P00376Q29RI1DYR_BOVINDihydrofolate reductase1.5.1.3DHFRBos taurusBovineEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBosNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Structure of dihydrofolate reductase: primary sequence of the bovine liver enzyme.PROTEIN SEQUENCE OF 2-187Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPHCofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.Homodimer.MitochondrionCytoplasmBelongs to the dihydrofolate reductase family.CytoplasmDirect protein sequencingMethotrexate resistanceMitochondrionNADPOne-carbon metabolismOxidoreductaseReference proteomeRNA-bindingNADP(+)NADP(+)substrateNADP(+)substrateNADP(+)NADP(+)DNEQMVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
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