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Protein

Azurin

Gene

azu

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transfers electrons from cytochrome c551 to cytochrome oxidase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66Copper1 Publication1
Metal bindingi132Copper1 Publication1
Metal bindingi137Copper1 Publication1
Metal bindingi141Copper1

GO - Molecular functioni

  • copper ion binding Source: PseudoCAP
  • electron carrier activity Source: InterPro
  • transition metal ion binding Source: PseudoCAP
  • zinc ion binding Source: PseudoCAP

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Azurin
Gene namesi
Name:azu
Ordered Locus Names:PA4922
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4922.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000000286321 – 148AzurinAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 46

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP00282.
PRIDEiP00282.

Interactioni

Protein-protein interaction databases

DIPiDIP-48787N.
MINTiMINT-8099376.
STRINGi208964.PA4922.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi31 – 33Combined sources3
Beta strandi34 – 36Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi47 – 54Combined sources8
Beta strandi57 – 59Combined sources3
Helixi61 – 64Combined sources4
Beta strandi69 – 72Combined sources4
Turni73 – 75Combined sources3
Helixi76 – 86Combined sources11
Helixi88 – 90Combined sources3
Beta strandi101 – 103Combined sources3
Beta strandi112 – 118Combined sources7
Helixi119 – 121Combined sources3
Beta strandi124 – 126Combined sources3
Beta strandi128 – 131Combined sources4
Turni135 – 140Combined sources6
Beta strandi142 – 148Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG0X-ray2.40A/B20-148[»]
1AZNX-ray2.60A/B/C/D21-148[»]
1AZRX-ray2.40A/B/C/D21-148[»]
1AZUX-ray2.70A21-148[»]
1BEXX-ray2.30A/B21-148[»]
1CC3X-ray1.65A/B21-148[»]
1E5YX-ray2.00A/B/C/D21-148[»]
1E5ZX-ray2.00A/B/C/D21-148[»]
1E65X-ray1.85A/B/C/D21-148[»]
1E67X-ray2.14A/B/C/D21-148[»]
1ETJX-ray2.30A/B/C/D21-148[»]
1EZLX-ray2.00A/B/C/D21-148[»]
1GR7X-ray1.80A/B/C/D21-148[»]
1I53X-ray1.80A/B21-148[»]
1ILSX-ray2.20A/B/C/D21-148[»]
1ILUX-ray2.30A/B/C/D/E/F/G/H/I/K/L/M21-148[»]
1JVLX-ray2.00A/B21-148[»]
1JVOX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
1JZEX-ray1.60A21-148[»]
1JZFX-ray1.50A21-148[»]
1JZGX-ray1.40A21-148[»]
1JZHX-ray1.70A21-148[»]
1JZIX-ray1.62A/B21-148[»]
1JZJX-ray1.80A/B21-148[»]
1NZRX-ray2.20A/B/C/D21-148[»]
1R1CX-ray1.90A/B/C/D21-148[»]
1VLXX-ray1.90A/B/C/D21-148[»]
1XB3X-ray1.50A/B21-148[»]
1XB6X-ray1.82A/B21-148[»]
1XB8X-ray2.00A/C21-148[»]
2AZUX-ray1.90A/B/C/D21-148[»]
2FNWX-ray1.40A/B21-148[»]
2FT6X-ray1.25A21-148[»]
2FT7X-ray1.40A21-148[»]
2FT8X-ray1.55A21-148[»]
2FTAX-ray1.61A/B/C/D21-148[»]
2GHZX-ray1.60A/B21-148[»]
2GI0X-ray1.70A/B21-148[»]
2HX7X-ray1.55A/B21-148[»]
2HX8X-ray1.60A/B21-148[»]
2HX9X-ray1.70A/B21-148[»]
2HXAX-ray2.21A/B21-148[»]
2I7OX-ray1.50A21-148[»]
2I7SX-ray1.35A/B/C/D21-148[»]
2IDFX-ray2.25A/B21-148[»]
2IWEX-ray2.83A/D/G/J21-148[»]
2OJ1X-ray2.30A/B21-148[»]
2TSAX-ray2.20A/B/C/D21-148[»]
2TSBX-ray2.30A/B/C/D21-148[»]
2XV0X-ray1.60A21-148[»]
2XV2X-ray1.60A21-148[»]
2XV3X-ray2.30A/B21-148[»]
3AZUX-ray2.10A/B/C/D21-148[»]
3FPYX-ray2.10A21-148[»]
3FQ1X-ray1.90A21-148[»]
3FQ2X-ray1.91A21-148[»]
3FQYX-ray1.90A21-148[»]
3FS9X-ray1.05A21-132[»]
A141-148[»]
3FSAX-ray0.98A21-132[»]
A141-148[»]
3FSVX-ray2.30A21-132[»]
A141-148[»]
3FSWX-ray2.00A/B/C/D21-132[»]
A/B/C/D141-148[»]
3FSZX-ray2.00A/B21-132[»]
A/B141-148[»]
3FT0X-ray1.80A/B21-132[»]
A/B141-148[»]
3IBOX-ray1.45A/B/C/D21-148[»]
3IN0X-ray2.35A/B/C/D21-148[»]
3IN2X-ray2.60A21-148[»]
3JT2X-ray2.10A/B21-148[»]
3JTBX-ray1.80A/B/C/D21-148[»]
3N2JX-ray1.35A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
3NP3X-ray2.10A21-148[»]
3NP4X-ray2.25A21-148[»]
3OQRX-ray2.40A21-148[»]
3U25X-ray1.18A/B22-148[»]
3UGEX-ray1.70A/B/C/D21-148[»]
4AZUX-ray1.90A/B/C/D21-148[»]
4BWWX-ray1.48A/B/C/D21-148[»]
4HHGX-ray1.60A21-148[»]
4HHWX-ray2.00A/B21-148[»]
4HIPX-ray1.90A/B21-148[»]
4HZ1X-ray2.20A/B/C/D21-148[»]
4JKNX-ray1.54A/B/C/D21-148[»]
4K9JX-ray1.70A21-148[»]
4KO5X-ray1.79A/B21-148[»]
4KO6X-ray1.74A/B/C/D21-148[»]
4KO7X-ray2.07A/B/C/D21-148[»]
4KO9X-ray2.05A/B/C/D21-148[»]
4KOBX-ray1.87A/B/C/D21-148[»]
4KOCX-ray1.46A21-148[»]
4MFHX-ray1.54A/B/C21-148[»]
4QKTX-ray1.64A/B21-148[»]
4QLWX-ray2.00A/B/C/D21-148[»]
4WKXX-ray1.94A/B21-148[»]
5AZUX-ray1.90A/B/C/D21-148[»]
5I26X-ray1.89A/B/C/D21-148[»]
5I28X-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P21-148[»]
ProteinModelPortaliP00282.
SMRiP00282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00282.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 148Plastocyanin-likeAdd BLAST128

Sequence similaritiesi

Contains 1 plastocyanin-like domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41090JD. Bacteria.
COG3241. LUCA.
HOGENOMiHOG000280572.
InParanoidiP00282.
OMAiKSCKTFT.
PhylomeDBiP00282.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKLAAVSL LSLLSAPLLA AECSVDIQGN DQMQFNTNAI TVDKSCKQFT
60 70 80 90 100
VNLSHPGNLP KNVMGHNWVL STAADMQGVV TDGMASGLDK DYLKPDDSRV
110 120 130 140
IAHTKLIGSG EKDSVTFDVS KLKEGEQYMF FCTFPGHSAL MKGTLTLK
Length:148
Mass (Da):16,008
Last modified:July 1, 1989 - v2
Checksum:i9C3881D7B6D64B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07317 Genomic DNA. Translation: CAA30279.1.
M30389 Genomic DNA. Translation: AAA25730.1.
AE004091 Genomic DNA. Translation: AAG08307.1.
PIRiJQ0644. AZPSCA.
RefSeqiNP_253609.1. NC_002516.2.
WP_003095591.1. NZ_ASJY01000787.1.

Genome annotation databases

EnsemblBacteriaiAAG08307; AAG08307; PA4922.
GeneIDi878046.
KEGGipae:PA4922.
PATRICi19844648. VBIPseAer58763_5155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07317 Genomic DNA. Translation: CAA30279.1.
M30389 Genomic DNA. Translation: AAA25730.1.
AE004091 Genomic DNA. Translation: AAG08307.1.
PIRiJQ0644. AZPSCA.
RefSeqiNP_253609.1. NC_002516.2.
WP_003095591.1. NZ_ASJY01000787.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG0X-ray2.40A/B20-148[»]
1AZNX-ray2.60A/B/C/D21-148[»]
1AZRX-ray2.40A/B/C/D21-148[»]
1AZUX-ray2.70A21-148[»]
1BEXX-ray2.30A/B21-148[»]
1CC3X-ray1.65A/B21-148[»]
1E5YX-ray2.00A/B/C/D21-148[»]
1E5ZX-ray2.00A/B/C/D21-148[»]
1E65X-ray1.85A/B/C/D21-148[»]
1E67X-ray2.14A/B/C/D21-148[»]
1ETJX-ray2.30A/B/C/D21-148[»]
1EZLX-ray2.00A/B/C/D21-148[»]
1GR7X-ray1.80A/B/C/D21-148[»]
1I53X-ray1.80A/B21-148[»]
1ILSX-ray2.20A/B/C/D21-148[»]
1ILUX-ray2.30A/B/C/D/E/F/G/H/I/K/L/M21-148[»]
1JVLX-ray2.00A/B21-148[»]
1JVOX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
1JZEX-ray1.60A21-148[»]
1JZFX-ray1.50A21-148[»]
1JZGX-ray1.40A21-148[»]
1JZHX-ray1.70A21-148[»]
1JZIX-ray1.62A/B21-148[»]
1JZJX-ray1.80A/B21-148[»]
1NZRX-ray2.20A/B/C/D21-148[»]
1R1CX-ray1.90A/B/C/D21-148[»]
1VLXX-ray1.90A/B/C/D21-148[»]
1XB3X-ray1.50A/B21-148[»]
1XB6X-ray1.82A/B21-148[»]
1XB8X-ray2.00A/C21-148[»]
2AZUX-ray1.90A/B/C/D21-148[»]
2FNWX-ray1.40A/B21-148[»]
2FT6X-ray1.25A21-148[»]
2FT7X-ray1.40A21-148[»]
2FT8X-ray1.55A21-148[»]
2FTAX-ray1.61A/B/C/D21-148[»]
2GHZX-ray1.60A/B21-148[»]
2GI0X-ray1.70A/B21-148[»]
2HX7X-ray1.55A/B21-148[»]
2HX8X-ray1.60A/B21-148[»]
2HX9X-ray1.70A/B21-148[»]
2HXAX-ray2.21A/B21-148[»]
2I7OX-ray1.50A21-148[»]
2I7SX-ray1.35A/B/C/D21-148[»]
2IDFX-ray2.25A/B21-148[»]
2IWEX-ray2.83A/D/G/J21-148[»]
2OJ1X-ray2.30A/B21-148[»]
2TSAX-ray2.20A/B/C/D21-148[»]
2TSBX-ray2.30A/B/C/D21-148[»]
2XV0X-ray1.60A21-148[»]
2XV2X-ray1.60A21-148[»]
2XV3X-ray2.30A/B21-148[»]
3AZUX-ray2.10A/B/C/D21-148[»]
3FPYX-ray2.10A21-148[»]
3FQ1X-ray1.90A21-148[»]
3FQ2X-ray1.91A21-148[»]
3FQYX-ray1.90A21-148[»]
3FS9X-ray1.05A21-132[»]
A141-148[»]
3FSAX-ray0.98A21-132[»]
A141-148[»]
3FSVX-ray2.30A21-132[»]
A141-148[»]
3FSWX-ray2.00A/B/C/D21-132[»]
A/B/C/D141-148[»]
3FSZX-ray2.00A/B21-132[»]
A/B141-148[»]
3FT0X-ray1.80A/B21-132[»]
A/B141-148[»]
3IBOX-ray1.45A/B/C/D21-148[»]
3IN0X-ray2.35A/B/C/D21-148[»]
3IN2X-ray2.60A21-148[»]
3JT2X-ray2.10A/B21-148[»]
3JTBX-ray1.80A/B/C/D21-148[»]
3N2JX-ray1.35A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
3NP3X-ray2.10A21-148[»]
3NP4X-ray2.25A21-148[»]
3OQRX-ray2.40A21-148[»]
3U25X-ray1.18A/B22-148[»]
3UGEX-ray1.70A/B/C/D21-148[»]
4AZUX-ray1.90A/B/C/D21-148[»]
4BWWX-ray1.48A/B/C/D21-148[»]
4HHGX-ray1.60A21-148[»]
4HHWX-ray2.00A/B21-148[»]
4HIPX-ray1.90A/B21-148[»]
4HZ1X-ray2.20A/B/C/D21-148[»]
4JKNX-ray1.54A/B/C/D21-148[»]
4K9JX-ray1.70A21-148[»]
4KO5X-ray1.79A/B21-148[»]
4KO6X-ray1.74A/B/C/D21-148[»]
4KO7X-ray2.07A/B/C/D21-148[»]
4KO9X-ray2.05A/B/C/D21-148[»]
4KOBX-ray1.87A/B/C/D21-148[»]
4KOCX-ray1.46A21-148[»]
4MFHX-ray1.54A/B/C21-148[»]
4QKTX-ray1.64A/B21-148[»]
4QLWX-ray2.00A/B/C/D21-148[»]
4WKXX-ray1.94A/B21-148[»]
5AZUX-ray1.90A/B/C/D21-148[»]
5I26X-ray1.89A/B/C/D21-148[»]
5I28X-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P21-148[»]
ProteinModelPortaliP00282.
SMRiP00282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48787N.
MINTiMINT-8099376.
STRINGi208964.PA4922.

Proteomic databases

PaxDbiP00282.
PRIDEiP00282.

Protocols and materials databases

DNASUi878046.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08307; AAG08307; PA4922.
GeneIDi878046.
KEGGipae:PA4922.
PATRICi19844648. VBIPseAer58763_5155.

Organism-specific databases

PseudoCAPiPA4922.

Phylogenomic databases

eggNOGiENOG41090JD. Bacteria.
COG3241. LUCA.
HOGENOMiHOG000280572.
InParanoidiP00282.
OMAiKSCKTFT.
PhylomeDBiP00282.

Miscellaneous databases

EvolutionaryTraceiP00282.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZUR_PSEAE
AccessioniPrimary (citable) accession number: P00282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.