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P00181

- CP2C2_RABIT

UniProt

P00181 - CP2C2_RABIT

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Protein

Cytochrome P450 2C2

Gene

CYP2C2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C2 (EC:1.14.14.1)
Alternative name(s):
CYPIIC2
Cytochrome P450 PBc2
Cytochrome P450 PHP2
Laurate omega-1 hydroxylase
Gene namesi
Name:CYP2C2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C2PRO_0000051693Add
BLAST

Expressioni

Inductioni

By phenobarbital.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INSIG1O155033EBI-4320576,EBI-6252425From a different organism.
PGRMC1O002646EBI-4320576,EBI-1045534From a different organism.
PORP164354EBI-4320576,EBI-726554From a different organism.

Protein-protein interaction databases

IntActiP00181. 27 interactions.
STRINGi9986.ENSOCUP00000013127.

Structurei

3D structure databases

ProteinModelPortaliP00181.
SMRiP00181. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00181.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00181 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDLVVVLGLC LSCLLLPSLW KQSHGGGKLP PGPTPFPILG NVLQLDFKDL
60 70 80 90 100
SKSLTNLSKV YGPVFTVYLG MKPTVVVHGY EAVKEALVDL GHELSGRSRF
110 120 130 140 150
LVTAKLNKGF GVIFSNGKRW TETRRFSLMT LRNFGMGKRS IEERVQEEAH
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GAAPCNVICS VIFQNRFDYT DQDFLSLMGK
210 220 230 240 250
FNENFKILNS PWVQFCNCFP ILFDYFPGSH RKAVKNIFYV KNYITEQIKE
260 270 280 290 300
HQKSLDINNP RDFIDCFLIK MEQEKCNQQS EFTIENLLTT VSDVFMAGTE
310 320 330 340 350
TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
TVHEIQRYIN LIPNNVPHTT ICNLKFRNYL IPKGTDVLTS LSSVLHDDKE
410 420 430 440 450
FPNPDRFDPG HFLDASGNFR KSDYFMPFST GKRVCVGEAL ARMELFLFLT
460 470 480 490
AILQNFTPKP LVNPNNVDEN PFSSGIVRVP PLYRVSFIPV
Length:490
Mass (Da):55,776
Last modified:July 1, 1989 - v2
Checksum:iC105A6C6F3687E23
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → L in AAA31210. (PubMed:6546520)Curated
Sequence conflicti17 – 171P → L in AAA31208. (PubMed:3780371)Curated
Sequence conflicti471 – 4711P → L in AAA31210. (PubMed:6546520)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19137 mRNA. Translation: AAA31217.1.
K01521 mRNA. Translation: AAA31210.1.
M14955 Genomic DNA. Translation: AAA31208.1.
PIRiA27718. O4RBP2.
RefSeqiNP_001164584.1. NM_001171113.1.
UniGeneiOcu.1850.

Genome annotation databases

GeneIDi100328924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19137 mRNA. Translation: AAA31217.1 .
K01521 mRNA. Translation: AAA31210.1 .
M14955 Genomic DNA. Translation: AAA31208.1 .
PIRi A27718. O4RBP2.
RefSeqi NP_001164584.1. NM_001171113.1.
UniGenei Ocu.1850.

3D structure databases

ProteinModelPortali P00181.
SMRi P00181. Positions 28-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00181. 27 interactions.
STRINGi 9986.ENSOCUP00000013127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328924.

Organism-specific databases

CTDi 100328924.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P00181.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits."
    Imai Y., Komori M., Sato R.
    Biochemistry 27:80-88(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
    Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
    Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-490.
  3. "Structure of genes in the cytochrome P-450PBc subfamily: conservation of intron locations in the phenobarbital-inducible family."
    Govind S., Bell P.A.
    DNA 5:371-382(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.

Entry informationi

Entry nameiCP2C2_RABIT
AccessioniPrimary (citable) accession number: P00181
Secondary accession number(s): Q28683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3