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Reviewed, UniProtKB/Swiss-Prot P00368 (DHE3_CHICK)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutamate dehydrogenase 1, mitochondrial
      Short name=GDH
    EC=1.4.1.3
Gene names
Name: GLUD1
Synonyms: GLUD
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate By similarity.

Catalytic activity

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Enzyme regulation

Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP By similarity.

Subunit structure

Homohexamer.

Subcellular location

Mitochondrion matrix.

Miscellaneous

ADP can occupy the NADH binding site and activate the enzyme By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

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Ontologies

Keywords
   Cellular componentMitochondrion
   LigandATP-binding
GTP-binding
NADP
Nucleotide-binding
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processamino acid metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Glutamate dehydrogenase 1, mitochondrial
PRO_0000182742

Regions

Nucleotide binding87 – 893NAD By similarity

Sites

Active site1291 Ref.1
Binding site931Substrate By similarity
Binding site1171Substrate By similarity
Binding site1221NAD By similarity
Binding site1981NAD By similarity
Binding site2121GTP By similarity
Binding site2161GTP By similarity
Binding site2651GTP By similarity
Binding site2681GTP By similarity
Binding site3841Substrate By similarity
Binding site3891NAD By similarity
Binding site3951ADP By similarity
Binding site4611ADP By similarity

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Sequences

Sequence LengthMass (Da)Tools
P00368-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 340DDB45BB0A5B04

FASTA50355,712
        10         20         30         40         50         60 
CZAADKEDDP NFFKMVEGFF DRGASIVEDK LVEGLRTRQS MEQRRHRVRG ILRIIKPCNH 

        70         80         90        100        110        120 
VLSVSFPIKR DDGZWEVIEG YRAQHSHQRT PCKGGIRYSL DVSVDEVKAL ASLMTYKCAV 

       130        140        150        160        170        180 
VDVPFGGAKA GVKINPKNYT DEDLEKITRR FTMELAKKGF IGPGVDVPAP NMSTGEREMS 

       190        200        210        220        230        240 
WIADTYASTI GHYDINAHAC VTKPGISQGG IHGRISATGR GLFGHIENFI ENASYMSILG 

       250        260        270        280        290        300 
MTPGFGDKTF AVQGFGNVGL HSMRYLHRFG AKCVAVGEFD GSIWNPDGID PKELEDYKLQ 

       310        320        330        340        350        360 
HGTIMGFPKA QKLEGSILET DCDILIPAAS EKQLTKANAH KVKAKIIAEG ANGPTTPQAD 

       370        380        390        400        410        420 
KIFLERNIMV IPDLYLNAGG VTVSAFZZKN LNHVSYGRLT FKYERDSNYH LLMSVQESLE 

       430        440        450        460        470        480 
RKFGKHGGTI PVVPTAEFQD RISGASEKDI VHSGLAYTME RSARQIMRTA MKYNLGLDLR 

       490        500 
TAAYVNAIEK VFKVYNEAGL TFT

« Hide

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References

[1]"Amino acd sequence of chicken liver glutamate dehydrogenase."
Moon K., Piszkiewicz D., Smith E.L.
J. Biol. Chem. 248:3093-3107(1973) [PubMed: 4735574] [Abstract]
Cited for: PROTEIN SEQUENCE, ACTIVE SITE.
Tissue: Liver.

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Cross-references

Sequence databases

IPIIPI00598425.
PIRDECHE. A00380.
UniGeneGga.16450

3D structure databases

HSSPHSSP built from PDB template 1HWX based on UniProtKB P00366.
SMRP00368. Positions 4-503.
ModBaseSearch...

Proteomic databases

PRIDEP00368.

Genome annotation databases

EnsemblENSGALG00000002020. Gallus gallus. [Contig view]

Phylogenomic databases

HOGENOMP00368.
HOVERGENP00368.

Enzyme and pathway databases

BRENDA1.4.1.3. 4.

Family and domain databases

InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11606:SF2. GLFV_DH. 1 hit.
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDHE3_CHICK
AccessionPrimary (citable) accession number: P00368
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents