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P00158 (CYB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:Mt-Cyb
Synonyms:Cob, Cytb, mt-Cytb, Mtcyb
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence caution

The sequence CAA24092.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Cytochrome b
PRO_0000061211

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane348 – 36821Helical; Potential

Sites

Metal binding831Iron 1 (heme b562 axial ligand)
Metal binding971Iron 2 (heme b566 axial ligand)
Metal binding1821Iron 1 (heme b562 axial ligand)
Metal binding1961Iron 2 (heme b566 axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P00158 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 6B46D5B1DD8E001A

FASTA38143,210
        10         20         30         40         50         60 
MTNMRKTHPL FKIINHSFID LPAPSNISSW WNFGSLLGVC LMVQIITGLF LAMHYTSDTM 

        70         80         90        100        110        120 
TAFSSVTHIC RDVNYGWLIR YMHANGASMF FICLFLHVGR GLYYGSYTFM ETWNIGVLLL 

       130        140        150        160        170        180 
FAVMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTTL VEWIWGGFSV DKATLTRFFA 

       190        200        210        220        230        240 
FHFILPFIIA ALAIVHLLFL HETGSNNPTG LNSDADKIPF HPYYTIKDIL GILIMFLILM 

       250        260        270        280        290        300 
TLVLFFPDML GDPDNYMPAN PLNTPPHIKP EWYFLFAYAI LRSIPNKLGG VLALILSILI 

       310        320        330        340        350        360 
LALMPFLHTS KQRSLMFRPI TQILYWILVA NLLILTWIGG QPVEHPFIII GQLASISYFS 

       370        380 
IILILMPISG IIEDKMLKLY P 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses."
Shan B., Vazquez E., Lewis J.A.
EMBO J. 9:4307-4314(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-381.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48656.1.
V00711 Genomic DNA. Translation: CAA24092.1. Different initiation.
X57780 mRNA. Translation: CAA40926.1.
PIRCBMS. A00153.
RefSeqNP_904340.1. NC_005089.1.

3D structure databases

ProteinModelPortalP00158.
SMRP00158. Positions 15-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00158. 1 interaction.

PTM databases

PhosphoSiteP00158.

Proteomic databases

PaxDbP00158.
PRIDEP00158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082421; ENSMUSP00000081003; ENSMUSG00000064370.
GeneID17711.
KEGGmmu:17711.

Organism-specific databases

CTD4519.
MGIMGI:102501. mt-Cytb.

Phylogenomic databases

eggNOGCOG1290.
HOGENOMHOG000255206.
HOVERGENHBG017694.
InParanoidP00158.
KOK00412.
OMAALVIVHI.
OrthoDBEOG7BGHKX.
PhylomeDBP00158.
TreeFamTF353088.

Gene expression databases

BgeeP00158.
GenevestigatorP00158.

Family and domain databases

Gene3D1.20.810.10. 1 hit.
InterProIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292321.
PROP00158.
SOURCESearch...

Entry information

Entry nameCYB_MOUSE
AccessionPrimary (citable) accession number: P00158
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot