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P00182 (CP2C3_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C3

EC=1.14.14.1
Alternative name(s):
CYPIIC3
Cytochrome P450 PBc3
Cytochrome P450 form 3B
Gene names
Name:CYP2C3
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Cytochrome P450 2C3
PRO_0000051694

Sites

Metal binding4341Iron (heme axial ligand)

Experimental info

Sequence conflict491D → N in AAA31175. Ref.3
Sequence conflict491D → N in BAA05139. Ref.4
Sequence conflict82 – 843GVI → TVK in AAA31175. Ref.3
Sequence conflict82 – 843GVI → TVK in BAA05139. Ref.4
Sequence conflict891D → Y AA sequence Ref.1
Sequence conflict1781I → M in BAA05139. Ref.4
Sequence conflict2221L → LG AA sequence Ref.1
Sequence conflict2561S → L in AAA31175. Ref.3
Sequence conflict3381M → S AA sequence Ref.1
Sequence conflict3421T → S AA sequence Ref.1
Sequence conflict3641S → T in BAA05139. Ref.4
Sequence conflict4291A → T AA sequence Ref.1
Sequence conflict4711V → L in BAA05139. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P00182 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 860D36E42D554C75

FASTA48955,794
        10         20         30         40         50         60 
MDLLIILGIC LSCVVLLSLW KKTHGKGKLP PGPTPLPVVG NLLQLETKDI NKSLSMLAKE 

        70         80         90        100        110        120 
YGSIFTLYFG MKPAVVLYGY EGVIEALIDR GEEFSGRGIF PVFDRVTKGL GIVFSSGEKW 

       130        140        150        160        170        180 
KETRRFSLTV LRNLGMGKKT IEERIQEEAL CLIQALRKTN ASPCDPTFLL FCVPCNVICS 

       190        200        210        220        230        240 
VIFQNRFDYD DEKFKTLIKY FHENFELLGT PWIQLYNIFP ILHYLPGSHR QLFKNIDGQI 

       250        260        270        280        290        300 
KFILEKVQEH QESLDSNNPR DFVDHFLIKM EKEKHKKQSE FTMDNLITTI WDVFSAGTDT 

       310        320        330        340        350        360 
TSNTLKFALL LLLKHPEITA KVQEEIEHVI GRHRSPCMQD RTRMPYTDAV MHEIQRYVDL 

       370        380        390        400        410        420 
VPTSLPHAVT QDIEFNGYLI PKGTDIIPSL TSVLYDDKEF PNPEKFDPGH FLDESGNFKK 

       430        440        450        460        470        480 
SDYFMPFSAG KRACVGEGLA RMELFLLLTT ILQHFTLKPL VDPKDIDPTP VENGFVSVPP 


SYELCFVPV 

« Hide

References

[1]"The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450."
Ozols J., Heinemann F.S., Johnson E.F.
J. Biol. Chem. 260:5427-5434(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure of the rabbit cytochrome P450IIC3 gene, a constitutive member of the P450IIC subfamily."
Chan G.
Biochemistry 29:3743-3750(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"A member of cytochrome P450 2C family which is identical to rabbit P450pc3."
Noshiro M., Ishida H., Okuda K.
Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01523 mRNA. Translation: AAA31212.1.
M31254 expand/collapse EMBL AC list , M31245, M31247, M31248, M31249, M31250, M31251, M31252, M31253 Genomic DNA. Translation: AAA31175.1.
D26152 mRNA. Translation: BAA05139.1.
PIRO4RBP3. A00183.
RefSeqNP_001164736.1. NM_001171265.1.
UniGeneOcu.1852.

3D structure databases

ProteinModelPortalP00182.
SMRP00182. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000016913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328933.

Organism-specific databases

CTD100328933.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2C3_RABIT
AccessionPrimary (citable) accession number: P00182
Secondary accession number(s): Q29509, Q29525
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 15, 1998
Last modified: March 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families