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Protein

Alcohol dehydrogenase

Gene

adh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalytic1
Metal bindingi69Zinc 1; catalytic1
Metal bindingi100Zinc 21
Metal bindingi103Zinc 21
Metal bindingi106Zinc 21
Metal bindingi114Zinc 21
Metal bindingi156Zinc 1; catalytic1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: PomBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • ethanol biosynthetic process involved in glucose fermentation to ethanol Source: PomBase
  • NADH oxidation Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh1
Synonyms:adh
ORF Names:SPCC13B11.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC13B11.01
PomBaseiSPCC13B11.01 adh1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607291 – 350Alcohol dehydrogenaseAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Phosphothreonine1 Publication1
Modified residuei250Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP00332
PaxDbiP00332
PRIDEiP00332

PTM databases

iPTMnetiP00332

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi275480, 8 interactors
STRINGi4896.SPCC13B11.01.1

Structurei

3D structure databases

ProteinModelPortaliP00332
SMRiP00332
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiP00332
KOiK13953
OMAiQYAHNVF
OrthoDBiEOG092C2Q8E
PhylomeDBiP00332

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P00332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPDKQLAA VFHTHGGPEN VKFEEVPVAE PGQDEVLVNI KYTGVCHTDL
60 70 80 90 100
HALQGDWPLP AKMPLIGGHE GAGVVVKVGA GVTRLKIGDR VGVKWMNSSC
110 120 130 140 150
GNCEYCMKAE ETICPHIQLS GYTVDGTFQH YCIANATHAT IIPESVPLEV
160 170 180 190 200
AAPIMCAGIT CYRALKESKV GPGEWICIPG AGGGLGHLAV QYAKAMAMRV
210 220 230 240 250
VAIDTGDDKA ELVKSFGAEV FLDFKKEADM IEAVKAATNG GAHGTLVLST
260 270 280 290 300
SPKSYEQAAG FARPGSTMVT VSMPAGAKLG ADIFWLTVKM LKICGSHVGN
310 320 330 340 350
RIDSIEALEY VSRGLVKPYY KVQPFSTLPD VYRLMHENKI AGRIVLDLSK
Length:350
Mass (Da):37,396
Last modified:January 11, 2001 - v2
Checksum:iF80BE1341F727CC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237A → C in J01341 (PubMed:6294096).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01341 Genomic DNA No translation available.
CU329672 Genomic DNA Translation: CAA21782.1
AB001834 mRNA Translation: BAA19458.1
PIRiA00341 DEZPA
RefSeqiNP_588244.1, NM_001023234.2

Genome annotation databases

EnsemblFungiiSPCC13B11.01.1; SPCC13B11.01.1:pep; SPCC13B11.01
GeneIDi2538902
KEGGispo:SPCC13B11.01

Similar proteinsi

Entry informationi

Entry nameiADH_SCHPO
AccessioniPrimary (citable) accession number: P00332
Secondary accession number(s): Q9URT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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