CYP2C3

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	434	Iron (heme axial ligand)		1

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
heme binding Source: InterPro
iron ion binding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2C3 (EC:1.14.14.1) Alternative name(s): CYPIIC3 Cytochrome P450 PBc3 Cytochrome P450 form 3B
Gene namesⁱ	Name:CYP2C3
Organismⁱ	Oryctolagus cuniculus (Rabbit)
Taxonomic identifierⁱ	9986 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
Proteomesⁱ	UP000001811 Componentⁱ: Unplaced

Subcellular locationⁱ

GO - Cellular componentⁱ

endoplasmic reticulum membrane Source: UniProtKB-SubCell
organelle membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051694	1 – 489	Cytochrome P450 2C3Add BLAST		489

Expressionⁱ

Inductionⁱ

Constitutively expressed.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000016913.

STRINGⁱ

9986.ENSOCUP00000016913.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P00182.
SMRⁱ	P00182.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156. Eukaryota. COG2124. LUCA.
HOGENOMⁱ	HOG000036992.
HOVERGENⁱ	HBG015789.
InParanoidⁱ	P00182.
KEGG Orthology (KO) More...KOⁱ	K07413.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067. p450. 1 hit.
PRINTSⁱ	PR00463. EP450I. PR00385. P450.
SUPFAMⁱ	SSF48264. SSF48264. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00086. CYTOCHROME_P450. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P00182-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLLIILGIC LSCVVLLSLW KKTHGKGKLP PGPTPLPVVG NLLQLETKDI 
        60         70         80         90        100
NKSLSMLAKE YGSIFTLYFG MKPAVVLYGY EGVIEALIDR GEEFSGRGIF 
       110        120        130        140        150
PVFDRVTKGL GIVFSSGEKW KETRRFSLTV LRNLGMGKKT IEERIQEEAL 
       160        170        180        190        200
CLIQALRKTN ASPCDPTFLL FCVPCNVICS VIFQNRFDYD DEKFKTLIKY 
       210        220        230        240        250
FHENFELLGT PWIQLYNIFP ILHYLPGSHR QLFKNIDGQI KFILEKVQEH 
       260        270        280        290        300
QESLDSNNPR DFVDHFLIKM EKEKHKKQSE FTMDNLITTI WDVFSAGTDT 
       310        320        330        340        350
TSNTLKFALL LLLKHPEITA KVQEEIEHVI GRHRSPCMQD RTRMPYTDAV 
       360        370        380        390        400
MHEIQRYVDL VPTSLPHAVT QDIEFNGYLI PKGTDIIPSL TSVLYDDKEF 
       410        420        430        440        450
PNPEKFDPGH FLDESGNFKK SDYFMPFSAG KRACVGEGLA RMELFLLLTT 
       460        470        480 
ILQHFTLKPL VDPKDIDPTP VENGFVSVPP SYELCFVPV

Length:489

Mass (Da):55,794

Last modified:December 15, 1998 - v2

Checksum:ⁱ860D36E42D554C75

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49	D → N in AAA31175 (PubMed:2340269).Curated	1
Sequence conflictⁱ	49	D → N in BAA05139 (Ref. 4) Curated	1
Sequence conflictⁱ	82 – 84	GVI → TVK in AAA31175 (PubMed:2340269).Curated	3
Sequence conflictⁱ	82 – 84	GVI → TVK in BAA05139 (Ref. 4) Curated	3
Sequence conflictⁱ	89	D → Y AA sequence (PubMed:3988762).Curated	1
Sequence conflictⁱ	178	I → M in BAA05139 (Ref. 4) Curated	1
Sequence conflictⁱ	222	L → LG AA sequence (PubMed:3988762).Curated	1
Sequence conflictⁱ	256	S → L in AAA31175 (PubMed:2340269).Curated	1
Sequence conflictⁱ	338	M → S AA sequence (PubMed:3988762).Curated	1
Sequence conflictⁱ	342	T → S AA sequence (PubMed:3988762).Curated	1
Sequence conflictⁱ	364	S → T in BAA05139 (Ref. 4) Curated	1
Sequence conflictⁱ	429	A → T AA sequence (PubMed:3988762).Curated	1
Sequence conflictⁱ	471	V → L in BAA05139 (Ref. 4) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K01523 mRNA. Translation: AAA31212.1. M31254 M31253 Genomic DNA. Translation: AAA31175.1. D26152 mRNA. Translation: BAA05139.1.
PIRⁱ	A00183. O4RBP3.
NCBI Reference Sequences More...RefSeqⁱ	NP_001164736.1. NM_001171265.1.
UniGeneⁱ	Ocu.1852.

Genome annotation databases

GeneIDⁱ	100328933.
KEGGⁱ	ocu:100328933.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K01523 mRNA. Translation: AAA31212.1. M31254 M31253 Genomic DNA. Translation: AAA31175.1. D26152 mRNA. Translation: BAA05139.1.
PIRⁱ	A00183. O4RBP3.
NCBI Reference Sequences More...RefSeqⁱ	NP_001164736.1. NM_001171265.1.
UniGeneⁱ	Ocu.1852.

3D structure databases

ProteinModelPortalⁱ	P00182.
SMRⁱ	P00182.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000016913.

STRINGⁱ

9986.ENSOCUP00000016913.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100328933.
KEGGⁱ	ocu:100328933.

Organism-specific databases

CTDⁱ	100328933.

Phylogenomic databases

eggNOGⁱ	KOG0156. Eukaryota. COG2124. LUCA.
HOGENOMⁱ	HOG000036992.
HOVERGENⁱ	HBG015789.
InParanoidⁱ	P00182.
KEGG Orthology (KO) More...KOⁱ	K07413.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067. p450. 1 hit.
PRINTSⁱ	PR00463. EP450I. PR00385. P450.
SUPFAMⁱ	SSF48264. SSF48264. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00086. CYTOCHROME_P450. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2C3_RABIT
Accessionⁱ	P00182Primary (citable) accession number: P00182 Secondary accession number(s): Q29509, Q29525
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	December 15, 1998
	Last modified:	May 10, 2017
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P00182 (CP2C3_RABIT)

Your basket is currently empty.

Cytochrome P450 2C3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ