: AAR93824.1 .
AY495193 Genomic DNA. Translation: AAR93837.1 .
AY495194 Genomic DNA. Translation: AAR93850.1 .
AY495195 Genomic DNA. Translation: AAR93863.1 .
AY495196 Genomic DNA. Translation: AAR93876.1 .
AY495197 Genomic DNA. Translation: AAR93889.1 .
AY495198 Genomic DNA. Translation: AAR93902.1 .
AY495199 Genomic DNA. Translation: AAR93915.1 .
AY495200 Genomic DNA. Translation: AAR93928.1 .
AY495201 Genomic DNA. Translation: AAR93941.1 .
AY495202 Genomic DNA. Translation: AAR93954.1 .
AY495203 Genomic DNA. Translation: AAR93967.1 .
AY495204 Genomic DNA. Translation: AAR93980.1 .
AY495205 Genomic DNA. Translation: AAR93993.1 .
AY495206 Genomic DNA. Translation: AAR94006.1 .
AY495207 Genomic DNA. Translation: AAR94019.1 .
AY495208 Genomic DNA. Translation: AAR94032.1 .
AY495209 Genomic DNA. Translation: AAR94045.1 .
AY495210 Genomic DNA. Translation: AAR94058.1 .
AY495211 Genomic DNA. Translation: AAR94071.1 .
AY495212 Genomic DNA. Translation: AAR94084.1 .
AY495213 Genomic DNA. Translation: AAR94097.1 .
AY495214 Genomic DNA. Translation: AAR94110.1 .
AY495215 Genomic DNA. Translation: AAR94123.1 .
AY495216 Genomic DNA. Translation: AAR94136.1 .
AY495217 Genomic DNA. Translation: AAR94149.1 .
AY495218 Genomic DNA. Translation: AAR94162.1 .
AY495219 Genomic DNA. Translation: AAR94175.1 .
AY495220 Genomic DNA. Translation: AAR94188.1 .
AY495221 Genomic DNA. Translation: AAR94201.1 .
AY495222 Genomic DNA. Translation: AAR94214.1 .
AY495223 Genomic DNA. Translation: AAR94227.1 .
AY495224 Genomic DNA. Translation: AAR94240.1 .
AY495225 Genomic DNA. Translation: AAR94253.1 .
AY495226 Genomic DNA. Translation: AAR94266.1 .
AY495228 Genomic DNA. Translation: AAR94292.1 .
AY495230 Genomic DNA. Translation: AAR94318.1 .
AY495231 Genomic DNA. Translation: AAR94331.1 .
AY495232 Genomic DNA. Translation: AAR94344.1 .
AY495233 Genomic DNA. Translation: AAR94357.1 .
AY495234 Genomic DNA. Translation: AAR94370.1 .
AY495235 Genomic DNA. Translation: AAR94383.1 .
AY495236 Genomic DNA. Translation: AAR94396.1 .
AY495237 Genomic DNA. Translation: AAR94409.1 .
AY495239 Genomic DNA. Translation: AAR94435.1 .
AY495240 Genomic DNA. Translation: AAR94448.1 .
AY495241 Genomic DNA. Translation: AAR94461.1 .
AY495242 Genomic DNA. Translation: AAR94474.1 .
AY495243 Genomic DNA. Translation: AAR94487.1 .
AY495244 Genomic DNA. Translation: AAR94500.1 .
AY495245 Genomic DNA. Translation: AAR94513.1 .
AY495246 Genomic DNA. Translation: AAR94526.1 .
AY495247 Genomic DNA. Translation: AAR94539.1 .
AY495248 Genomic DNA. Translation: AAR94552.1 .
AY495249 Genomic DNA. Translation: AAR94565.1 .
AY495250 Genomic DNA. Translation: AAR94578.1 .
AY495251 Genomic DNA. Translation: AAR94591.1 .
AY495252 Genomic DNA. Translation: AAR94604.1 .
AY495253 Genomic DNA. Translation: AAR94617.1 .
AY495254 Genomic DNA. Translation: AAR94630.1 .
AY495255 Genomic DNA. Translation: AAR94643.1 .
AY495256 Genomic DNA. Translation: AAR94656.1 .
AY495258 Genomic DNA. Translation: AAR94682.1 .
AY495259 Genomic DNA. Translation: AAR94695.1 .
AY495261 Genomic DNA. Translation: AAR94721.1 .
AY495262 Genomic DNA. Translation: AAR94734.1 .
AY495263 Genomic DNA. Translation: AAR94747.1 .
AY495264 Genomic DNA. Translation: AAR94760.1 .
AY495265 Genomic DNA. Translation: AAR94773.1 .
AY495266 Genomic DNA. Translation: AAR94786.1 .
AY495267 Genomic DNA. Translation: AAR94799.1 .
AY495268 Genomic DNA. Translation: AAR94812.1 .
AY495269 Genomic DNA. Translation: AAR94825.1 .
AY495270 Genomic DNA. Translation: AAR94838.1 .
AY495271 Genomic DNA. Translation: AAR94851.1 .
AY495272 Genomic DNA. Translation: AAR94864.1 .
AY495273 Genomic DNA. Translation: AAR94877.1 .
AY495274 Genomic DNA. Translation: AAR94890.1 .
AY495275 Genomic DNA. Translation: AAR94903.1 .
AY495276 Genomic DNA. Translation: AAR94916.1 .
AY495277 Genomic DNA. Translation: AAR94929.1 .
AY495278 Genomic DNA. Translation: AAR94942.1 .
AY495279 Genomic DNA. Translation: AAR94955.1 .
AY495280 Genomic DNA. Translation: AAR94968.1 .
AY495281 Genomic DNA. Translation: AAR94981.1 .
AY495282 Genomic DNA. Translation: AAR94994.1 .
AY495283 Genomic DNA. Translation: AAR95007.1 .
AY495284 Genomic DNA. Translation: AAR95020.1 .
AY495285 Genomic DNA. Translation: AAR95033.1 .
AY495286 Genomic DNA. Translation: AAR95046.1 .
AY495287 Genomic DNA. Translation: AAR95059.1 .
AY495288 Genomic DNA. Translation: AAR95072.1 .
AY495289 Genomic DNA. Translation: AAR95085.1 .
AY495290 Genomic DNA. Translation: AAR95098.1 .
AY495291 Genomic DNA. Translation: AAR95111.1 .
AY495292 Genomic DNA. Translation: AAR95124.1 .
AY495293 Genomic DNA. Translation: AAR95137.1 .
AY495294 Genomic DNA. Translation: AAR95150.1 .
AY495295 Genomic DNA. Translation: AAR95163.1 .
AY495297 Genomic DNA. Translation: AAR95189.1 .
AY495298 Genomic DNA. Translation: AAR95202.1 .
AY495299 Genomic DNA. Translation: AAR95215.1 .
AY495300 Genomic DNA. Translation: AAR95228.1 .
AY495301 Genomic DNA. Translation: AAR95241.1 .
AY495302 Genomic DNA. Translation: AAR95254.1 .
AY495303 Genomic DNA. Translation: AAR95267.1 .
AY495304 Genomic DNA. Translation: AAR95280.1 .
AY495305 Genomic DNA. Translation: AAR95293.1 .
AY495306 Genomic DNA. Translation: AAR95306.1 .
AY495307 Genomic DNA. Translation: AAR95319.1 .
AY495308 Genomic DNA. Translation: AAR95332.1 .
AY495309 Genomic DNA. Translation: AAR95345.1 .
AY495310 Genomic DNA. Translation: AAR95358.1 .
AY495311 Genomic DNA. Translation: AAR95371.1 .
AY495312 Genomic DNA. Translation: AAR95384.1 .
AY495313 Genomic DNA. Translation: AAR95397.1 .
AY495314 Genomic DNA. Translation: AAR95410.1 .
AY495315 Genomic DNA. Translation: AAR95423.1 .
AY495316 Genomic DNA. Translation: AAR95436.1 .
AY495317 Genomic DNA. Translation: AAR95449.1 .
AY495318 Genomic DNA. Translation: AAR95462.1 .
AY495319 Genomic DNA. Translation: AAR95475.1 .
AY495320 Genomic DNA. Translation: AAR95488.1 .
AY495322 Genomic DNA. Translation: AAR95514.1 .
AY495323 Genomic DNA. Translation: AAR95527.1 .
AY495324 Genomic DNA. Translation: AAR95540.1 .
AY495325 Genomic DNA. Translation: AAR95553.1 .
AY495326 Genomic DNA. Translation: AAR95566.1 .
AY495327 Genomic DNA. Translation: AAR95579.1 .
AY495328 Genomic DNA. Translation: AAR95592.1 .
AY495329 Genomic DNA. Translation: AAR95605.1 .
AY495330 Genomic DNA. Translation: AAR95618.1 .
M10546 Genomic DNA. Translation: AAA65503.1 .
PIRi A00463. ODHU1.
RefSeqi YP_003024028.1. NC_012920.1.

3D structure databases

ProteinModelPortali P00395.
SMRi P00395. Positions 2-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110615. 12 interactions.
IntActi P00395. 13 interactions.
MINTi MINT-4773455.

Chemistry

BindingDBi P00395.
ChEMBLi CHEMBL6173.
DrugBanki DB00711. Diethylcarbamazine.

Protein family/group databases

TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSitei P00395.

Polymorphism databases

DMDMi 116977.

Proteomic databases

PaxDbi P00395.
PRIDEi P00395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361624 ; ENSP00000354499 ; ENSG00000198804 .
GeneIDi 4512.
KEGGi hsa:4512.

Organism-specific databases

CTDi 4512.
GeneCardsi GCMTP005906.
GeneReviewsi MT-CO1.
HGNCi HGNC:7419. MT-CO1.
HPAi CAB016241.
MIMi 114500. phenotype.
220110. phenotype.
500008. phenotype.
516030. gene.
535000. phenotype.
550500. phenotype.
neXtProti NX_P00395.
Orphaneti 99845. Genetic recurrent myoglobinuria.
254905. Isolated cytochrome C oxidase deficiency.
104. Leber hereditary optic neuropathy.
255210. Maternally-inherited Leigh syndrome.
550. MELAS syndrome.
90641. Mitochondrial nonsyndromic sensorineural deafness.
168609. Mitochondrial nonsyndromic sensorineural deafness with susceptibility to aminoglycoside exposure.
PharmGKBi PA31225.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0843.
HOVERGENi HBG003841.
InParanoidi P00395.
KOi K02256.
OMAi HTFEKPP.
OrthoDBi EOG7Q8CMW.
PhylomeDBi P00395.
TreeFami TF353096.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BRENDAi 1.9.3.1. 2681.
Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GeneWikii MT-CO1.
GenomeRNAii 4512.
NextBioi 17428.
PROi P00395.
SOURCEi Search...

Gene expression databases

Bgeei P00395.
Genevestigatori P00395.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."
    Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.
    Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-235 AND ALA-415.
    Tissue: Placenta.
  3. "Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."
    Moilanen J.S., Finnila S., Majamaa K.
    Mol. Biol. Evol. 20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Mitochondrial genome variation and the origin of modern humans."
    Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
    Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."
    Ingman M., Gyllensten U.
    Genome Res. 13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."
    Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., Irwin J.A., Parsons T.J.
    Int. J. Legal Med. 118:137-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing."
    Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.
    J. Mol. Biol. 143:161-178(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
  8. "Heterogenous point mutations in the mitochondrial tRNA Ser(UCN) precursor coexisting with the A1555G mutation in deaf students from Mongolia."
    Pandya A., Xia X.J., Erdenetungalag R., Amendola M., Landa B., Radnaabazar J., Dangaasuren B., Van Tuyle G., Nance W.E.
    Am. J. Hum. Genet. 65:1803-1806(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN DFNM.
  9. "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."
    Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E.
    Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305.
  10. "A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I."
    Brown M.D., Yang C.-C., Trounce I., Torroni A., Lott M.T., Wallace D.C.
    Am. J. Hum. Genet. 51:378-385(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LHON LYS-GLN-LYS-513 INS.
  11. "Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia."
    Gattermann N., Retzlaff S., Wang Y.L., Hofhaus G., Heinisch J., Aul C., Schneider W.
    Blood 90:4961-4972(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-273 AND THR-280, POSSIBLE INVOLVEMENT IN ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA.
  12. "MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase."
    Broker S., Meunier B., Rich P., Gattermann N., Hofhaus G.
    Eur. J. Biochem. 258:132-138(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-273 AND THR-280, POSSIBLE INVOLVEMENT IN ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA.
  13. "Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA."
    Karadimas C.L., Greenstein P., Sue C.M., Joseph J.T., Tanji K., Haller R.G., Taivassalo T., Davidson M.M., Shanske S., Bonilla E., DiMauro S.
    Neurology 55:644-649(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RM-MT.
  14. Cited for: VARIANT MT-C4D ILE-196.
  15. "Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient."
    Lucioli S., Hoffmeier K., Carrozzo R., Tessa A., Ludwig B., Santorelli F.M.
    Neurogenetics 7:51-57(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MT-C4D PHE-142, CHARACTERIZATION OF VARIANT MT-C4D PHE-142.
  16. Cited for: VARIANTS CRC ASP-125 AND PRO-458.
  17. "A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase."
    Namslauer I., Brzezinski P.
    Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANTS CRC ASP-125 AND PRO-458.

Entry informationi

Entry nameiCOX1_HUMAN
AccessioniPrimary (citable) accession number: P00395
Secondary accession number(s): Q34770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi