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P00180

- CP2C1_RABIT

UniProt

P00180 - CP2C1_RABIT

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Protein

Cytochrome P450 2C1

Gene

CYP2C1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C1 (EC:1.14.14.1)
Alternative name(s):
CYPIIC1
Cytochrome P-450 IIC1
Cytochrome P450 PBc1
Gene namesi
Name:CYP2C1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C1PRO_0000051692Add
BLAST

Expressioni

Inductioni

By phenobarbital.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INSIG1O155032EBI-6251821,EBI-6252425From a different organism.

Protein-protein interaction databases

IntActiP00180. 2 interactions.
STRINGi9986.ENSOCUP00000019969.

Structurei

3D structure databases

ProteinModelPortaliP00180.
SMRiP00180. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00180.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00180-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVVVLGLC LSCLLLLSLW KQSYGGGKLP PGPTPFPILG NILQIGIQDI
60 70 80 90 100
SKSFTKLSEV YGPVFTVYLG MKPTVVIHGY DAVKEALVDL GEEFSGRIVF
110 120 130 140 150
PLTAKINKGY GIVFSNGKRW KETRRFSLMT LRDFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCNPTFIL GAAPCNVICS VIFQNRFDYT DQDFLSLMGK
210 220 230 240 250
LNENFKILNS PWVQMCNNFP ILIDYLPGSH NKILRNNIYI RNYVLEKIKE
260 270 280 290 300
HQETLDINNP RDFIDCFLIK MEQEKDNQQS EFTIENLMTT LSDVFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
TVHEIQRYIN LIPNNVPRAT TCNVKFRSYL IPKGTAVITS LTSMLYNDKE
410 420 430 440 450
FPNPDRFDPG HFLDASGKFR KSDYFMPFST GKRVCVGEVL ARMELFLFLT
460 470 480 490
AILQNFTPKP LVDPKDIDTT PLVSGLGRVP PLYQLSFIPA
Length:490
Mass (Da):55,615
Last modified:February 1, 2005 - v2
Checksum:i2054D538A83E7D17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74199 Genomic DNA. Translation: AAA31436.1.
K01522 mRNA. Translation: AAA31211.1.
PIRiA00181. O4RBP1.
UniGeneiOcu.1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74199 Genomic DNA. Translation: AAA31436.1 .
K01522 mRNA. Translation: AAA31211.1 .
PIRi A00181. O4RBP1.
UniGenei Ocu.1851.

3D structure databases

ProteinModelPortali P00180.
SMRi P00180. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00180. 2 interactions.
STRINGi 9986.ENSOCUP00000019969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P00180.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
    Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
    DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: New Zealand white.
    Tissue: Liver.
  2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
    Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
    Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490.

Entry informationi

Entry nameiCP2C1_RABIT
AccessioniPrimary (citable) accession number: P00180
Secondary accession number(s): Q00172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3