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Protein

Azurin

Gene

azu

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transfers electrons from cytochrome c551 to cytochrome oxidase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Copper1 Publication
Metal bindingi132 – 1321Copper1 Publication
Metal bindingi137 – 1371Copper1 Publication
Metal bindingi141 – 1411Copper

GO - Molecular functioni

  • copper ion binding Source: PseudoCAP
  • electron carrier activity Source: InterPro
  • transition metal ion binding Source: PseudoCAP
  • zinc ion binding Source: PseudoCAP

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Azurin
Gene namesi
Name:azu
Ordered Locus Names:PA4922
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4922.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20202 PublicationsAdd
BLAST
Chaini21 – 148128AzurinPRO_0000002863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 46

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP00282.

Interactioni

Protein-protein interaction databases

DIPiDIP-48787N.
MINTiMINT-8099376.
STRINGi208964.PA4922.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 296Combined sources
Beta strandi31 – 333Combined sources
Beta strandi34 – 363Combined sources
Beta strandi38 – 436Combined sources
Beta strandi47 – 548Combined sources
Beta strandi57 – 593Combined sources
Helixi61 – 644Combined sources
Beta strandi69 – 724Combined sources
Turni73 – 753Combined sources
Helixi76 – 8611Combined sources
Helixi88 – 903Combined sources
Beta strandi101 – 1033Combined sources
Beta strandi112 – 1187Combined sources
Helixi119 – 1213Combined sources
Beta strandi124 – 1263Combined sources
Beta strandi128 – 1314Combined sources
Turni135 – 1406Combined sources
Beta strandi142 – 1487Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AG0X-ray2.40A/B20-148[»]
1AZNX-ray2.60A/B/C/D21-148[»]
1AZRX-ray2.40A/B/C/D21-148[»]
1AZUX-ray2.70A21-148[»]
1BEXX-ray2.30A/B21-148[»]
1CC3X-ray1.65A/B21-148[»]
1E5YX-ray2.00A/B/C/D21-148[»]
1E5ZX-ray2.00A/B/C/D21-148[»]
1E65X-ray1.85A/B/C/D21-148[»]
1E67X-ray2.14A/B/C/D21-148[»]
1ETJX-ray2.30A/B/C/D21-148[»]
1EZLX-ray2.00A/B/C/D21-148[»]
1GR7X-ray1.80A/B/C/D21-148[»]
1I53X-ray1.80A/B21-148[»]
1ILSX-ray2.20A/B/C/D21-148[»]
1ILUX-ray2.30A/B/C/D/E/F/G/H/I/K/L/M21-148[»]
1JVLX-ray2.00A/B21-148[»]
1JVOX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
1JZEX-ray1.60A21-148[»]
1JZFX-ray1.50A21-148[»]
1JZGX-ray1.40A21-148[»]
1JZHX-ray1.70A21-148[»]
1JZIX-ray1.62A/B21-148[»]
1JZJX-ray1.80A/B21-148[»]
1NZRX-ray2.20A/B/C/D21-148[»]
1R1CX-ray1.90A/B/C/D21-148[»]
1VLXX-ray1.90A/B/C/D21-148[»]
1XB3X-ray1.50A/B21-148[»]
1XB6X-ray1.82A/B21-148[»]
1XB8X-ray2.00A/C21-148[»]
2AZUX-ray1.90A/B/C/D21-148[»]
2FNWX-ray1.40A/B21-148[»]
2FT6X-ray1.25A21-148[»]
2FT7X-ray1.40A21-148[»]
2FT8X-ray1.55A21-148[»]
2FTAX-ray1.61A/B/C/D21-148[»]
2GHZX-ray1.60A/B21-148[»]
2GI0X-ray1.70A/B21-148[»]
2HX7X-ray1.55A/B21-148[»]
2HX8X-ray1.60A/B21-148[»]
2HX9X-ray1.70A/B21-148[»]
2HXAX-ray2.21A/B21-148[»]
2I7OX-ray1.50A21-148[»]
2I7SX-ray1.35A/B/C/D21-148[»]
2IDFX-ray2.25A/B21-148[»]
2IWEX-ray2.83A/D/G/J21-148[»]
2OJ1X-ray2.30A/B21-148[»]
2TSAX-ray2.20A/B/C/D21-148[»]
2TSBX-ray2.30A/B/C/D21-148[»]
2XV0X-ray1.60A21-148[»]
2XV2X-ray1.60A21-148[»]
2XV3X-ray2.30A/B21-148[»]
3AZUX-ray2.10A/B/C/D21-148[»]
3FPYX-ray2.10A21-148[»]
3FQ1X-ray1.90A21-148[»]
3FQ2X-ray1.91A21-148[»]
3FQYX-ray1.90A21-148[»]
3FS9X-ray1.05A21-132[»]
A141-148[»]
3FSAX-ray0.98A21-132[»]
A141-148[»]
3FSVX-ray2.30A21-132[»]
A141-148[»]
3FSWX-ray2.00A/B/C/D21-132[»]
A/B/C/D141-148[»]
3FSZX-ray2.00A/B21-132[»]
A/B141-148[»]
3FT0X-ray1.80A/B21-132[»]
A/B141-148[»]
3IBOX-ray1.45A/B/C/D21-148[»]
3IN0X-ray2.35A/B/C/D21-148[»]
3IN2X-ray2.60A21-148[»]
3JT2X-ray2.10A/B21-148[»]
3JTBX-ray1.80A/B/C/D21-148[»]
3N2JX-ray1.35A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
3NP3X-ray2.10A21-148[»]
3NP4X-ray2.25A21-148[»]
3OQRX-ray2.40A21-148[»]
3U25X-ray1.18A/B22-148[»]
3UGEX-ray1.70A/B/C/D21-148[»]
4AZUX-ray1.90A/B/C/D21-148[»]
4BWWX-ray1.48A/B/C/D21-148[»]
4HHGX-ray1.60A21-148[»]
4HHWX-ray2.00A/B21-148[»]
4HIPX-ray1.90A/B21-148[»]
4HZ1X-ray2.20A/B/C/D21-148[»]
4JKNX-ray1.54A/B/C/D21-148[»]
4K9JX-ray1.70A21-148[»]
4KO5X-ray1.79A/B21-148[»]
4KO6X-ray1.74A/B/C/D21-148[»]
4KO7X-ray2.07A/B/C/D21-148[»]
4KO9X-ray2.05A/B/C/D21-148[»]
4KOBX-ray1.87A/B/C/D21-148[»]
4KOCX-ray1.46A21-148[»]
4MFHX-ray1.54A/B/C21-148[»]
4QKTX-ray1.64A/B21-148[»]
4QLWX-ray2.00A/B/C/D21-148[»]
4WKXX-ray1.94A/B21-148[»]
5AZUX-ray1.90A/B/C/D21-148[»]
5I26X-ray1.89A/B/C/D21-148[»]
5I28X-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P21-148[»]
ProteinModelPortaliP00282.
SMRiP00282. Positions 21-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00282.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 148128Plastocyanin-likeAdd
BLAST

Sequence similaritiesi

Contains 1 plastocyanin-like domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41090JD. Bacteria.
COG3241. LUCA.
HOGENOMiHOG000280572.
InParanoidiP00282.
OMAiKSCKTFT.
PhylomeDBiP00282.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKLAAVSL LSLLSAPLLA AECSVDIQGN DQMQFNTNAI TVDKSCKQFT
60 70 80 90 100
VNLSHPGNLP KNVMGHNWVL STAADMQGVV TDGMASGLDK DYLKPDDSRV
110 120 130 140
IAHTKLIGSG EKDSVTFDVS KLKEGEQYMF FCTFPGHSAL MKGTLTLK
Length:148
Mass (Da):16,008
Last modified:July 1, 1989 - v2
Checksum:i9C3881D7B6D64B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07317 Genomic DNA. Translation: CAA30279.1.
M30389 Genomic DNA. Translation: AAA25730.1.
AE004091 Genomic DNA. Translation: AAG08307.1.
PIRiJQ0644. AZPSCA.
RefSeqiNP_253609.1. NC_002516.2.
WP_003095591.1. NZ_ASJY01000787.1.

Genome annotation databases

EnsemblBacteriaiAAG08307; AAG08307; PA4922.
GeneIDi878046.
KEGGipae:PA4922.
PATRICi19844648. VBIPseAer58763_5155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07317 Genomic DNA. Translation: CAA30279.1.
M30389 Genomic DNA. Translation: AAA25730.1.
AE004091 Genomic DNA. Translation: AAG08307.1.
PIRiJQ0644. AZPSCA.
RefSeqiNP_253609.1. NC_002516.2.
WP_003095591.1. NZ_ASJY01000787.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AG0X-ray2.40A/B20-148[»]
1AZNX-ray2.60A/B/C/D21-148[»]
1AZRX-ray2.40A/B/C/D21-148[»]
1AZUX-ray2.70A21-148[»]
1BEXX-ray2.30A/B21-148[»]
1CC3X-ray1.65A/B21-148[»]
1E5YX-ray2.00A/B/C/D21-148[»]
1E5ZX-ray2.00A/B/C/D21-148[»]
1E65X-ray1.85A/B/C/D21-148[»]
1E67X-ray2.14A/B/C/D21-148[»]
1ETJX-ray2.30A/B/C/D21-148[»]
1EZLX-ray2.00A/B/C/D21-148[»]
1GR7X-ray1.80A/B/C/D21-148[»]
1I53X-ray1.80A/B21-148[»]
1ILSX-ray2.20A/B/C/D21-148[»]
1ILUX-ray2.30A/B/C/D/E/F/G/H/I/K/L/M21-148[»]
1JVLX-ray2.00A/B21-148[»]
1JVOX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
1JZEX-ray1.60A21-148[»]
1JZFX-ray1.50A21-148[»]
1JZGX-ray1.40A21-148[»]
1JZHX-ray1.70A21-148[»]
1JZIX-ray1.62A/B21-148[»]
1JZJX-ray1.80A/B21-148[»]
1NZRX-ray2.20A/B/C/D21-148[»]
1R1CX-ray1.90A/B/C/D21-148[»]
1VLXX-ray1.90A/B/C/D21-148[»]
1XB3X-ray1.50A/B21-148[»]
1XB6X-ray1.82A/B21-148[»]
1XB8X-ray2.00A/C21-148[»]
2AZUX-ray1.90A/B/C/D21-148[»]
2FNWX-ray1.40A/B21-148[»]
2FT6X-ray1.25A21-148[»]
2FT7X-ray1.40A21-148[»]
2FT8X-ray1.55A21-148[»]
2FTAX-ray1.61A/B/C/D21-148[»]
2GHZX-ray1.60A/B21-148[»]
2GI0X-ray1.70A/B21-148[»]
2HX7X-ray1.55A/B21-148[»]
2HX8X-ray1.60A/B21-148[»]
2HX9X-ray1.70A/B21-148[»]
2HXAX-ray2.21A/B21-148[»]
2I7OX-ray1.50A21-148[»]
2I7SX-ray1.35A/B/C/D21-148[»]
2IDFX-ray2.25A/B21-148[»]
2IWEX-ray2.83A/D/G/J21-148[»]
2OJ1X-ray2.30A/B21-148[»]
2TSAX-ray2.20A/B/C/D21-148[»]
2TSBX-ray2.30A/B/C/D21-148[»]
2XV0X-ray1.60A21-148[»]
2XV2X-ray1.60A21-148[»]
2XV3X-ray2.30A/B21-148[»]
3AZUX-ray2.10A/B/C/D21-148[»]
3FPYX-ray2.10A21-148[»]
3FQ1X-ray1.90A21-148[»]
3FQ2X-ray1.91A21-148[»]
3FQYX-ray1.90A21-148[»]
3FS9X-ray1.05A21-132[»]
A141-148[»]
3FSAX-ray0.98A21-132[»]
A141-148[»]
3FSVX-ray2.30A21-132[»]
A141-148[»]
3FSWX-ray2.00A/B/C/D21-132[»]
A/B/C/D141-148[»]
3FSZX-ray2.00A/B21-132[»]
A/B141-148[»]
3FT0X-ray1.80A/B21-132[»]
A/B141-148[»]
3IBOX-ray1.45A/B/C/D21-148[»]
3IN0X-ray2.35A/B/C/D21-148[»]
3IN2X-ray2.60A21-148[»]
3JT2X-ray2.10A/B21-148[»]
3JTBX-ray1.80A/B/C/D21-148[»]
3N2JX-ray1.35A/B/C/D/E/F/G/H/I/J/K/L21-148[»]
3NP3X-ray2.10A21-148[»]
3NP4X-ray2.25A21-148[»]
3OQRX-ray2.40A21-148[»]
3U25X-ray1.18A/B22-148[»]
3UGEX-ray1.70A/B/C/D21-148[»]
4AZUX-ray1.90A/B/C/D21-148[»]
4BWWX-ray1.48A/B/C/D21-148[»]
4HHGX-ray1.60A21-148[»]
4HHWX-ray2.00A/B21-148[»]
4HIPX-ray1.90A/B21-148[»]
4HZ1X-ray2.20A/B/C/D21-148[»]
4JKNX-ray1.54A/B/C/D21-148[»]
4K9JX-ray1.70A21-148[»]
4KO5X-ray1.79A/B21-148[»]
4KO6X-ray1.74A/B/C/D21-148[»]
4KO7X-ray2.07A/B/C/D21-148[»]
4KO9X-ray2.05A/B/C/D21-148[»]
4KOBX-ray1.87A/B/C/D21-148[»]
4KOCX-ray1.46A21-148[»]
4MFHX-ray1.54A/B/C21-148[»]
4QKTX-ray1.64A/B21-148[»]
4QLWX-ray2.00A/B/C/D21-148[»]
4WKXX-ray1.94A/B21-148[»]
5AZUX-ray1.90A/B/C/D21-148[»]
5I26X-ray1.89A/B/C/D21-148[»]
5I28X-ray1.95A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P21-148[»]
ProteinModelPortaliP00282.
SMRiP00282. Positions 21-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48787N.
MINTiMINT-8099376.
STRINGi208964.PA4922.

Proteomic databases

PaxDbiP00282.

Protocols and materials databases

DNASUi878046.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08307; AAG08307; PA4922.
GeneIDi878046.
KEGGipae:PA4922.
PATRICi19844648. VBIPseAer58763_5155.

Organism-specific databases

PseudoCAPiPA4922.

Phylogenomic databases

eggNOGiENOG41090JD. Bacteria.
COG3241. LUCA.
HOGENOMiHOG000280572.
InParanoidiP00282.
OMAiKSCKTFT.
PhylomeDBiP00282.

Miscellaneous databases

EvolutionaryTraceiP00282.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZUR_PSEAE
AccessioniPrimary (citable) accession number: P00282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.