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P00184

- CP1A1_MOUSE

UniProt

P00184 - CP1A1_MOUSE

Protein

Cytochrome P450 1A1

Gene

Cyp1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateBy similarity
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. demethylase activity Source: Ensembl
    3. flavonoid 3'-monooxygenase activity Source: Ensembl
    4. heme binding Source: InterPro
    5. iron ion binding Source: InterPro
    6. monooxygenase activity Source: MGI
    7. oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
    8. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: MGI
    9. steroid hydroxylase activity Source: Ensembl
    10. vitamin D 24-hydroxylase activity Source: Ensembl

    GO - Biological processi

    1. 9-cis-retinoic acid biosynthetic process Source: Ensembl
    2. aging Source: Ensembl
    3. amine metabolic process Source: MGI
    4. camera-type eye development Source: Ensembl
    5. cell proliferation Source: Ensembl
    6. cellular response to organic cyclic compound Source: MGI
    7. coumarin metabolic process Source: Ensembl
    8. digestive tract development Source: Ensembl
    9. drug metabolic process Source: Ensembl
    10. embryo development ending in birth or egg hatching Source: Ensembl
    11. flavonoid metabolic process Source: Ensembl
    12. hepatocyte differentiation Source: Ensembl
    13. heterocycle metabolic process Source: MGI
    14. hydrogen peroxide biosynthetic process Source: MGI
    15. insecticide metabolic process Source: Ensembl
    16. maternal process involved in parturition Source: Ensembl
    17. porphyrin-containing compound metabolic process Source: Ensembl
    18. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    19. response to antibiotic Source: Ensembl
    20. response to arsenic-containing substance Source: Ensembl
    21. response to drug Source: Ensembl
    22. response to food Source: Ensembl
    23. response to herbicide Source: Ensembl
    24. response to hyperoxia Source: Ensembl
    25. response to hypoxia Source: Ensembl
    26. response to iron(III) ion Source: Ensembl
    27. response to lipopolysaccharide Source: Ensembl
    28. response to nematode Source: Ensembl
    29. response to toxic substance Source: MGI
    30. response to virus Source: Ensembl
    31. response to vitamin A Source: Ensembl
    32. response to wounding Source: Ensembl
    33. toxin metabolic process Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_198602. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Cytochrome P450-P1
    Gene namesi
    Name:Cyp1a1
    Synonyms:Cyp1a-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88588. Cyp1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Cytochrome P450 1A1PRO_0000051631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP00184.
    PRIDEiP00184.

    PTM databases

    PhosphoSiteiP00184.

    Expressioni

    Inductioni

    By 3-methylcholanthrene (3MC).

    Gene expression databases

    ArrayExpressiP00184.
    BgeeiP00184.
    GenevestigatoriP00184.

    Structurei

    3D structure databases

    ProteinModelPortaliP00184.
    SMRiP00184. Positions 40-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiP00184.
    KOiK07408.
    OMAiENANIQV.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP00184.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00184-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL    50
    PFIGHMLTVG KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL 100
    VRQGDDFKGR PDLYSFTLIT NGKSMTFNPD SGPVWAARRR LAQNALKSFS 150
    IASDPTSASS CYLEEHVSKE ANYLVSKLQK VMAEVGHFDP YKYLVVSVAN 200
    VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF IPVLRYLPNS 250
    SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE 300
    NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE 350
    LDTVIGRDRQ PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL 400
    NGFYIPKGCC VFVNQWQVNH DRELWGDPNE FRPERFLTPS GTLDKRLSEK 450
    VTLFGLGKRK CIGETIGRSE VFLFLAILLQ QIEFKVSPGE KVDMTPTYGL 500
    TLKHARCEHF QVQMRSSGPQ HLQA 524
    Length:524
    Mass (Da):59,230
    Last modified:February 1, 1996 - v2
    Checksum:iE31D9E9CBA7B2B02
    GO

    Sequence cautioni

    The sequence AAA37506.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00071 mRNA. Translation: CAA68277.1.
    X01681 Genomic DNA. Translation: CAA25836.1.
    K02588 mRNA. Translation: AAA37506.1. Different initiation.
    M10021 Genomic DNA. Translation: AAA37507.1.
    AK005000 mRNA. Translation: BAB23734.1.
    M25623 Genomic DNA. Translation: AAA39868.1.
    CCDSiCCDS23230.1.
    PIRiA23923. O4MSM1.
    RefSeqiNP_001129531.1. NM_001136059.2.
    NP_034122.1. NM_009992.4.
    XP_006510873.1. XM_006510810.1.
    UniGeneiMm.14089.

    Genome annotation databases

    EnsembliENSMUST00000034865; ENSMUSP00000034865; ENSMUSG00000032315.
    GeneIDi13076.
    KEGGimmu:13076.
    UCSCiuc009pvn.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00071 mRNA. Translation: CAA68277.1 .
    X01681 Genomic DNA. Translation: CAA25836.1 .
    K02588 mRNA. Translation: AAA37506.1 . Different initiation.
    M10021 Genomic DNA. Translation: AAA37507.1 .
    AK005000 mRNA. Translation: BAB23734.1 .
    M25623 Genomic DNA. Translation: AAA39868.1 .
    CCDSi CCDS23230.1.
    PIRi A23923. O4MSM1.
    RefSeqi NP_001129531.1. NM_001136059.2.
    NP_034122.1. NM_009992.4.
    XP_006510873.1. XM_006510810.1.
    UniGenei Mm.14089.

    3D structure databases

    ProteinModelPortali P00184.
    SMRi P00184. Positions 40-516.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL6171.

    PTM databases

    PhosphoSitei P00184.

    Proteomic databases

    PaxDbi P00184.
    PRIDEi P00184.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034865 ; ENSMUSP00000034865 ; ENSMUSG00000032315 .
    GeneIDi 13076.
    KEGGi mmu:13076.
    UCSCi uc009pvn.3. mouse.

    Organism-specific databases

    CTDi 1543.
    MGIi MGI:88588. Cyp1a1.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi P00184.
    KOi K07408.
    OMAi ENANIQV.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P00184.
    TreeFami TF105095.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 283020.
    PROi P00184.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P00184.
    Bgeei P00184.
    Genevestigatori P00184.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences."
      Kimura S., Gonzalez F.J., Nebert D.W.
      J. Biol. Chem. 259:10705-10713(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: C57BL/6.
      Tissue: Liver.
    2. "Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes."
      Gonzalez F.J., Kimura S., Nebert D.W.
      J. Biol. Chem. 260:5040-5049(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast."
      Kimura S., Smith H.H., Hankinson O., Nebert D.W.
      EMBO J. 6:1929-1933(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    4. "Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450."
      Gonzalez F.J., McKenzie P.I., Kimura S., Nebert D.W.
      Gene 29:281-292(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    6. "Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450."
      Cheng K.C., Park S.S., Krutzsch H.C., Grantham P.H., Gelboin H.V., Friedman F.K.
      Biochemistry 25:2397-2402(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-25.
      Strain: C57BL/6.
    7. "Methylation differences in the murine P-1-450 and P-3-450 genes in wild-type and mutant hepatoma cell culture."
      Peterson T.C., Gonzalez F.J., Nebert D.W.
      Biochem. Pharmacol. 35:2107-2114(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 280-321.

    Entry informationi

    Entry nameiCP1A1_MOUSE
    AccessioniPrimary (citable) accession number: P00184
    Secondary accession number(s): Q61455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3