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P00181

- CP2C2_RABIT

UniProt

P00181 - CP2C2_RABIT

Protein

Cytochrome P450 2C2

Gene

CYP2C2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. protein binding Source: IntAct

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC2
    Cytochrome P450 PBc2
    Cytochrome P450 PHP2
    Laurate omega-1 hydroxylase
    Gene namesi
    Name:CYP2C2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C2PRO_0000051693Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INSIG1O155033EBI-4320576,EBI-6252425From a different organism.
    PGRMC1O002646EBI-4320576,EBI-1045534From a different organism.
    PORP164354EBI-4320576,EBI-726554From a different organism.

    Protein-protein interaction databases

    IntActiP00181. 27 interactions.
    STRINGi9986.ENSOCUP00000013127.

    Structurei

    3D structure databases

    ProteinModelPortaliP00181.
    SMRiP00181. Positions 28-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00181-1 [UniParc]FASTAAdd to Basket

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    MDLVVVLGLC LSCLLLPSLW KQSHGGGKLP PGPTPFPILG NVLQLDFKDL    50
    SKSLTNLSKV YGPVFTVYLG MKPTVVVHGY EAVKEALVDL GHELSGRSRF 100
    LVTAKLNKGF GVIFSNGKRW TETRRFSLMT LRNFGMGKRS IEERVQEEAH 150
    CLVEELRKTN ASPCDPTFIL GAAPCNVICS VIFQNRFDYT DQDFLSLMGK 200
    FNENFKILNS PWVQFCNCFP ILFDYFPGSH RKAVKNIFYV KNYITEQIKE 250
    HQKSLDINNP RDFIDCFLIK MEQEKCNQQS EFTIENLLTT VSDVFMAGTE 300
    TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA 350
    TVHEIQRYIN LIPNNVPHTT ICNLKFRNYL IPKGTDVLTS LSSVLHDDKE 400
    FPNPDRFDPG HFLDASGNFR KSDYFMPFST GKRVCVGEAL ARMELFLFLT 450
    AILQNFTPKP LVNPNNVDEN PFSSGIVRVP PLYRVSFIPV 490
    Length:490
    Mass (Da):55,776
    Last modified:July 1, 1989 - v2
    Checksum:iC105A6C6F3687E23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171P → L in AAA31210. (PubMed:6546520)Curated
    Sequence conflicti17 – 171P → L in AAA31208. (PubMed:3780371)Curated
    Sequence conflicti471 – 4711P → L in AAA31210. (PubMed:6546520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19137 mRNA. Translation: AAA31217.1.
    K01521 mRNA. Translation: AAA31210.1.
    M14955 Genomic DNA. Translation: AAA31208.1.
    PIRiA27718. O4RBP2.
    RefSeqiNP_001164584.1. NM_001171113.1.
    UniGeneiOcu.1850.

    Genome annotation databases

    GeneIDi100328924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19137 mRNA. Translation: AAA31217.1 .
    K01521 mRNA. Translation: AAA31210.1 .
    M14955 Genomic DNA. Translation: AAA31208.1 .
    PIRi A27718. O4RBP2.
    RefSeqi NP_001164584.1. NM_001171113.1.
    UniGenei Ocu.1850.

    3D structure databases

    ProteinModelPortali P00181.
    SMRi P00181. Positions 28-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00181. 27 interactions.
    STRINGi 9986.ENSOCUP00000013127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328924.

    Organism-specific databases

    CTDi 100328924.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits."
      Imai Y., Komori M., Sato R.
      Biochemistry 27:80-88(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
      Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
      Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-490.
    3. "Structure of genes in the cytochrome P-450PBc subfamily: conservation of intron locations in the phenobarbital-inducible family."
      Govind S., Bell P.A.
      DNA 5:371-382(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.

    Entry informationi

    Entry nameiCP2C2_RABIT
    AccessioniPrimary (citable) accession number: P00181
    Secondary accession number(s): Q28683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3