UniProtKB - P00182 (CP2C3_RABIT)
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Protein
Cytochrome P450 2C3
Gene
CYP2C3
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 434 | Iron (heme axial ligand) | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2C3 (EC:1.14.14.1)Alternative name(s): CYPIIC3 Cytochrome P450 PBc3 Cytochrome P450 form 3B |
Gene namesi | Name:CYP2C3 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051694 | 1 – 489 | Cytochrome P450 2C3Add BLAST | 489 |
Expressioni
Inductioni
Constitutively expressed.
Structurei
3D structure databases
ProteinModelPortali | P00182 |
SMRi | P00182 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156 Eukaryota COG2124 LUCA |
HOGENOMi | HOG000036992 |
HOVERGENi | HBG015789 |
InParanoidi | P00182 |
KOi | K07413 |
Family and domain databases
Gene3Di | 1.10.630.101 hit |
InterProi | View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf |
Pfami | View protein in Pfam PF00067 p450, 1 hit |
PRINTSi | PR00463 EP450I PR00385 P450 |
SUPFAMi | SSF48264 SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
P00182-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLLIILGIC LSCVVLLSLW KKTHGKGKLP PGPTPLPVVG NLLQLETKDI
60 70 80 90 100
NKSLSMLAKE YGSIFTLYFG MKPAVVLYGY EGVIEALIDR GEEFSGRGIF
110 120 130 140 150
PVFDRVTKGL GIVFSSGEKW KETRRFSLTV LRNLGMGKKT IEERIQEEAL
160 170 180 190 200
CLIQALRKTN ASPCDPTFLL FCVPCNVICS VIFQNRFDYD DEKFKTLIKY
210 220 230 240 250
FHENFELLGT PWIQLYNIFP ILHYLPGSHR QLFKNIDGQI KFILEKVQEH
260 270 280 290 300
QESLDSNNPR DFVDHFLIKM EKEKHKKQSE FTMDNLITTI WDVFSAGTDT
310 320 330 340 350
TSNTLKFALL LLLKHPEITA KVQEEIEHVI GRHRSPCMQD RTRMPYTDAV
360 370 380 390 400
MHEIQRYVDL VPTSLPHAVT QDIEFNGYLI PKGTDIIPSL TSVLYDDKEF
410 420 430 440 450
PNPEKFDPGH FLDESGNFKK SDYFMPFSAG KRACVGEGLA RMELFLLLTT
460 470 480
ILQHFTLKPL VDPKDIDPTP VENGFVSVPP SYELCFVPV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | D → N in AAA31175 (PubMed:2340269).Curated | 1 | |
Sequence conflicti | 49 | D → N in BAA05139 (Ref. 4) Curated | 1 | |
Sequence conflicti | 82 – 84 | GVI → TVK in AAA31175 (PubMed:2340269).Curated | 3 | |
Sequence conflicti | 82 – 84 | GVI → TVK in BAA05139 (Ref. 4) Curated | 3 | |
Sequence conflicti | 89 | D → Y AA sequence (PubMed:3988762).Curated | 1 | |
Sequence conflicti | 178 | I → M in BAA05139 (Ref. 4) Curated | 1 | |
Sequence conflicti | 222 | L → LG AA sequence (PubMed:3988762).Curated | 1 | |
Sequence conflicti | 256 | S → L in AAA31175 (PubMed:2340269).Curated | 1 | |
Sequence conflicti | 338 | M → S AA sequence (PubMed:3988762).Curated | 1 | |
Sequence conflicti | 342 | T → S AA sequence (PubMed:3988762).Curated | 1 | |
Sequence conflicti | 364 | S → T in BAA05139 (Ref. 4) Curated | 1 | |
Sequence conflicti | 429 | A → T AA sequence (PubMed:3988762).Curated | 1 | |
Sequence conflicti | 471 | V → L in BAA05139 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01523 mRNA Translation: AAA31212.1 M31254 M31253 Genomic DNA Translation: AAA31175.1 D26152 mRNA Translation: BAA05139.1 |
PIRi | A00183 O4RBP3 |
RefSeqi | NP_001164736.1, NM_001171265.1 |
UniGenei | Ocu.1852 |
Genome annotation databases
GeneIDi | 100328933 |
KEGGi | ocu:100328933 |
Similar proteinsi
Entry informationi
Entry namei | CP2C3_RABIT | |
Accessioni | P00182Primary (citable) accession number: P00182 Secondary accession number(s): Q29509, Q29525 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 28, 2018 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |