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P00395 (COX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 156. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded onMitochondrion
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Involvement in disease

Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

MT-CO1 may play a role in the pathogenesis of acquired idiopathic sideroblastic anemia, a disease characterized by inadequate formation of heme and excessive accumulation of iron in mitochondria. Mitochondrial iron overload may be attributable to mutations of mitochondrial DNA because these can cause respiratory chain dysfunction, thereby impairing reduction of ferric iron to ferrous iron. The reduced form of iron is essential to the last step of mitochondrial heme biosynthesis.

Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14 Ref.15

Recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]: Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine.
Note: The gene represented in this entry may be involved in disease pathogenesis. Ref.13

Deafness, sensorineural, mitochondrial (DFNM) [MIM:500008]: A form of non-syndromic deafness with maternal inheritance. Affected individuals manifest progressive, postlingual, sensorineural hearing loss involving high frequencies.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Note: The gene represented in this entry may be involved in disease pathogenesis. Ref.16 Ref.17

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityPolymorphism
   DiseaseDeafness
Disease mutation
Leber hereditary optic neuropathy
Non-syndromic deafness
   DomainTransmembrane
Transmembrane helix
   LigandCopper
Heme
Iron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic respiration

Inferred from electronic annotation. Source: InterPro

cellular metabolic process

Traceable author statement. Source: Reactome

hydrogen ion transmembrane transport

Inferred from mutant phenotype Ref.14. Source: GOC

oxidative phosphorylation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

respiratory electron transport chain

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Traceable author statement. Source: Reactome

respiratory chain complex IV

Inferred from direct assay PubMed 1651240. Source: UniProtKB

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 23260140. Source: IntAct

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Cytochrome c oxidase subunit 1
PRO_0000183345

Regions

Topological domain1 – 1919Mitochondrial matrix Potential
Transmembrane20 – 4223Helical; Name=1; Potential
Topological domain43 – 5614Mitochondrial intermembrane Potential
Transmembrane57 – 7923Helical; Name=2; Potential
Topological domain80 – 9920Mitochondrial matrix Potential
Transmembrane100 – 12223Helical; Name=3; Potential
Topological domain123 – 14624Mitochondrial intermembrane Potential
Transmembrane147 – 16923Helical; Name=4; Potential
Topological domain170 – 18112Mitochondrial matrix Potential
Transmembrane182 – 20423Helical; Name=5; Potential
Topological domain205 – 23531Mitochondrial intermembrane Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27012Mitochondrial matrix Potential
Transmembrane271 – 29323Helical; Name=7; Potential
Topological domain294 – 3029Mitochondrial intermembrane Potential
Transmembrane303 – 32523Helical; Name=8; Potential
Topological domain326 – 33611Mitochondrial matrix Potential
Transmembrane337 – 35923Helical; Name=9; Potential
Topological domain360 – 37314Mitochondrial intermembrane Potential
Transmembrane374 – 39623Helical; Name=10; Potential
Topological domain397 – 40812Mitochondrial matrix Potential
Transmembrane409 – 43123Helical; Name=11; Potential
Topological domain432 – 45019Mitochondrial intermembrane Potential
Transmembrane451 – 47323Helical; Name=12; Potential
Topological domain474 – 51340Mitochondrial matrix Potential

Sites

Metal binding611Iron (heme A axial ligand) Probable
Metal binding2401Copper B Probable
Metal binding2441Copper B Probable
Metal binding2901Copper B Probable
Metal binding2911Copper B Probable
Metal binding3761Iron (heme A3 axial ligand) Probable
Metal binding3781Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Natural variations

Natural variant101T → A. Ref.9
VAR_008566
Natural variant941F → C. Ref.9
VAR_008567
Natural variant1251G → D in CRC; displays steady-state catalytic activity linked to proton pumping that is approximately 34% of wild-type; an intrinsic proton leak is find in the enzyme, which will lead to decreased overall energy-conversion efficiency of the respiratory chain, perturbing transport processes such as protein, ion and metabolite trafficking. Ref.16 Ref.17
VAR_064154
Natural variant1421S → F in MT-C4D; significant decrease in enzyme activity. Ref.15
VAR_033055
Natural variant1551V → L. Ref.9
VAR_008568
Natural variant1961L → I in MT-C4D. Ref.14
VAR_033056
Natural variant2241G → A. Ref.9
VAR_008569
Natural variant2351F → S. Ref.2
VAR_011342
Natural variant2731M → T Found in two patients with acquired idiopathic sideroblastic anemia. Ref.11 Ref.12
VAR_008385
Natural variant2801I → T Found in two patients with acquired idiopathic sideroblastic anemia. Ref.11 Ref.12
VAR_008386
Natural variant3051F → L. Ref.9
VAR_008570
Natural variant4151T → A. Ref.2
VAR_011343
Natural variant4581S → P in CRC; the mutant is probably not expressed, indicating that the amino acid substitution results in a severely altered overall structure of the enzyme. Ref.16 Ref.17
VAR_064155
Natural variant5131S → SKQK in LHON; secondary mutation; does not seem to directly cause the disease. Ref.10
VAR_008387

Sequences

Sequence LengthMass (Da)Tools
P00395 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: DBCBFE808650AE0D

FASTA51357,041
        10         20         30         40         50         60 
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA 

        70         80         90        100        110        120 
HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA 

       130        140        150        160        170        180 
GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ 

       190        200        210        220        230        240 
TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN 

       370        380        390        400        410        420 
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG 

       430        440        450        460        470        480 
VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR 

       490        500        510 
KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and organization of the human mitochondrial genome."
Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R., Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H., Smith A.J.H., Staden R., Young I.G.
Nature 290:457-465(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs."
Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-235 AND ALA-415.
Tissue: Placenta.
[3]"Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J."
Moilanen J.S., Finnila S., Majamaa K.
Mol. Biol. Evol. 20:2132-2142(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Mitochondrial genome variation and the origin of modern humans."
Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.
Nature 408:708-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines."
Ingman M., Gyllensten U.
Genome Res. 13:1600-1606(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians."
Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T., Irwin J.A., Parsons T.J.
Int. J. Legal Med. 118:137-146(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing."
Sanger F., Coulson A.R., Barrell B.G., Smith A.J.H., Roe B.A.
J. Mol. Biol. 143:161-178(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-187.
[8]"Heterogenous point mutations in the mitochondrial tRNA Ser(UCN) precursor coexisting with the A1555G mutation in deaf students from Mongolia."
Pandya A., Xia X.J., Erdenetungalag R., Amendola M., Landa B., Radnaabazar J., Dangaasuren B., Van Tuyle G., Nance W.E.
Am. J. Hum. Genet. 65:1803-1806(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN DFNM.
[9]"Normal variants of human mitochondrial DNA and translation products: the building of a reference data base."
Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R., Utthanaphol P., Byrne E.
Hum. Genet. 88:139-145(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305.
[10]"A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I."
Brown M.D., Yang C.-C., Trounce I., Torroni A., Lott M.T., Wallace D.C.
Am. J. Hum. Genet. 51:378-385(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LHON LYS-GLN-LYS-513 INS.
[11]"Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia."
Gattermann N., Retzlaff S., Wang Y.L., Hofhaus G., Heinisch J., Aul C., Schneider W.
Blood 90:4961-4972(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-273 AND THR-280, POSSIBLE INVOLVEMENT IN ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA.
[12]"MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase."
Broker S., Meunier B., Rich P., Gattermann N., Hofhaus G.
Eur. J. Biochem. 258:132-138(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-273 AND THR-280, POSSIBLE INVOLVEMENT IN ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA.
[13]"Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA."
Karadimas C.L., Greenstein P., Sue C.M., Joseph J.T., Tanji K., Haller R.G., Taivassalo T., Davidson M.M., Shanske S., Bonilla E., DiMauro S.
Neurology 55:644-649(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN RM-MT.
[14]"Metabolic consequences of a novel missense mutation of the mtDNA CO I gene."
Varlamov D.A., Kudin A.P., Vielhaber S., Schroeder R., Sassen R., Becker A., Kunz D., Haug K., Rebstock J., Heils A., Elger C.E., Kunz W.S.
Hum. Mol. Genet. 11:1797-1805(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MT-C4D ILE-196.
[15]"Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient."
Lucioli S., Hoffmeier K., Carrozzo R., Tessa A., Ludwig B., Santorelli F.M.
Neurogenetics 7:51-57(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MT-C4D PHE-142, CHARACTERIZATION OF VARIANT MT-C4D PHE-142.
[16]"Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission."
Greaves L.C., Preston S.L., Tadrous P.J., Taylor R.W., Barron M.J., Oukrif D., Leedham S.J., Deheragoda M., Sasieni P., Novelli M.R., Jankowski J.A.Z., Turnbull D.M., Wright N.A., McDonald S.A.C.
Proc. Natl. Acad. Sci. U.S.A. 103:714-719(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CRC ASP-125 AND PRO-458.
[17]"A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase."
Namslauer I., Brzezinski P.
Proc. Natl. Acad. Sci. U.S.A. 106:3402-3407(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS CRC ASP-125 AND PRO-458.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00662 Genomic DNA. Translation: CAA24028.1.
J01415 Genomic DNA. Translation: AAB58945.1.
D38112 Genomic DNA. Translation: BAA07292.1.
AY339402 Genomic DNA. Translation: AAP89038.1.
AY339403 Genomic DNA. Translation: AAP89051.1.
AY339404 Genomic DNA. Translation: AAP89064.1.
AY339405 Genomic DNA. Translation: AAP89077.1.
AY339406 Genomic DNA. Translation: AAP89090.1.
AY339407 Genomic DNA. Translation: AAP89103.1.
AY339408 Genomic DNA. Translation: AAP89116.1.
AY339409 Genomic DNA. Translation: AAP89129.1.
AY339410 Genomic DNA. Translation: AAP89142.1.
AY339411 Genomic DNA. Translation: AAP89155.1.
AY339412 Genomic DNA. Translation: AAP89168.1.
AY339421 Genomic DNA. Translation: AAP89285.1.
AY339422 Genomic DNA. Translation: AAP89298.1.
AY339423 Genomic DNA. Translation: AAP89311.1.
AY339424 Genomic DNA. Translation: AAP89324.1.
AY339425 Genomic DNA. Translation: AAP89337.1.
AY339426 Genomic DNA. Translation: AAP89350.1.
AY339427 Genomic DNA. Translation: AAP89363.1.
AY339428 Genomic DNA. Translation: AAP89376.1.
AY339429 Genomic DNA. Translation: AAP89389.1.
AY339430 Genomic DNA. Translation: AAP89402.1.
AY339431 Genomic DNA. Translation: AAP89415.1.
AY339432 Genomic DNA. Translation: AAP89428.1.
AY339433 Genomic DNA. Translation: AAP89441.1.
AY339434 Genomic DNA. Translation: AAP89454.1.
AY339435 Genomic DNA. Translation: AAP89467.1.
AY339436 Genomic DNA. Translation: AAP89480.1.
AY339437 Genomic DNA. Translation: AAP89493.1.
AY339438 Genomic DNA. Translation: AAP89506.1.
AY339439 Genomic DNA. Translation: AAP89519.1.
AY339440 Genomic DNA. Translation: AAP89532.1.
AY339441 Genomic DNA. Translation: AAP89545.1.
AY339442 Genomic DNA. Translation: AAP89558.1.
AY339443 Genomic DNA. Translation: AAP89571.1.
AY339444 Genomic DNA. Translation: AAP89584.1.
AY339445 Genomic DNA. Translation: AAP89597.1.
AY339451 Genomic DNA. Translation: AAP89675.1.
AY339452 Genomic DNA. Translation: AAP89688.1.
AY339453 Genomic DNA. Translation: AAP89701.1.
AY339454 Genomic DNA. Translation: AAP89714.1.
AY339455 Genomic DNA. Translation: AAP89727.1.
AY339456 Genomic DNA. Translation: AAP89740.1.
AY339457 Genomic DNA. Translation: AAP89753.1.
AY339458 Genomic DNA. Translation: AAP89766.1.
AY339459 Genomic DNA. Translation: AAP89779.1.
AY339460 Genomic DNA. Translation: AAP89792.1.
AY339461 Genomic DNA. Translation: AAP89805.1.
AY339462 Genomic DNA. Translation: AAP89818.1.
AY339463 Genomic DNA. Translation: AAP89831.1.
AY339464 Genomic DNA. Translation: AAP89844.1.
AY339465 Genomic DNA. Translation: AAP89857.1.
AY339466 Genomic DNA. Translation: AAP89870.1.
AY339467 Genomic DNA. Translation: AAP89883.1.
AY339468 Genomic DNA. Translation: AAP89896.1.
AY339469 Genomic DNA. Translation: AAP89909.1.
AY339470 Genomic DNA. Translation: AAP89922.1.
AY339471 Genomic DNA. Translation: AAP89935.1.
AY339472 Genomic DNA. Translation: AAP89948.1.
AY339473 Genomic DNA. Translation: AAP89961.1.
AY339474 Genomic DNA. Translation: AAP89974.1.
AY339475 Genomic DNA. Translation: AAP89987.1.
AY339476 Genomic DNA. Translation: AAP90000.1.
AY339477 Genomic DNA. Translation: AAP90013.1.
AY339478 Genomic DNA. Translation: AAP90026.1.
AY339479 Genomic DNA. Translation: AAP90039.1.
AY339480 Genomic DNA. Translation: AAP90052.1.
AY339481 Genomic DNA. Translation: AAP90065.1.
AY339482 Genomic DNA. Translation: AAP90078.1.
AY339483 Genomic DNA. Translation: AAP90091.1.
AY339484 Genomic DNA. Translation: AAP90104.1.
AY339485 Genomic DNA. Translation: AAP90117.1.
AY339486 Genomic DNA. Translation: AAP90130.1.
AY339487 Genomic DNA. Translation: AAP90143.1.
AY339488 Genomic DNA. Translation: AAP90156.1.
AY339489 Genomic DNA. Translation: AAP90169.1.
AY339490 Genomic DNA. Translation: AAP90182.1.
AY339491 Genomic DNA. Translation: AAP90195.1.
AY339492 Genomic DNA. Translation: AAP90208.1.
AY339493 Genomic DNA. Translation: AAP90221.1.
AY339494 Genomic DNA. Translation: AAP90234.1.
AY339495 Genomic DNA. Translation: AAP90247.1.
AY339496 Genomic DNA. Translation: AAP90260.1.
AY339497 Genomic DNA. Translation: AAP90273.1.
AY339498 Genomic DNA. Translation: AAP90286.1.
AY339499 Genomic DNA. Translation: AAP90299.1.
AY339500 Genomic DNA. Translation: AAP90312.1.
AY339501 Genomic DNA. Translation: AAP90325.1.
AY339502 Genomic DNA. Translation: AAP90338.1.
AY339503 Genomic DNA. Translation: AAP90351.1.
AY339504 Genomic DNA. Translation: AAP90364.1.
AY339505 Genomic DNA. Translation: AAP90377.1.
AY339506 Genomic DNA. Translation: AAP90390.1.
AY339507 Genomic DNA. Translation: AAP90403.1.
AY339508 Genomic DNA. Translation: AAP90416.1.
AY339509 Genomic DNA. Translation: AAP90429.1.
AY339510 Genomic DNA. Translation: AAP90442.1.
AY339511 Genomic DNA. Translation: AAP90455.1.
AY339512 Genomic DNA. Translation: AAP90468.1.
AY339513 Genomic DNA. Translation: AAP90481.1.
AY339514 Genomic DNA. Translation: AAP90494.1.
AY339515 Genomic DNA. Translation: AAP90507.1.
AY339516 Genomic DNA. Translation: AAP90520.1.
AY339517 Genomic DNA. Translation: AAP90533.1.
AY339518 Genomic DNA. Translation: AAP90546.1.
AY339519 Genomic DNA. Translation: AAP90559.1.
AY339520 Genomic DNA. Translation: AAP90572.1.
AY339521 Genomic DNA. Translation: AAP90585.1.
AY339522 Genomic DNA. Translation: AAP90598.1.
AY339523 Genomic DNA. Translation: AAP90611.1.
AY339524 Genomic DNA. Translation: AAP90624.1.
AY339525 Genomic DNA. Translation: AAP90637.1.
AY339526 Genomic DNA. Translation: AAP90650.1.
AY339527 Genomic DNA. Translation: AAP90663.1.
AY339528 Genomic DNA. Translation: AAP90676.1.
AY339529 Genomic DNA. Translation: AAP90689.1.
AY339530 Genomic DNA. Translation: AAP90702.1.
AY339531 Genomic DNA. Translation: AAP90715.1.
AY339532 Genomic DNA. Translation: AAP90728.1.
AY339533 Genomic DNA. Translation: AAP90741.1.
AY339534 Genomic DNA. Translation: AAP90754.1.
AY339535 Genomic DNA. Translation: AAP90767.1.
AY339536 Genomic DNA. Translation: AAP90780.1.
AY339537 Genomic DNA. Translation: AAP90793.1.
AY339538 Genomic DNA. Translation: AAP90806.1.
AY339539 Genomic DNA. Translation: AAP90819.1.
AY339540 Genomic DNA. Translation: AAP90832.1.
AY339541 Genomic DNA. Translation: AAP90845.1.
AY339542 Genomic DNA. Translation: AAP90858.1.
AY339543 Genomic DNA. Translation: AAP90871.1.
AY339544 Genomic DNA. Translation: AAP90884.1.
AY339545 Genomic DNA. Translation: AAP90897.1.
AY339546 Genomic DNA. Translation: AAP90910.1.
AY339547 Genomic DNA. Translation: AAP90923.1.
AY339548 Genomic DNA. Translation: AAP90936.1.
AY339549 Genomic DNA. Translation: AAP90949.1.
AY339550 Genomic DNA. Translation: AAP90962.1.
AY339551 Genomic DNA. Translation: AAP90975.1.
AY339552 Genomic DNA. Translation: AAP90988.1.
AY339553 Genomic DNA. Translation: AAP91001.1.
AY339554 Genomic DNA. Translation: AAP91014.1.
AY339555 Genomic DNA. Translation: AAP91027.1.
AY339556 Genomic DNA. Translation: AAP91040.1.
AY339557 Genomic DNA. Translation: AAP91053.1.
AY339558 Genomic DNA. Translation: AAP91066.1.
AY339559 Genomic DNA. Translation: AAP91079.1.
AY339560 Genomic DNA. Translation: AAP91092.1.
AY339563 Genomic DNA. Translation: AAP91131.1.
AY339564 Genomic DNA. Translation: AAP91144.1.
AY339566 Genomic DNA. Translation: AAP91170.1.
AY339567 Genomic DNA. Translation: AAP91183.1.
AY339568 Genomic DNA. Translation: AAP91196.1.
AY339569 Genomic DNA. Translation: AAP91209.1.
AY339570 Genomic DNA. Translation: AAP91222.1.
AY339571 Genomic DNA. Translation: AAP91235.1.
AY339572 Genomic DNA. Translation: AAP91248.1.
AY339573 Genomic DNA. Translation: AAP91261.1.
AY339574 Genomic DNA. Translation: AAP91274.1.
AY339575 Genomic DNA. Translation: AAP91287.1.
AY339576 Genomic DNA. Translation: AAP91300.1.
AY339577 Genomic DNA. Translation: AAP91313.1.
AY339578 Genomic DNA. Translation: AAP91326.1.
AY339579 Genomic DNA. Translation: AAP91339.1.
AY339580 Genomic DNA. Translation: AAP91352.1.
AY339581 Genomic DNA. Translation: AAP91365.1.
AY339582 Genomic DNA. Translation: AAP91378.1.
AY339583 Genomic DNA. Translation: AAP91391.1.
AY339584 Genomic DNA. Translation: AAP91404.1.
AY339585 Genomic DNA. Translation: AAP91417.1.
AY339586 Genomic DNA. Translation: AAP91430.1.
AY339587 Genomic DNA. Translation: AAP91443.1.
AY339588 Genomic DNA. Translation: AAP91456.1.
AY339589 Genomic DNA. Translation: AAP91469.1.
AY339590 Genomic DNA. Translation: AAP91482.1.
AY339591 Genomic DNA. Translation: AAP91495.1.
AY339592 Genomic DNA. Translation: AAP91508.1.
AY339593 Genomic DNA. Translation: AAP91521.1.
AF346963 Genomic DNA. Translation: AAK17209.1.
AF346964 Genomic DNA. Translation: AAK17222.1.
AF346965 Genomic DNA. Translation: AAK17235.1.
AF346966 Genomic DNA. Translation: AAK17248.1.
AF346967 Genomic DNA. Translation: AAK17261.1.
AF346970 Genomic DNA. Translation: AAK17300.1.
AF346971 Genomic DNA. Translation: AAK17313.1.
AF346972 Genomic DNA. Translation: AAK17326.1.
AF346973 Genomic DNA. Translation: AAK17339.1.
AF346974 Genomic DNA. Translation: AAK17352.1.
AF346975 Genomic DNA. Translation: AAK17365.1.
AF346976 Genomic DNA. Translation: AAK17378.1.
AF346977 Genomic DNA. Translation: AAK17391.1.
AF346978 Genomic DNA. Translation: AAK17404.1.
AF346979 Genomic DNA. Translation: AAK17417.1.
AF346980 Genomic DNA. Translation: AAK17430.1.
AF346981 Genomic DNA. Translation: AAK17443.1.
AF346982 Genomic DNA. Translation: AAK17456.1.
AF346983 Genomic DNA. Translation: AAK17469.1.
AF346984 Genomic DNA. Translation: AAK17482.1.
AF346988 Genomic DNA. Translation: AAK17534.1.
AF346989 Genomic DNA. Translation: AAK17547.1.
AF346990 Genomic DNA. Translation: AAK17560.1.
AF346991 Genomic DNA. Translation: AAK17573.1.
AF346993 Genomic DNA. Translation: AAK17599.1.
AF346994 Genomic DNA. Translation: AAK17612.1.
AF346995 Genomic DNA. Translation: AAK17625.1.
AF346998 Genomic DNA. Translation: AAK17664.1.
AF347000 Genomic DNA. Translation: AAK17690.1.
AF347001 Genomic DNA. Translation: AAK17703.1.
AF347003 Genomic DNA. Translation: AAK17729.1.
AF347004 Genomic DNA. Translation: AAK17742.1.
AF347007 Genomic DNA. Translation: AAK17781.1.
AF347010 Genomic DNA. Translation: AAK17820.1.
AF347011 Genomic DNA. Translation: AAK17833.1.
AF347012 Genomic DNA. Translation: AAK17846.1.
AF347013 Genomic DNA. Translation: AAK17859.1.
AF347014 Genomic DNA. Translation: AAK17872.1.
AF347015 Genomic DNA. Translation: AAK17885.1.
AY289051 Genomic DNA. Translation: AAP47882.1.
AY289052 Genomic DNA. Translation: AAP47895.1.
AY289053 Genomic DNA. Translation: AAP47908.1.
AY289055 Genomic DNA. Translation: AAP47934.1.
AY289056 Genomic DNA. Translation: AAP47947.1.
AY289057 Genomic DNA. Translation: AAP47960.1.
AY289058 Genomic DNA. Translation: AAP47973.1.
AY289059 Genomic DNA. Translation: AAP47986.1.
AY289060 Genomic DNA. Translation: AAP47999.1.
AY289061 Genomic DNA. Translation: AAP48012.1.
AY289062 Genomic DNA. Translation: AAP48025.1.
AY289064 Genomic DNA. Translation: AAP48051.1.
AY289065 Genomic DNA. Translation: AAP48064.1.
AY289066 Genomic DNA. Translation: AAP48077.1.
AY289067 Genomic DNA. Translation: AAP48090.1.
AY289068 Genomic DNA. Translation: AAP48103.1.
AY289069 Genomic DNA. Translation: AAP48116.1.
AY289070 Genomic DNA. Translation: AAP48129.1.
AY289071 Genomic DNA. Translation: AAP48142.1.
AY289073 Genomic DNA. Translation: AAP48168.1.
AY289074 Genomic DNA. Translation: AAP48181.1.
AY289075 Genomic DNA. Translation: AAP48194.1.
AY289076 Genomic DNA. Translation: AAP48207.1.
AY289077 Genomic DNA. Translation: AAP48220.1.
AY289078 Genomic DNA. Translation: AAP48233.1.
AY289079 Genomic DNA. Translation: AAP48246.1.
AY289080 Genomic DNA. Translation: AAP48259.1.
AY289081 Genomic DNA. Translation: AAP48272.1.
AY289082 Genomic DNA. Translation: AAP48285.1.
AY289083 Genomic DNA. Translation: AAP48298.1.
AY289084 Genomic DNA. Translation: AAP48311.1.
AY289085 Genomic DNA. Translation: AAP48324.1.
AY289086 Genomic DNA. Translation: AAP48337.1.
AY289088 Genomic DNA. Translation: AAP48363.1.
AY289089 Genomic DNA. Translation: AAP48376.1.
AY289090 Genomic DNA. Translation: AAP48389.1.
AY289092 Genomic DNA. Translation: AAP48415.1.
AY289093 Genomic DNA. Translation: AAP48427.1.
AY289094 Genomic DNA. Translation: AAP48440.1.
AY289095 Genomic DNA. Translation: AAP48453.1.
AY289096 Genomic DNA. Translation: AAP48466.1.
AY289097 Genomic DNA. Translation: AAP48479.1.
AY289098 Genomic DNA. Translation: AAP48492.1.
AY289099 Genomic DNA. Translation: AAP48505.1.
AY289100 Genomic DNA. Translation: AAP48518.1.
AY289101 Genomic DNA. Translation: AAP48531.1.
AY289102 Genomic DNA. Translation: AAP48544.1.
AY495090 Genomic DNA. Translation: AAR92498.1.
AY495091 Genomic DNA. Translation: AAR92511.1.
AY495092 Genomic DNA. Translation: AAR92524.1.
AY495093 Genomic DNA. Translation: AAR92537.1.
AY495094 Genomic DNA. Translation: AAR92550.1.
AY495095 Genomic DNA. Translation: AAR92563.1.
AY495096 Genomic DNA. Translation: AAR92576.1.
AY495097 Genomic DNA. Translation: AAR92589.1.
AY495098 Genomic DNA. Translation: AAR92602.1.
AY495099 Genomic DNA. Translation: AAR92615.1.
AY495100 Genomic DNA. Translation: AAR92628.1.
AY495101 Genomic DNA. Translation: AAR92641.1.
AY495102 Genomic DNA. Translation: AAR92654.1.
AY495103 Genomic DNA. Translation: AAR92667.1.
AY495104 Genomic DNA. Translation: AAR92680.1.
AY495105 Genomic DNA. Translation: AAR92693.1.
AY495106 Genomic DNA. Translation: AAR92706.1.
AY495107 Genomic DNA. Translation: AAR92719.1.
AY495108 Genomic DNA. Translation: AAR92732.1.
AY495109 Genomic DNA. Translation: AAR92745.1.
AY495110 Genomic DNA. Translation: AAR92758.1.
AY495111 Genomic DNA. Translation: AAR92771.1.
AY495112 Genomic DNA. Translation: AAR92784.1.
AY495113 Genomic DNA. Translation: AAR92797.1.
AY495114 Genomic DNA. Translation: AAR92810.1.
AY495116 Genomic DNA. Translation: AAR92836.1.
AY495117 Genomic DNA. Translation: AAR92849.1.
AY495118 Genomic DNA. Translation: AAR92862.1.
AY495119 Genomic DNA. Translation: AAR92875.1.
AY495120 Genomic DNA. Translation: AAR92888.1.
AY495121 Genomic DNA. Translation: AAR92901.1.
AY495122 Genomic DNA. Translation: AAR92914.1.
AY495123 Genomic DNA. Translation: AAR92927.1.
AY495124 Genomic DNA. Translation: AAR92940.1.
AY495125 Genomic DNA. Translation: AAR92953.1.
AY495126 Genomic DNA. Translation: AAR92966.1.
AY495127 Genomic DNA. Translation: AAR92979.1.
AY495128 Genomic DNA. Translation: AAR92992.1.
AY495129 Genomic DNA. Translation: AAR93005.1.
AY495130 Genomic DNA. Translation: AAR93018.1.
AY495131 Genomic DNA. Translation: AAR93031.1.
AY495132 Genomic DNA. Translation: AAR93044.1.
AY495133 Genomic DNA. Translation: AAR93057.1.
AY495134 Genomic DNA. Translation: AAR93070.1.
AY495135 Genomic DNA. Translation: AAR93083.1.
AY495136 Genomic DNA. Translation: AAR93096.1.
AY495137 Genomic DNA. Translation: AAR93109.1.
AY495138 Genomic DNA. Translation: AAR93122.1.
AY495139 Genomic DNA. Translation: AAR93135.1.
AY495140 Genomic DNA. Translation: AAR93148.1.
AY495141 Genomic DNA. Translation: AAR93161.1.
AY495142 Genomic DNA. Translation: AAR93174.1.
AY495143 Genomic DNA. Translation: AAR93187.1.
AY495144 Genomic DNA. Translation: AAR93200.1.
AY495145 Genomic DNA. Translation: AAR93213.1.
AY495147 Genomic DNA. Translation: AAR93239.1.
AY495148 Genomic DNA. Translation: AAR93252.1.
AY495149 Genomic DNA. Translation: AAR93265.1.
AY495150 Genomic DNA. Translation: AAR93278.1.
AY495151 Genomic DNA. Translation: AAR93291.1.
AY495152 Genomic DNA. Translation: AAR93304.1.
AY495153 Genomic DNA. Translation: AAR93317.1.
AY495154 Genomic DNA. Translation: AAR93330.1.
AY495155 Genomic DNA. Translation: AAR93343.1.
AY495156 Genomic DNA. Translation: AAR93356.1.
AY495157 Genomic DNA. Translation: AAR93369.1.
AY495158 Genomic DNA. Translation: AAR93382.1.
AY495159 Genomic DNA. Translation: AAR93395.1.
AY495160 Genomic DNA. Translation: AAR93408.1.
AY495161 Genomic DNA. Translation: AAR93421.1.
AY495162 Genomic DNA. Translation: AAR93434.1.
AY495163 Genomic DNA. Translation: AAR93447.1.
AY495164 Genomic DNA. Translation: AAR93460.1.
AY495165 Genomic DNA. Translation: AAR93473.1.
AY495166 Genomic DNA. Translation: AAR93486.1.
AY495167 Genomic DNA. Translation: AAR93499.1.
AY495168 Genomic DNA. Translation: AAR93512.1.
AY495169 Genomic DNA. Translation: AAR93525.1.
AY495170 Genomic DNA. Translation: AAR93538.1.
AY495171 Genomic DNA. Translation: AAR93551.1.
AY495172 Genomic DNA. Translation: AAR93564.1.
AY495173 Genomic DNA. Translation: AAR93577.1.
AY495174 Genomic DNA. Translation: AAR93590.1.
AY495175 Genomic DNA. Translation: AAR93603.1.
AY495176 Genomic DNA. Translation: AAR93616.1.
AY495177 Genomic DNA. Translation: AAR93629.1.
AY495178 Genomic DNA. Translation: AAR93642.1.
AY495179 Genomic DNA. Translation: AAR93655.1.
AY495180 Genomic DNA. Translation: AAR93668.1.
AY495181 Genomic DNA. Translation: AAR93681.1.
AY495182 Genomic DNA. Translation: AAR93694.1.
AY495183 Genomic DNA. Translation: AAR93707.1.
AY495184 Genomic DNA. Translation: AAR93720.1.
AY495185 Genomic DNA. Translation: AAR93733.1.
AY495186 Genomic DNA. Translation: AAR93746.1.
AY495187 Genomic DNA. Translation: AAR93759.1.
AY495188 Genomic DNA. Translation: AAR93772.1.
AY495189 Genomic DNA. Translation: AAR93785.1.
AY495190 Genomic DNA. Translation: AAR93798.1.
AY495191 Genomic DNA. Translation: AAR93811.1.
AY495192 Genomic DNA. Translation: AAR93824.1.
AY495193 Genomic DNA. Translation: AAR93837.1.
AY495194 Genomic DNA. Translation: AAR93850.1.
AY495195 Genomic DNA. Translation: AAR93863.1.
AY495196 Genomic DNA. Translation: AAR93876.1.
AY495197 Genomic DNA. Translation: AAR93889.1.
AY495198 Genomic DNA. Translation: AAR93902.1.
AY495199 Genomic DNA. Translation: AAR93915.1.
AY495200 Genomic DNA. Translation: AAR93928.1.
AY495201 Genomic DNA. Translation: AAR93941.1.
AY495202 Genomic DNA. Translation: AAR93954.1.
AY495203 Genomic DNA. Translation: AAR93967.1.
AY495204 Genomic DNA. Translation: AAR93980.1.
AY495205 Genomic DNA. Translation: AAR93993.1.
AY495206 Genomic DNA. Translation: AAR94006.1.
AY495207 Genomic DNA. Translation: AAR94019.1.
AY495208 Genomic DNA. Translation: AAR94032.1.
AY495209 Genomic DNA. Translation: AAR94045.1.
AY495210 Genomic DNA. Translation: AAR94058.1.
AY495211 Genomic DNA. Translation: AAR94071.1.
AY495212 Genomic DNA. Translation: AAR94084.1.
AY495213 Genomic DNA. Translation: AAR94097.1.
AY495214 Genomic DNA. Translation: AAR94110.1.
AY495215 Genomic DNA. Translation: AAR94123.1.
AY495216 Genomic DNA. Translation: AAR94136.1.
AY495217 Genomic DNA. Translation: AAR94149.1.
AY495218 Genomic DNA. Translation: AAR94162.1.
AY495219 Genomic DNA. Translation: AAR94175.1.
AY495220 Genomic DNA. Translation: AAR94188.1.
AY495221 Genomic DNA. Translation: AAR94201.1.
AY495222 Genomic DNA. Translation: AAR94214.1.
AY495223 Genomic DNA. Translation: AAR94227.1.
AY495224 Genomic DNA. Translation: AAR94240.1.
AY495225 Genomic DNA. Translation: AAR94253.1.
AY495226 Genomic DNA. Translation: AAR94266.1.
AY495228 Genomic DNA. Translation: AAR94292.1.
AY495230 Genomic DNA. Translation: AAR94318.1.
AY495231 Genomic DNA. Translation: AAR94331.1.
AY495232 Genomic DNA. Translation: AAR94344.1.
AY495233 Genomic DNA. Translation: AAR94357.1.
AY495234 Genomic DNA. Translation: AAR94370.1.
AY495235 Genomic DNA. Translation: AAR94383.1.
AY495236 Genomic DNA. Translation: AAR94396.1.
AY495237 Genomic DNA. Translation: AAR94409.1.
AY495239 Genomic DNA. Translation: AAR94435.1.
AY495240 Genomic DNA. Translation: AAR94448.1.
AY495241 Genomic DNA. Translation: AAR94461.1.
AY495242 Genomic DNA. Translation: AAR94474.1.
AY495243 Genomic DNA. Translation: AAR94487.1.
AY495244 Genomic DNA. Translation: AAR94500.1.
AY495245 Genomic DNA. Translation: AAR94513.1.
AY495246 Genomic DNA. Translation: AAR94526.1.
AY495247 Genomic DNA. Translation: AAR94539.1.
AY495248 Genomic DNA. Translation: AAR94552.1.
AY495249 Genomic DNA. Translation: AAR94565.1.
AY495250 Genomic DNA. Translation: AAR94578.1.
AY495251 Genomic DNA. Translation: AAR94591.1.
AY495252 Genomic DNA. Translation: AAR94604.1.
AY495253 Genomic DNA. Translation: AAR94617.1.
AY495254 Genomic DNA. Translation: AAR94630.1.
AY495255 Genomic DNA. Translation: AAR94643.1.
AY495256 Genomic DNA. Translation: AAR94656.1.
AY495258 Genomic DNA. Translation: AAR94682.1.
AY495259 Genomic DNA. Translation: AAR94695.1.
AY495261 Genomic DNA. Translation: AAR94721.1.
AY495262 Genomic DNA. Translation: AAR94734.1.
AY495263 Genomic DNA. Translation: AAR94747.1.
AY495264 Genomic DNA. Translation: AAR94760.1.
AY495265 Genomic DNA. Translation: AAR94773.1.
AY495266 Genomic DNA. Translation: AAR94786.1.
AY495267 Genomic DNA. Translation: AAR94799.1.
AY495268 Genomic DNA. Translation: AAR94812.1.
AY495269 Genomic DNA. Translation: AAR94825.1.
AY495270 Genomic DNA. Translation: AAR94838.1.
AY495271 Genomic DNA. Translation: AAR94851.1.
AY495272 Genomic DNA. Translation: AAR94864.1.
AY495273 Genomic DNA. Translation: AAR94877.1.
AY495274 Genomic DNA. Translation: AAR94890.1.
AY495275 Genomic DNA. Translation: AAR94903.1.
AY495276 Genomic DNA. Translation: AAR94916.1.
AY495277 Genomic DNA. Translation: AAR94929.1.
AY495278 Genomic DNA. Translation: AAR94942.1.
AY495279 Genomic DNA. Translation: AAR94955.1.
AY495280 Genomic DNA. Translation: AAR94968.1.
AY495281 Genomic DNA. Translation: AAR94981.1.
AY495282 Genomic DNA. Translation: AAR94994.1.
AY495283 Genomic DNA. Translation: AAR95007.1.
AY495284 Genomic DNA. Translation: AAR95020.1.
AY495285 Genomic DNA. Translation: AAR95033.1.
AY495286 Genomic DNA. Translation: AAR95046.1.
AY495287 Genomic DNA. Translation: AAR95059.1.
AY495288 Genomic DNA. Translation: AAR95072.1.
AY495289 Genomic DNA. Translation: AAR95085.1.
AY495290 Genomic DNA. Translation: AAR95098.1.
AY495291 Genomic DNA. Translation: AAR95111.1.
AY495292 Genomic DNA. Translation: AAR95124.1.
AY495293 Genomic DNA. Translation: AAR95137.1.
AY495294 Genomic DNA. Translation: AAR95150.1.
AY495295 Genomic DNA. Translation: AAR95163.1.
AY495297 Genomic DNA. Translation: AAR95189.1.
AY495298 Genomic DNA. Translation: AAR95202.1.
AY495299 Genomic DNA. Translation: AAR95215.1.
AY495300 Genomic DNA. Translation: AAR95228.1.
AY495301 Genomic DNA. Translation: AAR95241.1.
AY495302 Genomic DNA. Translation: AAR95254.1.
AY495303 Genomic DNA. Translation: AAR95267.1.
AY495304 Genomic DNA. Translation: AAR95280.1.
AY495305 Genomic DNA. Translation: AAR95293.1.
AY495306 Genomic DNA. Translation: AAR95306.1.
AY495307 Genomic DNA. Translation: AAR95319.1.
AY495308 Genomic DNA. Translation: AAR95332.1.
AY495309 Genomic DNA. Translation: AAR95345.1.
AY495310 Genomic DNA. Translation: AAR95358.1.
AY495311 Genomic DNA. Translation: AAR95371.1.
AY495312 Genomic DNA. Translation: AAR95384.1.
AY495313 Genomic DNA. Translation: AAR95397.1.
AY495314 Genomic DNA. Translation: AAR95410.1.
AY495315 Genomic DNA. Translation: AAR95423.1.
AY495316 Genomic DNA. Translation: AAR95436.1.
AY495317 Genomic DNA. Translation: AAR95449.1.
AY495318 Genomic DNA. Translation: AAR95462.1.
AY495319 Genomic DNA. Translation: AAR95475.1.
AY495320 Genomic DNA. Translation: AAR95488.1.
AY495322 Genomic DNA. Translation: AAR95514.1.
AY495323 Genomic DNA. Translation: AAR95527.1.
AY495324 Genomic DNA. Translation: AAR95540.1.
AY495325 Genomic DNA. Translation: AAR95553.1.
AY495326 Genomic DNA. Translation: AAR95566.1.
AY495327 Genomic DNA. Translation: AAR95579.1.
AY495328 Genomic DNA. Translation: AAR95592.1.
AY495329 Genomic DNA. Translation: AAR95605.1.
AY495330 Genomic DNA. Translation: AAR95618.1.
M10546 Genomic DNA. Translation: AAA65503.1.
PIRODHU1. A00463.
RefSeqYP_003024028.1. NC_012920.1.

3D structure databases

ProteinModelPortalP00395.
SMRP00395. Positions 2-511.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110615. 12 interactions.
IntActP00395. 13 interactions.
MINTMINT-4773455.

Chemistry

BindingDBP00395.
ChEMBLCHEMBL6173.
DrugBankDB00711. Diethylcarbamazine.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteP00395.

Polymorphism databases

DMDM116977.

Proteomic databases

PaxDbP00395.
PRIDEP00395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361624; ENSP00000354499; ENSG00000198804.
GeneID4512.
KEGGhsa:4512.

Organism-specific databases

CTD4512.
GeneCardsGCMTP005906.
GeneReviewsMT-CO1.
HGNCHGNC:7419. MT-CO1.
HPACAB016241.
MIM114500. phenotype.
220110. phenotype.
500008. phenotype.
516030. gene.
535000. phenotype.
550500. phenotype.
neXtProtNX_P00395.
Orphanet99845. Genetic recurrent myoglobinuria.
254905. Isolated cytochrome C oxidase deficiency.
104. Leber hereditary optic neuropathy.
255210. Maternally-inherited Leigh syndrome.
550. MELAS syndrome.
90641. Mitochondrial nonsyndromic sensorineural deafness.
168609. Mitochondrial nonsyndromic sensorineural deafness with susceptibility to aminoglycoside exposure.
PharmGKBPA31225.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0843.
HOVERGENHBG003841.
InParanoidP00395.
KOK02256.
OMAHTFEKPP.
OrthoDBEOG7Q8CMW.
PhylomeDBP00395.
TreeFamTF353096.

Enzyme and pathway databases

BRENDA1.9.3.1. 2681.
ReactomeREACT_111217. Metabolism.
UniPathwayUPA00705.

Gene expression databases

BgeeP00395.
GenevestigatorP00395.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMT-CO1.
GenomeRNAi4512.
NextBio17428.
PROP00395.
SOURCESearch...

Entry information

Entry nameCOX1_HUMAN
AccessionPrimary (citable) accession number: P00395
Secondary accession number(s): Q34770
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations