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Protein

Cytochrome P450 1A1

Gene

Cyp1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228SubstrateBy similarity1
Metal bindingi461Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211981 Xenobiotics
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
R-MMU-9018681 Biosynthesis of protectins

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P450-P1
Gene namesi
Name:Cyp1a1
Synonyms:Cyp1a-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88588 Cyp1a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516311 – 524Cytochrome P450 1A1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP00184
PeptideAtlasiP00184
PRIDEiP00184

PTM databases

iPTMnetiP00184
PhosphoSitePlusiP00184

Expressioni

Inductioni

By 3-methylcholanthrene (3MC).

Gene expression databases

BgeeiENSMUSG00000032315
ExpressionAtlasiP00184 baseline and differential
GenevisibleiP00184 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034865

Structurei

3D structure databases

ProteinModelPortaliP00184
SMRiP00184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036991
HOVERGENiHBG106944
InParanoidiP00184
KOiK07408
OMAiNNWQDYI
OrthoDBiEOG091G0BT8
PhylomeDBiP00184
TreeFamiTF105095

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008066 Cyt_P450_E_grp-I_CYP1
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01683 EP450ICYP1A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P00184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL
60 70 80 90 100
PFIGHMLTVG KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL
110 120 130 140 150
VRQGDDFKGR PDLYSFTLIT NGKSMTFNPD SGPVWAARRR LAQNALKSFS
160 170 180 190 200
IASDPTSASS CYLEEHVSKE ANYLVSKLQK VMAEVGHFDP YKYLVVSVAN
210 220 230 240 250
VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF IPVLRYLPNS
260 270 280 290 300
SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE
310 320 330 340 350
NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE
360 370 380 390 400
LDTVIGRDRQ PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL
410 420 430 440 450
NGFYIPKGCC VFVNQWQVNH DRELWGDPNE FRPERFLTPS GTLDKRLSEK
460 470 480 490 500
VTLFGLGKRK CIGETIGRSE VFLFLAILLQ QIEFKVSPGE KVDMTPTYGL
510 520
TLKHARCEHF QVQMRSSGPQ HLQA
Length:524
Mass (Da):59,230
Last modified:February 1, 1996 - v2
Checksum:iE31D9E9CBA7B2B02
GO

Sequence cautioni

The sequence AAA37506 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00071 mRNA Translation: CAA68277.1
X01681 Genomic DNA Translation: CAA25836.1
K02588 mRNA Translation: AAA37506.1 Different initiation.
M10021 Genomic DNA Translation: AAA37507.1
AK005000 mRNA Translation: BAB23734.1
M25623 Genomic DNA Translation: AAA39868.1
CCDSiCCDS23230.1
PIRiA23923 O4MSM1
RefSeqiNP_001129531.1, NM_001136059.2
NP_034122.1, NM_009992.4
XP_006510873.1, XM_006510810.3
UniGeneiMm.14089

Genome annotation databases

EnsembliENSMUST00000034865; ENSMUSP00000034865; ENSMUSG00000032315
ENSMUST00000216433; ENSMUSP00000150277; ENSMUSG00000032315
GeneIDi13076
KEGGimmu:13076
UCSCiuc009pvn.3 mouse

Similar proteinsi

Entry informationi

Entry nameiCP1A1_MOUSE
AccessioniPrimary (citable) accession number: P00184
Secondary accession number(s): Q61455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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