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Protein

Alcohol dehydrogenase S chain

Gene
N/A
Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi174Zinc 1; catalytic1
Binding sitei223NAD1
Binding sitei228NAD1
Binding sitei369NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NAD6
Nucleotide bindingi292 – 294NAD3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

SABIO-RKP00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase S chain (EC:1.1.1.1)
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111372.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606572 – 374Alcohol dehydrogenase S chainAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PeptideAtlasiP00328.
PRIDEiP00328.

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci.

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Beta strandi23 – 29Combined sources7
Beta strandi36 – 45Combined sources10
Helixi48 – 55Combined sources8
Beta strandi56 – 58Combined sources3
Beta strandi62 – 65Combined sources4
Beta strandi69 – 77Combined sources9
Beta strandi89 – 92Combined sources4
Beta strandi99 – 101Combined sources3
Helixi102 – 105Combined sources4
Beta strandi106 – 108Combined sources3
Beta strandi129 – 132Combined sources4
Beta strandi135 – 138Combined sources4
Turni141 – 143Combined sources3
Beta strandi146 – 153Combined sources8
Helixi154 – 156Combined sources3
Beta strandi157 – 159Combined sources3
Helixi166 – 169Combined sources4
Helixi170 – 173Combined sources4
Helixi175 – 184Combined sources10
Turni185 – 187Combined sources3
Beta strandi194 – 198Combined sources5
Helixi202 – 213Combined sources12
Beta strandi217 – 222Combined sources6
Helixi226 – 228Combined sources3
Helixi229 – 234Combined sources6
Beta strandi238 – 241Combined sources4
Helixi243 – 245Combined sources3
Helixi250 – 257Combined sources8
Beta strandi262 – 267Combined sources6
Helixi272 – 281Combined sources10
Turni284 – 286Combined sources3
Beta strandi288 – 291Combined sources4
Beta strandi301 – 303Combined sources3
Helixi306 – 309Combined sources4
Beta strandi313 – 316Combined sources4
Helixi319 – 321Combined sources3
Helixi324 – 336Combined sources13
Helixi343 – 345Combined sources3
Beta strandi346 – 351Combined sources6
Helixi352 – 354Combined sources3
Helixi355 – 363Combined sources9
Beta strandi368 – 373Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EE2X-ray1.54A/B2-374[»]
ProteinModelPortaliP00328.
SMRiP00328.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00328.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195.
KOiK13951.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAGKVIKC KAAVLWEQKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD
60 70 80 90 100
DHVVSGTLVA PLPVIAGHEA AGIVESIGEG VTTVRPGDKV IPLFIPQCGK
110 120 130 140 150
CSVCKHPEGN LCLKNLSMPR GTMQDGTSRF TCRGKPIHHF LGTSTFSQYT
160 170 180 190 200
VVDEISVAKI DAASPLEKVC LVGCGFSTGY GSAVKVAKVT QGSTCAVFGL
210 220 230 240 250
GGVGLSVIMG CKAAGAARII GVDINKDKFA KAKEVGATEC VNPQDYKKPI
260 270 280 290 300
QEVLTEMSNG GVDFSFEVIG RLDTMVAALS CCQEAYGVSV IVGVPPDSQN
310 320 330 340 350
LSMNPMLLLS GRTWKGAIFG GFKSKDSVPK LVADFMAKKF ALDPLITHVL
360 370
PFEKINEGFD LLRSGKSIRT ILTF
Length:374
Mass (Da):39,623
Last modified:January 23, 2007 - v3
Checksum:i2B15710A038DA013
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44A → T AA sequence (PubMed:5466062).Curated1
Sequence conflicti60A → T AA sequence (PubMed:5466062).Curated1
Sequence conflicti116L → SL AA sequence (PubMed:5466062).Curated1
Sequence conflicti172V → I AA sequence (PubMed:5466062).Curated1
Sequence conflicti277A → T AA sequence (PubMed:5466062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64865 mRNA. Translation: AAA30932.1.
PIRiB39872. DEHOAS.
RefSeqiNP_001075414.1. NM_001081945.1.
UniGeneiEca.13101.

Genome annotation databases

GeneIDi100034175.
KEGGiecb:100034175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64865 mRNA. Translation: AAA30932.1.
PIRiB39872. DEHOAS.
RefSeqiNP_001075414.1. NM_001081945.1.
UniGeneiEca.13101.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EE2X-ray1.54A/B2-374[»]
ProteinModelPortaliP00328.
SMRiP00328.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2111372.

Proteomic databases

PeptideAtlasiP00328.
PRIDEiP00328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034175.
KEGGiecb:100034175.

Phylogenomic databases

HOVERGENiHBG000195.
KOiK13951.

Enzyme and pathway databases

SABIO-RKP00328.

Miscellaneous databases

EvolutionaryTraceiP00328.
PROiP00328.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH1S_HORSE
AccessioniPrimary (citable) accession number: P00328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.