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P00180 (CP2C1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C1

EC=1.14.14.1
Alternative name(s):
CYPIIC1
Cytochrome P-450 IIC1
Cytochrome P450 PBc1
Gene names
Name:CYP2C1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

INSIG1O155032EBI-6251821,EBI-6252425From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C1
PRO_0000051692

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P00180 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 2054D538A83E7D17

FASTA49055,615
        10         20         30         40         50         60 
MDPVVVLGLC LSCLLLLSLW KQSYGGGKLP PGPTPFPILG NILQIGIQDI SKSFTKLSEV 

        70         80         90        100        110        120 
YGPVFTVYLG MKPTVVIHGY DAVKEALVDL GEEFSGRIVF PLTAKINKGY GIVFSNGKRW 

       130        140        150        160        170        180 
KETRRFSLMT LRDFGMGKRS IEDRVQEEAR CLVEELRKTN GSPCNPTFIL GAAPCNVICS 

       190        200        210        220        230        240 
VIFQNRFDYT DQDFLSLMGK LNENFKILNS PWVQMCNNFP ILIDYLPGSH NKILRNNIYI 

       250        260        270        280        290        300 
RNYVLEKIKE HQETLDINNP RDFIDCFLIK MEQEKDNQQS EFTIENLMTT LSDVFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA TVHEIQRYIN 

       370        380        390        400        410        420 
LIPNNVPRAT TCNVKFRSYL IPKGTAVITS LTSMLYNDKE FPNPDRFDPG HFLDASGKFR 

       430        440        450        460        470        480 
KSDYFMPFST GKRVCVGEVL ARMELFLFLT AILQNFTPKP LVDPKDIDTT PLVSGLGRVP 

       490 
PLYQLSFIPA 

« Hide

References

[1]"Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: New Zealand white.
Tissue: Liver.
[2]"Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74199 Genomic DNA. Translation: AAA31436.1.
K01522 mRNA. Translation: AAA31211.1.
PIRO4RBP1. A00181.
UniGeneOcu.1851.

3D structure databases

ProteinModelPortalP00180.
SMRP00180. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00180. 2 interactions.
STRING9986.ENSOCUP00000019969.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2C1_RABIT
AccessionPrimary (citable) accession number: P00180
Secondary accession number(s): Q00172
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families