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P00184

- CP1A1_MOUSE

UniProt

P00184 - CP1A1_MOUSE

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Protein

Cytochrome P450 1A1

Gene

Cyp1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281SubstrateBy similarity
Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. demethylase activity Source: Ensembl
  3. flavonoid 3'-monooxygenase activity Source: Ensembl
  4. heme binding Source: InterPro
  5. iron ion binding Source: InterPro
  6. monooxygenase activity Source: MGI
  7. oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
  8. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: MGI
  9. steroid hydroxylase activity Source: Ensembl
  10. vitamin D 24-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. 9-cis-retinoic acid biosynthetic process Source: Ensembl
  2. aging Source: Ensembl
  3. amine metabolic process Source: MGI
  4. camera-type eye development Source: Ensembl
  5. cell proliferation Source: Ensembl
  6. cellular response to organic cyclic compound Source: MGI
  7. coumarin metabolic process Source: Ensembl
  8. digestive tract development Source: Ensembl
  9. drug metabolic process Source: Ensembl
  10. embryo development ending in birth or egg hatching Source: Ensembl
  11. flavonoid metabolic process Source: Ensembl
  12. hepatocyte differentiation Source: Ensembl
  13. heterocycle metabolic process Source: MGI
  14. hydrogen peroxide biosynthetic process Source: MGI
  15. insecticide metabolic process Source: Ensembl
  16. maternal process involved in parturition Source: Ensembl
  17. porphyrin-containing compound metabolic process Source: Ensembl
  18. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  19. response to antibiotic Source: Ensembl
  20. response to arsenic-containing substance Source: Ensembl
  21. response to drug Source: Ensembl
  22. response to food Source: Ensembl
  23. response to herbicide Source: Ensembl
  24. response to hyperoxia Source: Ensembl
  25. response to hypoxia Source: Ensembl
  26. response to iron(III) ion Source: Ensembl
  27. response to lipopolysaccharide Source: Ensembl
  28. response to nematode Source: Ensembl
  29. response to toxic substance Source: MGI
  30. response to virus Source: Ensembl
  31. response to vitamin A Source: Ensembl
  32. response to wounding Source: Ensembl
  33. toxin metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P450-P1
Gene namesi
Name:Cyp1a1
Synonyms:Cyp1a-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88588. Cyp1a1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Cytochrome P450 1A1PRO_0000051631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP00184.
PaxDbiP00184.
PRIDEiP00184.

PTM databases

PhosphoSiteiP00184.

Expressioni

Inductioni

By 3-methylcholanthrene (3MC).

Gene expression databases

BgeeiP00184.
ExpressionAtlasiP00184. baseline and differential.
GenevestigatoriP00184.

Structurei

3D structure databases

ProteinModelPortaliP00184.
SMRiP00184. Positions 40-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP00184.
KOiK07408.
OMAiENANIQV.
OrthoDBiEOG7RBZ85.
PhylomeDBiP00184.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00184-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL
60 70 80 90 100
PFIGHMLTVG KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL
110 120 130 140 150
VRQGDDFKGR PDLYSFTLIT NGKSMTFNPD SGPVWAARRR LAQNALKSFS
160 170 180 190 200
IASDPTSASS CYLEEHVSKE ANYLVSKLQK VMAEVGHFDP YKYLVVSVAN
210 220 230 240 250
VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF IPVLRYLPNS
260 270 280 290 300
SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE
310 320 330 340 350
NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE
360 370 380 390 400
LDTVIGRDRQ PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL
410 420 430 440 450
NGFYIPKGCC VFVNQWQVNH DRELWGDPNE FRPERFLTPS GTLDKRLSEK
460 470 480 490 500
VTLFGLGKRK CIGETIGRSE VFLFLAILLQ QIEFKVSPGE KVDMTPTYGL
510 520
TLKHARCEHF QVQMRSSGPQ HLQA
Length:524
Mass (Da):59,230
Last modified:February 1, 1996 - v2
Checksum:iE31D9E9CBA7B2B02
GO

Sequence cautioni

The sequence AAA37506.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00071 mRNA. Translation: CAA68277.1.
X01681 Genomic DNA. Translation: CAA25836.1.
K02588 mRNA. Translation: AAA37506.1. Different initiation.
M10021 Genomic DNA. Translation: AAA37507.1.
AK005000 mRNA. Translation: BAB23734.1.
M25623 Genomic DNA. Translation: AAA39868.1.
CCDSiCCDS23230.1.
PIRiA23923. O4MSM1.
RefSeqiNP_001129531.1. NM_001136059.2.
NP_034122.1. NM_009992.4.
XP_006510873.1. XM_006510810.1.
UniGeneiMm.14089.

Genome annotation databases

EnsembliENSMUST00000034865; ENSMUSP00000034865; ENSMUSG00000032315.
GeneIDi13076.
KEGGimmu:13076.
UCSCiuc009pvn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00071 mRNA. Translation: CAA68277.1 .
X01681 Genomic DNA. Translation: CAA25836.1 .
K02588 mRNA. Translation: AAA37506.1 . Different initiation.
M10021 Genomic DNA. Translation: AAA37507.1 .
AK005000 mRNA. Translation: BAB23734.1 .
M25623 Genomic DNA. Translation: AAA39868.1 .
CCDSi CCDS23230.1.
PIRi A23923. O4MSM1.
RefSeqi NP_001129531.1. NM_001136059.2.
NP_034122.1. NM_009992.4.
XP_006510873.1. XM_006510810.1.
UniGenei Mm.14089.

3D structure databases

ProteinModelPortali P00184.
SMRi P00184. Positions 40-516.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL6171.

PTM databases

PhosphoSitei P00184.

Proteomic databases

MaxQBi P00184.
PaxDbi P00184.
PRIDEi P00184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034865 ; ENSMUSP00000034865 ; ENSMUSG00000032315 .
GeneIDi 13076.
KEGGi mmu:13076.
UCSCi uc009pvn.3. mouse.

Organism-specific databases

CTDi 1543.
MGIi MGI:88588. Cyp1a1.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P00184.
KOi K07408.
OMAi ENANIQV.
OrthoDBi EOG7RBZ85.
PhylomeDBi P00184.
TreeFami TF105095.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi 283020.
PROi P00184.
SOURCEi Search...

Gene expression databases

Bgeei P00184.
ExpressionAtlasi P00184. baseline and differential.
Genevestigatori P00184.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences."
    Kimura S., Gonzalez F.J., Nebert D.W.
    J. Biol. Chem. 259:10705-10713(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. "Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes."
    Gonzalez F.J., Kimura S., Nebert D.W.
    J. Biol. Chem. 260:5040-5049(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast."
    Kimura S., Smith H.H., Hankinson O., Nebert D.W.
    EMBO J. 6:1929-1933(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. "Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450."
    Gonzalez F.J., McKenzie P.I., Kimura S., Nebert D.W.
    Gene 29:281-292(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  6. "Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450."
    Cheng K.C., Park S.S., Krutzsch H.C., Grantham P.H., Gelboin H.V., Friedman F.K.
    Biochemistry 25:2397-2402(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-25.
    Strain: C57BL/6.
  7. "Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture."
    Peterson T.C., Gonzalez F.J., Nebert D.W.
    Biochem. Pharmacol. 35:2107-2114(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 280-321.

Entry informationi

Entry nameiCP1A1_MOUSE
AccessioniPrimary (citable) accession number: P00184
Secondary accession number(s): Q61455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3