Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi175Zinc 1; catalytic1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

GO - Biological processi

  • acetaldehyde biosynthetic process Source: MGI
  • behavioral response to ethanol Source: MGI
  • ethanol catabolic process Source: MGI
  • ethanol oxidation Source: MGI
  • response to retinoic acid Source: MGI
  • response to steroid hormone Source: MGI
  • response to testosterone Source: MGI
  • retinoic acid metabolic process Source: MGI
  • retinoid metabolic process Source: MGI
  • retinol metabolic process Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2161541 Abacavir metabolism
R-MMU-5365859 RA biosynthesis pathway
R-MMU-71384 Ethanol oxidation
SABIO-RKiP00329

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
ADH-A2
Alcohol dehydrogenase A subunit
Gene namesi
Name:Adh1
Synonyms:Adh-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:87921 Adh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001606662 – 375Alcohol dehydrogenase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei234N6-succinyllysineCombined sources1
Modified residuei340N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00329
PeptideAtlasiP00329
PRIDEiP00329

PTM databases

iPTMnetiP00329
PhosphoSitePlusiP00329
SwissPalmiP00329

Expressioni

Tissue specificityi

Expressed at high levels in the liver, small intestine and eye, at moderate levels in kidney, ovary and uterus, and at low levels in the spinal cord, thymus, heart, stomach mucosa, skin and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000074207
CleanExiMM_ADH1
ExpressionAtlasiP00329 baseline and differential
GenevisibleiP00329 MM

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi197984, 1 interactor
IntActiP00329, 4 interactors
MINTiP00329
STRINGi10090.ENSMUSP00000004232

Structurei

3D structure databases

ProteinModelPortaliP00329
SMRiP00329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP00329
KOiK13951
OMAiCNVCKHP
OrthoDBiEOG091G08N3
PhylomeDBiP00329
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWELHK PFTIEDIEVA PPKAHEVRIK MVATGVCRSD
60 70 80 90 100
DHVVSGTLVT PLPAVLGHEG AGIVESVGEG VTCVKPGDKV IPLFSPQCGE
110 120 130 140 150
CRICKHPESN FCSRSDLLMP RGTLREGTSR FSCKGKQIHN FISTSTFSQY
160 170 180 190 200
TVVDDIAVAK IDGASPLDKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYSKP
260 270 280 290 300
IQEVLQEMTD GGVDFSFEVI GRLDTMTSAL LSCHAACGVS VVVGVPPNAQ
310 320 330 340 350
NLSMNPMLLL LGRTWKGAIF GGFKSKDSVP KLVADFMAKK FPLDPLITHV
360 370
LPFEKINEAF DLLRSGKSIR TVLTF
Length:375
Mass (Da):39,771
Last modified:January 23, 2007 - v2
Checksum:i7B8AF94C95D35108
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18480
, M18472, M18473, M18474, M18475, M18476, M18477, M18478 Genomic DNA Translation: AAA37178.1
M22679
, M22671, M22672, M22673, M22674, M22675, M22676, M22677 Genomic DNA Translation: AAA37179.1
M11307 mRNA Translation: AAA37180.1
BC013477 mRNA Translation: AAH13477.1
BC054467 mRNA Translation: AAH54467.1
Z32540 Genomic DNA No translation available.
M22611 mRNA Translation: AAA37181.1
CCDSiCCDS17867.1
PIRiA27322 DEMSAA
RefSeqiNP_031435.1, NM_007409.2
UniGeneiMm.2409
Mm.412004

Genome annotation databases

EnsembliENSMUST00000004232; ENSMUSP00000004232; ENSMUSG00000074207
GeneIDi11522
KEGGimmu:11522
UCSCiuc008rnf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADH1_MOUSE
AccessioniPrimary (citable) accession number: P00329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health