ID   ADH1_MAIZE              Reviewed;         379 AA.
AC   P00333;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   16-JUN-2009, entry version 81.
DE   RecName: Full=Alcohol dehydrogenase 1;
DE            EC=1.1.1.1;
GN   Name=ADH1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACCAD clade; Panicoideae; Andropogoneae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=84221411; PubMed=6328449; DOI=10.1093/nar/12.9.3983;
RA   Dennis E.S., Gerlach W.L., Pryor A.J., Bennetzen J.L., Inglis A.,
RA   Llewellyn D.J., Sachs M.M., Ferl R.J., Peacock W.J.;
RT   "Molecular analysis of the alcohol dehydrogenase (Adh1) gene of
RT   maize.";
RL   Nucleic Acids Res. 12:3983-4000(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=85215511; PubMed=2987807; DOI=10.1093/nar/13.3.727;
RA   Dennis E.S., Sachs M.M., Gerlach W.L., Finnegan E.J., Peacock W.J.;
RT   "Molecular analysis of the alcohol dehydrogenase 2 (Adh2) gene of
RT   maize.";
RL   Nucleic Acids Res. 13:727-743(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=84261418; PubMed=6378620;
RA   Braenden C.-I., Eklund H., Cambillau C., Pryor A.J.;
RT   "Correlation of exons with structural domains in alcohol
RT   dehydrogenase.";
RL   EMBO J. 3:1307-1310(1984).
RN   [4]
RP   NUCLEOTIDE SEQUENCE (ALLELE ADH1-F).
RC   STRAIN=cv. Berkeley Fast;
RX   PubMed=17246333;
RA   Sachs M.M., Dennis E.S., Gerlach W.L., Peacock W.J.;
RT   "Two alleles of maize alcohol dehydrogenase 1 have 3'-structural and
RT   poly(A) addition polymorphisms.";
RL   Genetics 113:449-467(1986).
RN   [5]
RP   NUCLEOTIDE SEQUENCE (ALLELE ADH1-CM).
RX   MEDLINE=92003667; PubMed=2577507; DOI=10.1007/BF00016138;
RA   Osterman J.C., Dennis E.S.;
RT   "Molecular analysis of the ADH1-Cm allele of maize.";
RL   Plant Mol. Biol. 13:203-212(1989).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 212-379.
RX   PubMed=16593188; DOI=10.1073/pnas.79.9.2981;
RA   Gerlach W.L., Pryor A.J., Dennis E.S., Ferl R.J., Sachs M.M.,
RA   Peacock W.J.;
RT   "cDNA cloning and induction of the alcohol dehydrogenase gene (Adh1)
RT   of maize.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2981-2985(1982).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- POLYMORPHISM: The sequence shown is that of allele ADH1-F.
CC   -!- MISCELLANEOUS: In maize there are two isozymes.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; X04049; CAA27681.1; -; Genomic_DNA.
DR   EMBL; X00580; CAA25239.1; -; mRNA.
DR   EMBL; X04050; CAA27682.1; -; Genomic_DNA.
DR   EMBL; M32984; AAA33434.1; -; Genomic_DNA.
DR   PIR; S04571; S04571.
DR   RefSeq; NP_001105409.1; -.
DR   UniGene; Zm.1540; -.
DR   HSSP; P11766; 1M6H.
DR   GeneID; 542363; -.
DR   Gramene; P00333; -.
DR   MaizeGDB; 13844; -.
DR   BRENDA; 1.1.1.1; 289.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; NAD; Oxidoreductase; Polymorphism; Zinc.
FT   CHAIN         1    379       Alcohol dehydrogenase 1.
FT                                /FTId=PRO_0000160703.
FT   NP_BIND     202    207       NAD (By similarity).
FT   NP_BIND     295    297       NAD (By similarity).
FT   METAL        47     47       Zinc 1; catalytic (By similarity).
FT   METAL        69     69       Zinc 1; catalytic (By similarity).
FT   METAL        99     99       Zinc 2 (By similarity).
FT   METAL       102    102       Zinc 2 (By similarity).
FT   METAL       105    105       Zinc 2 (By similarity).
FT   METAL       113    113       Zinc 2 (By similarity).
FT   METAL       177    177       Zinc 1; catalytic (By similarity).
FT   BINDING     226    226       NAD (By similarity).
FT   BINDING     231    231       NAD (By similarity).
FT   BINDING     372    372       NAD (By similarity).
FT   VARIANT      52     52       Y -> D (in allele ADH1-Cm).
FT   VARIANT     127    127       A -> G (in allele ADH1-S).
FT   VARIANT     179    179       Y -> I (in allele ADH1-Cm and allele
FT                                ADH1-S).
FT   VARIANT     363    363       D -> N (in allele ADH1-S).
SQ   SEQUENCE   379 AA;  40981 MW;  5E0618F7E1A4B973 CRC64;
     MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILFTSLCHTD VYFWEAKGQT
     PVFPRIFGHE AGGIIESVGE GVTDVAPGDH VLPVFTGECK ECAHCKSAES NMCDLLRINT
     DRGVMIADGK SRFSINGKPI YHFVGTSTFS EYTVMHVGCV AKINPQAPLD KVCVLSCGYS
     TGLGASINVA KPPKGSTVAV FGLGAVGLAA AEGARIAGAS RIIGVDLNPS RFEEARKFGC
     TEFVNPKDHN KPVQEVLAEM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK
     DAEFKTHPMN FLNERTLKGT FFGNYKPRTD LPNVVELYMK KELEVEKFIT HSVPFAEINK
     AFDLMAKGEG IRCIIRMEN
//