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P00329

- ADH1_MOUSE

UniProt

P00329 - ADH1_MOUSE

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Protein

Alcohol dehydrogenase 1

Gene

Adh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn(2+) ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalytic
Metal bindingi68 – 681Zinc 1; catalytic
Metal bindingi98 – 981Zinc 2
Metal bindingi101 – 1011Zinc 2
Metal bindingi104 – 1041Zinc 2
Metal bindingi112 – 1121Zinc 2
Metal bindingi175 – 1751Zinc 1; catalytic
Binding sitei224 – 2241NADBy similarity
Binding sitei229 – 2291NADBy similarity
Binding sitei370 – 3701NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056NADBy similarity
Nucleotide bindingi293 – 2953NADBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: MGI
  2. protein homodimerization activity Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. behavioral response to ethanol Source: MGI
  2. ethanol catabolic process Source: MGI
  3. response to retinoic acid Source: MGI
  4. response to steroid hormone Source: MGI
  5. response to testosterone Source: MGI
  6. retinoic acid metabolic process Source: MGI
  7. retinoid metabolic process Source: MGI
  8. retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_196553. Abacavir metabolism.
REACT_260489. Ethanol oxidation.
SABIO-RKP00329.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
ADH-A2
Alcohol dehydrogenase A subunit
Gene namesi
Name:Adh1
Synonyms:Adh-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:87921. Adh1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: MGI
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 375374Alcohol dehydrogenase 1PRO_0000160666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei234 – 2341N6-succinyllysine1 Publication
Modified residuei340 – 3401N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP00329.
PaxDbiP00329.
PRIDEiP00329.

PTM databases

PhosphoSiteiP00329.

Expressioni

Tissue specificityi

Expressed at high levels in the liver, small intestine and eye, at moderate levels in kidney, ovary and uterus, and at low levels in the spinal cord, thymus, heart, stomach mucosa, skin and testis.1 Publication

Gene expression databases

BgeeiP00329.
CleanExiMM_ADH1.
ExpressionAtlasiP00329. baseline and differential.
GenevestigatoriP00329.

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.

Protein-protein interaction databases

IntActiP00329. 4 interactions.
MINTiMINT-1869642.
STRINGi10090.ENSMUSP00000004232.

Structurei

3D structure databases

ProteinModelPortaliP00329.
SMRiP00329. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiP00329.
KOiK13951.
OMAiWGSATHI.
OrthoDBiEOG72NRQ6.
PhylomeDBiP00329.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00329-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWELHK PFTIEDIEVA PPKAHEVRIK MVATGVCRSD
60 70 80 90 100
DHVVSGTLVT PLPAVLGHEG AGIVESVGEG VTCVKPGDKV IPLFSPQCGE
110 120 130 140 150
CRICKHPESN FCSRSDLLMP RGTLREGTSR FSCKGKQIHN FISTSTFSQY
160 170 180 190 200
TVVDDIAVAK IDGASPLDKV CLIGCGFSTG YGSAVKVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVII GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYSKP
260 270 280 290 300
IQEVLQEMTD GGVDFSFEVI GRLDTMTSAL LSCHAACGVS VVVGVPPNAQ
310 320 330 340 350
NLSMNPMLLL LGRTWKGAIF GGFKSKDSVP KLVADFMAKK FPLDPLITHV
360 370
LPFEKINEAF DLLRSGKSIR TVLTF
Length:375
Mass (Da):39,771
Last modified:January 23, 2007 - v2
Checksum:i7B8AF94C95D35108
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18480
, M18472, M18473, M18474, M18475, M18476, M18477, M18478 Genomic DNA. Translation: AAA37178.1.
M22679
, M22671, M22672, M22673, M22674, M22675, M22676, M22677 Genomic DNA. Translation: AAA37179.1.
M11307 mRNA. Translation: AAA37180.1.
BC013477 mRNA. Translation: AAH13477.1.
BC054467 mRNA. Translation: AAH54467.1.
Z32540 Genomic DNA. No translation available.
M22611 mRNA. Translation: AAA37181.1.
CCDSiCCDS17867.1.
PIRiA27322. DEMSAA.
RefSeqiNP_031435.1. NM_007409.2.
UniGeneiMm.2409.
Mm.412004.

Genome annotation databases

EnsembliENSMUST00000004232; ENSMUSP00000004232; ENSMUSG00000074207.
GeneIDi11522.
KEGGimmu:11522.
UCSCiuc008rnf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18480
, M18472 , M18473 , M18474 , M18475 , M18476 , M18477 , M18478 Genomic DNA. Translation: AAA37178.1 .
M22679
, M22671 , M22672 , M22673 , M22674 , M22675 , M22676 , M22677 Genomic DNA. Translation: AAA37179.1 .
M11307 mRNA. Translation: AAA37180.1 .
BC013477 mRNA. Translation: AAH13477.1 .
BC054467 mRNA. Translation: AAH54467.1 .
Z32540 Genomic DNA. No translation available.
M22611 mRNA. Translation: AAA37181.1 .
CCDSi CCDS17867.1.
PIRi A27322. DEMSAA.
RefSeqi NP_031435.1. NM_007409.2.
UniGenei Mm.2409.
Mm.412004.

3D structure databases

ProteinModelPortali P00329.
SMRi P00329. Positions 2-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00329. 4 interactions.
MINTi MINT-1869642.
STRINGi 10090.ENSMUSP00000004232.

PTM databases

PhosphoSitei P00329.

Proteomic databases

MaxQBi P00329.
PaxDbi P00329.
PRIDEi P00329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004232 ; ENSMUSP00000004232 ; ENSMUSG00000074207 .
GeneIDi 11522.
KEGGi mmu:11522.
UCSCi uc008rnf.1. mouse.

Organism-specific databases

CTDi 11522.
MGIi MGI:87921. Adh1.

Phylogenomic databases

eggNOGi COG1062.
HOGENOMi HOG000294674.
HOVERGENi HBG000195.
InParanoidi P00329.
KOi K13951.
OMAi WGSATHI.
OrthoDBi EOG72NRQ6.
PhylomeDBi P00329.
TreeFami TF300429.

Enzyme and pathway databases

Reactomei REACT_196553. Abacavir metabolism.
REACT_260489. Ethanol oxidation.
SABIO-RK P00329.

Miscellaneous databases

NextBioi 278960.
PROi P00329.
SOURCEi Search...

Gene expression databases

Bgeei P00329.
CleanExi MM_ADH1.
ExpressionAtlasi P00329. baseline and differential.
Genevestigatori P00329.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase."
    Edenberg H.J., Zhang K., Fong K., Bosron W.F., Li T.-K.
    Proc. Natl. Acad. Sci. U.S.A. 82:2262-2266(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3."
    Ceci J.D., Zheng Y.W., Felder M.R.
    Gene 59:171-182(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity."
    Zhang K., Bosron W.F., Edenberg H.J.
    Gene 57:27-36(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Kidney.
  5. "Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor."
    Caubin J., Iglesias T., Bernal J., Munoz A., Marquez G., Barbero J.L., Zaballos A.
    Nucleic Acids Res. 22:4132-4138(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-51.
  6. "Androgen induction of alcohol dehydrogenase in mouse kidney. Studies with a cDNA probe confirmed by nucleotide sequence analysis."
    Ceci J.D., Lawther R., Duester G., Hatfield G.W., Smith M., O'Malley M.P., Felder M.R.
    Gene 41:217-224(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 224-375.
    Strain: SWR/J.
    Tissue: Liver.
  7. "Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family."
    Zgombic-Knight M., Ang H.L., Foglio M.H., Duester G.
    J. Biol. Chem. 270:10868-10877(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: FVB/N.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-234 AND LYS-340, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADH1_MOUSE
AccessioniPrimary (citable) accession number: P00329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3