Reviewed, UniProtKB/Swiss-Prot P00258 (ADX_PIG)

Names and origin

Protein names

Recommended name:
    Adrenodoxin, mitochondrial
Alternative name(s):
    Adrenal ferredoxin
    Ferredoxin-1

Gene names

Name:

FDX1

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Adrenodoxin transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450.
Cofactor	Binds 1 2Fe-2S cluster.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 58	58	Mitochondrion Ref.2 Ref.3
	Chain	59 – 186	128	Adrenodoxin, mitochondrial		PRO_0000000990
Regions
	Domain	65 – 169	105	2Fe-2S ferredoxin-type
Sites
	Metal binding	104	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	110	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	113	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	150	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00258-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: BA6372223C403931	FASTA	186	19,932
	10 20 30 40 50 60 MAVRLLRVAS AALGDTAVRW QPLVGPRAGN RGPGGSIWLG LGGRAAAART LSLSARAWSS 70 80 90 100 110 120 SEDKITVHFI NRDGKTLTTQ GKVGDSLLDV VIENNLDIDG FGACEGTLAC STCHLIFEDH 130 140 150 160 170 180 IFEKLEAITD EENDMLDLAY GLTDRSRLGC QICLTKAMDN MTVRVPEAVA DARESIDLGK NSSKLE

References

[1]	"Molecular cloning and immunological characterization of porcine kidney ferredoxin." Omdahl J.L., Wilson K., Swerdlow H., Driscoll W.J. Arch. Biochem. Biophys. 293:213-218(1992) [PubMed: 1536558] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Adrenodoxin." Akhrem A.A., Lapko A.G., Lapko V.N., Morozova L.A., Repin V.A., Tishchenko I.V., Chashchin V.L. Bioorg. Khim. 4:462-475(1978) Cited for: PROTEIN SEQUENCE OF 59-175.
[3]	"Characterization and N-terminal amino acid sequence of multiple ferredoxins in kidney and adrenal mitochondria." Driscoll W.J., Omdahl J.L. Eur. J. Biochem. 185:181-187(1989) [PubMed: 2553401] [Abstract] Cited for: PROTEIN SEQUENCE OF 59-76.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M57674 mRNA. Translation: AAA31030.1.
PIR	AXPG. S20332.
RefSeq	NP_999230.1.
UniGene	Ssc.231
3D structure databases
SMR	P00258. Positions 63-166.
ModBase	Search...
Genome annotation databases
GeneID	397133.
KEGG	ssc:397133.
Organism-specific databases
CTD	397133.
Phylogenomic databases
HOVERGEN	P00258.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADX_PIG

Accession

Primary (citable) accession number: P00258

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)