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Protein

Alcohol dehydrogenase

Gene

adh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalytic1
Metal bindingi69Zinc 1; catalytic1
Metal bindingi100Zinc 21
Metal bindingi103Zinc 21
Metal bindingi106Zinc 21
Metal bindingi114Zinc 21
Metal bindingi156Zinc 1; catalytic1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: PomBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • ethanol biosynthetic process involved in glucose fermentation to ethanol Source: PomBase
  • NADH oxidation Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh1
Synonyms:adh
ORF Names:SPCC13B11.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC13B11.01.
PomBaseiSPCC13B11.01. adh1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607291 – 350Alcohol dehydrogenaseAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Phosphothreonine1 Publication1
Modified residuei250Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP00332.
PRIDEiP00332.

PTM databases

iPTMnetiP00332.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi275480. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliP00332.
SMRiP00332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP00332.
KOiK13953.
OMAiNATHATI.
OrthoDBiEOG092C2Q8E.
PhylomeDBiP00332.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P00332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPDKQLAA VFHTHGGPEN VKFEEVPVAE PGQDEVLVNI KYTGVCHTDL
60 70 80 90 100
HALQGDWPLP AKMPLIGGHE GAGVVVKVGA GVTRLKIGDR VGVKWMNSSC
110 120 130 140 150
GNCEYCMKAE ETICPHIQLS GYTVDGTFQH YCIANATHAT IIPESVPLEV
160 170 180 190 200
AAPIMCAGIT CYRALKESKV GPGEWICIPG AGGGLGHLAV QYAKAMAMRV
210 220 230 240 250
VAIDTGDDKA ELVKSFGAEV FLDFKKEADM IEAVKAATNG GAHGTLVLST
260 270 280 290 300
SPKSYEQAAG FARPGSTMVT VSMPAGAKLG ADIFWLTVKM LKICGSHVGN
310 320 330 340 350
RIDSIEALEY VSRGLVKPYY KVQPFSTLPD VYRLMHENKI AGRIVLDLSK
Length:350
Mass (Da):37,396
Last modified:January 11, 2001 - v2
Checksum:iF80BE1341F727CC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237A → C in J01341 (PubMed:6294096).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01341 Genomic DNA. No translation available.
CU329672 Genomic DNA. Translation: CAA21782.1.
AB001834 mRNA. Translation: BAA19458.1.
PIRiA00341. DEZPA.
RefSeqiNP_588244.1. NM_001023234.2.

Genome annotation databases

EnsemblFungiiSPCC13B11.01.1; SPCC13B11.01.1:pep; SPCC13B11.01.
GeneIDi2538902.
KEGGispo:SPCC13B11.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01341 Genomic DNA. No translation available.
CU329672 Genomic DNA. Translation: CAA21782.1.
AB001834 mRNA. Translation: BAA19458.1.
PIRiA00341. DEZPA.
RefSeqiNP_588244.1. NM_001023234.2.

3D structure databases

ProteinModelPortaliP00332.
SMRiP00332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275480. 7 interactors.

PTM databases

iPTMnetiP00332.

Proteomic databases

MaxQBiP00332.
PRIDEiP00332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC13B11.01.1; SPCC13B11.01.1:pep; SPCC13B11.01.
GeneIDi2538902.
KEGGispo:SPCC13B11.01.

Organism-specific databases

EuPathDBiFungiDB:SPCC13B11.01.
PomBaseiSPCC13B11.01. adh1.

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP00332.
KOiK13953.
OMAiNATHATI.
OrthoDBiEOG092C2Q8E.
PhylomeDBiP00332.

Miscellaneous databases

PROiP00332.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_SCHPO
AccessioniPrimary (citable) accession number: P00332
Secondary accession number(s): Q9URT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 11, 2001
Last modified: March 15, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.