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P00180

- CP2C1_RABIT

UniProt

P00180 - CP2C1_RABIT

Protein

Cytochrome P450 2C1

Gene

CYP2C1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. protein binding Source: IntAct

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC1
    Cytochrome P-450 IIC1
    Cytochrome P450 PBc1
    Gene namesi
    Name:CYP2C1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C1PRO_0000051692Add
    BLAST

    Expressioni

    Inductioni

    By phenobarbital.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INSIG1O155032EBI-6251821,EBI-6252425From a different organism.

    Protein-protein interaction databases

    IntActiP00180. 2 interactions.
    STRINGi9986.ENSOCUP00000019969.

    Structurei

    3D structure databases

    ProteinModelPortaliP00180.
    SMRiP00180. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVVVLGLC LSCLLLLSLW KQSYGGGKLP PGPTPFPILG NILQIGIQDI    50
    SKSFTKLSEV YGPVFTVYLG MKPTVVIHGY DAVKEALVDL GEEFSGRIVF 100
    PLTAKINKGY GIVFSNGKRW KETRRFSLMT LRDFGMGKRS IEDRVQEEAR 150
    CLVEELRKTN GSPCNPTFIL GAAPCNVICS VIFQNRFDYT DQDFLSLMGK 200
    LNENFKILNS PWVQMCNNFP ILIDYLPGSH NKILRNNIYI RNYVLEKIKE 250
    HQETLDINNP RDFIDCFLIK MEQEKDNQQS EFTIENLMTT LSDVFGAGTE 300
    TTSTTLRYGL LLLMKHPEVI AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA 350
    TVHEIQRYIN LIPNNVPRAT TCNVKFRSYL IPKGTAVITS LTSMLYNDKE 400
    FPNPDRFDPG HFLDASGKFR KSDYFMPFST GKRVCVGEVL ARMELFLFLT 450
    AILQNFTPKP LVDPKDIDTT PLVSGLGRVP PLYQLSFIPA 490
    Length:490
    Mass (Da):55,615
    Last modified:February 1, 2005 - v2
    Checksum:i2054D538A83E7D17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74199 Genomic DNA. Translation: AAA31436.1.
    K01522 mRNA. Translation: AAA31211.1.
    PIRiA00181. O4RBP1.
    UniGeneiOcu.1851.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74199 Genomic DNA. Translation: AAA31436.1 .
    K01522 mRNA. Translation: AAA31211.1 .
    PIRi A00181. O4RBP1.
    UniGenei Ocu.1851.

    3D structure databases

    ProteinModelPortali P00180.
    SMRi P00180. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00180. 2 interactions.
    STRINGi 9986.ENSOCUP00000019969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes."
      Zhao J., Chan G., Govind S., Bell P., Kemper B.W.
      DNA Cell Biol. 9:37-48(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: New Zealand white.
      Tissue: Liver.
    2. "Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form."
      Leighton J.K., Debrunner-Vossbrinck B.A., Kemper B.
      Biochemistry 23:204-210(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490.

    Entry informationi

    Entry nameiCP2C1_RABIT
    AccessioniPrimary (citable) accession number: P00180
    Secondary accession number(s): Q00172
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3