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Protein

Ferredoxin

Gene

fdx

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

Cofactori

[2Fe-2S] clusterNote: Binds 1 [2Fe-2S] cluster.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi69 – 691Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi72 – 721Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin
Gene namesi
Name:fdx
Synonyms:fer2
Ordered Locus Names:VNG_2293G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 129128FerredoxinPRO_0000189387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 1191N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP00216.
PRIDEiP00216.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG2293G.

Structurei

Secondary structure

1
129
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi9 – 157Combined sources
Beta strandi19 – 224Combined sources
Helixi24 – 318Combined sources
Turni35 – 373Combined sources
Beta strandi38 – 425Combined sources
Helixi49 – 546Combined sources
Turni55 – 573Combined sources
Beta strandi66 – 705Combined sources
Beta strandi75 – 795Combined sources
Beta strandi87 – 893Combined sources
Helixi91 – 955Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi109 – 1168Combined sources
Helixi118 – 1203Combined sources
Helixi122 – 1254Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E0ZNMR-A2-129[»]
1E10NMR-A2-129[»]
ProteinModelPortaliP00216.
SMRiP00216. Positions 2-129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00216.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 120922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 2Fe2S plant-type ferredoxin family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG02844. Archaea.
COG0633. LUCA.
InParanoidiP00216.
OMAiQGEYILE.
PhylomeDBiP00216.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTVEYLNYE TLDDQGWDMD DDDLFEKAAD AGLDGEDYGT MEVAEGEYIL
60 70 80 90 100
EAAEAQGYDW PFSCRAGACA NCASIVKEGE IDMDMQQILS DEEVEEKDVR
110 120
LTCIGSPAAD EVKIVYNAKH LDYLQNRVI
Length:129
Mass (Da):14,418
Last modified:January 23, 2007 - v2
Checksum:i787BA486807ADCA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68103 Genomic DNA. Translation: CAA48224.1.
AE004437 Genomic DNA. Translation: AAG20406.1.
PIRiB84380.
S35235. FEHS.
RefSeqiWP_010903707.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG20406; AAG20406; VNG_2293G.
GeneIDi5953323.
KEGGihal:VNG2293G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68103 Genomic DNA. Translation: CAA48224.1.
AE004437 Genomic DNA. Translation: AAG20406.1.
PIRiB84380.
S35235. FEHS.
RefSeqiWP_010903707.1. NC_002607.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E0ZNMR-A2-129[»]
1E10NMR-A2-129[»]
ProteinModelPortaliP00216.
SMRiP00216. Positions 2-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG2293G.

Proteomic databases

PaxDbiP00216.
PRIDEiP00216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG20406; AAG20406; VNG_2293G.
GeneIDi5953323.
KEGGihal:VNG2293G.

Phylogenomic databases

eggNOGiarCOG02844. Archaea.
COG0633. LUCA.
InParanoidiP00216.
OMAiQGEYILE.
PhylomeDBiP00216.

Miscellaneous databases

EvolutionaryTraceiP00216.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The fdx gene encoding the [2Fe-2S] ferredoxin of Halobacterium salinarium (H. halobium)."
    Pfeifer F., Griffig J., Oesterhelt D.
    Mol. Gen. Genet. 239:66-71(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.
  3. "Complete amino acid sequence of Halobacterium halobium ferredoxin containing an Nepsilon-acetyllysine residue."
    Hase T., Wakabayashi S., Matsubara H., Kerscher L., Oesterhelt D., Rao K.K., Hall D.O.
    J. Biochem. 83:1657-1670(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-129, ACETYLATION AT LYS-119.

Entry informationi

Entry nameiFER_HALSA
AccessioniPrimary (citable) accession number: P00216
Secondary accession number(s): Q9HN15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.