Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00181 (CP2C2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C2

EC=1.14.14.1
Alternative name(s):
CYPIIC2
Cytochrome P450 PBc2
Cytochrome P450 PHP2
Laurate omega-1 hydroxylase
Gene names
Name:CYP2C2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

INSIG1O155033EBI-4320576,EBI-6252425From a different organism.
PGRMC1O002646EBI-4320576,EBI-1045534From a different organism.
PORP164354EBI-4320576,EBI-726554From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C2
PRO_0000051693

Sites

Metal binding4351Iron (heme axial ligand)

Experimental info

Sequence conflict171P → L in AAA31210. Ref.2
Sequence conflict171P → L in AAA31208. Ref.3
Sequence conflict4711P → L in AAA31210. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P00181 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: C105A6C6F3687E23

FASTA49055,776
        10         20         30         40         50         60 
MDLVVVLGLC LSCLLLPSLW KQSHGGGKLP PGPTPFPILG NVLQLDFKDL SKSLTNLSKV 

        70         80         90        100        110        120 
YGPVFTVYLG MKPTVVVHGY EAVKEALVDL GHELSGRSRF LVTAKLNKGF GVIFSNGKRW 

       130        140        150        160        170        180 
TETRRFSLMT LRNFGMGKRS IEERVQEEAH CLVEELRKTN ASPCDPTFIL GAAPCNVICS 

       190        200        210        220        230        240 
VIFQNRFDYT DQDFLSLMGK FNENFKILNS PWVQFCNCFP ILFDYFPGSH RKAVKNIFYV 

       250        260        270        280        290        300 
KNYITEQIKE HQKSLDINNP RDFIDCFLIK MEQEKCNQQS EFTIENLLTT VSDVFMAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA TVHEIQRYIN 

       370        380        390        400        410        420 
LIPNNVPHTT ICNLKFRNYL IPKGTDVLTS LSSVLHDDKE FPNPDRFDPG HFLDASGNFR 

       430        440        450        460        470        480 
KSDYFMPFST GKRVCVGEAL ARMELFLFLT AILQNFTPKP LVNPNNVDEN PFSSGIVRVP 

       490 
PLYRVSFIPV 

« Hide

References

[1]"Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits."
Imai Y., Komori M., Sato R.
Biochemistry 27:80-88(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-490.
[3]"Structure of genes in the cytochrome P-450PBc subfamily: conservation of intron locations in the phenobarbital-inducible family."
Govind S., Bell P.A.
DNA 5:371-382(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19137 mRNA. Translation: AAA31217.1.
K01521 mRNA. Translation: AAA31210.1.
M14955 Genomic DNA. Translation: AAA31208.1.
PIRO4RBP2. A27718.
RefSeqNP_001164584.1. NM_001171113.1.
UniGeneOcu.1850.

3D structure databases

ProteinModelPortalP00181.
SMRP00181. Positions 28-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00181. 27 interactions.
STRING9986.ENSOCUP00000013127.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328924.

Organism-specific databases

CTD100328924.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2C2_RABIT
AccessionPrimary (citable) accession number: P00181
Secondary accession number(s): Q28683
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families