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P00158

- CYB_MOUSE

UniProt

P00158 - CYB_MOUSE

Protein

Cytochrome b

Gene

Mt-Cyb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Iron 1 (heme b562 axial ligand)
    Metal bindingi97 – 971Iron 2 (heme b566 axial ligand)
    Metal bindingi182 – 1821Iron 1 (heme b562 axial ligand)
    Metal bindingi196 – 1961Iron 2 (heme b566 axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. respiratory electron transport chain Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b
    Alternative name(s):
    Complex III subunit 3
    Complex III subunit III
    Cytochrome b-c1 complex subunit 3
    Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
    Gene namesi
    Name:Mt-Cyb
    Synonyms:Cob, Cytb, mt-Cytb, Mtcyb
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102501. mt-Cytb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI
    5. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Cytochrome bPRO_0000061211Add
    BLAST

    Proteomic databases

    PaxDbiP00158.
    PRIDEiP00158.

    PTM databases

    PhosphoSiteiP00158.

    Expressioni

    Gene expression databases

    BgeeiP00158.
    GenevestigatoriP00158.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

    Protein-protein interaction databases

    IntActiP00158. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP00158.
    SMRiP00158. Positions 15-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome b family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1290.
    HOGENOMiHOG000255206.
    HOVERGENiHBG017694.
    InParanoidiP00158.
    KOiK00412.
    OMAiALVIVHI.
    OrthoDBiEOG7BGHKX.
    PhylomeDBiP00158.
    TreeFamiTF353088.

    Family and domain databases

    Gene3Di1.20.810.10. 1 hit.
    InterProiIPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view]
    PfamiPF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEiPS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00158-1 [UniParc]FASTAAdd to Basket

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    MTNMRKTHPL FKIINHSFID LPAPSNISSW WNFGSLLGVC LMVQIITGLF    50
    LAMHYTSDTM TAFSSVTHIC RDVNYGWLIR YMHANGASMF FICLFLHVGR 100
    GLYYGSYTFM ETWNIGVLLL FAVMATAFMG YVLPWGQMSF WGATVITNLL 150
    SAIPYIGTTL VEWIWGGFSV DKATLTRFFA FHFILPFIIA ALAIVHLLFL 200
    HETGSNNPTG LNSDADKIPF HPYYTIKDIL GILIMFLILM TLVLFFPDML 250
    GDPDNYMPAN PLNTPPHIKP EWYFLFAYAI LRSIPNKLGG VLALILSILI 300
    LALMPFLHTS KQRSLMFRPI TQILYWILVA NLLILTWIGG QPVEHPFIII 350
    GQLASISYFS IILILMPISG IIEDKMLKLY P 381
    Length:381
    Mass (Da):43,210
    Last modified:July 21, 1986 - v1
    Checksum:i6B46D5B1DD8E001A
    GO

    Sequence cautioni

    The sequence CAA24092.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48656.1.
    V00711 Genomic DNA. Translation: CAA24092.1. Different initiation.
    X57780 mRNA. Translation: CAA40926.1.
    PIRiA00153. CBMS.
    RefSeqiNP_904340.1. NC_005089.1.

    Genome annotation databases

    EnsembliENSMUST00000082421; ENSMUSP00000081003; ENSMUSG00000064370.
    GeneIDi17711.
    KEGGimmu:17711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48656.1 .
    V00711 Genomic DNA. Translation: CAA24092.1 . Different initiation.
    X57780 mRNA. Translation: CAA40926.1 .
    PIRi A00153. CBMS.
    RefSeqi NP_904340.1. NC_005089.1.

    3D structure databases

    ProteinModelPortali P00158.
    SMRi P00158. Positions 15-378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00158. 1 interaction.

    PTM databases

    PhosphoSitei P00158.

    Proteomic databases

    PaxDbi P00158.
    PRIDEi P00158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082421 ; ENSMUSP00000081003 ; ENSMUSG00000064370 .
    GeneIDi 17711.
    KEGGi mmu:17711.

    Organism-specific databases

    CTDi 4519.
    MGIi MGI:102501. mt-Cytb.

    Phylogenomic databases

    eggNOGi COG1290.
    HOGENOMi HOG000255206.
    HOVERGENi HBG017694.
    InParanoidi P00158.
    KOi K00412.
    OMAi ALVIVHI.
    OrthoDBi EOG7BGHKX.
    PhylomeDBi P00158.
    TreeFami TF353088.

    Miscellaneous databases

    NextBioi 292321.
    PROi P00158.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00158.
    Genevestigatori P00158.

    Family and domain databases

    Gene3Di 1.20.810.10. 1 hit.
    InterProi IPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view ]
    Pfami PF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEi PS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses."
      Shan B., Vazquez E., Lewis J.A.
      EMBO J. 9:4307-4314(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-381.

    Entry informationi

    Entry nameiCYB_MOUSE
    AccessioniPrimary (citable) accession number: P00158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3