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P00335 (RIDH_ENTAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribitol 2-dehydrogenase

Short name=RDH
EC=1.1.1.56
Gene names
Name:rbtD
OrganismEnterobacter aerogenes (Aerobacter aerogenes)
Taxonomic identifier548 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Ribitol + NAD+ = D-ribulose + NADH.

Subunit structure

Homotetramer.

Miscellaneous

The sequence shown is that of strain A.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

ribitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Ribitol 2-dehydrogenase
PRO_0000054756

Regions

Nucleotide binding20 – 4324NAD By similarity

Sites

Active site1601Proton acceptor By similarity

Natural variations

Natural variant1961A → P in strain: D.

Experimental info

Sequence conflict146 – 1472AV → SS in AAA25140. Ref.2
Sequence conflict2121N → D AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00335 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: C34896C276CC8FBC

FASTA24926,514
        10         20         30         40         50         60 
MKHSVSSMNT SLSGKVAAIT GAASGIGLEC ARTLLGAGAK VVLIDREGEK LNKLVAELGE 

        70         80         90        100        110        120 
NAFALQVDLM QADQVDNLLQ GILQLTGRLD IFHANAGAYI GGPVAEGDPD VWDRVLHLNI 

       130        140        150        160        170        180 
NAAFRCVRSV LPHLIAQKSG DIIFTAVIAG VVPVIWEPVY TASKFAVQAF VHTTRRQVAQ 

       190        200        210        220        230        240 
YGVRVGAVLP GPVVTALLDD WPKAKMDEAL ANGSLMQPIE VAESVLFMVT RSKNVTVRDI 


VILPNSVDL 

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References

[1]"Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains."
Dothie J.M., Giglio J.R., Moore C.H., Taylor S.S., Hartley B.S.
Biochem. J. 230:569-578(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: A and D.
[2]"Ribitol dehydrogenase of Klebsiella aerogenes. Sequence of the structural gene."
Loviny T., Norton P.M., Hartley B.S.
Biochem. J. 230:579-585(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure of wild-type and mutant repressors and of the control region of the rbt operon of Klebsiella aerogenes."
Wu J.C., Anderton-Loviny T., Smith C.A., Hartley B.S.
EMBO J. 4:1339-1344(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25606 Genomic DNA. Translation: AAA25140.1.
X02448 Genomic DNA. Translation: CAA26292.1.
PIRDEKBR. A94585.
S07134.

3D structure databases

ProteinModelPortalP00335.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12237.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIDH_ENTAE
AccessionPrimary (citable) accession number: P00335
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families