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Protein

Azurin

Gene

azu

Organism
Achromobacter denitrificans (Alcaligenes denitrificans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transfers electrons from cytochrome c551 to cytochrome oxidase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66Copper1 Publication1
Metal bindingi132Copper1 Publication1
Metal bindingi137Copper1 Publication1
Metal bindingi141Copper1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Azurin
Gene namesi
Name:azu
OrganismiAchromobacter denitrificans (Alcaligenes denitrificans)
Taxonomic identifieri32002 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000285821 – 149AzurinAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 46

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 29Combined sources7
Beta strandi31 – 33Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi47 – 55Combined sources9
Beta strandi57 – 59Combined sources3
Helixi61 – 64Combined sources4
Beta strandi69 – 72Combined sources4
Turni73 – 75Combined sources3
Helixi76 – 84Combined sources9
Helixi88 – 90Combined sources3
Beta strandi100 – 103Combined sources4
Beta strandi112 – 118Combined sources7
Helixi119 – 121Combined sources3
Beta strandi127 – 131Combined sources5
Helixi137 – 139Combined sources3
Beta strandi141 – 148Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4AX-ray1.89A/B21-149[»]
1A4BX-ray1.91A/B21-149[»]
1A4CX-ray2.45A/B/C/D21-149[»]
1AIZX-ray1.80A/B21-149[»]
1AZBX-ray2.20A/B21-149[»]
1AZCX-ray1.80A/B21-149[»]
1URIX-ray1.94A/B21-149[»]
2AZAX-ray1.80A/B21-149[»]
ProteinModelPortaliP00280.
SMRiP00280.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00280.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 149Plastocyanin-likeAdd BLAST129

Sequence similaritiesi

Contains 1 plastocyanin-like domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAKATLAIV LSAASLPVLA AQCEATIESN DAMQYNLKEM VVDKSCKQFT
60 70 80 90 100
VHLKHVGKMA KVAMGHNWVL TKEADKQGVA TDGMNAGLAQ DYVKAGDTRV
110 120 130 140
IAHTKVIGGG ESDSVTFDVS KLTPGEAYAY FCSFPGHWAM MKGTLKLSN
Length:149
Mass (Da):15,924
Last modified:November 1, 1990 - v2
Checksum:i849F182DD6B1BE3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77Q → E AA sequence (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30388 Genomic DNA. Translation: AAA21954.1.
PIRiJQ0643. AZALCD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30388 Genomic DNA. Translation: AAA21954.1.
PIRiJQ0643. AZALCD.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4AX-ray1.89A/B21-149[»]
1A4BX-ray1.91A/B21-149[»]
1A4CX-ray2.45A/B/C/D21-149[»]
1AIZX-ray1.80A/B21-149[»]
1AZBX-ray2.20A/B21-149[»]
1AZCX-ray1.80A/B21-149[»]
1URIX-ray1.94A/B21-149[»]
2AZAX-ray1.80A/B21-149[»]
ProteinModelPortaliP00280.
SMRiP00280.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP00280.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR014068. Azurin_proteobac.
IPR000923. BlueCu_1.
IPR028871. BlueCu_1_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00127. Copper-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
TIGRFAMsiTIGR02695. azurin. 1 hit.
PROSITEiPS00196. COPPER_BLUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZUR_ACHDE
AccessioniPrimary (citable) accession number: P00280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.