SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00182

- CP2C3_RABIT

UniProt

P00182 - CP2C3_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 2C3
Gene
CYP2C3
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C3 (EC:1.14.14.1)
Alternative name(s):
CYPIIC3
Cytochrome P450 PBc3
Cytochrome P450 form 3B
Gene namesi
Name:CYP2C3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450 2C3
PRO_0000051694Add
BLAST

Expressioni

Inductioni

Constitutively expressed.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016913.

Structurei

3D structure databases

ProteinModelPortaliP00182.
SMRiP00182. Positions 30-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00182-1 [UniParc]FASTAAdd to Basket

« Hide

MDLLIILGIC LSCVVLLSLW KKTHGKGKLP PGPTPLPVVG NLLQLETKDI    50
NKSLSMLAKE YGSIFTLYFG MKPAVVLYGY EGVIEALIDR GEEFSGRGIF 100
PVFDRVTKGL GIVFSSGEKW KETRRFSLTV LRNLGMGKKT IEERIQEEAL 150
CLIQALRKTN ASPCDPTFLL FCVPCNVICS VIFQNRFDYD DEKFKTLIKY 200
FHENFELLGT PWIQLYNIFP ILHYLPGSHR QLFKNIDGQI KFILEKVQEH 250
QESLDSNNPR DFVDHFLIKM EKEKHKKQSE FTMDNLITTI WDVFSAGTDT 300
TSNTLKFALL LLLKHPEITA KVQEEIEHVI GRHRSPCMQD RTRMPYTDAV 350
MHEIQRYVDL VPTSLPHAVT QDIEFNGYLI PKGTDIIPSL TSVLYDDKEF 400
PNPEKFDPGH FLDESGNFKK SDYFMPFSAG KRACVGEGLA RMELFLLLTT 450
ILQHFTLKPL VDPKDIDPTP VENGFVSVPP SYELCFVPV 489
Length:489
Mass (Da):55,794
Last modified:December 15, 1998 - v2
Checksum:i860D36E42D554C75
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491D → N in AAA31175. 1 Publication
Sequence conflicti49 – 491D → N in BAA05139. 1 Publication
Sequence conflicti82 – 843GVI → TVK in AAA31175. 1 Publication
Sequence conflicti82 – 843GVI → TVK in BAA05139. 1 Publication
Sequence conflicti89 – 891D → Y AA sequence 1 Publication
Sequence conflicti178 – 1781I → M in BAA05139. 1 Publication
Sequence conflicti222 – 2221L → LG AA sequence 1 Publication
Sequence conflicti256 – 2561S → L in AAA31175. 1 Publication
Sequence conflicti338 – 3381M → S AA sequence 1 Publication
Sequence conflicti342 – 3421T → S AA sequence 1 Publication
Sequence conflicti364 – 3641S → T in BAA05139. 1 Publication
Sequence conflicti429 – 4291A → T AA sequence 1 Publication
Sequence conflicti471 – 4711V → L in BAA05139. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01523 mRNA. Translation: AAA31212.1.
M31254
, M31245, M31247, M31248, M31249, M31250, M31251, M31252, M31253 Genomic DNA. Translation: AAA31175.1.
D26152 mRNA. Translation: BAA05139.1.
PIRiA00183. O4RBP3.
RefSeqiNP_001164736.1. NM_001171265.1.
UniGeneiOcu.1852.

Genome annotation databases

GeneIDi100328933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01523 mRNA. Translation: AAA31212.1 .
M31254
, M31245 , M31247 , M31248 , M31249 , M31250 , M31251 , M31252 , M31253 Genomic DNA. Translation: AAA31175.1 .
D26152 mRNA. Translation: BAA05139.1 .
PIRi A00183. O4RBP3.
RefSeqi NP_001164736.1. NM_001171265.1.
UniGenei Ocu.1852.

3D structure databases

ProteinModelPortali P00182.
SMRi P00182. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000016913.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328933.

Organism-specific databases

CTDi 100328933.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450."
    Ozols J., Heinemann F.S., Johnson E.F.
    J. Biol. Chem. 260:5427-5434(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
    Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
    Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure of the rabbit cytochrome P450IIC3 gene, a constitutive member of the P450IIC subfamily."
    Chan G.
    Biochemistry 29:3743-3750(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "A member of cytochrome P450 2C family which is identical to rabbit P450pc3."
    Noshiro M., Ishida H., Okuda K.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.

Entry informationi

Entry nameiCP2C3_RABIT
AccessioniPrimary (citable) accession number: P00182
Secondary accession number(s): Q29509, Q29525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 15, 1998
Last modified: March 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi