Cytochrome P450 2C3 - Oryctolagus cuniculus (Rabbit)

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P00182 (CP2C3_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 2C3
EC=1.14.14.1

Alternative name(s):
CYPIIC3
Cytochrome P450 PBc3
Cytochrome P450 form 3B

Gene names

Name:

CYP2C3

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	Constitutively expressed.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: UniProtKB-EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 489

489

Cytochrome P450 2C3

PRO_0000051694

Sites

Metal binding

434

Iron (heme axial ligand)

Experimental info

Sequence conflict

D → N in AAA31175. Ref.3

Sequence conflict

D → N in BAA05139. Ref.4

Sequence conflict

82 – 84

GVI → TVK in AAA31175. Ref.3

Sequence conflict

82 – 84

GVI → TVK in BAA05139. Ref.4

Sequence conflict

D → Y AA sequence Ref.1

Sequence conflict

178

I → M in BAA05139. Ref.4

Sequence conflict

222

L → LG AA sequence Ref.1

Sequence conflict

256

S → L in AAA31175. Ref.3

Sequence conflict

338

M → S AA sequence Ref.1

Sequence conflict

342

T → S AA sequence Ref.1

Sequence conflict

364

S → T in BAA05139. Ref.4

Sequence conflict

429

A → T AA sequence Ref.1

Sequence conflict

471

V → L in BAA05139. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P00182 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 860D36E42D554C75
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FASTA

489

55,794

        10         20         30         40         50         60 
MDLLIILGIC LSCVVLLSLW KKTHGKGKLP PGPTPLPVVG NLLQLETKDI NKSLSMLAKE 

        70         80         90        100        110        120 
YGSIFTLYFG MKPAVVLYGY EGVIEALIDR GEEFSGRGIF PVFDRVTKGL GIVFSSGEKW 

       130        140        150        160        170        180 
KETRRFSLTV LRNLGMGKKT IEERIQEEAL CLIQALRKTN ASPCDPTFLL FCVPCNVICS 

       190        200        210        220        230        240 
VIFQNRFDYD DEKFKTLIKY FHENFELLGT PWIQLYNIFP ILHYLPGSHR QLFKNIDGQI 

       250        260        270        280        290        300 
KFILEKVQEH QESLDSNNPR DFVDHFLIKM EKEKHKKQSE FTMDNLITTI WDVFSAGTDT 

       310        320        330        340        350        360 
TSNTLKFALL LLLKHPEITA KVQEEIEHVI GRHRSPCMQD RTRMPYTDAV MHEIQRYVDL 

       370        380        390        400        410        420 
VPTSLPHAVT QDIEFNGYLI PKGTDIIPSL TSVLYDDKEF PNPEKFDPGH FLDESGNFKK 

       430        440        450        460        470        480 
SDYFMPFSAG KRACVGEGLA RMELFLLLTT ILQHFTLKPL VDPKDIDPTP VENGFVSVPP 


SYELCFVPV

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References

[1]	"The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450." Ozols J., Heinemann F.S., Johnson E.F. J. Biol. Chem. 260:5427-5434(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form." Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B. Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Structure of the rabbit cytochrome P450IIC3 gene, a constitutive member of the P450IIC subfamily." Chan G. Biochemistry 29:3743-3750(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"A member of cytochrome P450 2C family which is identical to rabbit P450pc3." Noshiro M., Ishida H., Okuda K. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K01523 mRNA. Translation: AAA31212.1. M31254 M31253 Genomic DNA. Translation: AAA31175.1. D26152 mRNA. Translation: BAA05139.1.
PIR	O4RBP3. A00183.
RefSeq	NP_001164736.1. NM_001171265.1.
UniGene	Ocu.1852.
3D structure databases
ProteinModelPortal	P00182.
SMR	P00182. Positions 30-489.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100328933.
Organism-specific databases
CTD	100328933.
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000036992.
HOVERGEN	HBG015789.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. SSF48264. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2C3_RABIT

Accession

Primary (citable) accession number: P00182
Secondary accession number(s): Q29509, Q29525

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	December 15, 1998
Last modified:	November 13, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents