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P00158

- CYB_MOUSE

UniProt

P00158 - CYB_MOUSE

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Protein

Cytochrome b

Gene

Mt-Cyb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron 1 (heme b562 axial ligand)
Metal bindingi97 – 971Iron 2 (heme b566 axial ligand)
Metal bindingi182 – 1821Iron 1 (heme b562 axial ligand)
Metal bindingi196 – 1961Iron 2 (heme b566 axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:Mt-Cyb
Synonyms:Cob, Cytb, mt-Cytb, Mtcyb
Encoded oniMitochondrion
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102501. mt-Cytb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
  5. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Cytochrome bPRO_0000061211Add
BLAST

Proteomic databases

MaxQBiP00158.
PaxDbiP00158.
PRIDEiP00158.

PTM databases

PhosphoSiteiP00158.

Expressioni

Gene expression databases

BgeeiP00158.
ExpressionAtlasiP00158. baseline and differential.
GenevestigatoriP00158.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

IntActiP00158. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP00158.
SMRiP00158. Positions 15-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1290.
HOGENOMiHOG000255206.
HOVERGENiHBG017694.
InParanoidiP00158.
KOiK00412.
OMAiALVIVHI.
OrthoDBiEOG7BGHKX.
PhylomeDBiP00158.
TreeFamiTF353088.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00158-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNMRKTHPL FKIINHSFID LPAPSNISSW WNFGSLLGVC LMVQIITGLF
60 70 80 90 100
LAMHYTSDTM TAFSSVTHIC RDVNYGWLIR YMHANGASMF FICLFLHVGR
110 120 130 140 150
GLYYGSYTFM ETWNIGVLLL FAVMATAFMG YVLPWGQMSF WGATVITNLL
160 170 180 190 200
SAIPYIGTTL VEWIWGGFSV DKATLTRFFA FHFILPFIIA ALAIVHLLFL
210 220 230 240 250
HETGSNNPTG LNSDADKIPF HPYYTIKDIL GILIMFLILM TLVLFFPDML
260 270 280 290 300
GDPDNYMPAN PLNTPPHIKP EWYFLFAYAI LRSIPNKLGG VLALILSILI
310 320 330 340 350
LALMPFLHTS KQRSLMFRPI TQILYWILVA NLLILTWIGG QPVEHPFIII
360 370 380
GQLASISYFS IILILMPISG IIEDKMLKLY P
Length:381
Mass (Da):43,210
Last modified:July 21, 1986 - v1
Checksum:i6B46D5B1DD8E001A
GO

Sequence cautioni

The sequence CAA24092.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48656.1.
V00711 Genomic DNA. Translation: CAA24092.1. Different initiation.
X57780 mRNA. Translation: CAA40926.1.
PIRiA00153. CBMS.
RefSeqiNP_904340.1. NC_005089.1.

Genome annotation databases

EnsembliENSMUST00000082421; ENSMUSP00000081003; ENSMUSG00000064370.
GeneIDi17711.
KEGGimmu:17711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01420 Genomic DNA. Translation: AAB48656.1 .
V00711 Genomic DNA. Translation: CAA24092.1 . Different initiation.
X57780 mRNA. Translation: CAA40926.1 .
PIRi A00153. CBMS.
RefSeqi NP_904340.1. NC_005089.1.

3D structure databases

ProteinModelPortali P00158.
SMRi P00158. Positions 15-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00158. 1 interaction.

PTM databases

PhosphoSitei P00158.

Proteomic databases

MaxQBi P00158.
PaxDbi P00158.
PRIDEi P00158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082421 ; ENSMUSP00000081003 ; ENSMUSG00000064370 .
GeneIDi 17711.
KEGGi mmu:17711.

Organism-specific databases

CTDi 4519.
MGIi MGI:102501. mt-Cytb.

Phylogenomic databases

eggNOGi COG1290.
HOGENOMi HOG000255206.
HOVERGENi HBG017694.
InParanoidi P00158.
KOi K00412.
OMAi ALVIVHI.
OrthoDBi EOG7BGHKX.
PhylomeDBi P00158.
TreeFami TF353088.

Enzyme and pathway databases

Reactomei REACT_262523. Respiratory electron transport.

Miscellaneous databases

NextBioi 292321.
PROi P00158.
SOURCEi Search...

Gene expression databases

Bgeei P00158.
ExpressionAtlasi P00158. baseline and differential.
Genevestigatori P00158.

Family and domain databases

Gene3Di 1.20.810.10. 1 hit.
InterProi IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view ]
Pfami PF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEi PS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and gene organization of mouse mitochondrial DNA."
    Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
    Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses."
    Shan B., Vazquez E., Lewis J.A.
    EMBO J. 9:4307-4314(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-381.

Entry informationi

Entry nameiCYB_MOUSE
AccessioniPrimary (citable) accession number: P00158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3