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Protein

Pollen allergen Amb a 3

Gene
N/A
Organism
Ambrosia artemisiifolia var. elatior (Short ragweed) (Ambrosia elatior)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Amb a 3
Alternative name(s):
Allergen Amb a III
Allergen Ra3
Allergen: Amb a 3
OrganismiAmbrosia artemisiifolia var. elatior (Short ragweed) (Ambrosia elatior)
Taxonomic identifieri4215 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei27. Amb a 3.
3068. Amb a 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Pollen allergen Amb a 3PRO_0000085558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)1 Publication
Disulfide bondi61 ↔ 881 Publication
Glycosylationi84 – 841O-linked (Hex)1 Publication
Modified residuei97 – 971Cysteine derivative
Modified residuei101 – 1011Blocked carboxyl end (Arg)

Post-translational modificationi

The identity of the saccharide is not reported (PubMed:7459340). The sugar attached to Ser-84 is represented simply as Hex.1 Publication
Cys-97 sulfhydryl group is modified but does not form an interchain disulfide bond.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP00304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 101100PhytocyaninPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 phytocyanin domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR003245. Phytocyanin_dom.
[Graphical view]
PfamiPF02298. Cu_bind_like. 1 hit.
[Graphical view]
ProDomiPD003122. Plcyanin-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS51485. PHYTOCYANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GKVYLVGGPE LGGWKLQSDP RAYALWSARQ QFKTTDVLWF NFTTGEDSVA
60 70 80 90 100
EVWREEAYHA CDIKDPIRLE PGGPDRFTLL TPGSHFICTK DQKFVACVPG

R
Length:101
Mass (Da):11,375
Last modified:October 1, 1993 - v2
Checksum:i3CBD6721B85C01DD
GO

Sequence databases

PIRiA00313. ARRA3.

Cross-referencesi

Sequence databases

PIRiA00313. ARRA3.

3D structure databases

ProteinModelPortaliP00304.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei27. Amb a 3.
3068. Amb a 3.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR003245. Phytocyanin_dom.
[Graphical view]
PfamiPF02298. Cu_bind_like. 1 hit.
[Graphical view]
ProDomiPD003122. Plcyanin-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS51485. PHYTOCYANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE, DISULFIDE BOND, GLYCOSYLATION AT ASN-41 AND SER-84.
    Tissue: Pollen.

Entry informationi

Entry nameiMPAA3_AMBEL
AccessioniPrimary (citable) accession number: P00304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1993
Last modified: September 16, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.