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Protein

Cytochrome P450 2C5

Gene

CYP2C5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi432Iron (heme axial ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP00179.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C5 (EC:1.14.14.1)
Alternative name(s):
CYPIIC5
Cytochrome P450 1
Cytochrome P450IIC5
Progesterone 21-hydroxylase
Gene namesi
Name:CYP2C5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516961 – 487Cytochrome P450 2C5Add BLAST487

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020892.

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Helixi42 – 44Combined sources3
Helixi50 – 61Combined sources12
Beta strandi63 – 77Combined sources15
Helixi80 – 87Combined sources8
Turni88 – 94Combined sources7
Beta strandi95 – 97Combined sources3
Helixi103 – 107Combined sources5
Beta strandi111 – 114Combined sources4
Helixi117 – 130Combined sources14
Turni133 – 136Combined sources4
Beta strandi137 – 139Combined sources3
Helixi141 – 157Combined sources17
Turni158 – 161Combined sources4
Helixi167 – 183Combined sources17
Helixi192 – 207Combined sources16
Helixi214 – 217Combined sources4
Helixi220 – 225Combined sources6
Helixi227 – 254Combined sources28
Helixi263 – 272Combined sources10
Beta strandi273 – 275Combined sources3
Helixi281 – 312Combined sources32
Helixi314 – 327Combined sources14
Beta strandi330 – 332Combined sources3
Helixi336 – 341Combined sources6
Helixi343 – 356Combined sources14
Beta strandi371 – 373Combined sources3
Beta strandi376 – 378Combined sources3
Beta strandi383 – 386Combined sources4
Helixi388 – 392Combined sources5
Turni395 – 397Combined sources3
Beta strandi398 – 400Combined sources3
Helixi406 – 409Combined sources4
Beta strandi412 – 415Combined sources4
Helixi428 – 430Combined sources3
Helixi435 – 452Combined sources18
Beta strandi453 – 459Combined sources7
Helixi461 – 463Combined sources3
Beta strandi472 – 476Combined sources5
Beta strandi482 – 486Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT6X-ray3.00A22-487[»]
1N6BX-ray2.30A19-487[»]
1NR6X-ray2.10A19-487[»]
ProteinModelPortaliP00179.
SMRiP00179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00179.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00179.
KOiK07413.
OMAiHTWREIR.
OrthoDBiEOG091G0BT8.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVVVLVLG LCCLLLLSIW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI
60 70 80 90 100
SKSLTKFSEC YGPVFTVYLG MKPTVVLHGY EAVKEALVDL GEEFAGRGSV
110 120 130 140 150
PILEKVSKGL GIAFSNAKTW KEMRRFSLMT LRNFGMGKRS IEDRIQEEAR
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHNRFDYK DEEFLKLMES
210 220 230 240 250
LNENVRILSS PWLQVYNNFP ALLDYFPGIH KTLLKNADYI KNFIMEKVKE
260 270 280 290 300
HQKLLDVNNP RDFIDCFLIK MEQENNLEFT LESLVIAVSD LFGAGTETTS
310 320 330 340 350
TTLRYSLLLL LKHPEVAARV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH
360 370 380 390 400
EIQRFIDLLP TNLPHAVTRD VRFRNYFIPK GTDIITSLTS VLHDEKAFPN
410 420 430 440 450
PKVFDPGHFL DESGNFKKSD YFMPFSAGKR MCVGEGLARM ELFLFLTSIL
460 470 480
QNFKLQSLVE PKDLDITAVV NGFVSVPPSY QLCFIPI
Length:487
Mass (Da):55,275
Last modified:September 5, 2006 - v2
Checksum:iED67B2E255DF5EA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97R → T in AAA31209 (PubMed:3902818).Curated1
Sequence conflicti252Q → E in AAA31209 (PubMed:3902818).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11299 mRNA. Translation: AAA31209.1.
M55664 mRNA. Translation: AAA63461.1.
PIRiA00180. O4RBP4.
RefSeqiNP_001164397.1. NM_001170926.1.
UniGeneiOcu.1857.

Genome annotation databases

EnsembliENSOCUT00000021366; ENSOCUP00000020892; ENSOCUG00000021501.
GeneIDi100328549.
KEGGiocu:100328549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11299 mRNA. Translation: AAA31209.1.
M55664 mRNA. Translation: AAA63461.1.
PIRiA00180. O4RBP4.
RefSeqiNP_001164397.1. NM_001170926.1.
UniGeneiOcu.1857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DT6X-ray3.00A22-487[»]
1N6BX-ray2.30A19-487[»]
1NR6X-ray2.10A19-487[»]
ProteinModelPortaliP00179.
SMRiP00179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020892.

Chemistry databases

ChEMBLiCHEMBL1907985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000021366; ENSOCUP00000020892; ENSOCUG00000021501.
GeneIDi100328549.
KEGGiocu:100328549.

Organism-specific databases

CTDi100328549.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP00179.
KOiK07413.
OMAiHTWREIR.
OrthoDBiEOG091G0BT8.
TreeFamiTF352043.

Enzyme and pathway databases

SABIO-RKP00179.

Miscellaneous databases

EvolutionaryTraceiP00179.
PROiP00179.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C5_RABIT
AccessioniPrimary (citable) accession number: P00179
Secondary accession number(s): Q29511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.