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Protein

Cytochrome P450 2C1

Gene

CYP2C1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C1 (EC:1.14.14.1)
Alternative name(s):
CYPIIC1
Cytochrome P-450 IIC1
Cytochrome P450 PBc1
Gene namesi
Name:CYP2C1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C1PRO_0000051692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Inductioni

By phenobarbital.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
INSIG1O155032EBI-6251821,EBI-6252425From a different organism.

Protein-protein interaction databases

IntActiP00180. 2 interactions.
STRINGi9986.ENSOCUP00000019969.

Structurei

3D structure databases

ProteinModelPortaliP00180.
SMRiP00180. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00180.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVVVLGLC LSCLLLLSLW KQSYGGGKLP PGPTPFPILG NILQIGIQDI
60 70 80 90 100
SKSFTKLSEV YGPVFTVYLG MKPTVVIHGY DAVKEALVDL GEEFSGRIVF
110 120 130 140 150
PLTAKINKGY GIVFSNGKRW KETRRFSLMT LRDFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCNPTFIL GAAPCNVICS VIFQNRFDYT DQDFLSLMGK
210 220 230 240 250
LNENFKILNS PWVQMCNNFP ILIDYLPGSH NKILRNNIYI RNYVLEKIKE
260 270 280 290 300
HQETLDINNP RDFIDCFLIK MEQEKDNQQS EFTIENLMTT LSDVFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
TVHEIQRYIN LIPNNVPRAT TCNVKFRSYL IPKGTAVITS LTSMLYNDKE
410 420 430 440 450
FPNPDRFDPG HFLDASGKFR KSDYFMPFST GKRVCVGEVL ARMELFLFLT
460 470 480 490
AILQNFTPKP LVDPKDIDTT PLVSGLGRVP PLYQLSFIPA
Length:490
Mass (Da):55,615
Last modified:January 31, 2005 - v2
Checksum:i2054D538A83E7D17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74199 Genomic DNA. Translation: AAA31436.1.
K01522 mRNA. Translation: AAA31211.1.
PIRiA00181. O4RBP1.
UniGeneiOcu.1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74199 Genomic DNA. Translation: AAA31436.1.
K01522 mRNA. Translation: AAA31211.1.
PIRiA00181. O4RBP1.
UniGeneiOcu.1851.

3D structure databases

ProteinModelPortaliP00180.
SMRiP00180. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00180. 2 interactions.
STRINGi9986.ENSOCUP00000019969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00180.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
    Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
    DNA Cell Biol. 9:37-48(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: New Zealand white.
    Tissue: Liver.
  2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
    Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
    Biochemistry 23:204-210(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490.

Entry informationi

Entry nameiCP2C1_RABIT
AccessioniPrimary (citable) accession number: P00180
Secondary accession number(s): Q00172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: January 31, 2005
Last modified: March 3, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.